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Human Disease Gene Search
MYF5 Gene Summary Expression Other Species Expression JBrowse Gene Official Symbol MYF5 Official Full Name myogenic factor 5 CGNC ID 8312 also known as myf-5, myogenic factor 5|Myf5 homolog, Myogenic Factor 5, MYF5 gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Links to other databases
Entry 1 GEISHA Id pgm1c.pk001.m21 Data Source GEISHA ISH Analysis Forward cDNA Template Probe show CTAATTGCGGAGGGAATCGCTGCATTGCGCTGCGAGCTGCCAGCCCACACTGCTGCCTTGGACGAAGAGATGGAGGTGA
Entry 2 GEISHA Id Myf5.Amthor.2006 Data Source Publication Complete cDNA Template Probe show ATGGAGGTGATGGACAGCTGCCAGTTCTCCCCATCCGAGCTCTTCTATGACAGCTCCTGCCTGTCGTCCCCTGAGGGCG
Citation Amthor H, Otto A, Macharia R, McKinnell I, Patel K. Myostatin imposes reversible quiescence on embryonic muscle precursors. Dev Dyn. 2006 Mar;235(3):672-80. Copyright Copyright © 2006 Wiley-Liss, Inc. Comments The following probes were used in this study: MyoD, clone CMD9 1.5-kb full-length fragment (a gift from Professor Bruce Patterson); Pax-3, a 645-bp fragment corresponding to nucleotides 468-1,113 (a gift from Dr. Martin Goulding); Myf-5, a 1.1-kb fragment and Myogenin, a 1.2-kb fragment (both kind gifts from Professor Antony Graham); Pax-7 a 582-bp fragment (a kind gift from Dr. Susanne Dietrich).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-22 stage 22
Limb Buds Wing
Entry 3 GEISHA Id Myf5.Noden.2006 Data Source Publication Complete cDNA Template Probe show ATGGAGGTGATGGACAGCTGCCAGTTCTCCCCATCCGAGCTCTTCTATGACAGCTCCTGCCTGTCGTCCCCTGAGGGCG
Citation Noden DM, Francis-West P. The differentiation and morphogenesis of craniofacial muscles. Dev Dyn. 2006 May;235(5):1194-218. Review. Copyright Copyright © 2006 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_001030363).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-21 stage 21
Pharyngeal Arches and Clefts
Entry 4 GEISHA Id Myf5.Bothe.2006 Data Source Publication Complete cDNA Template Probe show ATGGAGGTGATGGACAGCTGCCAGTTCTCCCCATCCGAGCTCTTCTATGACAGCTCCTGCCTGTCGTCCCCTGAGGGCG
Citation Bothe I, Dietrich S. The molecular setup of the avian head mesoderm and its implication for craniofacial myogenesis. Dev Dyn. 2006 Oct;235(10):2845-60. Copyright Copyright © 2006 Wiley-Liss, Inc. Comments Insufficient information provided to verify exact probe sequence. Sequence obtained from NCBI (NM_001030363).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-10 stage 10
stage 10
Somites
Entry 5 GEISHA Id Myf5.Ahmed.2006 Data Source Publication Complete cDNA Template Probe show ATGGAGGTGATGGACAGCTGCCAGTTCTCCCCATCCGAGCTCTTCTATGACAGCTCCTGCCTGTCGTCCCCTGAGGGCG
Citation Ahmed MU, Cheng L, Dietrich S. Establishment of the epaxial-hypaxial boundary in the avian myotome. Dev Dyn. 2006 Jul;235(7):1884-94. Copyright Copyright © 2006 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_001030363).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 22
stage 22
stage 24
Myotome 25 stage 25
Myotome
Entry 6 GEISHA Id MYF5.Bothe.2007 Data Source Publication Complete cDNA Template Probe show ATGGAGGTGATGGACAGCTGCCAGTTCTCCCCATCCGAGCTCTTCTATGACAGCTCCTGCCTGTCGTCCCCTGAGGGCG
Citation Bothe I, Ahmed MU, Winterbottom FL, von Scheven G, Dietrich S. Extrinsic versus intrinsic cues in avian paraxial mesoderm patterning and differentiation. Dev Dyn. 2007 Sep;236(9):2397-409. Copyright Copyright © 2007 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_001030363).
