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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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HAND2
heart and neural crest derivatives expressed 2

Gene

Official Symbol	HAND2
Official Full Name	heart and neural crest derivatives expressed 2
CGNC ID	49493
also known as	dHAND, heart- and neural crest derivatives-expressed protein 2\|deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2, Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2, dHAND, Heart- and neural crest derivatives-expressed protein 2
gene type	protein-coding

Genomic Map

	Ensembl ID not known
	NCBI
	UCSC

Sequence Information

Genomic
RNA	NM_204966
Polypeptide	NP_990297

Gene Expression

In Situ Hybridization

GEISHA

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly	34379			FBgn0032209
Human	9464	ENSG00000164107		MIM:602407
Mouse	15111	ENSMUSG00000038193	All phenotypic alleles (9):Targeted, knock-out(3) Targeted, other(6)	MGI:103580
Xenopus	100101704, 373641, 373833			481425
Zebrafish	58150	ENSDARG00000008305	ZDB-GENE-000511-1	ZFIN:ZDB-GENE-000511-1

Gene Ontology

Molecular Function	DNA binding, protein dimerization activity
Biological Process	multicellular organismal development, regulation of transcription, DNA-templated, more...transcription, DNA-templated
Cellular Component	nucleus

Links to other databases

Entrez Gene	395813
Ensembl Gene
KEGG	gga:395813

Entry 1

GEISHA Id	HAND2.UAlinear	Data Source	GEISHA ISH Analysis
Forward cDNA Template Probe	show TCCGGCTGGCTTTCAGCAGCCACCCGGAGATGTCCCCCCCCGACTACAGCATGGCTCTGTCCTACAGCCCCGAGTACGC CAACGGGGCGCCGGGCATGGACCACTCCCATTACNGGGGGGTGCCGCCCGGGAGCGGCCCGCCCGGGCTCGGGGGGCCC CGGCCGGTGAAGCGCAGGGGCACGGCNAACCGCAAGGAGCGGCGCAGGACTCAGAGCATCAACAGCGCCTTCGCGGAGC TGCGCGAGTGCATCCCCAACGTGCCCGCCGACACCAANCTCTCTAANATNAAAACCCTCCGCCTGGCCACCAGCTACAT CGCCTACCTCATGGACCTGCTGGCCAAGGACGACCAGAACGGGNAGGCGGAGGCTTTCAAGGCAGAGATCAAGAAGACG GACGTGAAGGAGGAGAAGAGGAAGAAGGAGCTGAACGAAATCTTGAAAAGCACAGTTAGCAGCAGCGATAAGCCTTTAG TGAGGGTTAATTTTCTAGAGCAA

Stage

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Location (click to highlight)

Comments (click to highlight)

1-3

stage 3

Area Opaca
Early Mesoderm
Extraembryonic Mesoderm

4-6

stage 4

stage 6

Extraembryonic Mesoderm
Lateral Plate Mesoderm

7-12

stage 8

stage 9

stage 10

stage 11

Anterior Intestinal Portal
Anterior/Second Heart Field
Extraembryonic Mesoderm
Heart Tube
Lateral Plate Mesoderm

13-18

stage 15

stage 16

Anterior/Second Heart Field
Extraembryonic Mesoderm
Heart
Lateral Plate Mesoderm
Pharyngeal Arches and Clefts

19-24

stage 21

stage 24

Allantois
Extraembryonic
Heart
Lateral Plate Mesoderm
Leg Mesenchyme
Limb Buds
Neural Plate/Tube
Pharyngeal Arches and Clefts
Wing Mesenchyme

