GEISHA - A Chicken Embryo Gene Expression Database
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CXCL12
C-X-C motif chemokine ligand 12

The human orthologue of this gene is associated
with the following human disease:
Gene
Official SymbolCXCL12
Official Full NameC-X-C motif chemokine ligand 12
CGNC ID4705
also known asSDF1, stromal cell-derived factor 1|chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)|chemokine ligand 12b|stromal cell derived factor 1|stromal cell-derived factor-1 beta
gene typeprotein-coding
Genomic Map
 Ensembl ID not known
NCBI
UCSC
Sequence Information
Genomic
RNANM_204510
PolypeptideNP_989841
Gene Expression
In Situ HybridizationGEISHA
Orthology
Entrez GeneEnsembl GeneGenetic PhenotypesMOD
Fruit Fly
Human6387ENSG00000107562MIM:609423MIM:600835
Mouse20315ENSMUSG00000061353All phenotypic alleles (7):Targeted, knock-out(1) Targeted, other(6) MGI:103556
Xenopus548481, 399030919852
Zebrafish352944, 799354ENSDARG00000037116, ENSDARG00000055100ZDB-GENE-030318-1, ZDB-GENE-030721-1ZFIN:ZDB-GENE-030318-1, ZFIN:ZDB-GENE-030721-1
Gene Ontology
Molecular Function
Biological Process
Cellular Component
Links to other databases
Entrez Gene395180
Ensembl Gene
KEGGgga:395180

Entry 1

GEISHA IdCXCL12.UApcrData SourceGEISHA ISH Analysis
Forward cDNA Template PrimerCGGAGGAGAAGCCTGTCAGC
Reverse cDNA Template PrimerATTAACCCTCACTAAAGGAAAAGAGGATGAGTTGGGGACCcDNA Template Length473
Forward cDNA Template Probeshow
CTTTAGGGANAGATTTTGCCTCAAATCCTGGCAAAATTCTTGGTTCAACATTTAGGGACATGCTAGAAGCTGTTGTTTT
AATACAGACTAGGCCAACTCCAAACCCATCTTCAAAACAATATGTGATTTCACAAATACTTTGTCCACATGGTTAAAGC
CAGCCCTTAACGTTCTACCCTTGAATAACTCAGGATGTGTTAGCTGTTAAGTCCATTTGTCTCTTGCCTTACTTGTTTA
AAGCTTTCTCCAGATATTCCTGGATCCATTTTAGCTTGGGATCAATGCACACTTGCTTGCTGTTGCTCTTGAGCCTTGC
AACAATCTGAAGCGAGCAGTTGGGAGTGGAAAGGATTTTGAGGTGCTTAATGTTGGCCCTCGCCACGTTGCTCTCGAAG
AATCGACAGGGGCATCGGTAAGTCAGGCTGACAGGCTTTCTCCTCCGA
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
1-3
stage 3
Epiblast
 
4-6
stage 4
Epiblast
 
7-12
stage 7
stage 8
stage 8
stage 9
stage 9
stage 9
stage 9
stage 9
stage 10
stage 10
stage 11
stage 11
Ectoderm
Endoderm
Forebrain
Foregut
Head Mesenchyme
Headfold
Lateral Plate Mesoderm
Notochord
 
13-18
stage 13
stage 14
stage 14
stage 14
stage 14
stage 15
stage 15
stage 15
Blood Vessels
Ectoderm
Forebrain
Foregut
Head Mesenchyme
Hindbrain
Midbrain
Nasal Placode/Nerve
Notochord
Oral Pharynx
Pancreas
Paraxial Mesoderm
Somites
ventral
19-24
stage 20
stage 20
stage 20
stage 20
stage 20
stage 20
stage 20
stage 20
Aorta
Blood Vessels
Ear/Otic Placode
Eye
Face Mesenchyme
Forebrain
Hindbrain
Midbrain
Pharyngeal Arches and Clefts
Sclerotome
Somatic Mesoderm
Tail
Trunk Mesenchyme
 
