Geisha

home

contact

A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

Quick Search

Data Class

Enter Text:

Gene Family QuickSearch

	Transcription Factors
	Growth Factors
	Receptors
	MicroRNAs

Human Disease Gene Search

	Downloads
	Protocols
	About GEISHA
	Contact Us

	Transgenic Birds
	Model Organism Databases
	Gene Expression Databases
	Genomic Resources
	Anatomical Atlases
	Chicken Stage Series

TBX4
T-box 4

The human orthologue of this gene is associated
with the following human disease:

Small patella syndrome

Gene

Official Symbol	TBX4
Official Full Name	T-box 4
CGNC ID	48992
also known as	T-box transcription factor TBX4\|T-Box protein 4
gene type	protein-coding

Genomic Map

	Ensembl ID not known
	NCBI
	UCSC

Sequence Information

Genomic
RNA	NM_001030537
Polypeptide	NP_001025708

Gene Expression

In Situ Hybridization

GEISHA

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	9496	ENSG00000121075	MIM:147891	MIM:601719
Mouse	21387	ENSMUSG00000000094	All phenotypic alleles (9):Targeted, knock-out(1) Targeted, other(8)	MGI:102556
Xenopus	100488041, 373555			951381
Zebrafish	100333554, 30070	ENSDARG00000030058	ZDB-GENE-991124-5	ZFIN:ZDB-GENE-991124-5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Links to other databases

Entrez Gene	373989
Ensembl Gene
KEGG	gga:373989

Entry 1

GEISHA Id	TBX4.UApcr	Data Source	GEISHA ISH Analysis
Forward cDNA Template Primer	GTGACCTCCTACCAGAACCACAAG
Reverse cDNA Template Primer	ATTAACCCTCACTAAAGGGGAACTCATTGGCAGCGTTG	cDNA Template Length	889
Forward cDNA Template Probe	show AAAAGTGTGGGGAGGGCTTCTCTCCACACGGACGGATGCACTCTTTCCCTTGGGAAAGATGATGGGGGGACACGCTCCC GAACCTGAGACTGGGCCAGCTGGTTGTAGACGCTGAAGTGGCTGTTCCCTGGGGGCTGCGAGCCCTGCCCTGCGATAGA AGGGAGCCGCGGCATCATGGTGGTGGCTGTGAAATGGGCTGGGAAGGGCTGGTAGGGCACAGTTTCCATTGTCTGAACA CTGTAGCTGGTGTAAGGTGCGACTGAAGTCCACATATTGCAGCTCAGCGGGGGAGGCGGAGGTGGCAAGTCATCCACTG CCGGCACACCCGCGATCTCAGCCCCTGACCCAGAGTACATGCAGGCTTCCCGCGGGGCCACCTCACTGCAGTAGGACGG GCTCAGCATCTGCTGCTCGTAGGGTGGTGGGGAGCGGAAGTAGTGATCGTCACCCACCGATGAGGAGGCCTCCAGGTAG GAGCGCTTGCAGGGCAGGTCCAGGTGCCGCGCGCTTTCTCTTCTCTTCAGGCAGTGATAGAAGAGCCCTGAATCTCTCT GTGCTGTGAAGGTGTTGAGTGACAGGTCTTGAGTATCTGAGGCTGCAAACTGCATGTGAGCACCATTCTCATACTGATA GTGTTGTAGGGTCTGGTGACTGCCATGGAGCGGGTTAACATCTGGCTTGGTCGAGAGCTGGCCATGGCTGGACACCAAT CTCTGCCTCATGATGCTTTTGGAAATCACTGGGTATTCTTTGCTTTGGAGCCGTGCCACGCGCAAGTCGCTGTCGTCAC TTCCCCTGAATCCCTTTGCAAAGGGGTTGTTCTCAATTTTCANCTGAATTATCTTGTGGTTCTGGTAGGAAGTCACAA

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

13-18

stage 13

stage 15

stage 17

Foregut
Lateral Plate Mesoderm
Leg
Limb Buds
Lung

Low level expression observed in the lung.

19-24

stage 19

stage 20

Allantois
Hindbrain
Leg
Lung
Outflow Tract

25-26

stage 25

stage 26

Leg Mesenchyme
Lung
Outflow Tract

Left side.
Right side.
Ventral view with the heart removed.

