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Human Disease Gene Search
SOX10 The human orthologue of this gene is associated
Gene Summary Expression Other Species Expression JBrowse Gene Official Symbol SOX10 Official Full Name SRY-box 10 CGNC ID 49382 also known as SOX-10, transcription factor SOX-10|SRY (sex determining region Y)-box 10|Sry-boxntranscription factor, SOX-10|cSOX10, SOX-10, cSOX10, sex determining region Y-box 10 gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Molecular Function RNA polymerase II core promoter proximal region sequence-specific DNA binding , more... RNA polymerase II distal enhancer sequence-specific DNA binding , RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity , RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription , chromatin binding , identical protein binding Biological Process cardiac neuron development , cell maturation , developmental growth , digestive tract morphogenesis , more... enteric nervous system development , in utero embryonic development , melanocyte differentiation , negative regulation of apoptotic process , negative regulation of canonical Wnt signaling pathway , neural crest cell migration , oligodendrocyte differentiation , peripheral nervous system development , positive regulation of gliogenesis , positive regulation of neuroblast proliferation Cellular Component extrinsic component of mitochondrial outer membrane , nucleus
Links to other databases
Entry 1 GEISHA Id pgp1n.pk012.c24 Data Source GEISHA ISH Analysis Forward cDNA Template Probe show TGGGACAGGAGCTGCAGCCTTCACAGGGTTTGCTGCCCGCACCAGCCAGCAATTGAGAAGAAGGAAGTCACCATGGCTG
Entry 2 GEISHA Id ChEST904h7 Data Source GEISHA ISH Analysis Forward cDNA Template Probe show GGCTCGAGCTCATTTCATAGCCCGTATGTGTGCATGCGTATTTGTGTAAGGAGTTGAAGAGAGGTGGGGAAGGATCTGT
Entry 3 GEISHA Id Sox10.McKeown.2005 Data Source Publication Complete cDNA Template Probe show AATTCGGCACGAGAGCCGGGGCATTAGTAAAAACCAAGCCTCCCTCCAGGAATGGCACTTGCCTGAGCACCTCCCCGGC
Citation McKeown S, Lee V, Bronner-Fraser M, Newgreen D, Farlie P. Sox10 Overexpression Induces Neural Crest-Like Cells From All Dorsoventral Levels of the Neural Tube but Inhibits Differentiation. Dev Dyn. 2005 Jun;233(2):430-44. Copyright Copyright © 2005 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # AF152356).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-12 stage 10
Neural Crest 13-18 stage 18
Neural Crest
Entry 4 GEISHA Id Sox10.Schmidt.2007 Data Source Publication Complete cDNA Template Probe show ATTAGTAAAAACCAAGCCTCCCTCCAGGAATGGCACTTGCCTGAGCACCTCCCCGGCAGCACGCCCCACAGCCGGAGGG
Citation Schmidt C, McGonnell IM, Allen S, Otto A, Patel K. Wnt6 controls amniote neural crest induction through the non-canonical signaling pathway.Dev Dyn. 2007 Sep;236(9):2502-11. Copyright Copyright © 2007 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204792).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-12 stage 12
Neural Crest 13-18 stage 18
Neural Crest
Entry 5 GEISHA Id Sox10.Barembaum.2007 Data Source Publication Complete cDNA Template Probe show ATTAGTAAAAACCAAGCCTCCCTCCAGGAATGGCACTTGCCTGAGCACCTCCCCGGCAGCACGCCCCACAGCCGGAGGG
Citation Barembaum M, Bronner-Fraser M. Spalt4 mediates invagination and otic placode gene expression in cranial ectoderm. Development. 2007 Nov;134(21):3805-14. Copyright Published by The Company of Biologists 2007 Comments According to the authors, "The Sox10 expression construct was described previously (McKeown et al., 2005)." As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (NM_204792).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-14 stage 14
