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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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MMP2
matrix metallopeptidase 2

The human orthologue of this gene is associated
with the following human disease:

Torg-Winchester syndrome

Gene

Official Symbol	MMP2
Official Full Name	matrix metallopeptidase 2
CGNC ID	49157
also known as	72 kDa type IV collagenase\|72 kDa gelatinase\|MMP-2\|gelatinase A\|matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)\|matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)\|matrix metalloproteinase-2, 72 kDa type IV collagenase precursor , 72 kDa gelatinase, Matrix metalloproteinase-2 (MMP-2) , Gelatinase A
gene type	protein-coding

Genomic Map

	Ensembl ID not known
	NCBI
	UCSC

Sequence Information

Genomic
RNA	NM_204420
Polypeptide	NP_989751

Gene Expression

In Situ Hybridization

GEISHA

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	4313	ENSG00000087245	MIM:259600	MIM:120360
Mouse	17390	ENSMUSG00000031740	All phenotypic alleles (1):Targeted, knock-out(1)	MGI:97009
Xenopus	548506, 380389			482840
Zebrafish	337179	ENSDARG00000017676	ZDB-GENE-030131-9123	ZFIN:ZDB-GENE-030131-9123

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Links to other databases

Entrez Gene	386583
Ensembl Gene
KEGG	gga:386583

Entry 1

GEISHA Id	MMP2.UApcr	Data Source	GEISHA ISH Analysis
Forward cDNA Template Primer	GATGGATTCCTCTGGTGTTC
Reverse cDNA Template Primer	ATTAACCCTCACTAAAGGGGTGAGTTTCTTTGGATAGCC	cDNA Template Length	930
Forward cDNA Template Probe	show CCCTATCGGGTGCTGGCTGTATAAACCCAGTACTCATTTCCTGCAAAAAATACAGCCTTCTCATCCTGAGGGGACTCGT AGACAGCATCGATTTTCTCTGGCAGATCAGGCCAGAATGTAGCAACGAGAAGAGGACCTGTGGGTTTTCCTCGAGGGTT TACAGTCCTCCACATGAATCTGTCTTTGAAGAAAAATATTTCTCCTCTAATTTGTGCAACTCCATCAAATACAATGTCG TGCTTGCAGAGCTCTGGAGTGACAGGTCCAAGGGTAGGACGTGGTCCTGGCCCTGGTCCTGGCCCTGGTCCAGGTTCCA CATCAGGTGATACTTCATATAGCTCCTGAATCCCCTTAATGTCATCCTGAGAAAGGCGGAAGTTCTTGGTGTAGGTGTA GATCGGGGCCATGAGAGCTCCTGGGTCCTCGGAGTGCTCTAATCCCATCGCATGGCCAAATTCGTGGGCAGCAACCAAG AAGAGACTGTATCCTTGATCTGGACAAAAGCCCCACTTGCGGTCATCATCATAGCTGCTGGTAGAAGCACACCACAGCT TGCCATCATTGCGACCTGCACTTGTACAGGAGTCGTATTTATTCCCAAGGAAGATGAAGGGGAATACACAAGGAGCTCC TTCTGAATTTCCACCAACTGTTGACATGGCAGTTTCTGGGCAGAATCCGTATTTCTTATCTCTATCATAGTCTTCAGTG GTTCCACACCATCTGTATCCATCTGTCCTGCCTTCTGTTGTACACTGGTCATAGGACTGGCCTTGAAATTTAAAGGGAA ACTTGCAGGGCTGTCCATCACCATTGCCACCCATTGTAAAAAGTGACTCATGGGGACAAAAGCCATATTTGCCATCTGC ATCAAAGTCTTTGGTTGTGGAACACCA

Stage

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Location (click to highlight)

Comments (click to highlight)

7-12

stage 7

stage 8

stage 9

stage 10

stage 11

Blood Islands
Blood Vessels
Extraembryonic
Extraembryonic Blood Vessels
Forebrain
Head Mesenchyme
Heart
Hindbrain
Lateral Plate Mesoderm
Mesencephalon
Midbrain
Notochord
Somites

13-18

stage 15

stage 16

Anterior/Second Heart Field
Endocardium
Extraembryonic Blood Vessels
Forebrain
Heart
Hindbrain
Midbrain
Neural Crest
Pharyngeal Arches and Clefts
Sclerotome
Somites
Surface Ectoderm
Trunk Mesenchyme

19-24

stage 19

stage 20

Dermomyotome
Eye
Forebrain
Gut
Heart
Hindbrain
Liver
Midbrain
Neural Crest
Pharyngeal Arches and Clefts
Sclerotome
Surface Ectoderm

25-26

stage 26

Dermomyotome
Eye
Gut
Leg Mesenchyme
Liver
Mesonephros
Pharyngeal Arches and Clefts
Sclerotome
Wing Mesenchyme

