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Human Disease Gene Search
ISL1 Gene Summary Expression Other Species Expression JBrowse Gene Official Symbol ISL1 Official Full Name ISL LIM homeobox 1 CGNC ID 11048 also known as ISL-1, ISLET-1, insulin gene enhancer protein ISL-1|ISL1 transcription factor, LIM/homeodomain, (islet-1)|domesticus (clone 1.7 kB) islet-1 gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Molecular Function RNA polymerase II activating transcription factor binding , more... RNA polymerase II transcription coactivator activity , bHLH transcription factor binding , enhancer sequence-specific DNA binding , sequence-specific DNA binding transcription factor activity , zinc ion binding Biological Process atrial septum morphogenesis , cardiac cell fate determination , cardiac right ventricle morphogenesis , more... endocardial cushion morphogenesis , innervation , negative regulation of inflammatory response , negative regulation of neuron apoptotic process , negative regulation of transcription from RNA polymerase II promoter , negative regulation of transcription, DNA-templated , neuron fate specification , outflow tract septum morphogenesis , peripheral nervous system neuron axonogenesis , pharyngeal system development , positive regulation of angiogenesis , positive regulation of granulocyte colony-stimulating factor production , positive regulation of granulocyte macrophage colony-stimulating factor production , positive regulation of interferon-gamma production , positive regulation of interleukin-1 alpha production , positive regulation of interleukin-1 beta production , positive regulation of interleukin-12 production , positive regulation of interleukin-6 production , positive regulation of tumor necrosis factor production , positive regulation vascular endothelial growth factor production , secondary heart field specification , sensory system development , trigeminal nerve development , ventricular cardiac muscle tissue morphogenesis Cellular Component nucleus
Links to other databases
Entry 1 GEISHA Id ISL1.UApcr Data Source GEISHA ISH Analysis Forward cDNA Template Primer TTATAAAAGCTTGCGGCCGCAGAATATCATCGGCTTCAGCAAGAACG Reverse cDNA Template Primer GCTCTAGAAATTAACCCTCACTAAAGGTCTCTCCAATAGGGTTGAGGGTAAG cDNA Template Length 923 Complete cDNA Template Probe show TTTTTTTAAAGTTGGGGCCGCAGAATATCATCGGCTTCAGCAAGAACGACTGTGATGCGCGCCCGCGCCAAGGGTGTAC
Entry 2 GEISHA Id Isl1.Bothe.2006 Data Source Publication Complete cDNA Template Probe show GCACGAGGGCGAGTGCCGAGCCGCCAGCGCCCAGTCCAGCACCGCCGCACCGCCGCACCGCACCGGCCCCGCAGCACCG
Citation Bothe I, Dietrich S. The molecular setup of the avian head mesoderm and its implication for craniofacial myogenesis. Dev Dyn. 2006 Oct;235(10):2845-60. Copyright Copyright © 2006 Wiley-Liss, Inc.
Entry 3 GEISHA Id Islet1.Gimeno.2007 Data Source Publication Complete cDNA Template Probe show GCACGAGGGCGAGTGCCGAGCCGCCAGCGCCCAGTCCAGCACCGCCGCACCGCCGCACCGCACCGGCCCCGCAGCACCG
Citation Gimeno L, Martinez S. Expression of chick Fgf19 and mouse Fgf15 orthologs is regulated in the developing brain by Fgf8 and Shh. Dev Dyn. 2007 Aug;236(8):2285-97. Copyright Copyright © 2007 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205414).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 24
Forebrain
Entry 4 GEISHA Id Islet1.Hargrave.2000 Data Source Publication Complete cDNA Template Probe show TCAAACCTACTTTGGGGTCTTAAAACGAAACCGTACACCATTTCACTGTGGACATTACACCCTCTTACAGATATGGGAG
Citation Hargrave M, Karunaratne A, Cox L, Wood S, Koopman P, Yamada T. The HMG box transcription factor gene Sox14 marks a novel subset of ventral interneurons and is regulated by sonic hedgehog. Dev Biol. 2000 Mar 1;219(1):142-53. Copyright Reprinted with permission from Elsevier.
