Geisha

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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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NOTO
notochord homeobox

Gene

Official Symbol	NOTO
Official Full Name	notochord homeobox
CGNC ID	49744
also known as	CNOT, GNOT1, notochord homeobox\|Gnot1 homeodomain protein, SMYD family member 5 , NOT1
gene type	protein-coding

Genomic Map

	Ensembl
	NCBI
	UCSC

Sequence Information

Genomic
RNA	NM_205354
Polypeptide	NP_990685

Gene Expression

In Situ Hybridization

GEISHA

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human
Mouse
Xenopus
Zebrafish

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Links to other databases

Entrez Gene	396302
Ensembl Gene	ENSGALG00000016090
KEGG	gga:396302

Entry 1

GEISHA Id	C09	Data Source	GEISHA ISH Analysis
Forward cDNA Template Probe	show GCTCAAGCAGCAGTACATGGTGGGCACAGAGCGAGTGGACCTGGCTGCAACGCTGCGTCTCACAGAGACCCAGGTGAAA GTCTGGTTCCAGAACCGGAGGATCAAATGGAGGAAGCAGAGCATGGAGCAGAAGAAGGCAAAGCTGTCACAGTTTGGGG TGATACAGCCCACCTCTGCTGGCCCCACGGATGTCAAGGAGCATGAGGAGGACACAGTGGAGGTTGAGCTTTGAGCAGC TGATGGGATGCAGCTGCCACTGTTGTTTTTGCAGCCACGCCTGCCTGATGGAGGTACTGGGGATGCAGGCACATCTGTG CTTGCTTTGTCCAAGCTAGACTTGAAGTTCTTGCTCTGAGAGTTTTGAGCTACAGAACTAAACTGCCATTGGGTGGGAA GAAGCATCCAAAAGTGTAGAGACCCCTATTTGGTAACCGGTGCTGTAACTCTTGGTCTTGATGGTGCCATCGTTGTGGC AAAGCATGTGATCTCATTTGCTCTCAAAGTGCTAGGAAGCACAGTTTCCAATAAAGAGGCTGGGGTGGCGGTCAGACGG TGTCTCTGATGGCAGTGAGCATGGCAGCATCTGAACATGG
Reverse cDNA Template Probe	show TTGGCGAGTACATCTGCAACCACACACTGCAGCTCGCTGTCGTATTCCTGGTGGGTGGGAGGGCTCGGAGGGGTCAGGA CTGAGTATTCACGTTTCCCTGTCTGTGTTTTAGTAATTCCTAGGGGCTGGTGTGCACAGCAGCAGCAGCAGCTTTTGGC CATGCAGCCGGTGCTCAGGCTGTCACCTCATCCCAGGGCACCAGGCACAACATCTCATGAGCTCAGGATAATTCATCAT GTCTCTTTCCAACCCCAGAATCATAGAATCATAGAATTGCCTGGGTTGAAAAGGACCACAGTGATCATCTGGTTCCAAC CCCCCCGCTATGTGCAGGGTCGCCAACCACCAGACCAGGCTGCCCAGAGCCACATCCATCCTGGCCTTGAATGCCTCCA GGGATGGGGCATCCACAGCCTCCTTGGGCAACCTGTTCCAGTGCGTCACCACCCTCTGAGTGGAAAAACTGTATATTGC CTTCCTCTAGTGTTAGAGAGAAAAGAAATAACATTTTTTTTTCTTTAAAAAAAAAAAAAAAAAA

