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Human Disease Gene Search
EPHB2 The human orthologue of this gene is associated
Gene Summary Expression Other Species Expression JBrowse Gene Official Symbol EPHB2 Official Full Name EPH receptor B2 CGNC ID 3515 also known as ephrin type-B receptor 2|EK5|EPH-like kinase 5|cEK5|chicken embryo kinase 5|embryo kinase 5 protein CEK5, Ephrin type-B receptor 2 gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Molecular Function ATP binding , protein binding , transmembrane-ephrin receptor activity Biological Process angiogenesis , axon guidance , axonal fasciculation , dendritic spine development , more... dendritic spine morphogenesis , ephrin receptor signaling pathway , peptidyl-tyrosine phosphorylation , positive regulation of synapse assembly Cellular Component axon , dendrite , integral component of plasma membrane , plasma membrane
Links to other databases
Entry 1 GEISHA Id EphB1 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show CAGAAACCCTGATGGACACACGGACAGCGACGGCTGAGCTGGGCTGGACTGCCAACCCTCCGTCAGGGTGGGAAGAAGT
Entry 2 GEISHA Id EphB3 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show CGGGGTCTCCTCGAGGGCGCGGCGGCCGCCGGGCAGCAGCAGGAGCAGCAGGAGGGGGGTGACCTCGGAGCTGGCATGG
Entry 3 GEISHA Id EphB1.Baker.2003 Data Source Publication Complete cDNA Template Probe show AGTGCCGGGCAGACCGGCGTGCCTGCTCCCGCTGCGACGACAACGTGGAGTTTGTGCCCCGACAGCTGGGGCTGACAGA
Citation Baker RK, Antin PB. Ephs and ephrins during early stages of chick embryogenesis Dev Dyn. 2003 Sep;228(1):128-42. Copyright 2003 Wiley-Liss, Inc.
Entry 4 GEISHA Id EphB3.Baker.2003 Data Source Publication Complete cDNA Template Probe show GAAAGGGATGGTTACTGAACAACTCCTCTCGTCTCCTTTGGGCAGGAAGCAGCGCAACAGCACAGATCCCGAGTACACA
Citation Baker RK, Antin PB. Ephs and ephrins during early stages of chick embryogenesis Dev Dyn. 2003 Sep;228(1):128-42. Copyright 2003 Wiley-Liss, Inc.
Entry 5 GEISHA Id EphB2.Mühleisen.2006 Data Source Publication Complete cDNA Template Probe show CGGCTTCTGATGCCCGGCCCGGAGCGCACCATGGGGCCGTTGTGGTTCTGCTGTTTGCCCCTCGCCCTCTTGCCTCTGC
Citation Mühleisen TW, Agoston Z, Schulte D. Retroviral misexpression of cVax disturbs retinal ganglion cell axon fasciculation and intraretinal pathfinding in vivo and guidance of nasal ganglion cell axons in vivo. Dev Biol. 2006 Sep 1;297(1):59-73. Copyright Reprinted from Developmental Biology, Volume 297, Thomas W. Mühleisen, Zsuzsa Agoston and Dorothea Schulte, Retroviral misexpression of cVax disturbs retinal ganglion cell axon fasciculation and intaretinal pathfinding in vivo and guidance of nasal ganglion cell axons in vitro, Pages 56-73, Copyright 2006, with permission from Elsevier.
