Quick Search
X XI XII XIII XIV 1 2 3 4 5 6 7 8 9 10 11 12
13 14 15 16 17 18 19 20 21 22 23 24
25 26 27 28 29 30 31 32 33 34 35 36
37 38 38 40 41 42 43 44
Gene Family QuickSearch
Human Disease Gene Search
BMPR1B The human orthologue of this gene is associated
Gene Summary Expression Other Species Expression JBrowse Gene Official Symbol BMPR1B Official Full Name bone morphogenetic protein receptor type 1B CGNC ID 49616 also known as RPK-1, bone morphogenetic protein receptor type-1B|ALK-6|BMP type-1B receptor|BMPR-1B|SKR6|activin receptor-like kinase 6|bone morphogenetic protein receptor, type IB|receptor protein kinase|serine/threonine-protein kinase receptor R6, Bone morphogenetic protein receptor type IB precursor, Serine/threonine-protein kinase receptor R6 (SKR6), Activin receptor-like kinase 6 (ALK-6), RPK-1 gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Links to other databases
Entry 1 GEISHA Id BMPR1B.UApcr Data Source GEISHA ISH Analysis Forward cDNA Template Primer 5'-TGTCAGTGCCACCACCATTGTC-3' Reverse cDNA Template Primer 5'-ATTAACCCTCACTAAAGGCCGTTCTTTTTCACCAGGATGTTC-3' cDNA Template Length 938 Complete cDNA Template Probe show TGTCAGTGCCACCACCATTGTCCTGAGGACTCAGTCAACAGCACCTGCAGCACTGATGGCTACTGCTTCACCATAATAG
Entry 2 GEISHA Id BMPR-1B.McPherson.2000 Data Source Publication Complete cDNA Template Probe show ATGCCCTTGCTTAGCTCCAGCAAGTTGAGCATGGAGAGCAGAAAAGAAGATGTCGAGGGCACAGCACCTGCCCCTCCAC
Citation McPherson CE, Varley JE, Maxwell GD. Expression and regulation of type I BMP receptors during early avian sympathetic ganglion development. Dev Biol. 2000 May 1;221(1):220-32. Copyright Reprinted with permission from Elsevier.
Copyright © 2000 Elsevier B.V. All rights reserved.
Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (AF189778) and is Quail, but the mapped gene is the chick homolog.
Entry 3 GEISHA Id BmprIB.Ashique.2002 Data Source Publication Complete cDNA Template Probe show GTTTTCCAGCAGACTGATGCTATAAATGCTCCACAACATGGAGAATGGTTTGGGTTGGAAGTAGACTTAAAGACCATCT
Citation Ashique AM, Fu K, Richman JM. Signalling via type IA and type IB bone morphogenetic protein receptors (BMPR) regulates intramembranous bone formation, chondrogenesis and feather formation in the chicken embryo. Int J Dev Biol. 2002 Mar;46(2):243-53. Copyright "Reprinted from Int. J. Dev. Biol., 46, Ashique AM, Fu K, Richman JM, Signalling via type IA and type IB bone morphogenetic protein receptors (BMPR) regulates intramembranous bone formation, chondrogenesis and feather formation in the chicken embryo, 243-53, Copyright (2002), with permission from Copyright © 2002 UBC Press". All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc #NM_205132).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-30 stage 30
stage 30
Face Mesenchyme 31-44 stage 32
stage 44
Face Mesenchyme
Entry 4 GEISHA Id BMPR-1B.Hyre.2003 Data Source Publication Complete cDNA Template Probe show GTTTTCCAGCAGACTGATGCTATAAATGCTCCACAACATGGAGAATGGTTTGGGTTGGAAGTAGACTTAAAGACCATCT
Citation Hyer J, Kuhlman J, Afif E, Mikawa T. Optic cup morphogenesis requires pre-lens ectoderm but not lens differentiation. Dev Biol. 2003 Jul 15;259(2):351-63. Copyright Copyright © 2003 Elsevier Science (USA) All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205132).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-11 stage 11
stage 11
Head Mesenchyme
Entry 5 GEISHA Id BMPR1B.Smith.2000 Data Source Publication Complete cDNA Template Probe show GTTTTCCAGCAGACTGATGCTATAAATGCTCCACAACATGGAGAATGGTTTGGGTTGGAAGTAGACTTAAAGACCATCT
Citation Smith DM, Grasty RC, Theodosiou NA, Tabin CJ, Nascone-Yoder NM. Evolutionary relationships between the amphibian, avian, and mammalian stomachs. Evol Dev. 2000 Nov-Dec;2(6):348-59. Copyright Copyright © 2000-2011 by John Wiley & Sons, Inc., or related companies. All rights reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc. # NM_205132)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 24
stage 24
Gizzard Splanchnic Mesoderm
Entry 6 GEISHA Id BMPR1B.Huber.2008 Data Source Publication Complete cDNA Template Probe show GTTTTCCAGCAGACTGATGCTATAAATGCTCCACAACATGGAGAATGGTTTGGGTTGGAAGTAGACTTAAAGACCATCT
Citation Huber K, Franke A, Brühl B, Krispin S, Ernsberger U, Schober A, von Bohlen und Halbach O, Rohrer H, Kalcheim C, Unsicker K. Persistent expression of BMP-4 in embryonic chick adrenal cortical cells and its role in chromaffin cell development. Neural Dev. 2008 Oct 22;3:28. Copyright © 2008 Huber et al; licensee BioMed Central Ltd. (requested from Dr. Unsicker) Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc # NM_205132.1)
Entry 7 GEISHA Id BMPR1b.Bobak.2009 Data Source Publication Complete cDNA Template Probe show GTTTTCCAGCAGACTGATGCTATAAATGCTCCACAACATGGAGAATGGTTTGGGTTGGAAGTAGACTTAAAGACCATCT
Citation Bobak N, Agoston Z, Schulte D. Evidence against involvement of Bmp receptor 1b signaling in fate specification of the chick mesencephalic alar plate at HH16. Neurosci Lett. 2009 Sep 25;461(3):223-8. Epub 2009 Jun 16 Copyright Reprinted with permission from Elsevier.