25
stage 25
stage 25
stage 25
stage 25
Aorta
Eye
Leg Mesenchyme
Pharyngeal Arches and Clefts
Sclerotome
Somites
Wing Mesenchyme
 

Entry 2

GEISHA IdSDF1.García-Andrés.2010Data SourcePublication
Complete cDNA Template Probeshow
AGCCGCTCCGAGCCTGCCCGCCTGCACCGTCGCCAGAATGGACCTCCGCGCCCTGGCTCTGCTCGCCTTTGCCCTGGCA
GTCATCTCCCTGTCGGAGGAGAAGCCTGTCAGCCTGACTTACCGATGCCCCTGTCGATTCTTCGAGAGCAACGTGGCGA
GGGCCAACATTAAGCACCTCAAAATCCTTTCCACTCCCAACTGCTCGCTTCAGATTGTTGCAAGGCTCAAGAGCAACAG
CAAGCAAGTGTGCATTGATCCCAAGCTAAAATGGATCCAGGAATATCTGGAGAAAGCTTTAAACAAGTAAGGCAAGAGA
CAAATGGACTTAACAGCTAACACATCCTGAGTTATTCAAGGGTAGAACGTTAAGGGCTGGCTTTAACCATGTGGACAAA
GTATTTGTGAAATCACATATTGTTTTGAAGATGGGTTTGGAGTTGGCCTAGTCTGTATTAAAACAACAGCTTCTAGCAT
GTCCTAAATGTTGAACCAAGAATTTTGCCAGGATTTGAGGCAAAATCTGTCCTAAAGTATCTGTGCTGGGGTCCCCAAC
TCATCCTCTTTTATAAAGAGCCGTTCTCCCAAGGAAAAA
CitationGarcía-Andrés C, Torres M. Comparative expression pattern analysis of the highly conserved chemokines SDF1 and CXCL14 during amniote embryonic development. Dev Dyn. 2010 Oct;239(10):2769-77.
Copyright© 2010 Wiley-Liss, Inc.
CommentsInsufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc #NM_204510).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
19-24
stage 20
stage 20
stage 20
stage 20
stage 20
stage 20
stage 20
stage 20
stage 20
stage 20
stage 20
stage 20
stage 20
stage 20
stage 20
Aorta
Arteries
Cranial Nerve
Eye
Forebrain
Gonad
Gut
Head Mesenchyme
Leg
Leg Mesenchyme
Mesonephros
Pharyngeal Arches and Clefts
Sclerotome
Trunk Mesenchyme
Rp, Rathke’s pouch
ba, branchial arch
baa, branchial arch artery
gr, genital ridge
nr, nephrogenic ridge
optic stalk
31
stage 31
stage 31
stage 31
stage 31
Leg Mesenchyme
at digits
at metacarpals
at zeugopod

Entry 3

GEISHA IdSDF1.Vasyutina.2005Data SourcePublication
Complete cDNA Template Probeshow
AGCCGCTCCGAGCCTGCCCGCCTGCACCGTCGCCAGAATGGACCTCCGCGCCCTGGCTCTGCTCGCCTTTGCCCTGGCA
GTCATCTCCCTGTCGGAGGAGAAGCCTGTCAGCCTGACTTACCGATGCCCCTGTCGATTCTTCGAGAGCAACGTGGCGA
GGGCCAACATTAAGCACCTCAAAATCCTTTCCACTCCCAACTGCTCGCTTCAGATTGTTGCAAGGCTCAAGAGCAACAG
CAAGCAAGTGTGCATTGATCCCAAGCTAAAATGGATCCAGGAATATCTGGAGAAAGCTTTAAACAAGTAAGGCAAGAGA
CAAATGGACTTAACAGCTAACACATCCTGAGTTATTCAAGGGTAGAACGTTAAGGGCTGGCTTTAACCATGTGGACAAA
GTATTTGTGAAATCACATATTGTTTTGAAGATGGGTTTGGAGTTGGCCTAGTCTGTATTAAAACAACAGCTTCTAGCAT
GTCCTAAATGTTGAACCAAGAATTTTGCCAGGATTTGAGGCAAAATCTGTCCTAAAGTATCTGTGCTGGGGTCCCCAAC
TCATCCTCTTTTATAAAGAGCCGTTCTCCCAAGGAAAAA
CitationVasyutina E, Stebler J, Brand-Saberi B, Schulz S, Raz E, Birchmeier C. CXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells. Genes Dev. 2005 September 15; 19(18): 2187–2198.
CopyrightCopyright © 2005, Cold Spring Harbor Laboratory Press
CommentsAs insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # AY451855.1).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
25
stage 25
stage 25
Myotome
Wing Muscles
 