Entry 2

GEISHA Id	Mmp2.Duong.2004	Data Source	Publication
Complete cDNA Template Probe	show `ACTCCTGTACAAGTGCAGGTCGCAATGATGGCAAGCTGTGGTGTGCTTCTACCAGCAGCTATGATGATGACCGCAAGTG GGGCTTTTGTCCAGATCAAGGATACAGTCTCTTCTTGGTTGCTGCCCACGAATTTGGCCATGCGATGGGATTAGAGCAC TCCGAGGACCCAGGAGCTCTCATGGCCCCGATCTACACCTACACCAAGAACTTCCGCCTTTCTCAGGATGACATTAAGG GGATTCAGGAGCTATATGAAGTATCACCTGATGTGGAACCTGGACCAGGGCCAGGACCAGGGCCAGGACCACGTCCTAC CCTTGGACCTGTCACTCCAGAGCTCTGCAAGCACGACATTGTATTTGATGGAGTTGCACAAATTAGAGGAGAAATATTT TTCTTCAAAGACAGATTCATGTGGAGGACTGTAAACCCTCGAGGAAAACCCACAGGTCCTCTTCTCGTTGCTACATTCT G`
Citation	Duong TD, Erickson CA.(2004) MMP-2 plays an essential role in producing epithelial-mesenchymal transformations in the avian embryo. Dev Dyn. Jan;229(1):42-53.
Copyright	Wiley-Liss, Inc. 2004

Stage

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Location (click to highlight)

Comments (click to highlight)

7-12

stage 12

Lateral Plate Mesoderm
Midbrain
Sclerotome
Somites

head mesenchyme

13-18

stage 15

stage 16

Eye
Face Mesenchyme
Myotome
Neural Crest
Neural Plate/Tube
Sclerotome
Somatopleure
Somites

head mesenchyme
somitocoel

19-24

stage 19

stage 21

stage 22

stage 24

Dermatome
Face Mesenchyme
Limb Buds
Pharyngeal Arches and Clefts
Sclerotome
Somatopleure
Somites
Wing Mesenchyme