Copyright © 2000 Elsevier B.V. All rights reserved.
Comments According to the authors, "The primers used in this study were cIslet1 (forward, ATCGCCGGGGATGAGCTGGCGGCT; reverse, TCAAACCTACTTTGGGGTCTTAAA; amplifying 426 nt at positions 211636 nt; Tanabe et al., 1995)." The sequence below was obtained from NCBI (NM_205414) using this information.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-18 stage 18
Spinal Cord 19-24 stage 24
Spinal Cord 25-28 stage 28
Entry 5 GEISHA Id Islet1.Agarwala.2005 Data Source Publication Complete cDNA Template Probe show GCACGAGGGCGAGTGCCGAGCCGCCAGCGCCCAGTCCAGCACCGCCGCACCGCCGCACCGCACCGGCCCCGCAGCACCG
Citation Agarwala S, Aglyamova GV, Marma AK, Fallon JF, Ragsdale CW. Differential susceptibility of midbrain and spinal cord patterning to floor plate defects in the talpid2 mutant. Dev Biol. 2005 Dec 1;288(1):206-20. Epub 2005 Oct 21. Copyright Copyright © 2005 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205414).
Entry 6 GEISHA Id ISL1.Thompson.2010 Data Source Publication Complete cDNA Template Probe show GCACGAGGGCGAGTGCCGAGCCGCCAGCGCCCAGTCCAGCACCGCCGCACCGCCGCACCGCACCGGCCCCGCAGCACCG
Citation Thompson H, Blentic A, Watson S, Begbie J, Graham A. The formation of the superior and jugular ganglia: insights into the generation of sensory neurons by the neural crest. Dev Dyn. 2010 Feb;239(2):439-45. Copyright Copyright © 2010 John Wiley & Sons, Inc. All Rights Reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_205414.1).
Entry 7 GEISHA Id ISL1.Agarwala.2002 Data Source Publication Complete cDNA Template Probe show GCACGAGGGCGAGTGCCGAGCCGCCAGCGCCCAGTCCAGCACCGCCGCACCGCCGCACCGCACCGGCCCCGCAGCACCG
Citation Agarwala S, Ragsdale CW. A role for midbrain arcs in nucleogenesis. Development. 2002 Dec;129(24):5779-88. Copyright Published by The Company of Biologists 2007. This material is protected by a copyright retained by the authors. Permission granted by Dr. Ragsdale. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_205414)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-18 stage 18
Midbrain 19-24 stage 21
stage 24
Midbrain 25-30 stage 28
stage 28
Diencephalon Midbrain 31-38 stage 38
stage 38
Midbrain
Entry 8 GEISHA Id ISL1.Hasan.2010 Data Source Publication Complete cDNA Template Probe show GCACGAGGGCGAGTGCCGAGCCGCCAGCGCCCAGTCCAGCACCGCCGCACCGCCGCACCGCACCGGCCCCGCAGCACCG
Citation Hasan KB, Agarwala S, Ragsdale CW. PHOX2A regulation of oculomotor complex nucleogenesis. Development. 2010 Apr;137(7):1205-13. Copyright Published by The Company of Biologists 2007. This material is protected by a copyright retained by the authors. Permission granted by Dr. Ragsdale.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-38 stage 38
stage 38
Spinal Cord
Entry 9 GEISHA Id ISL1.Chambers.2007 Data Source Publication Complete cDNA Template Probe show GCACGAGGGCGAGTGCCGAGCCGCCAGCGCCCAGTCCAGCACCGCCGCACCGCCGCACCGCACCGGCCCCGCAGCACCG
Citation Chambers D, Wilson L, Maden M, Lumsden A. RALDH-independent generation of retinoic acid during vertebrate embryogenesis by CYP1B1. Development. 2007 Apr;134(7):1369-83. Copyright © 2007 Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_205414.1).
