GEISHA - A Chicken Embryo Gene Expression Database
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SMAD3
SMAD family member 3

The human orthologue of this gene is associated
with the following human disease:
Gene
Official SymbolSMAD3
Official Full NameSMAD family member 3
CGNC ID5954
also known asmothers against decapentaplegic homolog 3|MAD homolog 3|SMAD 3|SMAD, mothers against DPP homolog 3|TGF-beta response effector Smad3|mad3|mothers against DPP homolog 3, SMAD3
gene typeprotein-coding
Genomic Map
 Ensembl ID not known
NCBI
UCSC
Gallus-Browse
Sequence Information
Genomic
RNANM_204475
PolypeptideNP_989806
Sequence Clusters/ESTsUnigene
Gene Expression
In Situ HybridizationGEISHA
EST ProfileGga.28197
Orthology
Entrez GeneEnsembl GeneGenetic PhenotypesMOD
Fruit Fly31738FBgn0025800
Human4088ENSG00000166949MIM:613795MIM:603109
Mouse17127ENSMUSG00000032402All phenotypic alleles (7):Targeted, knock-out(3) Targeted, other(4) MGI:1201674
Xenopus493272, 378633481991
Zebrafish326283, 58092ENSDARG00000010207, ENSDARG00000036096ZDB-GENE-030128-4, ZDB-GENE-000509-3ZFIN:ZDB-GENE-030128-4, ZFIN:ZDB-GENE-000509-3
Gene Ontology
Molecular Functionbeta-catenin binding, chromatin DNA binding, core promoter proximal region sequence-specific DNA binding, more...co-SMAD binding, phosphatase binding, protein binding transcription factor activity, protein homodimerization activity, protein kinase binding, RNA polymerase II activating transcription factor binding, R-SMAD binding, sequence-specific DNA binding transcription factor activity, transforming growth factor beta receptor binding, transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity, ubiquitin binding, ubiquitin protein ligase binding, zinc ion binding
Biological Processactivation of cysteine-type endopeptidase activity involved in apoptotic process, more...cell-cell junction organization, cell cycle arrest, evasion or tolerance of host defenses by virus, extrinsic apoptotic signaling pathway, immune response, negative regulation of cell growth, negative regulation of inflammatory response, negative regulation of mitotic cell cycle, negative regulation of osteoblast proliferation, negative regulation of protein catabolic process, negative regulation of protein phosphorylation, negative regulation of wound healing, nodal signaling pathway, osteoblast differentiation, positive regulation of canonical Wnt signaling pathway, positive regulation of catenin import into nucleus, positive regulation of chondrocyte differentiation, positive regulation of epithelial to mesenchymal transition, positive regulation of gene expression involved in extracellular matrix organization, positive regulation of transcription, DNA-templated, positive regulation of transcription factor import into nucleus, protein stabilization, regulation of immune response, regulation of transforming growth factor beta2 production, response to hypoxia, T cell activation, transcription, DNA-templated, transforming growth factor beta receptor signaling pathway, transport, ureteric bud development
Cellular Componentcytoplasm, nuclear inner membrane, nucleus, receptor complex, SMAD protein complex, more...transcription factor complex
Links to other databases
Entrez Gene395132
Ensembl Gene
KEGGgga:395132

Entry 1

GEISHA IdChEST553l8Data SourceGEISHA ISH Analysis
Forward cDNA Template Probeshow
GGCGGCTCGAGATTCGGATGAGCTTCGTCAAGGGTTGGGGAGCAGAATACAGGCGGCAGACGGTGACCAGCACTCCCTG
CTGGATTGAGCTGCACCTCAACGGCCCTCTGCAGTGGCTGGACAAGGTCCTCACACAGATGGGCTCCCCGAGCATCCGC
TGCTCCAGCGTCTCCTAAGGAAGCACCTCCTGGGGGCGGGCGGGGGAGCAAAGACTGGAGAGTGGAATTGGCTGAACCC
TTAGCAAAACACATAGAGAAGAGATTCCCAGTTACTGAAGTGATAAGGAGAAACAAATCTGCTCAAATAGTGGCTTTTC
TTGGTTTTGTTTCTTTTTTTTTTTTTTTTTAAACTTAAAGACCCATTGAAGCCACTTCCACTGAAACTGTTAGCACTTT
GGTTACAAGGCTGTGGGCCCTTGCAGTCAGAATGAAGCTGAAGTTTATCATGATAAAAGATGACTTTGTTTCAGCGGAG
ATAAGCCAGTGCTGTGCCTCCAGCCATGGCACGTCCCAGCCGCCCCACGCAGCCCCAGCATCTCCGACAGACACCACGG
GCCTTTGGGATGACTCTTGCTCATGCACTGCTGTCTCCATCCACCTGACGTGTGCCCATTCTTCCTGGGATTGCAGCAG
TAGGTGGAAAAGAAAGCGTGTAAAGCACATGCAAGGATTGATTGCCCGGTATTGCTCCTGAAAGGAACAGATTTCCACA
GTGCACAGCTCACTGAGAGGCAGCGCCTTGCTTTGTGCCCGAGCTGCCACTGTGCCCTGCTTGTCCCAGTCTGGATGTA
CATGAAGCAGAAGGCCAAAGTTACGGCCCTTTCTGACACTGCTGCAGCAACTTTTGACTAGAGCC
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
13-18
stage 18
stage 18
stage 18
stage 18
stage 18
stage 18
Endoderm
Extraembryonic
Face Mesenchyme
Hindbrain
Hindgut
Isthmus/MHB
Lens
Limb Buds
Paraxial Mesoderm
Retina
Somatopleure
Spinal Cord
 