Entry 2

GEISHA Id	Tbx4.Krause.2004	Data Source	Publication
Complete cDNA Template Probe	show GCGCCCCGCGCAGCCCCGCGCTGCCCCGTGCTCCCTTCATGCCGCAGCCGCCCCGAGACGAAGCCAGGAGCCCCCCGCT GCGCCCGCTGCCCCCCGGCCGGCAGTGAAATGCTCCAGGAGAAAAGCCTGTCTGAAACCGAGGAAGGGTTTCCAACAGC CCCCGCACCCGGCCATGCGGACTCCTCCGCGGGCTCCCCCGTCCTCGGCGTAGCCGGGGGCAGCAGCACTCCGCTCAGC AGCCCGCAGCTCCCCGACCCCGAGCAGACGATAGAAAACATCAAAGTCTATCTCCACGAGAAGGAGCTATGGAAGAAGT TCCATGAAGCGGGCACCGAAATGATCATAACCAAAGCAGGCAGGAGGATGTTTCCGAGCTACAAGGTCAAGGTGACTGG AATGAACCCCAAGACCAAGTACATTCTGTTGATTGACATTGTCCCAGCTGATGACCACCGGTATAAATTCTGTGACAAT AAATGGATGGTGGCTGGGAAGGCAGAACCCGCCATGCCGGGCCGGCTGTATGTGCACCCTGACTCGCCTGCCACTGGAG CGCACTGGATGCGGCAGCTCGTGTCCTTCCAGAAGCTGAAGCTCACCAACAACCACCTGGATCCCTTCGGGCATATCAT CCTCAATTCAATGCACAAATACCAGCCGCGGCTGCACATTGTGAAGGCAGATGAGAACAATGCTTTTGGCTCAAAGAAC ACGGCCTTCTGCACCCACGTGTTTCCAGAGACGTCCTTTATCTCGGTGACCTCCTACCAGAACCACAAGATAACTCAGC TGAAAATTGAGAACAACCCCTTTGCAAAGGGATTCAGGGGAAGTGACGACAGCGACCTGCGCGTGGCACGGCTCCAAAG CAAAGAATACCCAGTGATTTCCAAAAGCATCATGAGGCAGAGATTGGTGTCCAGCCATGGCCAGCTCTCGACCAAGCCA GATGTTAACCCGCTCCATGGCAGTCACCAGACCCTACAACACTATCAGTATGAGAATGGTGCTCACATGCAGTTTGCAG CCTCAGATACTCAAGACCTGTCACTCAACACCTTCACAGCACAGAGAGATTCAGGGCTCTTCTATCACTGCCTGAAGAG AAGAGAAAGTGCGCGGCACCTGGACCTGCCCTGCAAGCGCTCCTACCTGGAGGCCTCCTCATCGGTGGGTGACGATCAC TACTTCCGCTCCCCACCACCCTACGAGCAGCAGATGCTGAGCCCGTCCTACTGCAGTGAGGTGGCCCCGCGGGAAGCCT GCATGTACTCTGGGTCAGGGGCTGAGATCGCGGGTGTGCCGGCAGTGGATGACTTGCCACCTCCGCCTCCCCCGCTGAG CTGCAATATGTGGACTTCAGTCGCACCTTACACCAGCTACAGTGTTCAGACAATGGAAACTGTGCCCTACCAGCCCTTC CCAGCCCATTTCACAGCCACCACCATGATGCCGCGGCTCCCTTCTATCGCAGGGCAGGGCTCGCAGCCCCCAGGGAACA