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Human Disease Gene Search
FGF19 Gene Summary Expression Other Species Expression JBrowse Gene Official Symbol FGF19 Official Full Name fibroblast growth factor 19 CGNC ID 5704 also known as FGF-19, fibroblast growth factor 19, fibroblast growth factor 19 , FGF19 gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Molecular Function Biological Process Cellular Component
Links to other databases
Entry 1 GEISHA Id FGF19.UApcr Data Source GEISHA ISH Analysis Forward cDNA Template Primer TTATAAAAGCTTGCGGCCGCAGAATATAAGATTTTCTCCCGCTGTCTCAC Reverse cDNA Template Primer GCTCTAGAAATTAACCCTCACTAAAGGTTGAACTGCTCATTCCTACCAGATG cDNA Template Length 812 Complete cDNA Template Probe show TTCTACCTGTCCGTGAGGGAATTGGTGAATTGGGATTACAGCCGTTTGAGCCAGAGGTTATCTCGCCTCTCGAAACGGA
Entry 2 GEISHA Id FGF19.Gimeno.2007 Data Source Publication Complete cDNA Template Probe show GTGCCCAGTTGCCATATTCGAAAGAATTGCCTCTCCGTAGTATACTTGGAAAAGAAAAATTAAATAAGAGCAGCTTAAC
Citation Gimeno L, Martinez S. Expression of chick Fgf19 and mouse Fgf15 orthologs is regulated in the developing brain by Fgf8 and Shh. Dev Dyn. 2007 Aug;236(8):2285-97. Copyright Copyright © 2007 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204674). The primer pair successfully used for cloning Fgf19 cDNA were those given in the paper: 5'-GTGCCCAGTTGCCATATTCG-3' as forward primer and 5'-CTGACCTAGCACTTCATTGCC-3' as reverse primer.
Entry 3 GEISHA Id Fgf19.Sanchez-Calderon.2007 Data Source Publication Complete cDNA Template Probe show CACACCGCCAGCCGCACAGAGCGCCCAACCCCGTATCGCACCGCACCGCCCCGCACCGCCCGCGCAACGCCGCCGCCCG
Citation Sánchez-Calderón H, Francisco-Morcillo J, Martín-Partido G, Hidalgo-Sánchez M (2007). Fgf19 expression patterns in the developing chick inner ear.Gene Expr Patterns. Jan;7(1-2):30-8. Epub 2006 May 19. Copyright Copyright © 2007 Elsevier B.V. All rights reserved. Comments The Fgf-19 probe was obtained by screening a stage 11/12 chick lambda ZAP II cDNA library using a mouse Fgf-15 cDNA probe . The sequence has been deposited in GenBank (accession number AF315355).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-18 stage 14
stage 14
stage 15
Ear/Otic Placcode 19-24 stage 20
stage 20
stage 20
stage 20
stage 24
stage 24
stage 24
stage 24
stage 24
stage 24
Ear/Otic Placcode 25-30 stage 27
stage 27
stage 27
stage 27
stage 27
stage 27
stage 27
Cranial Ganglion Ear/Otic Placcode 31-34 stage 34
stage 34
stage 34
stage 34
Ear/Otic Placcode
Entry 4 GEISHA Id FGF19.Kurose.2004 Data Source Publication Complete cDNA Template Probe show CCGCAGAGTCTGTTGGAGATCCGCGCCGTGGCGGTGCGCACCGTGGCCATCAAGGGCGTGCAGAGCTCCCGCTACCTCT
Citation Kurose H, Bito T, Adachi T, Shimizu M, Noji S, Ohuchi H. Expression of Fibroblast growth factor 19 (Fgf19) during chicken embryogenesis and eye development, compared with Fgf15 expression in the mouse. Gene Expr Patterns. 2004 Oct;4(6):687-93. Copyright Reprinted with permission from Elsevier. Copyright © 2004 Elsevier B.V. All rights reserved. Comments According to the authors, "cDNA templates for ribopobes were obtained by EST sequencing of a HH stage 36 neural retina library constructed in the λZAPII phasmid vector (Stratagene) (chicken Fgf8, 0.9 kb; chicken Fgf10, 2.5 kb; chicken Fgf19, 1.9 kb) ... The obtained EST clone of chicken Fgf19 was submitted to Genbank/DDBJ under the accession number of AB111892."
Entry 5 GEISHA Id FGF19.Wright.2004 Data Source Publication Complete cDNA Template Probe show CACACCGCCAGCCGCACAGAGCGCCCAACCCCGTATCGCACCGCACCGCCCCGCACCGCCCGCGCAACGCCGCCGCCCG
Citation Wright TJ, Ladher R, McWhirter J, Murre C, Schoenwolf GC, Mansour SL (2004). Mouse FGF15 is the ortholog of human and chick FGF19, but is not uniquely required for otic induction. Dev Biol. 2004 May 1;269(1):264-75. Copyright Copyright © 2004 Published by Elsevier Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204674).
Entry 6 GEISHA Id FGF19.Paxton.2010 Data Source Publication Complete cDNA Template Probe show CACACCGCCAGCCGCACAGAGCGCCCAACCCCGTATCGCACCGCACCGCCCCGCACCGCCCGCGCAACGCCGCCGCCCG
Citation Paxton CN, Bleyl SB, Chapman SC, Schoenwolf GC.
Identification of differentially expressed genes in early inner ear development. Gene Expr Patterns. 2010 Jan;10(1):31-43. Epub 2009 Nov 11.
Copyright 2009 Elsevier B.V. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_204674).
Entry 7 GEISHA Id FGF19.Ladher.2005 Data Source Publication Complete cDNA Template Probe show CACACCGCCAGCCGCACAGAGCGCCCAACCCCGTATCGCACCGCACCGCCCCGCACCGCCCGCGCAACGCCGCCGCCCG
Citation Ladher RK, Wright TJ, Moon AM, Mansour SL, Schoenwolf GC. FGF8 initiates inner ear induction in chick and mouse. Genes Dev. 2005 Mar 1;19(5):603-13.
Copyright © 2005 by Cold Spring Harbor Laboratory Press Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_001031546).
Entry 8 GEISHA Id FGF19.Abello.2010 Data Source Publication Complete cDNA Template Probe show CACACCGCCAGCCGCACAGAGCGCCCAACCCCGTATCGCACCGCACCGCCCCGCACCGCCCGCGCAACGCCGCCGCCCG
Citation Abelló G, Khatri S, Radosevic M, Scotting PJ, Giráldez F, Alsina B., Independent regulation of Sox3 and Lmx1b by FGF and BMP signaling influences the neurogenic and non-neurogenic domains in the chick otic placode. Dev Biol. 2010 Mar 1;339(1):166-78. Epub 2010 Jan 4. Copyright Copyright © 2009 Elsevier Inc. All rights reserved. Comments An insufficient amount of information is provided in publication to verify exact sequence used to synthesize probe, the sequence was obtained from NCBI (acc #NM_204674.1)
Entry 9 GEISHA Id FGF19.Kumar.2012B Data Source Publication Complete cDNA Template Probe show CACACCGCCAGCCGCACAGAGCGCCCAACCCCGTATCGCACCGCACCGCCCCGCACCGCCCGCGCAACGCCGCCGCCCG
Citation Kumar M, Ray P, Chapman SC. Fibroblast growth factor and bone morphogenetic protein signaling are required for specifying prechondrogenic identity in neural crest-derived mesenchyme and initiating the chondrogenic program.
Dev Dyn. 2012 Jun;241(6):1091-103
Copyright Copyright © 2012 Wiley Periodicals, Inc. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_204674.1).
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