Entry 10 GEISHA Id ISL1.Kao.2009 Data Source Publication Complete cDNA Template Probe show GCACGAGGGCGAGTGCCGAGCCGCCAGCGCCCAGTCCAGCACCGCCGCACCGCCGCACCGCACCGGCCCCGCAGCACCG
Citation Kao TJ, Palmesino E, Kania A. SRC family kinases are required for limb trajectory selection by spinal motor axons. J Neurosci. 2009 Apr 29;29(17):5690-700. Copyright Copyright © 2009-12 by the Society for Neuroscience Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_205414.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-26 stage 26
stage 26
Spinal Cord
Entry 11 GEISHA Id ISL1.Yuan.2000 Data Source Publication Complete cDNA Template Probe show GCACGAGGGCGAGTGCCGAGCCGCCAGCGCCCAGTCCAGCACCGCCGCACCGCCGCACCGCACCGGCCCCGCAGCACCG
Citation Yuan S, Schoenwolf GC. Islet-1 marks the early heart rudiments and is asymmetrically expressed during early rotation of the foregut in the chick embryo. Anat Rec. 2000 Oct 1;260(2):204-7. Copyright Copyright © 2000 Wiley-Liss, Inc. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_205414.1).
Entry 12 GEISHA Id ISLET1.Davey.2006 Data Source Publication Complete cDNA Template Probe show GCACGAGGGCGAGTGCCGAGCCGCCAGCGCCCAGTCCAGCACCGCCGCACCGCCGCACCGCACCGGCCCCGCAGCACCG
Citation Davey MG, Paton IR, Yin Y, Schmidt M, Bangs FK, Morrice DR, Smith TG, Buxton P, Stamataki D, Tanaka M, Münsterberg AE, Briscoe J, Tickle C, Burt DW. The chicken talpid3 gene encodesa novel protein essentialfor Hedgehog signaling. Genes Dev. 2006 May 15; 20(10): 13651377. Copyright Copyright © 2006, Cold Spring Harbor Laboratory Press Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_205414.1 ).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-20 stage 20
stage 20
Spinal Cord
Entry 13 GEISHA Id ISLET1.Fischer.2009 Data Source Publication Complete cDNA Template Probe show GCACGAGGGCGAGTGCCGAGCCGCCAGCGCCCAGTCCAGCACCGCCGCACCGCCGCACCGCACCGGCCCCGCAGCACCG
Citation Fischer AJ, Foster S, Scott MA, Sherwood P.. The transient expression of LIM-domain transcription factors is coincident with the delayed maturation of photoreceptors in the chicken retina. J Comp Neurol. 2008 February 1; 506(4): 584603. Copyright Copyright © 2007 Wiley-Liss, Inc. Comments The probe was amplified by PCR using the following primers:
5′-CGC CTG ATT TCC CTA TGT GT -3′ and 5′-CGT ATC TGG GAG CTG AGA GG-3′ and was extracted from NCBI Acc# NM_205414.1.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-38 stage 38
stage 38
Retina
Entry 14 GEISHA Id ISLET1.Ferrario.2012 Data Source Publication Complete cDNA Template Probe show GCACGAGGGCGAGTGCCGAGCCGCCAGCGCCCAGTCCAGCACCGCCGCACCGCCGCACCGCACCGGCCCCGCAGCACCG
Citation Ferrario JE, Baskaran P, Clark C, Hendry A, Lerner O, Hintze M, Allen J, Chilton JK, Guthrie S. Axon guidance in the developing ocular motor system and Duane retraction syndrome depends on Semaphorin signaling via alpha2-chimaerin.
Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14669-74.