dermis
head mesenchyme
mesenchymal dermis

25-30

stage 28

stage 30

Dermatome
Wing Mesenchyme

dermis
dermis
developing feather germs

31-35

stage 35

dermis
developing feather germs

Entry 3

GEISHA Id	Mmp2.Linask.2005	Data Source	Publication
Complete cDNA Template Probe	show AATTCCGGCAAAAGAGAAAACGGTGCAGAGAGTTAAGATGTGCAGATAAGCAACTAGTGCACTGTGCAGCCAAAGTAAC TGACAGTCAGTCAGAGAAATCTTTTAAAGAGGATTGCAAAAATATAGGCAGAATGAAGACTCACAGTGTTTTTGGCTTC TTTTTTAAAGTACTATTAATCCAAGTGTATCTTTTTAACAAAACTTTAGCTGCACCGTCACCAATCATTAAGTTCCCTG GAGACAGCACTCCAAAAACAGACAAAGAGCTAGCAGTGCAATACCTGAATAAATATTATGGATGCCCAAAAGACAATTG CAACTTATTTGTATTGAAAGATACTTTGAAGAAAATGCAGAAATTTTTTGGGCTGCCTGAAACAGGAGATTTGGATCAA AACACAATTGAGACAATGAAGAAACCCCGCTGTGGTAACCCCGATGTGGCCAATTACAACTTCTTTCCAAGAAAGCCAA AATGGGAAAAGAATCATATAACATACAGGATTATAGGCTATACCCCGGATTTGGATCCTGAGACAGTAGATGATGCCTT TGCCCGAGCCTTTAAAGTCTGGAGTGATGTCACGCCACTGAGATTTAACCGAATAAATGATGGAGAGGCAGACATTATG ATTAATTTTGGCCGATGGGAACATGGTGATGGCTATCCATTTGATGGCAAAGATGGTCTCCTGGCTCACGCCTTTGCAC CGGGGCCAGGAATTGGAGGAGACTCCCATTTTGATGATGATGAACTGTGGACTCTTGGAGAAGGGCAAGTGGTTAGAGT AAAGTATGGAAATGCAGATGGTGAATACTGCAAATTTCCCTTCTGGTTCAATGGTAAGGAATACAACAGCTGCACAGAT GCAGGACGTAATGATGGATTCCTCTGGTGTTCCACAACCAAAGACTTTGATGCAGATGGCAAATATGGCTTTTGTCCCC ATGAGTCACTTTTTACAATGGGTGGCAATGGTGATGGACAGCCCTGCAAGTTTCCCTTTAAATTTCAAGGCCAGTCCTA TGACCAGTGTACAACAGAAGGCAGGACAGATGGATACAGATGGTGTGGAACCACTGAAGACTATGATAGAGATAAGAAA TACGGATTCTGCCCAGAAACTGCCATGTCAACAGTTGGTGGAAATTCAGAAGGAGCTCCTTGTGTATTCCCCTTCATCT TCCTTGGGAATAAATACGACTCCTGTACAAGTGCAGGTCGCAATGATGGCAAGCTGTGGTGTGCTTCTACCAGCAGCTA TGATGATGACCGCAAGTGGGGCTTTTGTCCAGATCAAGGATACAGTCTCTTCTTGGTTGCTGCCCACGAATTTGGCCAT GCGATGGGATTAGAGCACTCCGAGGACCCAGGAGCTCTCATGGCCCCGATCTACACCTACACCAAGAACTTCCGCCTTT CTCAGGATGACATTAAGGGGATTCAGGAGCTATATGAAGTATCACCTGATGTGGAACCTGGACCAGGGCCAGGACCAGG GCCAGGACCACGTCCTACCCTTGGACCTGTCACTCCAGAGCTCTGCAAGCACGACATTGTATTTGATGGAGTTGCACAA ATTAGAGGAGAAATATTTTTCTTCAAAGACAGATTCATGTGGAGGACTGTAAACCCTCGAGGAAAACCCACAGGTCCTC TTCTCGTTGCTACATTCTGGCCTGATCTGCCAGAGAAAATCGATGCTGTCTACGAGTCCCCTCAGGATGAGAAGGCTGT ATTTTTTGCAGGAAATGAGTACTGGGTTTATACAGCCAGCAACCTGGATAGGGGCTATCCAAAGAAACTCACCAGCCTG GGACTACCCCCTGATGTGCAACGCATTGATGCAGCCTTCAACTGGGGCAGAAACAAGAAGACATATATTTTCTCTGGAG ACAGATACTGGAAGTACAATGAAGAAAAGAAAAAAATGGAGCTTGCAACCCCAAAATTCATTGCGGATTCTTGGAATGG AGTTCCAGATAACCTCGATGCTGTCCTGGGTCTTACTGACAGCGGGTACACCTATTTTTTCAAAGACCAGTACTATCTA CAAATGGAAGACAAGAGTTTGAAGATTGTTAAAATTGGCAAGATAAGTTCTGACTGGTTGGGTTGCTGAACTGTAGAAT ATATTAATAACCAAATATTTACTTTTTTGTTATATACCTTATCTGTAATTAGAAATAGATCTGAATGTCAATTACTGGA CCAGTCAGGTACTGGCACCCAAACATTAAGTACCAGTACTGTACACATCTGATAATTTAAAAGTGTTTGCCTCCTCAAC ATACAAAAGATGTTTACGTATCTATTCTGGTACAATTTTTCAGTTTTTGTGCTAGTCATAGCAATGCTAGTAGCAGAAC ACGCACGGTTCTTTATTCCCCTGGTGCTTGAAGAAAGCATTGAAATCATTGGAGACTGGACCAGACCCCTGTGTTAAAT CCATCTCAAATAGCCTCAAGTAAGATGTACCAGCAGTGCACTTTGATTTTTTTTTAATTTTTTTTTTTAAATACAACTC TTTTATAAATAGATGGTTTGTGTTAATGTTTTAACCCTCTTGCGAGTTTGATCATTACTGCCATTTATTACATAATGAT ACAAAAGACTGTCAAAGGCACAGGTTGCCACGGGATTTGATTTGTATTGATGCATGATGGAATCATGGCAAGAAACTGT ATTAAAGTATTGTTTTAAAGTACTTTCTATTTTAAAACCTTAGTTCAACTTAGCAATTTGCTTCCTGCACTTTGTTACT ACTCTATAACTTGTCTATACAGACAGAATGACTCAGATGTTTTAAATCAATGTATTATACACAGAAGTCAAGTATTACT GTTTACCTTGTTTTATTTTTCTGTTCTTTATAATATTGAGTTTTTGTTTGGTTAGGCTTTCTGCTTAGGCATTGGGCAA CAGAAGGTGTTCCTTTCACATATGATGGAATGTTTCTCATTAAAAAAAAAAAAGGTTAAAAAAATCCAGAAAACAATGT CCCAAACATGAAATGCCAATGCTACAAATAAAATTAAATTACACTGTCAAAAAAAAAAAAAAACGGTTAAC
Citation	Linask K, Han M, Cai D, Brauer P, Manisastry, S. Cardiac Morphogenesis: Matrix Metalloproteinase Coordination of Cellular Mechanisms Underlying Heart Tube Formation and Directionality of Looping. Dev Dyn. 2005 Jul;233(3):739-53.
Copyright	Copyright © 2005 Wiley-Liss, Inc.
Comments	Insufficient information provided to verify exact probe sequence. Sequence provided is entire cDNA sequence from Accession # U07775.