Entry 7 GEISHA Id Myf5.Reijntjes.2007 Data Source Publication Complete cDNA Template Probe show ATGGAGGTGATGGACAGCTGCCAGTTCTCCCCATCCGAGCTCTTCTATGACAGCTCCTGCCTGTCGTCCCCTGAGGGCG
Citation Reijntjes S, Stricker S, Mankoo BS. A comparative analysis of Meox1 and Meox2 in the developing somites and limbs of the chick embryo. Int J Dev Biol.(2007); 51(8:753-9. Copyright Reprinted from Int. J. Dev. Biol., 51, Reijntjes S, Stricker S, Mankoo BS, A
comparative analysis of Meox1 and Meox2 in the developing somites and limbs of
the chick embryo, 753-9, Copyright © 2007 UBC Press, with permission. All rights
reserved. Comments According to authors , "MyoD, Pax3 and Myf5 anti-sense probes were a kind gift of Philippa Francis-West.." As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_001030363).
Entry 8 GEISHA Id Myf5.Duprez.2002 Data Source Publication Complete cDNA Template Probe show ATGGAGGTGATGGACAGCTGCCAGTTCTCCCCATCCGAGCTCTTCTATGACAGCTCCTGCCTGTCGTCCCCTGAGGGCG
Citation Duprez, D (2002). Signals regulating muscle formation in the limb during embryonic development. Int J Dev Biol. 2002;46(7):915-25. Copyright "Reprinted from Int. J. Dev. Biol., 46, Duprez, D, Signals regulating muscle formation in the limb during embryonic development, 915-25, Copyright (2002), with permission from Copyright © 2002 UBC Press". All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_001030363).
Entry 9 GEISHA Id Myf5.Pujades.2002 Data Source Publication Complete cDNA Template Probe show ATGGAGGTGATGGACAGCTGCCAGTTCTCCCCATCCGAGCTCTTCTATGACAGCTCCTGCCTGTCGTCCCCTGAGGGCG
Citation Pujades C, Guez-Guez B, Dunon D. Melanoma Cell Adhesion Molecule (MCAM) expression in the myogenic lineage during early chick embryonic development. Int J Dev Biol. 2002 Mar;46(2):263-6. Copyright "Reprinted from Int. J. Dev. Biol., 46, Pujades C, Guez-Guez B, Dunon D, Melanoma Cell Adhesion Molecule (MCAM) expression in the myogenic lineage during early chick embryonic development, 263-6, Copyright (2002), with permission from Copyright © 2002
UBC Press". All rights reserved. Comments According to authors, "Total RNA preparation, RT-PCR and oligonucleotides for amplification of Myf5 cDNA were as described (Montarras et al., 1991)" As access to Montarras et al., 1991 paper was unavailable to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_001030363).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-12 stage 12
Somites 13-17 stage 14
stage 17
Myotome
Entry 10 GEISHA Id MYF5.Kiefer.2001 Data Source Publication Forward cDNA Template Probe show ACTTTGTCTCGGGTCGCTAATTGCGGAGGGAATCGCTGCATTGTGCTGCGAGCTGCCAGCCCACACTGCTGCCTCGGAC
Reverse cDNA Template Probe show AGGGAACAGGTGGAGAACTACTATCACCTGCCGGGACAGAGCTGCTCCGAGCCCACCAGCCCCAGCTCCAGCTGCTCCG
Citation Kiefer JC, Hauschka SD (2001). Myf-5 is transiently expressed in nonmuscle mesoderm and exhibits dynamic regional changes within the presegmented mesoderm and somites I-IV. Dev Biol. 2001 Apr 1;232(1):77-90. Copyright Copyright © 2001 Academic Press All rights reserved. Comments According to the authors, "The reported Myf-5 expression patterns were confirmed with two in situ hybridization probes. One from accession # X73250..." The sequences below was obtained from NCBI (NM_001030363 and X73250) using the primers provided in the paper.
Entry 11 GEISHA Id MYF5.Wilm.2004 Data Source Publication Complete cDNA Template Probe show ATGGAGGTGATGGACAGCTGCCAGTTCTCCCCATCCGAGCTCTTCTATGACAGCTCCTGCCTGTCGTCCCCTGAGGGCG
Citation Wilm B, James RG, Schultheiss TM, Hogan BL (2004). The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate. Dev Biol. 2004 Jul 1;271(1):176-89. Copyright Copyright © 2004 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_001030363).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-35 stage 35
Dermomyotome Somites
Entry 12 GEISHA Id MYF5.Huang.2003 Data Source Publication Complete cDNA Template Probe show ATGGAGGTGATGGACAGCTGCCAGTTCTCCCCATCCGAGCTCTTCTATGACAGCTCCTGCCTGTCGTCCCCTGAGGGCG
Citation Huang R, Stolte D, Kurz H, Ehehalt F, Cann GM, Stockdale FE, Patel K, Christ B. Ventral axial organs regulate expression of myotomal Fgf-8 that influences rib development. Dev Biol. 2003 Mar 1;255(1):30-47. Copyright Copyright © 2003 Elsevier Science (USA) All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_001030363).
