Quick Search
X XI XII XIII XIV 1 2 3 4 5 6 7 8 9 10 11 12
13 14 15 16 17 18 19 20 21 22 23 24
25 26 27 28 29 30 31 32 33 34 35 36
37 38 38 40 41 42 43 44
Gene Family QuickSearch
Human Disease Gene Search
NOTCH1 The human orthologue of this gene is associated
Gene Summary Expression Other Species Expression JBrowse Gene Official Symbol NOTCH1 Official Full Name notch 1 CGNC ID 49424 also known as neurogenic locus notch homolog protein 1|NOTCH-1|Notch homolog 1, translocation-associated, Notch1 gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Molecular Function Biological Process Cellular Component
Links to other databases
Entry 1 GEISHA Id pgn1c.pk011.j11 Data Source GEISHA ISH Analysis Forward cDNA Template Probe show CGAGTGTGACTCCAAGCCCTGCCTGAACGGGGGCACGTGTCAGGACAGCTACGGGACGTACAAGTGCACCTGTCCCCAG
Entry 2 GEISHA Id Notch1.Barembaum.2007 Data Source Publication Complete cDNA Template Probe show ATGGGTTCGGGCTGCGGCTCTGCGACGGCTGCCTTCGCTCAGTGTGAAACTGCTTCGGCTGCCCCGAGAGCGGCAGAAG
Citation Barembaum M, Bronner-Fraser M. Spalt4 mediates invagination and otic placode gene expression in cranial ectoderm. Development. 2007 Nov;134(21):3805-14. Copyright Published by The Company of Biologists 2007 Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (XM_415420).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13 stage 13
Ectoderm
Entry 3 GEISHA Id Notch1.Politis.2007 Data Source Publication Complete cDNA Template Probe show ATGGGTTCGGGCTGCGGCTCTGCGACGGCTGCCTTCGCTCAGTGTGAAACTGCTTCGGCTGCCCCGAGAGCGGCAGAAG
Citation Politis PK, Rohrer H, Matsas R (2007). Expression pattern of BM88 in the developing nervous system of the chick and mouse embryo. Gene Expr Patterns. 2007 Jan;7(1-2):165-77. Epub 2006 Jul 4 Copyright Reprinted with permission from Elsevier.
Copyright © 2006 Elsevier B.V. All rights reserved. Comments According to authors , "The following probes were used: cSCG10, cNotch1, cOlig2 (kindly provided by Masato Nakafuku), cNkx6.1 (kindly provided by James Briscoe) and Mash1 (kindly provided by Francois Guillemot). As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #XM_415420)
Entry 4 GEISHA Id Notch1.Rodrigues.2006 Data Source Publication Complete cDNA Template Probe show ATGGGTTCGGGCTGCGGCTCTGCGACGGCTGCCTTCGCTCAGTGTGAAACTGCTTCGGCTGCCCCGAGAGCGGCAGAAG
Citation Rodrigues S, Santos J, Palmeirim I.
Molecular characterization of the rostral-most somites in early somitic stages of the chick embryo.
Gene Expr Patterns. 2006 Oct;6(7):673-7. Epub 2006 Feb 20. Copyright Reprinted with permission from Elsevier. Copyright © 2006 Elsevier B.V. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (XM_415420).
Entry 5 GEISHA Id Notch1.Hayes.2007 Data Source Publication Complete cDNA Template Probe show ATGGGTTCGGGCTGCGGCTCTGCGACGGCTGCCTTCGCTCAGTGTGAAACTGCTTCGGCTGCCCCGAGAGCGGCAGAAG
Citation Hayes S, Nelson BR, Buckingham B, Reh TA.
Notch signaling regulates regeneration in the avian retina (2007). Dev Biol. 2007 Dec 1;312(1):300-11. Epub 2007 Sep 29. Copyright Copyright © 2007 Elsevier Inc. All rights reserved. Comments According to authors , "Notch1 plasmid used to make probe came from D. Henrique (Henrique et al., 1997)." As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #XM_415420).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-44 stage 44
stage 44
stage 44
Eye
Entry 6 GEISHA Id Notch.Groves.2000 Data Source Publication Complete cDNA Template Probe show ATGGGTTCGGGCTGCGGCTCTGCGACGGCTGCCTTCGCTCAGTGTGAAACTGCTTCGGCTGCCCCGAGAGCGGCAGAAG
Citation Groves AK, Bronner-Fraser M. Competence, specification and commitment in otic placode induction. Development. 2000 Aug;127(16):3489-99.
Copyright This material is protected by copyright. The Company of Biologists' (publishers of Development) hold an Exclusive License obtained from the authors, who retain copyright. Comments According to the authors, chick Notch-1 was provided by Julian Lewis and David Ish-Horowicz. As information provided is insufficient to verify exact sequence used to synthesize the probe, the sequence below was obtained from NCBI (Acc# XM_415420.2).