GCCACTTCAGCGTCTACAACCAGCTGGCCCAGTCTCAGGTTCGGGAGCGTGTCCCCCCATCATCTTTCCCAAGGGAAAG AGTGCATCCGTCCGTGTGTGAGAGGAAGCCACCTTCCCCACACCTCAACGCTGCCAATGAGTTCCTCTACTCCCAAAGC TTCTCCTTGTCACGAGAGTCCTCGCTGCAGTACCATTCAGGAATGGGGACGGTGGAGAACTGGACGGACGGGTGACTCC GCGGGCCCAGCGGTGCCGCAGCTCGCATTACCGCTCCGGGACGGTGCTAAGGCAGCGTTATACCTGTGGGTAACTTGCA CTTGGGTGAGACGAGCATGCATTTCCCAGGGGCGCCGTGTGTGTGGGGAGCGCCCATCTCTGGGCACACTGAGAATTAC GGCTCCTGGATCCATCAGCCTCTGACTGACTTCCGAATGAATTAATTCTCACGTCTTCGTTACCGATCTGGTAGAAACC ATCTTCTAGACTAATGAGTGAAGTTGTCTGTCATTCGCTTTTGCCTGTAACAGTAAGCATCCGTGAGCAAATTTCGACT TTTTGGGAAAAGCACGAGCTTCACTTATATGGTACTCAGTTCGTGAAGTCACAGAATCCCCCAAACCAAAGGAAGAAGT GATCTGTTGGGCTGTGTAGCTCCAGGACTGCTGTAGCAGCACGTGTTAGGCTCTGTCCACCTGCAGAAATTCCCTTTCC TCTGAGGCCAGTGGTGAGGTGCCATTCCAAACTCCAGGCGCAGCGCAGAGAGGAGAAGCTCCGGTGCGCAAATGTCCCT TCTTCCCCCATTGACCGTGGCTGTGGGAGACCGAGAAGTGAAGCATTACGCCCCGGGCCAAA
Citation	Krause A, Zacharias W, Camarata T, Linkhart B, Law E, Lischke A, Miljan E, Simon HG. Tbx5 and Tbx4 transcription factors interact with a new chicken PDZ-LIM protein in limb and heart development. Dev Biol. 2004 Sep 1;273(1):106-20.
Copyright	Reprinted from Developmental Biology, Volume 273, Issue 1, Ange Krause, William Zacharias, Troy Camarata, Barbara Linkhart, Evelyn Law, Antje Lischke, Erik Miljan, and Hans-Georg Simon, Tbx5 and Tbx4 transcription factors interact with a new chicken PDZ-LIM protein in limb and heart development, Pages 106-120, Copyright 2004, with permission from Elsevier. Copyright © 2004 Elsevier B.V. All rights reserved.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence is from GenBank Entry NM_001030537.1