Entry 13 GEISHA Id MYF5.Tzahor.2003 Data Source Publication Complete cDNA Template Probe show ATGGAGGTGATGGACAGCTGCCAGTTCTCCCCATCCGAGCTCTTCTATGACAGCTCCTGCCTGTCGTCCCCTGAGGGCG
Citation Tzahor E, Kempf H, Mootoosamy RC, Poon AC, Abzhanov A, Tabin CJ, Dietrich S, Lassar AB. Antagonists of Wnt and BMP signaling promote the formation of vertebrate head muscle. Genes Dev. 2003 Dec 15;17(24):3087-99. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # NM_001030363.1).
Entry 14 GEISHA Id MYF5.Reijntjes.2010 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show ATGGAGGTGATGGACAGCTGCCAGTTCTCCCCATCCGAGCTCTTCTATGACAGCTCCTGCCTGTCGTCCCCTGAGGGCG
Citation Reijntjes S, Francis-West P, Mankoo BS. Retinoic acid is both necessary for and inhibits myogenic commitment and differentiation in the chick limb. Int J Dev Biol. 2010;54(1):125-34 Copyright © 2009 UBC Press Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence was obtained from NCBI (NM_001030363).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 22
Limb Buds 25 stage 25
stage 25
Limb Buds Somites all
Entry 15 GEISHA Id Myf5.Zhang.2006 Data Source Publication Complete cDNA Template Probe show ATGGAGGTGATGGACAGCTGCCAGTTCTCCCCATCCGAGCTCTTCTATGACAGCTCCTGCCTGTCGTCCCCTGAGGGCG
Citation Zhang X, Dai F, Weise C, Yusuf F, Bonafede A, Morosan-Puopolo G, Rehimi R, Wang J, Brand-Saberi B. Expression of the avian gene cNOC2 encoding nucleolar complex associated protein 2 during embryonic development. 2006 Nov;211(6):649-57 Copyright © Springer-Verlag 2006 Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # NM_001030363.1).
no images
Entry 16 GEISHA Id Myf-5.Cauthen.2001 Data Source Publication Complete cDNA Template Probe show ATGGAGGTGATGGACAGCTGCCAGTTCTCCCCATCCGAGCTCTTCTATGACAGCTCCTGCCTGTCGTCCCCTGAGGGCG
Citation Cauthen CA, Berdougo E, Sandler J, Burrus LW. Comparative analysis of the expression patterns of Wnts and Frizzleds during early myogenesis in chick embryos. Mech Dev. 2001 Jun;104(1-2):133-8. Copyright Copyright © 2001 Elsevier Science Ireland Ltd. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_001030363.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-10 stage 10
Somites all
Entry 17 GEISHA Id Myf5.Draga.2019 Data Source Publication Complete cDNA Template Probe show ATGGAGGTGATGGACAGCTGCCAGTTCTCCCCATCCGAGCTCTTCTATGACAGCTCCTGCCTGTCGTCCCCTGAGGGCG
Citation Margarethe Draga, Kathrin Heim, Renate Batke, Martin Wegele, Felicitas Pröls, Martin Scaal. Somite development in the avian tail. J Anat. 2019 Oct;235(4):716-724. Epub 2019 Jun 21. DOI: 10.1111/joa.13032. Copyright Copyright © 2019 Anatomical Society. Comments Authors indicated the probe was kindly provided by Bodo Christ. As insufficient information is provided in publication to verify exact sequence used to synthesize probe, above sequence was obtained from NCBI (NM_001030363.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 20
stage 20
stage 20
stage 20
stage 20
stage 23
stage 23
stage 23
stage 23
stage 23
Dermomyotome Myotome Unlabeled 25-27 stage 27
stage 27
stage 27
stage 27
stage 27
Myotome all
Entry 18 GEISHA Id MYF5.Kahane.2013 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show ATGGAGGTGATGGACAGCTGCCAGTTCTCCCCATCCGAGCTCTTCTATGACAGCTCCTGCCTGTCGTCCCCTGAGGGCG
Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence was obtained from NCBI (NM_001030363.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-17 stage 17
Myotome all
Mouse Frog Fruit Fly Zebra Finch Zebrafish