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

4-6

stage 5

stage 6

Area Pellucida
Head Mesenchyme
Head Process
Mesoderm, early
Notochord

7-12

stage 7

stage 9

stage 10

stage 12

Head Process
Mesoderm, early
Neural Plate/Tube
Notochord
Surface Ectoderm

13-18

stage 13

stage 15

stage 16

Diencephalon
Head Process
Notochord
Pineal Gland
Surface Ectoderm

19-23

stage 22

stage 23

Face Mesenchyme
Pharyngeal Arches and Clefts
Pineal Gland
Wing Mesenchyme

Entry 2

GEISHA Id	Not.Levin.1995	Data Source	Publication
Complete cDNA Template Probe	show CCCGCTGGGCCCTGCTGTGCTGTGGAGGTCTGGAGGGCCCTGCAAAATGAAGAGAGTGCGCACAGTCTTCAAACCGGAG CAGTTGGAGAGGCTGGAGCAAGAGTTCCTCAAGCAGCAGTACATGGTGGGCACAGAGCGAGTGGACCTGGCTGCAACGC TGCGTCTCACAGAGACCCAGGTGAAAGTCTGGTTCCAGAACCGGAGGATCAAATGGAGGAAGCAGAGCATGGAGCAGAA GAAGGCAAAGCTGTCACAGTTTGGGGTGATACAGCCCACCTCTGCTGGCCCCACGGATGTCAAGGAGCATGAGGAGGAC ACAGTGGAGGTTGAGCTTTGAGCAGCTGATGGGATGCAGCTGCCACTGTTGTTTTTGCAGCCACGCCTGCCTGATGGAG GTACTGGGGATGCAGGCACATCTGTGCTTGCTTTGTCCAAGCTAGACTTGAAGTTCTTGCTCTGAGAGTTTTGAGCTAC AGAACTAAACTGCCATTGGGTGGGAAGAAGCATCCAAAAGTGTAGAGACCCCTATTTGGTAACCGGTGCTGTAACTCTT GGTCTTGATGGTGCCATCGTTGTGGCAAAGCATGTGATCTCATTTGCTCTCAAAGTGCTAGGAAGCACAGTTTCCAATA GAGAGGCTGGGGTGGCGGTCAGACGGTGTCTCTGATGGCAGTGAGCATGGCAGCATCTGAACATGGGGTCACTCGTGTT TCAGGTGACTGTGTGCTCCTACGAGGGAGAGCTGTGCTGGGAGGAGATTTGCCTCTGATGGTTTCTCCTGGTCGTCTTG ATTCCCATGTTGGATGCTGAGATCACAACGACAACAAAGTGAAAACTGAAAAGTCAAAAAAAAAAAAAAAAAAAAA
Citation	Levin M, Johnson RL, Stern CD, Kuehn M, Tabin C (1995). A molecular pathway determining left-right asymmetry in chick embryogenesis. Cell. 1995 Sep 8;82(5):803-14.
Copyright	Copyright © 1995 Elsevier Inc. All Rights reserved.
Comments	Probe desig referenced in paper.

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

4-6

stage 4

stage 5

Head Process
Hensen's Node
Notochord

31-44

stage 44

Entry 3

GEISHA Id	NOTO.Anderson.2020	Data Source	Direct Submission
Complete cDNA Template Probe	show CCCGCTGGGCCCTGCTGTGCTGTGGAGGTCTGGAGGGCCCTGCAAAATGAAGAGAGTGCGCACAGTCTTCAAACCGGAG CAGTTGGAGAGGCTGGAGCAAGAGTTCCTCAAGCAGCAGTACATGGTGGGCACAGAGCGAGTGGACCTGGCTGCAACGC TGCGTCTCACAGAGACCCAGGTGAAAGTCTGGTTCCAGAACCGGAGGATCAAATGGAGGAAGCAGAGCATGGAGCAGAA GAAGGCAAAGCTGTCACAGTTTGGGGTGATACAGCCCACCTCTGCTGGCCCCACGGATGTCAAGGAGCATGAGGAGGAC ACAGTGGAGGTTGAGCTTTGAGCAGCTGATGGGATGCAGCTGCCACTGTTGTTTTTGCAGCCACGCCTGCCTGATGGAG GTACTGGGGATGCAGGCACATCTGTGCTTGCTTTGTCCAAGCTAGACTTGAAGTTCTTGCTCTGAGAGTTTTGAGCTAC AGAACTAAACTGCCATTGGGTGGGAAGAAGCATCCAAAAGTGTAGAGACCCCTATTTGGTAACCGGTGCTGTAACTCTT GGTCTTGATGGTGCCATCGTTGTGGCAAAGCATGTGATCTCATTTGCTCTCAAAGTGCTAGGAAGCACAGTTTCCAATA GAGAGGCTGGGGTGGCGGTCAGACGGTGTCTCTGATGGCAGTGAGCATGGCAGCATCTGAACATGGGGTCACTCGTGTT TCAGGTGACTGTGTGCTCCTACGAGGGAGAGCTGTGCTGGGAGGAGATTTGCCTCTGATGGTTTCTCCTGGTCGTCTTG ATTCCCATGTTGGATGCTGAGATCACAACGACAACAAAGTGAAAACTGAAAAGTCAAAAAAAAAAAAAAAAAAAAA
Comments	Images provided by Claire Anderson. The probe provided by Michael Kessel was synthesized from cDNA clone with Genbank accession X82575.

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

4-6

stage 4

Early Mesoderm
Epiblast
Hensen's Node

7-12

stage 7

stage 8

stage 12

Early Mesoderm
Forebrain
Neural Plate/Tube
Notochord

19-21

stage 21

Head Mesenchyme
Leg Mesenchyme
Notochord
Pharyngeal Arches and Clefts
Pineal Gland
Wing Mesenchyme