Entry 7 GEISHA Id NOTCH1.Sanders.2002 Data Source Publication Complete cDNA Template Probe show ATGGGTTCGGGCTGCGGCTCTGCGACGGCTGCCTTCGCTCAGTGTGAAACTGCTTCGGCTGCCCCGAGAGCGGCAGAAG
Citation Sanders TA, Lumsden A, Ragsdale CW. Arcuate plan of chick midbrain development. J Neurosci. 2002 Dec 15;22(24):10742-50. Copyright Copyright © 2002-2011 by the Society for Neuroscience Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI ( acc # XM_415420.2). This sequence is predicted.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 1 stage 1
stage 1
Midbrain
Entry 8 Entry 9 GEISHA Id NOTCH1.Moran.2011 Data Source Publication Complete cDNA Template Probe show ATGGGTTCGGGCTGCGGCTCTGCGACGGCTGCCTTCGCTCAGTGTGAAACTGCTTCGGCTGCCCCGAGAGCGGCAGAAG
Citation Moran CM, Salanga MC, Krieg PA. Hedgehog signaling regulates size of the dorsal aortae and density of the plexus during avian vascular development. Dev Dyn. 2011 Jun;240(6):1354-64.
Copyright Copyright © 2011 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # XM_415420).
Entry 10 GEISHA Id NOTCH1.Tenin.2010 Data Source Publication Complete cDNA Template Probe show GGGCCCCCGCTGCGAGATCGATGTCAATGAGTGCCTCTCCAACCCCTGCCAGAACGATGCCACCTGCCTGGACCAGATC
Citation Tenin G, Wright D, Ferjentsik Z, Bone R, McGrew MJ, Maroto M. The chick somitogenesis oscillator is arrested before all paraxial mesoderm is segmented into somites. BMC Dev Biol. 2010 Feb 25;10:24. Copyright authors retain copyright of their article, and grant any third party the right to use reproduce and disseminate the article, subject to the terms of BMC Developmental Biology copyright and license agreement Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI XM_004945970
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 24
Tail 25 stage 25
stage 25
Tail
Entry 11 GEISHA Id NOTCH1.Ware.2014 Data Source Publication Complete cDNA Template Probe show ATGGGGCGGTGTAGTGCTGCCCATCCCCGCGGTGGGGTGCATTGCCCCGGGCTCTGTGCTGTGCCTGACGCTCTCCTTC
Citation Ware M, Hamdi-Rozé H and Dupé V (2014) Notch signaling and proneural genes work together to control the neural building blocks for the initial scaffold in the hypothalamus. Front Neuroanat. 2014 Dec 2;8:140. doi: 10.3389/fnana.2014.00140. Copyright Copyright © 2014 Ware, Hamdi-Rozé and Dupé Comments Insufficient information provided in the publication to verify the exact sequence used to synthesize probe. The sequence was obtained from NCBI (Acc. # NM_001030295.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-12 stage 12
stage 12
Hypothalamus
Entry 12 GEISHA Id C-Notch-l.Hayashi.1996 Data Source Publication Complete cDNA Template Probe show AGGGGGGCTGGAGACTGGCAACAGCGAGGAGGAGGACGATGCCCCTGCAGTCATCTCAGATTTCATCTACCAAGGCGCC
Citation Hayashi H, Mochii M, Kodama R, Hamada Y, Mizuno N, Eguchi G, Tachi C. Isolation of a novel chick homolog of Serrate and its coexpression with C-Notch-1 in chick development. Int J Dev Biol. 1996 Dec;40(6):1089-96. Copyright © UBC Press Comments The complete cDNA template sequence was obtained from the information in the publication as described in Hayashi et al. 1996.
Entry 13 GEISHA Id Notch1.Vieceli.2013 Data Source Publication Complete cDNA Template Probe show CCTTCGAAGCCCACTACATCTGCCGCTGCACGGCCGGCTTCCACGGGGCCAACTGCAAGCAGGACGTGAACGAATGCAA
Citation Vieceli FM, Simões-Costa M, Turri JA, Kanno T, Bronner M, Yan CY. The transcription factor chicken Scratch2 is expressed in a subset of early postmitotic neural progenitors. Gene Expr Patterns. 2013 Jun-Jul;13(5-6):189-96. DOI: 10.1016/j.gep.2013.03.004. Copyright Copyright © 2013 Elsevier B.V. Comments Authors indicated the probe for Notch1 was synthesized from 500-4502 nucleotides of NCBI XM_415420 and provided by P.K. Politis. Above sequence was extracted from NCBI (XM_415420).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25 stage 25
Spinal Cord all
Mouse Frog Fruit Fly Zebra Finch Zebrafish