25-26

stage 26

Extraembryonic
Heart
Leg Mesenchyme
Pharyngeal Arches and Clefts
Wing Mesenchyme

Entry 2

GEISHA Id	dHand.Lopez-Sanchez.2009	Data Source	Publication
Complete cDNA Template Probe	show AGCAGCGGCGATGAGTCTTGTGGGCGGCTTCCCCCACCACCCGGTGGTGCACCATGAGGGTTACCCCCTTCGTCGTCGC CGCTGTCGTCGCCGCCGCCGTCACCCGCTGCGGCCACGAGGAGAACCCCTACTTCACGGCTGGCTTATCAGCAGCCACC CGGAGATGTCCCCCCCCGACTACAGCATGGCTCTGTCCTACAGCCCCGAGTACGCCAACGGGGCGCCGGGCATGGACCA CTCCCATTACGGGGGGGTGCCGCCCGGGAGCGGCCCGCCCGGGCTCGGGGGGCCCCGGCCGGTGAAGCGCAGGGGCACG GCGAACCGCAAGGAGCGGCGCAGGACTCAGAGCATCAACAGCGCCTTCGCGGAGCTGCGCGAGTGCATCCCCAACGTGC CCGCCGACACCAAGCTCTCTAAGATCAAAACCCTCCGCCTGGCCACCAGCTACATCGCCTACCTCATGGACCTGCTGCC CAAGGACGACCAGAACGGGGAGGCGGAGGCTTTCAAGGCAGAGATCAAGAAGACGGACGTGAAGGAGGAGAAGAGGAAG AAGGAGCTGAACGAAATCTTGAAAAGCACAGTTAGCAGCAGCGATAAGAAAACCAAAGGGCGGACAGGCTGGCCGCAGC ACGTCTGGGCGCTGGAGCTCAAGCAGTGAGCGCGGCGGG
Citation	Lopez-Sanchez C, Garcia-Masa N, Gañan CM, Garcia-Martinez V. Movement and commitment of primitive streak precardiac cells during cardiogenesis. Int J Dev Biol. 2009;53(8-10):1445-55.
Copyright	Reprinted from Int. J. Dev. Biol. Copyright (2009), with permission from UBC Press. All rights reserved.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (NM_204966.1)

Stage

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Location (click to highlight)

Comments (click to highlight)

7-9

stage 8

stage 9

Anterior/Second Heart Field
Lateral Plate Mesoderm

Entry 3

GEISHA Id	HAND2.Firulli.2005	Data Source	Publication
Complete cDNA Template Probe	show AGCAGCGGCGATGAGTCTTGTGGGCGGCTTCCCCCACCACCCGGTGGTGCACCATGAGGGTTACCCCCTTCGTCGTCGC CGCTGTCGTCGCCGCCGCCGTCACCCGCTGCGGCCACGAGGAGAACCCCTACTTCACGGCTGGCTTATCAGCAGCCACC CGGAGATGTCCCCCCCCGACTACAGCATGGCTCTGTCCTACAGCCCCGAGTACGCCAACGGGGCGCCGGGCATGGACCA CTCCCATTACGGGGGGGTGCCGCCCGGGAGCGGCCCGCCCGGGCTCGGGGGGCCCCGGCCGGTGAAGCGCAGGGGCACG GCGAACCGCAAGGAGCGGCGCAGGACTCAGAGCATCAACAGCGCCTTCGCGGAGCTGCGCGAGTGCATCCCCAACGTGC CCGCCGACACCAAGCTCTCTAAGATCAAAACCCTCCGCCTGGCCACCAGCTACATCGCCTACCTCATGGACCTGCTGCC CAAGGACGACCAGAACGGGGAGGCGGAGGCTTTCAAGGCAGAGATCAAGAAGACGGACGTGAAGGAGGAGAAGAGGAAG AAGGAGCTGAACGAAATCTTGAAAAGCACAGTTAGCAGCAGCGATAAGAAAACCAAAGGGCGGACAGGCTGGCCGCAGC ACGTCTGGGCGCTGGAGCTCAAGCAGTGAGCGCGGCGGG
Citation	Beth A. Firulli, Dayana Krawchuk, Victoria E. Centonze, David M. Virshup, Simon J. Conway, Peter Cserjesi, Ed Laufer, Anthony B. Firulli. Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities. Nat Genet. 2005 April; 37(4): 373381.
Copyright	© 2012 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
Comments	As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_204966.1 ).