right

Entry 4

GEISHA Id	CNOT1.Stein.1996	Data Source	Publication
Complete cDNA Template Probe	show CCCGCTGGGCCCTGCTGTGCTGTGGAGGTCTGGAGGGCCCTGCAAAATGAAGAGAGTGCGCACAGTCTTCAAACCGGAG CAGTTGGAGAGGCTGGAGCAAGAGTTCCTCAAGCAGCAGTACATGGTGGGCACAGAGCGAGTGGACCTGGCTGCAACGC TGCGTCTCACAGAGACCCAGGTGAAAGTCTGGTTCCAGAACCGGAGGATCAAATGGAGGAAGCAGAGCATGGAGCAGAA GAAGGCAAAGCTGTCACAGTTTGGGGTGATACAGCCCACCTCTGCTGGCCCCACGGATGTCAAGGAGCATGAGGAGGAC ACAGTGGAGGTTGAGCTTTGAGCAGCTGATGGGATGCAGCTGCCACTGTTGTTTTTGCAGCCACGCCTGCCTGATGGAG GTACTGGGGATGCAGGCACATCTGTGCTTGCTTTGTCCAAGCTAGACTTGAAGTTCTTGCTCTGAGAGTTTTGAGCTAC AGAACTAAACTGCCATTGGGTGGGAAGAAGCATCCAAAAGTGTAGAGACCCCTATTTGGTAACCGGTGCTGTAACTCTT GGTCTTGATGGTGCCATCGTTGTGGCAAAGCATGTGATCTCATTTGCTCTCAAAGTGCTAGGAAGCACAGTTTCCAATA GAGAGGCTGGGGTGGCGGTCAGACGGTGTCTCTGATGGCAGTGAGCATGGCAGCATCTGAACATGGGGTCACTCGTGTT TCAGGTGACTGTGTGCTCCTACGAGGGAGAGCTGTGCTGGGAGGAGATTTGCCTCTGATGGTTTCTCCTGGTCGTCTTG ATTCCCATGTTGGATGCTGAGATCACAACGACAACAAAGTGAAAACTGAAAAGTCAAAAAAAAAAAAAAAAAAAAA
Citation	S Stein, K Niss, M Kessel. Differential Activation of the Clustered Homeobox Genes CNOT2 and CNOT1 During Notogenesis in the Chick. Dev Biol. 1996 Dec 15;180(2):519-33. DOI: 10.1006/dbio.1996.0325.
Copyright	© 1996 Academic Press. All rights reserved.
Comments	The complete cDNA template sequence was obtained from the information from the publication as described in Stein et al. 1996. CNOT1 is also known as NOTO in NCBI.

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

X-XIV

stage XI

Hypoblast

prestreak embryo

7-12

stage 9

Forebrain

neural folds = prospective forebrain

19-24

stage 24

Limb Buds

all

Entry 5

GEISHA Id	Cnot.Stein.1995	Data Source	Publication
Complete cDNA Template Probe	show CCCGCTGGGCCCTGCTGTGCTGTGGAGGTCTGGAGGGCCCTGCAAAATGAAGAGAGTGCGCACAGTCTTCAAACCGGAG CAGTTGGAGAGGCTGGAGCAAGAGTTCCTCAAGCAGCAGTACATGGTGGGCACAGAGCGAGTGGACCTGGCTGCAACGC TGCGTCTCACAGAGACCCAGGTGAAAGTCTGGTTCCAGAACCGGAGGATCAAATGGAGGAAGCAGAGCATGGAGCAGAA GAAGGCAAAGCTGTCACAGTTTGGGGTGATACAGCCCACCTCTGCTGGCCCCACGGATGTCAAGGAGCATGAGGAGGAC ACAGTGGAGGTTGAGCTTTGAGCAGCTGATGGGATGCAGCTGCCACTGTTGTTTTTGCAGCCACGCCTGCCTGATGGAG GTACTGGGGATGCAGGCACATCTGTGCTTGCTTTGTCCAAGCTAGACTTGAAGTTCTTGCTCTGAGAGTTTTGAGCTAC AGAACTAAACTGCCATTGGGTGGGAAGAAGCATCCAAAAGTGTAGAGACCCCTATTTGGTAACCGGTGCTGTAACTCTT GGTCTTGATGGTGCCATCGTTGTGGCAAAGCATGTGATCTCATTTGCTCTCAAAGTGCTAGGAAGCACAGTTTCCAATA GAGAGGCTGGGGTGGCGGTCAGACGGTGTCTCTGATGGCAGTGAGCATGGCAGCATCTGAACATGGGGTCACTCGTGTT TCAGGTGACTGTGTGCTCCTACGAGGGAGAGCTGTGCTGGGAGGAGATTTGCCTCTGATGGTTTCTCCTGGTCGTCTTG ATTCCCATGTTGGATGCTGAGATCACAACGACAACAAAGTGAAAACTGAAAAGTCAAAAAAAAAAAAAAAAAAAAA
Citation	S Stein, M Kessel. A Homeobox Gene Involved in Node, Notochord and Neural Plate Formation of Chick Embryos. Mech Dev. 1995 Jan;49(1-2):37-48. doi: 10.1016/0925-4773(94)00300-c.
Copyright	© 1995 Published by Elsevier Ireland Ltd.
Comments	The complete cDNA template sequence was obtained from the information from the publication as described in Stein et al. 1995. CNOT is also known as NOTO in NCBI.