Quick Search
X XI XII XIII XIV 1 2 3 4 5 6 7 8 9 10 11 12
13 14 15 16 17 18 19 20 21 22 23 24
25 26 27 28 29 30 31 32 33 34 35 36
37 38 38 40 41 42 43 44
Gene Family QuickSearch
Human Disease Gene Search
SFRP2 Gene Summary Expression Other Species Expression JBrowse Gene Official Symbol SFRP2 Official Full Name secreted frizzled related protein 2 CGNC ID 7021 also known as SFRP-2, secreted frizzled-related protein 2, sFRP-2, Sdf5, Secreted frizzled-related protein 2 precursor gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Molecular Function PDZ domain binding , Wnt-activated receptor activity , Wnt-protein binding Biological Process apoptotic process , brain development , canonical Wnt signaling pathway , cell differentiation , more... embryo development , gonad development , vasculature development Cellular Component cell projection , cytoplasm , extracellular region , plasma membrane
Links to other databases
Entry 1 GEISHA Id sFRP2.Chapman.2004 Data Source Publication Complete cDNA Template Probe show CTCCGCTCAGCCCACCGCCCCGCCATGCCGCGCCGCCTCTGCGCCCTGCTCCTGCTGGCCTCCCAGTGCCTGGGTTCGA
Citation Chapman, S, Brown, R, Lees, L, Schoenwolf, G, Lumsden, A. Expression Analysis of Chick Wnt and Frizzled Genes and Selected Inhibitors in Early Chick Patterning. Dev Dyn. 2004 Mar;229(3):668-76. Copyright Wiley-Liss, Inc. 2004
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4-5
stage 4
stage 4
stage 4
stage 5
Epiblast Neural Plate/Tube
Entry 2 GEISHA Id SFRP2.Ladher.2000 Data Source Publication Complete cDNA Template Probe show CTCCGCTCAGCCCACCGCCCCGCCATGCCGCGCCGCCTCTGCGCCCTGCTCCTGCTGGCCTCCCAGTGCCTGGGTTCGA
Citation Ladher RK, Church VL, Allen S, Robson L, Abdelfattah A, Brown NA, Hattersley G, Rosen V, Luyten FP, Dale L, Francis-West PH. Cloning and expression of the Wnt antagonists Sfrp-2 and Frzb during chick development. Dev Biol. 2000 Feb 15;218(2):183-98. Copyright Reprinted with permission from Elsevier.
Copyright © 2000 Elsevier B.V. All rights reserved.
Comments According to the authors, "The Sfrp-2 antisense probe was generated by linearising the full-length clone with HindIII and transcribing with T3 RNA
polymerase." As information provided was insufficient to verify exact sequence used to synthesize probe,the sequence below was obtained from NCBI (NM_204773).
Entry 3 GEISHA Id Sdf5.Chapman.2008 Data Source Direct Submission Complete cDNA Template Probe show CTCCGCTCAGCCCACCGCCCCGCCATGCCGCGCCGCCTCTGCGCCCTGCTCCTGCTGGCCTCCCAGTGCCTGGGTTCGA
Comments Images Provided by Susan Chapman.
Entry 4 GEISHA Id sFRP2.Chapman.2008 Data Source Direct Submission Complete cDNA Template Probe show CTCCGCTCAGCCCACCGCCCCGCCATGCCGCGCCGCCTCTGCGCCCTGCTCCTGCTGGCCTCCCAGTGCCTGGGTTCGA
Comments Images Provided by Susan Chapman.
