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FZD1 Gene Summary Expression Other Species Expression JBrowse Gene Official Symbol FZD1 Official Full Name frizzled class receptor 1 CGNC ID 6896 also known as Fz-1, cFz-1, frizzled-1|7-transmembrane protein frizzled-1|frizzled family receptor 1|frizzled homolog 1, Frizzled 1 precursor, Frizzled-1, Fz-1, FzE1, hFz1 gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Molecular Function G-protein coupled receptor activity , PDZ domain binding , Wnt-activated receptor activity , more... Wnt-protein binding Biological Process G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger , more... Wnt signaling pathway, calcium modulating pathway , axonogenesis , brain development , embryo development , epithelial cell differentiation , gonad development , lung alveolus development , negative regulation of BMP signaling pathway , negative regulation of canonical Wnt signaling pathway , vasculature development Cellular Component apical part of cell , cytoplasm , integral component of membrane , neuron projection membrane
Links to other databases
Entry 1 GEISHA Id Frizzled1 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show CTCTCGGGCTGCTACACAGCCGTGGCCGTGGCCTACATCGCCGGCTTTCTGTTGGAGGAGAGGGTGGTCTGCAACGAGC
Entry 2 GEISHA Id Frizzled1.Chapman.2004 Data Source Publication Complete cDNA Template Probe show CGGCGGCGGCGGCGGAAGAGGCGGCGGCGGTAGTCGGATCGCGGCGGGAGGGAGCTGCCGCCGGAGCGGGCAGAGCTGC
Citation Chapman, S, Brown, R, Lees, L, Schoenwolf, G, Lumsden, A. Expression Analysis of Chick Wnt and Frizzled Genes and Selected Inhibitors in Early Chick Patterning. Dev Dyn. 2004 Mar;229(3):668-76. Copyright Wiley-Liss, Inc. 2004 Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # AF031830).
Entry 3 GEISHA Id FZD1.McCabe.2007 Data Source Publication Complete cDNA Template Probe show GATGGGAAAAATTTCCAGCAAAAGAAACCAAACCGACCCCTTTCCCTCTCCCCTACGCAGGTTTTGCAATGGCTTTGCT
Citation McCabe KL, Shiau CE, Bronner-Fraser M.
Identification of candidate secreted factors involved in trigeminal placode induction.
Dev Dyn. 2007 Oct;236(10):2925-35. Copyright Copyright © 2007 Wiley-Liss, Inc. Comments Sequence below was obtained from NCBI (AF224314) using the primers provided in the publication: Frizzeld1 forward primer, 5'-GATGGGAAAAATTTCCAGCA-3'; and reverse primer, 5'-CCTCCAAAGCCATCAGACAT-3'.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-10 stage 8
stage 10
Neural Crest Neural Plate/Tube
Entry 4 GEISHA Id Frz-1.Fuhrmann.2003 Data Source Publication Complete cDNA Template Probe show GCGGCGCTCAGCGAGCGGGGCATCTCCATCCCGGACCACGGCTACTGCCAACCCATCTCCATCCCGCTGTGCACAGACA
Citation Fuhrmann S, Stark MR, Heller S. Expression of Frizzled genes in the developing chick eye. Gene Expr Patterns. 2003 Oct;3(5):659-62. Copyright Reprinted from Developmental Biology, Volume 3 Issue 5, Sabine Fuhrmann, Michael R. Stark, and Stefan Heller, Expression of Frizzled genes in the developing chick eye, Pages 659-662, Copyright 2003, with permission from Elsevier.
Copyright © 2003 Elsevier B.V. All rights reserved.
Entry 5 GEISHA Id Fz1.Chapman.2008 Data Source Direct Submission Complete cDNA Template Probe show CGGCGGCGGCGGCGGAAGAGGCGGCGGCGGTAGTCGGATCGCGGCGGGAGGGAGCTGCCGCCGGAGCGGGCAGAGCTGC
Comments Images Provided by Susan Chapman
Entry 6 GEISHA Id Fz1.Theodosiou.2003 Data Source Publication Complete cDNA Template Probe show CGGCGGCGGCGGCGGAGGAGGCGGCGGCGGTAGTCGGAGCGCGGCGGGAGGGAGCTGCCGCCGGAGCGGGCAGAGCTGC
Citation Theodosiou NA, Tabin CJ. Wnt signaling during development of the gastrointestinal tract. Dev Biol. 2003 Jul 15;259(2):258-71. Copyright Copyright © 2003 Elsevier Science (USA). All rights reserved. Comments Authors indicated probe was from a
1.6kb partial cDNA. As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # AF031830.1).