Entry 4

GEISHA IdSDF1.Rehimi.2008Data SourcePublication
Complete cDNA Template Probeshow
GCCTGCACCGTCGCCAGAATGGACCTCCGCGCCCTGGCTCTGCTCGCCTTTGCCCTGGCAGTCATCTCCCTGTCGGAGG
AGAAGCCTGTCAGCCTGACTTACCGATGCCCCTGTCGATTCTTCGAGAGCAACGTGGCGAGGGCCAACATTAAGCACCT
CAAAATCCTTTCCACTCCCAACTGCTCGCTTCAGATTGTTGCAAGGCTCAAGAGCAACAGCAAGCAAGTGTGCATTGAT
CCCAAGCTAAAATGGATCCAGGAATATCTGGAGAAAGCTTTAAACAAGTAAGGCAAGAGACAAATGGACTTAACAGCTA
ACACATCCTGAGTTATTCAAGGGTAGAACGTTAAGGGCTGGCTTTAACCATGTGGACAAAGTATTTGTGAAATCACATA
TTGTTTTGAAGATGGGTTTGGAGTTGGCCT
CitationRehimi R, Khalida N, Yusuf F, Dai F, Morosan-Puopolo G, Brand-Saberi B. Stromal-derived factor-1 (SDF-1) expression during early chick development. Int J Dev Biol. 2008;52(1):87-92.
Copyright© UBC Press and the authors
CommentsThe probe was amplified by PCR using the following primers: 5_-GCCTGCACCGTCGCCAGAATG-3_ and 5_-AGGCCAACTCCAAACCCATCTTCA-3_ and was extracted from NCBI Acc#NM_204510.1.
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
1-3
stage 3
stage 3
Epiblast
Primitive Streak
 
4-6
stage 5
Epiblast
Extraembryonic
Primitive Streak
 
7-12
stage 12
stage 12
Diencephalon
Surface Ectoderm
 
13-18
stage 14
stage 14
stage 18
Paraxial Mesoderm
Surface Ectoderm
HH stage 18+
19-24
stage 20
stage 20
stage 20
stage 20
stage 21
Intermediate Mesoderm
Limb Buds
Pharyngeal Arches and Clefts
Sclerotome
Somites
Tail
Trunk Mesenchyme
HH stage 20+
25-30
stage 25
stage 25
stage 25
stage 28
stage 30
Limb Buds
Sclerotome
Splanchnic Mesoderm
Wing Mesenchyme
 