stage 14
stage 14
stage 14
stage 14
stage 14
stage 14
Cranial Ganglia Ear/Otic Placcode
Entry 6 GEISHA Id Sox10.Richman.2002 Data Source Publication Complete cDNA Template Probe show ATTAGTAAAAACCAAGCCTCCCTCCAGGAATGGCACTTGCCTGAGCACCTCCCCGGCAGCACGCCCCACAGCCGGAGGG
Citation Richman JM, Fu KK, Cox LL, Sibbons JP, Cox TC. Isolation and characterisation of the chick orthologue of the Opitz syndrome gene, Mid1, supports a conserved role in vertebrate development. Int J Dev Biol. 2002;46(4):441-8. Copyright "Reprinted from Int. J. Dev. Biol., 46, Richman JM, Fu KK, Cox LL, Sibbons JP, Cox TC, Isolation and characterisation of the chick orthologue of the Opitz syndrome gene, Mid1, supports a conserved role in vertebrate development, 441-8 , Copyright (2002), with permission from Copyright © 2002 UBC Press". All rights reserved. Comments Chicken Sox10 was generously
provided by P. Scotting (Cheng et al., 2000). NCBI accession number: NM_204792
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-12 stage 10
stage 10
stage 10
Neural Crest 31-44 stage 44
Hindbrain Neural Crest
Entry 7 GEISHA Id Sox10.Burns.2005 Data Source Publication Complete cDNA Template Probe show ATTAGTAAAAACCAAGCCTCCCTCCAGGAATGGCACTTGCCTGAGCACCTCCCCGGCAGCACGCCCCACAGCCGGAGGG
Citation Burns AJ, Delalande JM (2005). Neural crest cell origin for intrinsic ganglia of the developing chicken lung. Dev Biol. 2005 Jan 1;277(1):63-79.
Copyright Copyright © 2004 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204792).
Entry 8 GEISHA Id Sox10.Shiau.2008 Data Source Publication Complete cDNA Template Probe show ATTAGTAAAAACCAAGCCTCCCTCCAGGAATGGCACTTGCCTGAGCACCTCCCCGGCAGCACGCCCCACAGCCGGAGGG
Citation Shiau CE, Lwigale PY, Das RM, Wilson SA, Bronner-Fraser M. Robo2-Slit1 dependent cell-cell interactions mediate assembly of the trigeminal ganglion. Nat Neurosci. 2008 Mar;11(3):269-76. Epub 2008 Feb 17.
Copyright Copyright © 2008, Nature Publishing Group Comments Insufficient information provided in publication to verify exact sequence to synthesize probe. Sequence below was obtained from NCBI (NM_204792).
no images
Entry 9 GEISHA Id Sox10.Coles.2007 Data Source Publication Complete cDNA Template Probe show ATTAGTAAAAACCAAGCCTCCCTCCAGGAATGGCACTTGCCTGAGCACCTCCCCGGCAGCACGCCCCACAGCCGGAGGG
Citation Coles EG, Taneyhill LA, Bronner-Fraser M. A critical role for Cadherin6B in regulating avian neural crest emigration. Dev Biol. 2007 Dec 15;312(2):533-44. Epub 2007 Oct 5. Copyright Copyright © 2007 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence to synthesize probe. Sequence below was obtained from NCBI (NM_204792).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-10 stage 10
stage 10
Neural Crest
Entry 10 GEISHA Id Sox10.Chimal-Monroy.2003 Data Source Publication Complete cDNA Template Probe show ATTAGTAAAAACCAAGCCTCCCTCCAGGAATGGCACTTGCCTGAGCACCTCCCCGGCAGCACGCCCCACAGCCGGAGGG
Citation Chimal-Monroy J, Rodriguez-Leon J, Montero JA, Gañan Y, Macias D, Merino R, Hurle JM. Analysis of the molecular cascade responsible for mesodermal limb chondrogenesis: Sox genes and BMP signaling. Dev Biol. 2003 May 15;257(2):292-301. Copyright Reprinted with permission from Elsevier.