Entry 7 GEISHA Id FZ1.Quinlan.2009 Data Source Publication Complete cDNA Template Probe show CGGCGGCGGCGGCGGAAGAGGCGGCGGCGGTAGTCGGATCGCGGCGGGAGGGAGCTGCCGCCGGAGCGGGCAGAGCTGC
Citation Quinlan R, Graf M, Mason I, Lumsden A, Kiecker C. Complex and dynamic patterns of Wnt pathway gene expression in the developing chick forebrain. Neural Dev. 2009 Sep 4;4:35. Copyright Copyright © 2009 Quinlan et al; licensee BioMed Central Ltd. [This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.] Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (NM_001030337.1).
Entry 8 GEISHA Id FZD1.Geetha-Loganathan.2009 Data Source Publication Complete cDNA Template Probe show CGGCGGCGGCGGCGGAAGAGGCGGCGGCGGTAGTCGGATCGCGGCGGGAGGGAGCTGCCGCCGGAGCGGGCAGAGCTGC
Citation Geetha-Loganathan, P, Nimmagadda, S, Antoni, L, Fu, K, Whiting, C, Francis-West, P and Richman, J. Expression of WNT signalling pathway genes during chicken craniofacial development. DEVELOPMENTAL DYNAMICS
Volume 238, Issue 5, May 2009, Pages: 11501165. Copyright Dev. Dyn Copyright © 2009 John Wiley & Sons, Inc. All Rights Reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_001030337.1.)
Entry 9 GEISHA Id FZD1.Sienknecht.2009 Data Source Publication Complete cDNA Template Probe show GCCGTGGCCGTGGCCTACATCGCCGGCTTTCTGTTGGAGGAGAGGGTGGTCTGCAACGAGCGCTTCGCCGAGGACGGCT
Citation Sienknecht UJ, Fekete DM. Mapping of Wnt, frizzled, and Wnt inhibitor gene expression domains in the avian otic primordium. J Comp Neurol. 2009 Dec 20;517(6):751-64. Copyright Copyright © (2002 Wiley-Liss); This material is used by permission of Wiley-Liss, Inc., a subsidiary of John Wiley & Sons, Inc. Comments Authors indicated probe NCBI acc# in the paper.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-18 stage 16
stage 16
stage 17
Ear/Otic Placode Rhombomeres 19-24 stage 20
stage 20
stage 23
stage 24
Ear/Otic Placode
Entry 10 GEISHA Id Frizzled-1.Cauthen.2001 Data Source Publication Complete cDNA Template Probe show CGGCGGCGGCGGCGGAAGAGGCGGCGGCGGTAGTCGGATCGCGGCGGGAGGGAGCTGCCGCCGGAGCGGGCAGAGCTGC
Citation Cauthen CA, Berdougo E, Sandler J, Burrus LW. Comparative analysis of the expression patterns of Wnts and Frizzleds during early myogenesis in chick embryos. Mech Dev. 2001 Jun;104(1-2):133-8. Copyright Copyright © 2001 Elsevier Science Ireland Ltd. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_001030337.1). Frizzled-1 is also known as FZD1 in NCBI.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-44 stage 44
Entry 11 GEISHA Id FZD1.Olivera-Martinez.2014 Data Source Publication Complete cDNA Template Probe show CGGCGGCGGCGGCGGAAGAGGCGGCGGCGGTAGTCGGATCGCGGCGGGAGGGAGCTGCCGCCGGAGCGGGCAGAGCTGC
Citation Isabel Olivera-Martinez, Nick Schurch, Roman A Li, Junfang Song, Pamela A Halley, Raman M Das, Dave W Burt, Geoffrey J Barton, Kate G Storey. Major transcriptome re-organisation and abrupt changes in signalling, cell cycle and chromatin regulation at neural differentiation in vivo. Development 2014 Aug;141(16):3266-76. Epub 2014 Jul 25. DOI: 10.1242/dev.112623. Copyright Copyright © 2014. Published by The Company of Biologists Ltd. Comments Authors indicated the probe was made from gene construct provided by P. Francis-West. As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence above was obtained from NCBI (accession number NM_001030337.1).
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