31-33
stage 33
stage 33
Leg Mesenchyme
 

Entry 5

GEISHA IdCXCL12.Anderson.2020Data SourceGEISHA ISH Analysis
Complete cDNA Template Probeshow
GCCTGCACCGTCGCCAGAATGGACCTCCGCGCCCTGGCTCTGCTCGCCTTTGCCCTGGCAGTCATCTCCCTGTCGGAGG
AGAAGCCTGTCAGCCTGACTTACCGATGCCCCTGTCGATTCTTCGAGAGCAACGTGGCGAGGGCCAACATTAAGCACCT
CAAAATCCTTTCCACTCCCAACTGCTCGCTTCAGATTGTTGCAAGGCTCAAGAGCAACAGCAAGCAAGTGTGCATTGAT
CCCAAGCTAAAATGGATCCAGGAATATCTGGAGAAAGCTTTAAACAAGTAAGGCAAGAGACAAATGGACTTAACAGCTA
ACACATCCTGAGTTATTCAAGGGTAGAACGTTAAGGGCTGGCTTTAACCATGTGGACAAAGTATTTGTGAAATCACATA
TTGTTTTGAAGATGGGTTTGGAGTTGGCCT
CommentsImages provide by Claire Anderson. The complete cDNA template used to synthesize the probe was obtained from NCBI acc. # (NM_204510.1 ) using information provided in the publication as described in Rehimi et al. 2008; Related paper: Anderson C, Khan MAF, Wong F, Solovieva T, Oliveira NMM, Baldock RA, Tickle C, Burt DW, Stern CD. A strategy to discover new organizers identifies a putative heart organizer. Nat Commun. 2016 7:12656.
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
1-3
stage 3
stage 3
Epiblast
Primitive Streak
stage 3+
4-6
stage 6
Ectoderm
Headfold
Lateral Plate Mesoderm
 
7-12
stage 8
stage 10
stage 12
Blood Vessels
Ectoderm
Forebrain
Lateral Plate Mesoderm
Neural Plate/Tube
Notochord
Somites
extraembryonic ectoderm
extraembryonic mesoderm
stage 10+
19-24
stage 21
stage 24
Blood Vessels
Eye
Forebrain
Head Mesenchyme
Hindbrain
Leg Mesenchyme
Midbrain
Nasal Placode/Nerve
Pharyngeal Arches and Clefts
Wing Mesenchyme
stage 21+

Entry 6

GEISHA IdCXCL12.Ojeda.2013Data SourcePublication
Complete cDNA Template Probeshow
TGGCTCTGCTCGCCTTTGCCCTGGCAGTCATCTCCCTGTCGGAGGAGAAGCCTGTCAGCCTGACTTACCGATGCCCCTG
TCGATTCTTCGAGAGCAACGTGGCGAGGGCCAACATTAAGCACCTCAAAATCCTTTCCACTCCCAACTGCTCGCTTCAG
ATTGTTGCAAGGCTCAAGAGCAACAGCAAGCAAGTGTGCATTGATCCCAAGCTAAAATGGATCCAGGAATATCTGGAGA
AAGCTTTAAACAAGTAAGGCAAGAGACAAATGGACTTAACAGCTAACACATCCTGAGTTATTCAAGGGTAGAACGTTAA
GGGCTGGCTTTAACCATGTGGACAAAGTATTTGTGAAATCACATATTGTTTTGAAGATGGGTTTGGAGTTGGCCTAGTC
TGTATTAAAACAACAGCTTCTAGCATGTCCTAAATGTTGAACCAAGAATTTTGCCAGGATTTGAGGCAAAATCTGTCCT
AAAGTATCTGTGCTGGGGTCC
CitationOjeda AF, Munjaal RP, Lwigale PY. Expression of CXCL12 and CXCL14 during eye development in chick and mouse. Gene Expr Patterns. 2013 Dec;13(8):303-10. Epub 2013 May 30.
CopyrightCopyright © 2020 Elsevier B.V.
CommentsThe complete cDNA template sequence was obtained from the information from the publication as described in Ojeda et al. 2013.
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
25-30
stage 26
stage 30
stage 30
stage 30
Eye
Retina
 
31-38
stage 34
stage 38
stage 38
stage 38
Eye
Retina
 
all
 
 
 
  

Mouse

EmageMGI:103556
MGI GXDMGI:103556

Frog

Xenbase919852

Fruit Fly

BDGP

Zebra Finch

ZEBrA

Zebrafish

ZFINZDB-GENE-030318-1, ZDB-GENE-030721-1
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