Stage

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Location (click to highlight)

Comments (click to highlight)

19-24

stage 20

stage 21

stage 24

Limb Buds

25-30

stage 27

stage 30

Limb Buds

Entry 4

GEISHA Id	HAND2.Huber.2012	Data Source	Publication
Complete cDNA Template Probe	show AGCAGCGGCGATGAGTCTTGTGGGCGGCTTCCCCCACCACCCGGTGGTGCACCATGAGGGTTACCCCCTTCGTCGTCGC CGCTGTCGTCGCCGCCGCCGTCACCCGCTGCGGCCACGAGGAGAACCCCTACTTCACGGCTGGCTTATCAGCAGCCACC CGGAGATGTCCCCCCCCGACTACAGCATGGCTCTGTCCTACAGCCCCGAGTACGCCAACGGGGCGCCGGGCATGGACCA CTCCCATTACGGGGGGGTGCCGCCCGGGAGCGGCCCGCCCGGGCTCGGGGGGCCCCGGCCGGTGAAGCGCAGGGGCACG GCGAACCGCAAGGAGCGGCGCAGGACTCAGAGCATCAACAGCGCCTTCGCGGAGCTGCGCGAGTGCATCCCCAACGTGC CCGCCGACACCAAGCTCTCTAAGATCAAAACCCTCCGCCTGGCCACCAGCTACATCGCCTACCTCATGGACCTGCTGCC CAAGGACGACCAGAACGGGGAGGCGGAGGCTTTCAAGGCAGAGATCAAGAAGACGGACGTGAAGGAGGAGAAGAGGAAG AAGGAGCTGAACGAAATCTTGAAAAGCACAGTTAGCAGCAGCGATAAGAAAACCAAAGGGCGGACAGGCTGGCCGCAGC ACGTCTGGGCGCTGGAGCTCAAGCAGTGAGCGCGGCGGG
Citation	Huber L, Ferdin M, Holzmann J, Stubbusch J, Rohrer H. HoxB8 in noradrenergic specification and differentiation of the autonomic nervous system. Dev Biol. 2012 Mar 1;363(1):219-33. Epub 2011 Dec 24.
Copyright	Copyright © 2011 Elsevier Inc. All rights reserved.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # NM_204966.1).

Stage

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Location (click to highlight)

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25-30

stage 27

Head Mesenchyme

ciliary ganglia
control embryo

31-34

stage 34

Cranial Ganglia

control embryo

Entry 5

GEISHA Id	DHAND.Howard.2000	Data Source	Publication
Complete cDNA Template Probe	show AGCAGCGGCGATGAGTCTTGTGGGCGGCTTCCCCCACCACCCGGTGGTGCACCATGAGGGTTACCCCCTTCGTCGTCGC CGCTGTCGTCGCCGCCGCCGTCACCCGCTGCGGCCACGAGGAGAACCCCTACTTCACGGCTGGCTTATCAGCAGCCACC CGGAGATGTCCCCCCCCGACTACAGCATGGCTCTGTCCTACAGCCCCGAGTACGCCAACGGGGCGCCGGGCATGGACCA CTCCCATTACGGGGGGGTGCCGCCCGGGAGCGGCCCGCCCGGGCTCGGGGGGCCCCGGCCGGTGAAGCGCAGGGGCACG GCGAACCGCAAGGAGCGGCGCAGGACTCAGAGCATCAACAGCGCCTTCGCGGAGCTGCGCGAGTGCATCCCCAACGTGC CCGCCGACACCAAGCTCTCTAAGATCAAAACCCTCCGCCTGGCCACCAGCTACATCGCCTACCTCATGGACCTGCTGCC CAAGGACGACCAGAACGGGGAGGCGGAGGCTTTCAAGGCAGAGATCAAGAAGACGGACGTGAAGGAGGAGAAGAGGAAG AAGGAGCTGAACGAAATCTTGAAAAGCACAGTTAGCAGCAGCGATAAGAAAACCAAAGGGCGGACAGGCTGGCCGCAGC ACGTCTGGGCGCTGGAGCTCAAGCAGTGAGCGCGGCGGG
Citation	Howard MJ, Stanke M, Schneider C, Wu X, Rohrer H. The transcription factor dHAND is a downstream effector of BMPs in sympathetic neuron specification. Development. 2000 Sep;127(18):4073-81.
Copyright	Copyright is held by the authors. Published by The Company of Biologists, Ltd.
Comments	As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_204966.1

