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MRE11
MRE11 homolog, double strand break repair nuclease

The human orthologue of this gene is associated
with the following human disease:

Gene

Official Symbol	MRE11
Official Full Name	MRE11 homolog, double strand break repair nuclease
CGNC ID	12932
also known as	MRE11A, double-strand break repair protein MRE11\|MRE11 homolog A, double strand break repair nuclease\|MRE11 meiotic recombination 11 homolog A
gene type	protein-coding

Genomic Map

Sequence Information

Gene Expression

In Situ Hybridization

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly	34565			FBgn0020270
Human	4361	ENSG00000020922	MIM:604391	MIM:600814
Mouse	17535	ENSMUSG00000031928	All phenotypic alleles (5):Targeted, knock-out(2) Targeted, other(3)	MGI:1100512
Xenopus	100135381, 394308			957955
Zebrafish	406637		ZDB-GENE-040426-2638	ZFIN:ZDB-GENE-040426-2638

Gene Ontology

Molecular Function	endonuclease activity, exonuclease activity, manganese ion binding
Biological Process	DNA repair, double-strand break repair, double-strand break repair via homologous recombination, meiosis
Cellular Component	nucleoplasm

Links to other databases

GEISHA Id	MRE11A.UApcr	Data Source	GEISHA ISH Analysis
Forward cDNA Template Primer	TTATAAAAGCTTGCGGCCGCAGAATATACTCCAGCCCAAAACGAACAG
Reverse cDNA Template Primer	GCTCTAGAAATTAACCCTCACTAAAGGGAATGTCATCATCTGAATCACCCG	cDNA Template Length	931
Forward cDNA Template Probe	show `CGCCAGCCACAGAAGCCTCTCATTAGATTACGAGTTGATTACACGGGTGGCTTTGAGCCATTCATTGTCCATCGTTTCA GCCAGAAGTACATGGATAGGGTGGCCAACCCAAAGGACATCATACATTTTTTCAGACATCGTGAACAAAAAGAGAAAAA CGACAATGATATTAATTTTGGAAAGCTGCTTAGCAGACCTGCTTCTGAGGAGGTGACACTGAGAGTGGAAGACCTTGTA AAGCAGTATTTTCAGACAGCAGAGAAGAAAGTACAACTTTCACTTCTAACTGAAAGAGGAATGGGAGAAGCAGTGCAGG A`