Copyright © 2009 Elsevier B.V. All rights reserved.
Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc #NM_205132.1)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-16 stage 16
stage 16
Mesencephalon Midbrain
Entry 8 GEISHA Id BMPR1B.Ishii.2010 Data Source Publication Complete cDNA Template Probe show GTTTTCCAGCAGACTGATGCTATAAATGCTCCACAACATGGAGAATGGTTTGGGTTGGAAGTAGACTTAAAGACCATCT
Citation Ishii Y, Garriock RJ, Navetta AM, Coughlin LE, Mikawa T.. BMP Signals Promote Proepicardial Protrusion Necessary for Recruitment of Coronary Vessel and Epicardial Progenitors to the Heart. Dev Cell. 2010 August 17; 19(2): 307316. Copyright Copyright © 2010 Elsevier Inc. All rights reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_205132.1 ).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-16 stage 16
stage 16
Proepicardium
Entry 9 GEISHA Id BMPR1B.Inai.2008 Data Source Publication Complete cDNA Template Probe show GTTTTCCAGCAGACTGATGCTATAAATGCTCCACAACATGGAGAATGGTTTGGGTTGGAAGTAGACTTAAAGACCATCT
Citation Inai K, Norris RA, Hoffman S, Markwald RR, Sugi Y. BMP-2 induces cell migration and periostin expression during atrioventricular valvulogenesis. Dev Biol. 2008 Mar 15;315(2):383-96. Epub 2007 Dec 31. Copyright Copyright © 2012 Elsevier B.V. All rights reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_205132.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 24
stage 24
Heart
Entry 10 GEISHA Id BMPR1B.Okagawa.2007 Data Source Publication Complete cDNA Template Probe show TGCTACTTCAGGTACAAGCGGCAAGAAGCCAGGCCCCGCTACAGCATCGGGCTGGAGCAGGACGAGACCTACATTCCCC
Citation Okagawa H, Markwald RR, Sugi Y. Functional BMP receptor in endocardial cells is required in atrioventricular cushion mesenchymal cell formation in chick. Dev Biol. 2007 Jun 1;306(1):179-92. Epub 2007 Mar 16. Copyright Copyright © 2007 Elsevier Inc. All rights reserved. Comments The probe was amplified by PCR using the following primers:
5'-TGCTACTTCAGGTATAAGCGGC-3' and 5'-TTAGAGCTTAATGTCCTGCGAC-3' and was extracted from NCBI Acc# NM_205132.1.
Entry 11 GEISHA Id BMPR-1B.Zou.1997 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show GTTTTCCAGCAGACTGATGCTATAAATGCTCCACAACATGGAGAATGGTTTGGGTTGGAAGTAGACTTAAAGACCATCT
Citation Zou H, Wieser R, Massagué J, Niswander L. Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage. Genes Dev 1997 Sep 1;11(17):2191-203. Copyright Copyright © 1997, Cold Spring Harbor Laboratory Press Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # NM_205132.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-30 stage 27
stage 30
stage 30
Leg Wing
Entry 12 GEISHA Id BRK‐2.Belecky-Adams.2001 Data Source Publication Complete cDNA Template Probe show CTGCAGCACTGATGGCTACTGCTTCACCATAATAGAAGAAGATGATTCTGGTGGACATTTGGTCACCAAAGGATGTCTA
Citation Belecky-Adams T, Adler R. Developmental expression patterns of bone morphogenetic proteins, receptors, and binding proteins in the chick retina. J Comp Neurol. 2001 Feb 19;430(4):562-72. Copyright Copyright © 2001 Wiley‐Liss, Inc. Comments The complete cDNA template sequence was obtained from the information from the publication as described in Belecky-Adams et al. 2001. BRK-2 is also known as BMPR1B in NCBI.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-18 stage 18
stage 18
Eye 31-44 stage 34
stage 34
stage 34
stage 44
stage 44
stage 44
stage 44
Retina Unlabeled
Entry 13 GEISHA Id BMPR1B.Sela-Donenfeld.2002 Data Source Publication Complete cDNA Template Probe show GTTTTCCAGCAGACTGATGCTATAAATGCTCCACAACATGGAGAATGGTTTGGGTTGGAAGTAGACTTAAAGACCATCT
Citation Sela-Donenfeld D, Kalcheim C. Localized BMP4-noggin interactions generate the dynamic patterning of noggin expression in somites. Dev Biol. 2002 Jun 15;246(2):311-28. Copyright Copyright © 2002 Elsevier Science (USA). Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205132 )
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-18 stage 14
stage 14
stage 14
Dermomyotome Notochord Somites 31-44 stage 44
Mouse Frog Fruit Fly Zebra Finch Zebrafish