Copyright © 2006 Elsevier B.V. All rights reserved. Comments According to the authors, "The cDNA clones used to generate in situ probes for EphA3, EphA4, ephrin-A5, ephrin-A2, EphB2, EphB3, ephrin-B1, ephrin-B2 or RCS, which recognizes a viral core protein, were described elsewhere (Schulte et al., 1999) or were gifts from J. Flanagan, C. Cepko (Harvard Medical School, Boston), or E. Pasquale (The Burnham Institute, La Jolla, California; Holash and Pasquale, 1995 and Cheng et al., 1995). As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_206951).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-18 stage 15
Eye Retina 19-20 stage 20
stage 20
Eye Retina
Entry 6 GEISHA Id EphB3.Mühleisen.2006 Data Source Publication Complete cDNA Template Probe show ATGGCTCAGAGCCACGGGGCTGTCTTCCCGGAGACCCTGATGGACACGAAGTGGGTGACCTCGGAGCTGGCATGGACAA
Citation Mühleisen TW, Agoston Z, Schulte D. Retroviral misexpression of cVax disturbs retinal ganglion cell axon fasciculation and intraretinal pathfinding in vivo and guidance of nasal ganglion cell axons in vivo. Dev Biol. 2006 Sep 1;297(1):59-73. Copyright Reprinted from Developmental Biology, Volume 297, Thomas W. Mühleisen, Zsuzsa Agoston and Dorothea Schulte, Retroviral misexpression of cVax disturbs retinal ganglion cell axon fasciculation and intaretinal pathfinding in vivo and guidance of nasal ganglion cell axons in vitro, Pages 56-73, Copyright 2006, with permission from Elsevier.
Copyright © 2006 Elsevier B.V. All rights reserved. Comments According to the authors, "The cDNA clones used to generate in situ probes for EphA3, EphA4, ephrin-A5, ephrin-A2, EphB2, EphB3, ephrin-B1, ephrin-B2 or RCS, which recognizes a viral core protein, were described elsewhere (Schulte et al., 1999) or were gifts from J. Flanagan, C. Cepko (Harvard Medical School, Boston), or E. Pasquale (The Burnham Institute, La Jolla, California; Holash and Pasquale, 1995 and Cheng et al., 1995). As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # XM_422762)
Entry 7 GEISHA Id EPHB1.Mellott.2008 Data Source Publication Complete cDNA Template Probe show ATGGCTCATTCAGGTTTTTTTTTTTTTTCCTATTTATGTTGCGAGTCCCCCCGAGATGAATGCTCCCTCTATGCTTCTC
Citation Mellott DO, and Burke RD. Divergent roles for Eph and Ephrin in Avian Cranial Neural Crest. BMC Developmental Biology 2008, 8:56. Copyright © 2008 Mellott and Burke; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI XM_422685.4 Authors said: Degenerate codehop primers [15] designed against conserved protein sequences of B-type Eph receptors, EphB-F1 (5'-CATCCTGGTGAACTCCAACCTNGTNTGYAARG-3') and EphB-R1 (5'-TGGATGTGGTTCAGGATCTTCTTYTGRTGNCC-3'), were then used to amplify fragments of EphB receptors from the first strand cDNA by PCR.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-14 stage 14
stage 14
stage 14
stage 14
Head Mesenchyme
Entry 8 GEISHA Id EPHB2.Mellott.2008 Data Source Publication Complete cDNA Template Probe show GCGGCGGCCCCAGCCCCAGCGAGGGGCTCGGCTCTGCGCTCCGCCGCCTCCATGGAGCTCCGCCGCCGCTTCTGATGCC
Citation Mellott DO, and Burke RD. Divergent roles for Eph and Ephrin in Avian Cranial Neural Crest. BMC Developmental Biology 2008, 8:56. Copyright © 2008 Mellott and Burke; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_206951.3. Authors said: Degenerate codehop primers [15] designed against conserved protein sequences of B-type Eph receptors, EphB-F1 (5'-CATCCTGGTGAACTCCAACCTNGTNTGYAARG-3') and EphB-R1 (5'-TGGATGTGGTTCAGGATCTTCTTYTGRTGNCC-3'), were then used to amplify fragments of EphB receptors from the first strand cDNA by PCR.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-14 stage 14
stage 14
Head Mesenchyme
Entry 9 GEISHA Id EPHB2.Santiago.2002 Data Source Publication Complete cDNA Template Probe show GCGGCGGCCCCAGCCCCAGCGAGGGGCTCGGCTCTGCGCTCCGCCGCCTCCATGGAGCTCCGCCGCCGCTTCTGATGCC
Citation Santiago A, Ericsson CA. Ephrin-B ligands play a dual role in the control of neural crest cell migration. 2002 Aug;129(15):3621-32 Copyright Great Britain © The Company of Biologists Limited 2002 Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence was obtained from NCBI (Acc. # NM_206951.3).
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