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Human Disease Gene Search
HOXB4 Gene Summary Expression Other Species Expression JBrowse Gene Official Symbol HOXB4 Official Full Name homeobox B4 CGNC ID 15553 also known as Chox-Z, homeobox protein Hox-B4|homeo box B4|homeobox protein Hox-Z gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Links to other databases
Entry 1 GEISHA Id HOXB4.UApcr Data Source GEISHA ISH Analysis Forward cDNA Template Primer GGAAAACGAGTAAAGGGGGGGAC Reverse cDNA Template Primer AATTAACCCTCACTAAAGGAGAGGCACAGAGAATGGGCG cDNA Template Length 656 Forward cDNA Template Probe show NAAGGCGCAGAGGCGATTGACCTCGCCTCGGGTGAATACGGTTATAGTGGAATTCCTTCTCCAGCTCCAGGACCTGCTG
Entry 2 GEISHA Id HOXB4.Reid.2002 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show GCGGTGCCCGGGGAACGGGGCCGGAGGGGAGCGGGCGCCCCCGGCCGCCTCCCCGGGGATGCTCCGGGCCCCGGGAGAG
Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205293).
Entry 3 GEISHA Id Hoxb-4.Gaunt.2000 Data Source Publication Complete cDNA Template Probe show GCGGTGCCCGGGGAACGGGGCCGGAGGGGAGCGGGCGCCCCCGGCCGCCTCCCCGGGGATGCTCCGGGCCCCGGGAGAG
Citation Gaunt SJ. Evolutionary shifts of vertebrate structures and Hox expression up and down the axial series of segments: a consideration of possible mechanisms. Int J Dev Biol. 2000 Copyright Copyright © 2007 UBC Press Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_205293.1).
Entry 4 GEISHA Id HOXB4.Hughes.2011 Data Source Publication Complete cDNA Template Probe show GCGGTGCCCGGGGAACGGGGCCGGAGGGGAGCGGGCGCCCCCGGCCGCCTCCCCGGGGATGCTCCGGGCCCCGGGAGAG
Citation Hughes MW, Wu P, Jiang TX, Lin SJ, Dong CY, Li A, Hsieh FJ, Widelitz RB, Chuong CM. In search of the Golden Fleece: unraveling principles of morphogenesis by studying the integrative biology of skin appendages Integr Biol (Camb). 2011 Apr;3(4):388-407. Epub 2011 Mar 24.
Copyright © Royal Society of Chemistry 2011 Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_205293.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-29 stage 26
stage 26
stage 29
Dermis Limb Buds
Entry 5 GEISHA Id HOXB4.Barak.2012 Data Source Publication Complete cDNA Template Probe show GCGGTGCCCGGGGAACGGGGCCGGAGGGGAGCGGGCGCCCCCGGCCGCCTCCCCGGGGATGCTCCGGGCCCCGGGAGAG
Citation Barak H, Preger-Ben Noon E, Reshef R. Comparative spatiotemporal analysis of Hox gene expression in early stages of intermediate mesoderm formation. Dev Dyn. 2012 Oct;241(10):1637-49. Copyright Copyright © 2012 Wiley Periodicals, Inc. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_205293.1).
Entry 6 GEISHA Id Hoxb-4.Itasaki.1996 Data Source Publication Complete cDNA Template Probe show GCGGTGCCCGGGGAACGGGGCCGGAGGGGAGCGGGCGCCCCCGGCCGCCTCCCCGGGGATGCTCCGGGCCCCGGGAGAG
Citation Itasaki N, Sharpe J, Morrison A, Krumlauf R. Reprogramming Hox expression in the vertebrate hindbrain: influence of paraxial mesoderm and rhombomere transposition. Neuron. 1996 Mar;16(3):487-500. Copyright Copyright © 1996 Cell Press. Comments Complete cDNA template sequence was obtained from information referenced in the publication as described in Itasaki et al. 1996.
Entry 7 GEISHA Id Hoxb‐4.Gaunt.1996 Data Source Publication Complete cDNA Template Probe show CGGAATATTACAGCAGCCAGAGGCGAGAGAGCACTTTCCAACATGAAGCGATGTACCAGCCGCGGTCAGCATGCAGCGA
Citation Gaunt SJ, Strachan L. Temporal colinearity in expression of anterior Hox genes in developing chick embryos. Dev Dyn. 1996 Nov;207(3):270-80. Copyright Copyright © 1996 Wiley‐Liss, Inc. Comments The complete cDNA template sequence was obtained from the information from the publication as described in Gaunt et al. 1996.