Copyright © 2003 Elsevier B.V. All rights reserved.
Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc #NM_204792.1)
Entry 11 GEISHA Id SOX10.Blentic.2008 Data Source Publication Complete cDNA Template Probe show ATTAGTAAAAACCAAGCCTCCCTCCAGGAATGGCACTTGCCTGAGCACCTCCCCGGCAGCACGCCCCACAGCCGGAGGG
Citation Blentic A, Tandon P, Payton S, Walshe J, Carney T, Kelsh RN, Mason I, Graham A. The emergence of ectomesenchyme. Dev Dyn. 2008 Mar;237(3):592-601. Copyright Copyright © 2008 John Wiley & Sons, Inc. All Rights Reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc # NM_204792.1)
Entry 12 GEISHA Id SOX10.LeGuen Data Source Publication Complete cDNA Template Probe show ATTAGTAAAAACCAAGCCTCCCTCCAGGAATGGCACTTGCCTGAGCACCTCCCCGGCAGCACGCCCCACAGCCGGAGGG
Citation Le Guen L, Notarnicola C, de Santa Barbara P.
Intermuscular tendons are essential for the development of vertebrate stomach.
Development. 2009 Mar;136(5):791-801. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_204792 ).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-35 stage 35
stage 35
Stomach
Entry 13 GEISHA Id SOX10.Betancur.2011 Data Source Publication Complete cDNA Template Probe show ATTAGTAAAAACCAAGCCTCCCTCCAGGAATGGCACTTGCCTGAGCACCTCCCCGGCAGCACGCCCCACAGCCGGAGGG
Citation Betancur P, Sauka-Spengler T, Bronner M.
A Sox10 enhancer element common to the otic placode and neural crest is activated by tissue-specific paralogs. Development. 2011 Sep;138(17):3689-98.
Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_204792.1).
no images
Entry 14 GEISHA Id SOX10.Huber.2012 Data Source Publication Complete cDNA Template Probe show ATTAGTAAAAACCAAGCCTCCCTCCAGGAATGGCACTTGCCTGAGCACCTCCCCGGCAGCACGCCCCACAGCCGGAGGG
Citation Huber L, Ferdin M, Holzmann J, Stubbusch J, Rohrer H. HoxB8 in noradrenergic specification and differentiation of the autonomic nervous system.
Dev Biol. 2012 Mar 1;363(1):219-33. Epub 2011 Dec 24.
Copyright Copyright © 2011 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # NM_204792.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-30 stage 30
stage 30
Spinal Ganglia and Nerves
Entry 15 GEISHA Id SOX10.WatariGoshima.2011 Data Source Publication Complete cDNA Template Probe show AATGGCACTTGCCTGAGCACCTCCCCGGCAGCACGCCCCACAGCCGGAGGGAGAACAGGGGGGCACTGGGACAGGAGCT
Citation Watari-Goshima N, Chisaka O. Chicken HOXA3 Gene: Its Expression Pattern and Role in Branchial Nerve Precursor Cell Migration. Int J Biol Sci. 2011; 7(1): 87101. Published online 2011 January 19. Copyright Copyright © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. Comments The probe was amplified by PCR using the following primers:
5_-AATGGCACTTGCCTGAGCACCTC-3_ and 5_-CTCCGTGGCTGGTACTTGTAGTC-3_ and was extracted from NCBI Acc#NM_204792.1.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-20 stage 19
stage 19
stage 20
stage 20
Cranial Nerve Placode
Entry 16 GEISHA Id SOX10.Giovannone.2012 Data Source Publication Complete cDNA Template Probe show ATTAGTAAAAACCAAGCCTCCCTCCAGGAATGGCACTTGCCTGAGCACCTCCCCGGCAGCACGCCCCACAGCCGGAGGG
Citation Giovannone D, Reyes M, Reyes R, Correa L, Martinez D, Ra H, Gomez G, Kaiser J, Ma L, Stein MP, de Bellard ME. Slits affect the timely migration of neural crest cells via Robo receptor. Dev Dyn. 2012 Aug;241(8):1274-88. Copyright Copyright © 2012 Wiley Periodicals, Inc. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_204792.1).