Entry 5 GEISHA Id sFRP2.Theodosiou.2003 Data Source Publication Complete cDNA Template Probe show CTCCGCTCAGCCCACCGCCCCGCCATGCCGCGCCGCCTCTGCGCCCTGCTCCTGCTGGCCTCCCAGTGCCTGGGTTCGA
Citation Theodosiou NA, Tabin CJ. Wnt signaling during development of the gastrointestinal tract. Dev Biol. 2003 Jul 15;259(2):258-71. Copyright Copyright © 2003 Elsevier Science (USA). All rights reserved. Comments Authors indicated probe was 224 bp long. Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc #NM_204773.1)
Entry 6 GEISHA Id SFrp2.McBride.2003 Data Source Publication Complete cDNA Template Probe show CTCCGCTCAGCCCACCGCCCCGCCATGCCGCGCCGCCTCTGCGCCCTGCTCCTGCTGGCCTCCCAGTGCCTGGGTTCGA
Citation McBride HJ, Fatke B, Fraser SE. Wnt signaling components in the chicken intestinal tract. Dev Biol. 2003 Apr 1;256(1):18-33. Copyright With permission from Elsevier
Copyright © 2003 Elsevier B.V. All rights reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_204773).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 1-3 stage 1
Gut 19-24 stage 23
stage 23
Hindgut Midgut 25-30 stage 26
stage 28
stage 28
Gut Midgut 31-34 stage 34
stage 34
Midgut
Entry 7 GEISHA Id SFRP2.Quinlan.2009 Data Source Publication Complete cDNA Template Probe show CTCCGCTCAGCCCACCGCCCCGCCATGCCGCGCCGCCTCTGCGCCCTGCTCCTGCTGGCCTCCCAGTGCCTGGGTTCGA
Citation Quinlan R, Graf M, Mason I, Lumsden A, Kiecker C. Complex and dynamic patterns of Wnt pathway gene expression in the developing chick forebrain. Neural Dev. 2009 Sep 4;4:35. Copyright Copyright © 2009 Quinlan et al; licensee BioMed Central Ltd. [This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.] Comments Authors indicated probe was 224 nt long. As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_204773).
Entry 8 GEISHA Id SFRP2.Sienknecht.2009 Data Source Publication Complete cDNA Template Probe show CTCCGCTCAGCCCACCGCCCCGCCATGCCGCGCCGCCTCTGCGCCCTGCTCCTGCTGGCCTCCCAGTGCCTGGGTTCGA
Citation Sienknecht UJ, Fekete DM. Mapping of Wnt, frizzled, and Wnt inhibitor gene expression domains in the avian otic primordium. J Comp Neurol. 2009 Dec 20;517(6):751-64. Copyright Copyright © (2002 Wiley-Liss); This material is used by permission of Wiley-Liss, Inc., a subsidiary of John Wiley & Sons, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc # NM_204773)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-18 stage 16
stage 16
Ear/Otic Placode 19-24 stage 20
stage 20
stage 20
stage 24
stage 24
Ear/Otic Placode
Entry 9 GEISHA Id SFRP2.LinCT.2007 Data Source Publication Complete cDNA Template Probe show CCGCCATGCCGCGCCGCCTCTGCGCCCTGCTCCTGCTGGCCTCCCAGTGCCTGGGTTCGACCGCCGGGCTCTTCCCTTT
Citation Lin CT, Lin YT, Kuo TF. Investigation of mRNA expression for secreted frizzled-related protein 2 (sFRP2) in chick embryos. J Reprod Dev. 2007 Aug;53(4):801-10. Epub 2007 May 10. Copyright © 2012 researchgate.net. All rights reserved. Comments Authors indicate the probe was amplified by PCR using the following primers:
5_-ccgccatggcgcgccgcctc-3_ and 5_-ccaaagcttctaacactgcag-3_ and was extracted from NCBI Acc# NM_204773.1. Primer and sequence match is imperfect.
Entry 10 GEISHA Id SFRP2.Singh.2016 Data Source Publication Complete cDNA Template Probe show CACGGTTTCAGGAATACATCCTGTCCCAGCAAAAACTGGAGTGCTGCTTAACATAGCAAAGCTGTCCTCTTTCTATTGC
Citation Singh PN, Ray A, Azad K, Bandyopadhyay A. A comprehensive mRNA expression analysis of developing chicken articular cartilage. Gene Expr Patterns. 2016 Jan;20(1):22-31. Copyright Copyright © 2015 Elsevier B.V. All rights reserved. Comments The complete cDNA template sequence was obtained from the information provided in the publication as described in Singh et al. 2016. The probe was synthesized from cDNA clone ChEST712d9.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-30 stage 28
Limb Buds 31-38 stage 31
stage 34
stage 36
stage 38
Limb Buds all
Mouse Frog Fruit Fly Zebra Finch Zebrafish