Entry 8 GEISHA Id Hoxb4.Moreau.2019 Data Source Publication Complete cDNA Template Probe show GCGGTGCCCGGGGAACGGGGCCGGAGGGGAGCGGGCGCCCCCGGCCGCCTCCCCGGGGATGCTCCGGGCCCCGGGAGAG
Citation Chloe Moreau, Paolo Caldarelli, Didier Rocancourt, Julian Roussel, Nicolas Denans, Olivier Pourquie, Jerome Gros. Timed Collinear Activation of Hox Genes during Gastrulation Controls the Avian Forelimb Position. Curr Biol. 2019 Jan 7; 29(1):35-50.e4. Epub 2018 Dec 13. DOI: 10.1016/j.cub.2018.11.009. Copyright Copyright © 2018 The Author(s). Published by Elsevier Ltd.. All rights reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence above was obtained from NCBI (accession number NM_205293.1).
no images
Entry 9 GEISHA Id HOXB4.Olivera-Martinez.2014 Data Source Publication Complete cDNA Template Probe show GCGGTGCCCGGGGAACGGGGCCGGAGGGGAGCGGGCGCCCCCGGCCGCCTCCCCGGGGATGCTCCGGGCCCCGGGAGAG
Citation Isabel Olivera-Martinez, Nick Schurch, Roman A Li, Junfang Song, Pamela A Halley, Raman M Das, Dave W Burt, Geoffrey J Barton, Kate G Storey. Major transcriptome re-organisation and abrupt changes in signalling, cell cycle and chromatin regulation at neural differentiation in vivo. Development 2014 Aug;141(16):3266-76. Epub 2014 Jul 25. DOI: 10.1242/dev.112623. Copyright Copyright © 2014. Published by The Company of Biologists Ltd. Comments Authors indicated the probe was made from gene construct provided by R. Krumlauf. As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence above was obtained from NCBI (accession number NM_205293.1).
Entry 10 GEISHA Id Hoxb4.Iimura.2006 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show GCGGTGCCCGGGGAACGGGGCCGGAGGGGAGCGGGCGCCCCCGGCCGCCTCCCCGGGGATGCTCCGGGCCCCGGGAGAG
Citation Tadahiro Iimura, Olivier Pourquié. Collinear activation of Hoxb genes during gastrulation is linked to mesoderm cell ingression. Nature. 2006 Aug 3;442(7102):568-71. Epub 2006 Jun 7. DOI: 10.1038/nature04838. Copyright Copyright © 2006 Nature Publishing Group. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence above was obtained from NCBI (accession number NM_205293.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4-6 stage 4
stage 5
stage 6
Early Mesoderm Primitive Streak
Entry 11 GEISHA Id Hoxb4.Bel-Vialar.2002 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show GCGGTGCCCGGGGAACGGGGCCGGAGGGGAGCGGGCGCCCCCGGCCGCCTCCCCGGGGATGCTCCGGGCCCCGGGAGAG
Citation Sophie Bel-Vialar, Nobue Itasaki, Robb Krumlauf. Initiating Hox gene expression: in the early chick neural tube differential sensitivity to FGF and RA signaling subdivides the HoxB genes in two distinct groups. Development 2002 Nov;129(22):5103-15. Copyright Copyright © The Company of Biologists Limited 2002. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence above was obtained from NCBI (accession number NM_205293.1).
Entry 12 GEISHA Id HOXB4.Anderson.2021 Data Source Direct Submission Complete cDNA Template Probe show GCGGGGCCCGGGGAACGGGGCCGGAGGGGAGCGGGCGCCCCCGGCCGCCTCCCCGGGGATGCTCCGGGCCCCGGGAGAG
Comments Images provided by Claire Anderson. The probe was kindly supplied by R. Krumlauf. As insufficient information was provided to verify sequence used to synthesize probe, the sequence above was obtained from NCBI (accession number NM_205293.2). Related paper: Anderson C, Hill B, Lu HC, Moverley A, Yang Y, Oliveira NMM, Baldock RA, Stern CD. A 3D molecular atlas of the chick embryonic heart. Dev Biol. 2019 Dec 1;456(1):40-46. doi: 10.1016/j.ydbio.2019.07.003. Epub 2019 Jul 5.
Entry 13 GEISHA Id HOXB4.Anderson.2019 Data Source Publication Complete cDNA Template Probe show GCGGGGCCCGGGGAACGGGGCCGGAGGGGAGCGGGCGCCCCCGGCCGCCTCCCCGGGGATGCTCCGGGCCCCGGGAGAG
Citation Anderson C, Hill B, Lu HC, Moverley A, Yang Y, Oliveira NMM, Baldock RA, Stern CD. A 3D molecular atlas of the chick embryonic heart. Dev Biol. 2019 Dec 1;456(1):40-46. doi: 10.1016/j.ydbio.2019.07.003. Epub 2019 Jul 5. Copyright Copyright © 2019 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI ( NM_205293.3).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-12 stage 12
stage 12
Proepicardium
Mouse Frog Fruit Fly Zebra Finch Zebrafish