19-21
stage 21
stage 21
Leg AER
Leg Mesenchyme
Spinal Cord
Wing Mesenchyme
 

Entry 2

GEISHA IdSMAD3.GarciaCampmany.2007Data SourcePublication
Complete cDNA Template Probeshow
ATGTCCTCCATCCTGCCGTTCACCCCTCCCATCGTCAAGCGGCTCCTGGGCTGGAAGAAAGGGGAGCAGAACGGGCAGG
AGGAGAAATGGTGCGAGAAGGCGGTGAAGAGCCTGGTGAAGAAGCTGAAGAAGACGGGGCAGCTGGACGAGCTGGAGAA
GGCGATCACCACGCAGAACATCAACACCAAGTGCATCACCATCCCCAGGTCGCTGGATGGCCGGCTGCAGGTGTCCCAC
CGCAAGGGCCTTCCCCATGTCATCTACTGCCGGCTGTGGCGGTGGCCGGACCTGCATAGCCACCATGAGCTGCGGGCCA
TGGAGATGTGCGAGTACGCCTTCAACATGAAGAAGGACGAAGTCTGTGTGAATCCCTATCATTACCAACGAGTGGAGAC
CCCAGTGTTACCCCCAGTGCTGGTGCCTCGGCACACGGAGATCCCAGCTGAGTTCCCACCGTTGGACGATTACAGTCAC
TCTATCCCAGAGAACACTAACTTCCCAGCAGGCATTGAGCCGCAGAGCAACTACATCCCAGAGACACCTCCTCCAGGCT
ATTTGAGTGAGGATGGAGAAACTAGTGACCACCAGATGAACCCCAGCATGGATGCAGGTTCTCCAAACTTATCACCAAA
TCCTATGTCTCCGGCACACAATAATCTGGATCTGCAGCCCGTTACCTACTGCGAGCCGGCGTTCTGGTGCTCCATATCC
TACTATGAACTCAACCAGCGCGTGGGGGAGACGTTCCACGCCTCGCAGCCCTCCATGACCGTGGATGGTTTCACTGACC
CGTCGAATTCTGAACGCTTCTGCCTTGGTCTGCTCTCTAATGTGAACAGGAATGCAGCAGTGGAGCTCACGAGACGGCA
CATCGGAAGAGGAGTGAGGCTGTACTACATTGGTGGCGAGGTGTTTGCTGAGTGCCTTAGTGACAGTGCCATTTTTGTC
CAGTCTCCCAACTGCAACCAGCGCTACGGCTGGCACCCAGCAACAGTCTGCAAGATCCCACCAGGATGTAACTTGAAGA
TTTTTAACAACCAGGAATTCGCAGCTCTCTTGGCTCAGTCTGTAAACCAGGGCTTCGAAGCTGTGTACCAGCTGACCAG
GATGTGCACGATTCGGATGAGCTTCGTCAAGGGTTGGGGAGCAGAATACAGGCGGCAGACGGTGACTAGCACTCCCTGC
TGGATTGAGCTGCACCTCAACGGCCCTCTGCAGTGGCTGGACAAGGTCCTCACACAGATGGGCTCCCCGAGCATCCGCT
GCTCCAGCGTCTCCTAA
CitationGarcía-Campmany L, Martí E. The TGFbeta intracellular effector Smad3 regulates neuronal differentiation and cell fate specification in the developing spinal cord. Development. 2007 Jan;134(1):65-75. Epub 2006 Nov 30.
CopyrightCopyright by the authors. Published by the Company of Biologists Ltd.
CommentsAs insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_204475.1
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
4-6
stage 6
Neural Plate/Tube
HH Stage 6+
7-12
stage 12
stage 12
Spinal Cord
 
13-18
stage 13
stage 18
Spinal Cord
Tail
 
19-24
stage 20
stage 20
Spinal Cord
 
25
stage 25
stage 25
Spinal Cord
 
 Data from NCBI Unigene EST Profile
Unigene ID: Gga.28197

Mouse

EmageMGI:1201674
EurexpressMGI:1201674
MGI GXDMGI:1201674

Frog

Xenbase481991

Fruit Fly

BDGPFBgn0025800

Zebra Finch

ZEBrA

Zebrafish

ZFINZDB-GENE-030128-4, ZDB-GENE-000509-3
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