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EPHA3 Gene Summary Expression Other Species Expression JBrowse Gene Official Symbol EPHA3 Official Full Name EPH receptor A3 CGNC ID 11474 also known as CEK4, ETK1, ephrin type-A receptor 3|EK4|EPH-like kinase 4|receptor tyrosine kinase|tyrosine-protein kinase receptor ETK1, Tyrosine-protein kinase receptor ETK1, CEK4, Ephrin type-A receptor 3 precursor gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Molecular Function ATP binding , GPI-linked ephrin receptor activity , ephrin receptor activity Biological Process cell migration , ephrin receptor signaling pathway , fasciculation of motor neuron axon , more... fasciculation of sensory neuron axon , regulation of Rho GTPase activity , regulation of actin cytoskeleton organization , regulation of epithelial to mesenchymal transition , regulation of focal adhesion assembly , regulation of microtubule cytoskeleton organization Cellular Component early endosome , integral component of plasma membrane
Links to other databases
Entry 1 GEISHA Id EphA3 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show CGCTCTGCTCGCGCGCTGCTGCCCCGCCGACATGGACCGCCGCCGCCTGCCGCTGCTGCTGCTCTGCGCTGCCCTCGGC
Entry 2 GEISHA Id EphA3.Baker.2003 Data Source Publication Complete cDNA Template Probe show ATTTCAGTGGCCATCAAAACTCTGAAAGCTGGCTACACAGAAAAACAGAGAAGGGATTTCCTGGGAGAAGCAAGCATCA
Citation Baker RK, Antin PB. Ephs and ephrins during early stages of chick embryogenesis Dev Dyn. 2003 Sep;228(1):128-42. Copyright 2003 Wiley-Liss, Inc.
Entry 3 GEISHA Id EphA3.Mühleisen.2006 Data Source Publication Complete cDNA Template Probe show CGCTCTGCTCGCGCGCTGCTGCCCCGCCGACATGGACCGCCGCCGCCTGCCGCTGCTGCTGCTCTGCGCTGCCCTCGGC
Citation Mühleisen TW, Agoston Z, Schulte D. Retroviral misexpression of cVax disturbs retinal ganglion cell axon fasciculation and intraretinal pathfinding in vivo and guidance of nasal ganglion cell axons in vivo. Dev Biol. 2006 Sep 1;297(1):59-73. Copyright Reprinted from Developmental Biology, Volume 297, Thomas W. Mühleisen, Zsuzsa Agoston and Dorothea Schulte, Retroviral misexpression of cVax disturbs retinal ganglion cell axon fasciculation and intaretinal pathfinding in vivo and guidance of nasal ganglion cell axons in vitro, Pages 56-73, Copyright 2006, with permission from Elsevier.
Copyright © 2006 Elsevier B.V. All rights reserved. Comments According to the authors, "The cDNA clones used to generate in situ probes for EphA3, EphA4, ephrin-A5, ephrin-A2, EphB2, EphB3, ephrin-B1, ephrin-B2 or RCS, which recognizes a viral core protein, were described elsewhere (Schulte et al., 1999) or were gifts from J. Flanagan, C. Cepko (Harvard Medical School, Boston), or E. Pasquale (The Burnham Institute, La Jolla, California; Holash and Pasquale, 1995 and Cheng et al., 1995). As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_205430)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-22 stage 22
Eye Retina
Entry 4 GEISHA Id EphA3.Mellott.2008 Data Source Publication Complete cDNA Template Probe show CTGGGCACTTGCAAAGAGACTTTCAATCTGTATTACATGGAATCCGATGATGACCATTTGGCAAAGTTCAGAGAGCACC
Citation Mellott DO, and Burke RD. Divergent roles for Eph and Ephrin in Avian Cranial Neural Crest. BMC Developmental Biology 2008, 8:56. Copyright © 2008 Mellott and Burke; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_205430.2. Authors said: Primers EphA3-F1 (5'-GTCGACCTGGGCACTTGCAAAGAG-3') and EphA3-R1 (5'-GGTACCGCCAGCATTACACAAGCAC-3') were used to amplify a fragment of the chicken EphA3 gene that was subsequently subcloned between the BamHI and EcoRV sites of pBluescript II SK +.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-14 stage 14
stage 14
stage 14
stage 14
Head Mesenchyme
Entry 5 GEISHA Id EPHA3.Takahashi.2003 Data Source Publication Complete cDNA Template Probe show GATCTAGCTGCTCGTAATATACTCATCAATAGTAACTTGGTGTGCAAAGTCTCAGATTTTGGTCTTTCTCGTGTATTGG
Citation Takahashi H, Shintani T, Sakuta H, Noda M. CBF1 controls the retinotectal topographical map along the anteroposterior axis through multiple mechanisms. Development. 2003 Nov;130(21):5203-15. Epub 2003 Sep 3. Copyright Published by The Company of Biologists 2007. This material is protected by a copyright retained by the authors. Comments Authors indicated this sequence was the probe.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-18 stage 18
stage 18
stage 18
stage 18
Retina 31-34 stage 34
stage 34
stage 34
Retina
Entry 6 GEISHA Id EPH3A.Schulte.2005 Data Source Publication Complete cDNA Template Probe show GCTCTGCTCGCGCGCTGCTGCCCCGCCGACATGGACCGCCGCCGCCTGCCGCTGCTGCTGCTCTGCGCTGCCCTCGGCT
Citation Schulte D, Peters MA, Sen J, Cepko CL. The rod photoreceptor pattern is set at the optic vesicle stage and requires spatially restricted cVax expression. J Neurosci. 2005 Mar 16;25(11):2823-31. Copyright
Copyright © 2012 by the Society for Neuroscience
Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_205430.2 )
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31 stage 31
Diencephalon
Entry 7 GEISHA Id EPHA3.Jayasena.2005 Data Source Publication Complete cDNA Template Probe show ATTTCAGTGGCCATCAAAACTCTGAAAGCTGGCTACACAGAAAAACAGAGAAGGGATTTCCTGGGAGAAGCAAGCATCA
Citation Jayasena CS, Flood WD, Koblar SA. High EphA3 expressing ophthalmic trigeminal sensory axons are sensitive to ephrin-A5-Fc: implications for lobe specific axon guidance. Neuroscience. 2005;135(1):97-109. Copyright Copyright © 2005 IBRO. Published by Elsevier Ltd. All rights reserved. Comments The complete cDNA template sequence was obtained from the information provided in the publication as described in Jayasena et al., 2005.
Entry 8 Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-30 stage 27
stage 27
stage 27
stage 29
stage 29
stage 29
Spinal Cord 31-44 stage 32
stage 32
stage 32
stage 44
Spinal Cord
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