Stage

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Location (click to highlight)

Comments (click to highlight)

stage 19

Spinal Ganglia and Nerves

Entry 6

GEISHA Id	HAND2.Wu.2002	Data Source	Publication
Complete cDNA Template Probe	show GCAGCGGCGATGAGTCTGGTGGGCGGCTTCCCCCACCACCCGGTGGTGCACCATGAGGGTTACCCCTTCGCCGCCGCCG CTGCCGCCGCCGCCGCCGCCACCCGCTGCGGCCACGAGGAGAACCCCTACTTCCACGGCTGGCTTATCAGCAGCCACCC GGAGATGTCCCCCCCCGACTACAGCATGGCTCTGTCCTACAGCCCCGAGTACGCCAACGGGGCGCCGGGCATGGACCAC TCCCATTACGGGGGGGTGCCGCCCGGGAGCGGCCCGCCCGGGCTCGGGGGGCCCCGGCCGGTGAAGCGCAGGGGCACGG CGAACCGCAAGGAGCGGCGCAGGACTCAGAGCATCAACAGCGCTTTCGCTGAGCTGCGCGAGTGCATCCCCAACGTGCC CGCCGACACCAAGCTCTCTAAGATCAAAACCCTCCGCCTGGCCACCAGCTACATCGCCTACCTCATGGACCTGCTGGCC AAGGACGACCAGAACGGGGAGGCGGAGGCTTTCAAGGCAGAGATCAAGAAGACGGACGTGAAGGAGGAGAAGAGGAAGA AGGAGCTGAACGAAATCTTGAAAAGCACAGTTAGCAGCAGCGATAAGAAAACCAAAGGGCGGACAGGCTGGCCGCAGCA CGTCTGGGCGCTGGAGCTCAAGCAGTGAGCGCGGCGGG
Citation	Wu X, Howard MJ. Transcripts encoding HAND genes are differentially expressed and regulated by BMP4 and GDNF in developing avian gut. Gene Expr. 2002;10(5-6):279-93.
Copyright	copyright @ 2002 Cognizant Comm. Corp.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence was obtained from NCBI (NM_204966.2).

Stage

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Location (click to highlight)

Comments (click to highlight)

25-30

stage 25

Esophagus
Gizzard
Hindgut
Midgut

31-44

stage 34

stage 44

Esophagus
Gizzard
Hindgut
Midgut

Entry 7

GEISHA Id	HAND2.Anderson.2021	Data Source	Direct Submission
Complete cDNA Template Probe	show CAGCGGCGATGAGTCTGGTGGGCGGCTTCCCCCACCACCCGGTGGTGCACCATGAGGGTTACCCNTTCGCCGCCGCCGC TGCCGCCGCCGCCGCCGCCACCCGCTGCGGCCACGAGGAGAACCCCTACTTCCACGGCTGGCTTATCAGCAGCCACCCG GAGATGTCCCCCCCCGACTACAGCATGGCTCTGTCCTACAGCCCCGAGTACGCCAACGGGGCGCCGGGCATGGACCACT CCCATTACGGGGGGGTGCCGCCCGGGAGCGGCCCGCCCGGGCTCGGGGGGCCCCGGCCGGTGAAGCGCAGGGGCACGGC GAACCGCAAGGAGCGGCGCAGGACTCAGAGCATCAACAGCGCCTTCGCGGAGCTGCGCGAGTGCATCCCCAACGTGCCC GCCGACACCAAGCTCTCTAAGATCAAAACCCTCCGCCTGGCCACCAGCTACATCGCCTACCTCATGGACCTGCTGGCCA AGGACGACCAGAACGGGGAGGCGGAGGCTTTCAAGGCAGAGATCAAGAAGACGGACGTGAAGGAGGAGAAGAGGAAGAA GGAGCTGAACGAAATCTTGAAAAGCACAGTTAGCAGCAGCGATAAGAAAACCAAAGGGCGGACAGGCTGGCCGCAGCAC GTCTGGGCGCTGGAGCTCAAGCAGTGAGCGCGGCGGG
Comments	Images and probe sequence information provided by Claire Anderson.