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

13-18

stage 15

stage 18

Leg
Limb Buds

19-24

stage 21

Heart
Outflow Tract

25-30

stage 25

stage 29

Heart
Leg
Limb Buds
Outflow Tract
Ventricles

31-32

stage 32

Leg

Entry 3

GEISHA Id	Tbx4.Gibson-Brown.1998	Data Source	Publication
Complete cDNA Template Probe	show GCGCCCCGCGCAGCCCCGCGCTGCCCCGTGCTCCCTTCATGCCGCAGCCGCCCCGAGACGAAGCCAGGAGCCCCCCGCT GCGCCCGCTGCCCCCCGGCCGGCAGTGAAATGCTCCAGGAGAAAAGCCTGTCTGAAACCGAGGAAGGGTTTCCAACAGC CCCCGCACCCGGCCATGCGGACTCCTCCGCGGGCTCCCCCGTCCTCGGCGTAGCCGGGGGCAGCAGCACTCCGCTCAGC AGCCCGCAGCTCCCCGACCCCGAGCAGACGATAGAAAACATCAAAGTCTATCTCCACGAGAAGGAGCTATGGAAGAAGT TCCATGAAGCGGGCACCGAAATGATCATAACCAAAGCAGGCAGGAGGATGTTTCCGAGCTACAAGGTCAAGGTGACTGG AATGAACCCCAAGACCAAGTACATTCTGTTGATTGACATTGTCCCAGCTGATGACCACCGGTATAAATTCTGTGACAAT AAATGGATGGTGGCTGGGAAGGCAGAACCCGCCATGCCGGGCCGGCTGTATGTGCACCCTGACTCGCCTGCCACTGGAG CGCACTGGATGCGGCAGCTCGTGTCCTTCCAGAAGCTGAAGCTCACCAACAACCACCTGGATCCCTTCGGGCATATCAT CCTCAATTCAATGCACAAATACCAGCCGCGGCTGCACATTGTGAAGGCAGATGAGAACAATGCTTTTGGCTCAAAGAAC ACGGCCTTCTGCACCCACGTGTTTCCAGAGACGTCCTTTATCTCGGTGACCTCCTACCAGAACCACAAGATAACTCAGC TGAAAATTGAGAACAACCCCTTTGCAAAGGGATTCAGGGGAAGTGACGACAGCGACCTGCGCGTGGCACGGCTCCAAAG CAAAGAATACCCAGTGATTTCCAAAAGCATCATGAGGCAGAGATTGGTGTCCAGCCATGGCCAGCTCTCGACCAAGCCA GATGTTAACCCGCTCCATGGCAGTCACCAGACCCTACAACACTATCAGTATGAGAATGGTGCTCACATGCAGTTTGCAG CCTCAGATACTCAAGACCTGTCACTCAACACCTTCACAGCACAGAGAGATTCAGGGCTCTTCTATCACTGCCTGAAGAG AAGAGAAAGTGCGCGGCACCTGGACCTGCCCTGCAAGCGCTCCTACCTGGAGGCCTCCTCATCGGTGGGTGACGATCAC TACTTCCGCTCCCCACCACCCTACGAGCAGCAGATGCTGAGCCCGTCCTACTGCAGTGAGGTGGCCCCGCGGGAAGCCT GCATGTACTCTGGGTCAGGGGCTGAGATCGCGGGTGTGCCGGCAGTGGATGACTTGCCACCTCCGCCTCCCCCGCTGAG CTGCAATATGTGGACTTCAGTCGCACCTTACACCAGCTACAGTGTTCAGACAATGGAAACTGTGCCCTACCAGCCCTTC CCAGCCCATTTCACAGCCACCACCATGATGCCGCGGCTCCCTTCTATCGCAGGGCAGGGCTCGCAGCCCCCAGGGAACA GCCACTTCAGCGTCTACAACCAGCTGGCCCAGTCTCAGGTTCGGGAGCGTGTCCCCCCATCATCTTTCCCAAGGGAAAG AGTGCATCCGTCCGTGTGTGAGAGGAAGCCACCTTCCCCACACCTCAACGCTGCCAATGAGTTCCTCTACTCCCAAAGC TTCTCCTTGTCACGAGAGTCCTCGCTGCAGTACCATTCAGGAATGGGGACGGTGGAGAACTGGACGGACGGGTGACTCC GCGGGCCCAGCGGTGCCGCAGCTCGCATTACCGCTCCGGGACGGTGCTAAGGCAGCGTTATACCTGTGGGTAACTTGCA CTTGGGTGAGACGAGCATGCATTTCCCAGGGGCGCCGTGTGTGTGGGGAGCGCCCATCTCTGGGCACACTGAGAATTAC GGCTCCTGGATCCATCAGCCTCTGACTGACTTCCGAATGAATTAATTCTCACGTCTTCGTTACCGATCTGGTAGAAACC ATCTTCTAGACTAATGAGTGAAGTTGTCTGTCATTCGCTTTTGCCTGTAACAGTAAGCATCCGTGAGCAAATTTCGACT TTTTGGGAAAAGCACGAGCTTCACTTATATGGTACTCAGTTCGTGAAGTCACAGAATCCCCCAAACCAAAGGAAGAAGT GATCTGTTGGGCTGTGTAGCTCCAGGACTGCTGTAGCAGCACGTGTTAGGCTCTGTCCACCTGCAGAAATTCCCTTTCC TCTGAGGCCAGTGGTGAGGTGCCATTCCAAACTCCAGGCGCAGCGCAGAGAGGAGAAGCTCCGGTGCGCAAATGTCCCT TCTTCCCCCATTGACCGTGGCTGTGGGAGACCGAGAAGTGAAGCATTACGCCCCGGGCCAAA
Citation	Gibson-Brown JJ, I Agulnik S, Silver LM, Papaioannou VE. Expression of T-box genes Tbx2-Tbx5 during chick organogenesis. Mech Dev. 1998 Jun;74(1-2):165-9.
Copyright	Copyright © 1998 Elsevier Science Ireland Ltd.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence was obtained from NCBI (NM_001030537).