Entry 17 GEISHA Id SOX10.Hu.2012 Data Source Publication Complete cDNA Template Probe show ATTAGTAAAAACCAAGCCTCCCTCCAGGAATGGCACTTGCCTGAGCACCTCCCCGGCAGCACGCCCCACAGCCGGAGGG
Citation Hu N, Strobl-Mazzulla P, Sauka-Spengler T, Bronner ME. DNA methyltransferase3A as a molecular switch mediating the neural tube-to-neural crest fate transition. Genes Dev. 2012 November 1; 26(21): 23802385. Copyright Copyright © 2012 by Cold Spring Harbor Laboratory Press Comments
As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_204792
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-8 stage 8
stage 8
Neural Crest Neural Plate/Tube
Entry 18 GEISHA Id SOX10.Acloque.2008 Data Source Publication Complete cDNA Template Probe show ATTAGTAAAAACCAAGCCTCCCTCCAGGAATGGCACTTGCCTGAGCACCTCCCCGGCAGCACGCCCCACAGCCGGAGGG
Citation Acloque H, Wilkinson DG, Nieto MA. In situ hybridization analysis of chick embryos in whole-mount and tissue sections. Methods Cell Biol. 2008;87:169-85. doi: 10.1016/S0091-679X(08)00209-4. Copyright Copyright © 2013 Elsevier B.V. All rights reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_204792.1
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-9 stage 9
stage 9
stage 9
Neural Crest
Entry 19 GEISHA Id SOX10.Ferronha.2013 Data Source Publication Complete cDNA Template Probe show ATTAGTAAAAACCAAGCCTCCCTCCAGGAATGGCACTTGCCTGAGCACCTCCCCGGCAGCACGCCCCACAGCCGGAGGG
Citation Ferronha T, Rabadán MA, Gil-Guiñon E, Le Dréau G, de Torres C, Martí E.
LMO4 is an essential cofactor in the Snail2-mediated epithelial-to-mesenchymal transition of neuroblastoma and neural crest cells. J Neurosci. 2013 Feb 13;33(7):2773-83.
Copyright Copyright @ 2013 by the Society of Neuroscience
Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # NM_204269.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-10 stage 10
stage 10
Neural Crest
Entry 20 GEISHA Id SOX10.Zhou.2001 Data Source Publication Complete cDNA Template Probe show ATTAGTAAAAACCAAGCCTCCCTCCAGGAATGGCACTTGCCTGAGCACCTCCCCGGCAGCACGCCCCACAGCCGGAGGG
Citation Zhou Q, Choi G, Anderson DJ. The bHLH transcription factor Olig2 promotes oligodendrocyte differentiation in collaboration with Nkx2.2. Neuron. 2001 Sep 13;31(5):791-807 Copyright Copyright 2001 by Cell Press Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # NM_204792).
Entry 21 GEISHA Id Sox10.Betancur.2011 Data Source Publication Complete cDNA Template Probe show ATTAGTAAAAACCAAGCCTCCCTCCAGGAATGGCACTTGCCTGAGCACCTCCCCGGCAGCACGCCCCACAGCCGGAGGG
Citation Betancur P, Sauka-Spengler T, Bronner M. A Sox10 enhancer element common to the otic placode and neural crest is activated by tissue-specific paralogs. Development. 2011 Sep;138(17):3689-98. Copyright © 2011. Published by The Company of Biologists Ltd Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence was obtained from NCBI (NM_204792.1).
Mouse Frog Fruit Fly Zebra Finch Zebrafish