Copyright Copyright © 2012 National Academy of Sciences. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_205414.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-29 stage 29
Midbrain
Entry 15 GEISHA Id ISL1.Nathan.2008 Data Source Publication Complete cDNA Template Probe show GCACGAGGGCGAGTGCCGAGCCGCCAGCGCCCAGTCCAGCACCGCCGCACCGCCGCACCGCACCGGCCCCGCAGCACCG
Citation Nathan E, Monovich A, Tirosh-Finkel L, Harrelson Z, Rousso T, Rinon A, Harel I, Evans SM, Tzahor E. The contribution of Islet1-expressing splanchnic mesoderm cells to distinct branchiomeric muscles reveals significant heterogeneity in head muscle development. Development. 2008 Feb;135(4):647-57. doi: 10.1242/dev.007989. Epub 2008 Jan 9. Copyright Copyright held by the authors. Published by the Company of Biologists Ltd. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_205414.1
Entry 16 GEISHA Id ISL1.GarciaCampmany.2007 Data Source Publication Complete cDNA Template Probe show GCACGAGGGCGAGTGCCGAGCCGCCAGCGCCCAGTCCAGCACCGCCGCACCGCCGCACCGCACCGGCCCCGCAGCACCG
Citation García-Campmany L, Martí E. The TGFbeta intracellular effector Smad3 regulates neuronal differentiation and cell fate specification in the developing spinal cord. Development. 2007 Jan;134(1):65-75. Epub 2006 Nov 30. Copyright Copyright by the authors. Published by the Company of Biologists Ltd. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_205414.1
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19 stage 19
stage 19
Spinal Cord
Entry 17 GEISHA Id Islet‐1.Iwamasa.1999 Data Source Publication Complete cDNA Template Probe show GCCTGATTTCCCTATGTGTTGGTTGCGGCAATCAAATTCACGATCAGTATATTCTGAGGGTTTCTCCGGATTTGGAATG
Citation Iwamasa H, Ohta K, Yamada T, Ushijima K, Terasaki H, Tanaka H. Expression of Eph receptor tyrosine kinases and their ligands in chick embryonic motor neurons and hindlimb muscles. Dev Growth Differ. 1999 Dec;41(6):685-98. Copyright Copyright © 1999 John Wiley & Sons, Inc. Comments The complete cDNA template sequence was obtained from the information provided in the publication as described in Iwamasa et al. 1999.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-27 stage 27
stage 27
stage 27
Spinal Cord
Entry 18 GEISHA Id c-ISLET1.Adamska.2001 Data Source Publication Complete cDNA Template Probe show GCACGAGGGCGAGTGCCGAGCCGCCAGCGCCCAGTCCAGCACCGCCGCACCGCCGCACCGCACCGGCCCCGCAGCACCG
Citation Adamska M, Herbrand H, Adamski M, Krüger M, Braun T, Bober E. FGFs control the patterning of the inner ear but are not able to induce the full ear program. Mech Dev. 2001 Dec;109(2):303-13. Copyright Copyright © 2001 Elsevier Science Ireland Ltd. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence was obtained from NCBI (NM_205414.1)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-12 stage 10
Cranial Ganglia Ear/Otic Placode 31-44 stage 44
Entry 19 Entry 20 GEISHA Id ISL1.Anderson.2021 Data Source Direct Submission Complete cDNA Template Probe show GAGCGGGCCNAGCCTGGGNGCCGGGGATCCCCTCAGCCCCTTGCACCCGGCCCGACCGCTGCAGATGGCAGCAGAACCT
Comments Images and probe sequence provided by Claire Anderson. Related paper: Anderson C, Hill B, Lu HC, Moverley A, Yang Y, Oliveira NMM, Baldock RA, Stern CD. A 3D molecular atlas of the chick embryonic heart. Dev Biol. 2019 Dec 1;456(1):40-46. doi: 10.1016/j.ydbio.2019.07.003. Epub 2019 Jul 5.
Entry 21 GEISHA Id ISL1.Anderson.2019 Data Source Publication Complete cDNA Template Probe show AGCGCCCAGTCCAGCACCGCCGCACCGCCGCACCGCACCGCGCCCCGCAGCACCGCGCGGCAGGACCCCGCGGCAGGAC
Citation Anderson C, Hill B, Lu HC, Moverley A, Yang Y, Oliveira NMM, Baldock RA, Stern CD. A 3D molecular atlas of the chick embryonic heart. Dev Biol. 2019 Dec 1;456(1):40-46. doi: 10.1016/j.ydbio.2019.07.003. Epub 2019 Jul 5. Copyright Copyright © 2019 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205414).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-12 stage 12
stage 12
stage 12
stage 12
Heart all
Mouse Frog Fruit Fly Zebra Finch Zebrafish
