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Human Disease Gene Search
SNAI2 The human orthologue of this gene is associated
Gene Summary Expression Other Species Expression JBrowse Gene Official Symbol SNAI2 Official Full Name snail family transcriptional repressor 2 CGNC ID 54314 also known as zinc finger protein SNAI2|LOW QUALITY PROTEIN: zinc finger protein SNAI2|slug|snail family zinc finger 2|snail homolog 2, Slug, Snail-2 gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Molecular Function Biological Process Cellular Component
Links to other databases
Entry 1 GEISHA Id Slug Data Source GEISHA ISH Analysis Complete cDNA Template Probe show GCCACTACACAGCGGAGTGCATGGAGCAGACAATGCGATAGGGACCGATGCGCTCGCAGTGATAGTGTGCGCGTGTGCT
Entry 2 GEISHA Id pgf2n.pk005.p6 Data Source GEISHA ISH Analysis Forward cDNA Template Probe show GACCGATGCGCTCGCAGTGATAGTGTGCGCGTGTGCTGCACCGCTGCGCCGACCCAAAAGGAGAATCTGCAAGAAGGAG
Comments Snail-2 (Slug)
Entry 3 GEISHA Id Slug.Marin2.2004 Data Source Publication Complete cDNA Template Probe show GCCACTACACAGCGGAGTGCATGGAGCAGACAATGCGATAGGGACCGATGCGCTCGCAGTGATAGTGTGCGCGTGTGCT
Citation Marin, F, Nieto, MA. Expression of Chicken Slug and Snail in Mesenchymal Components of the Developing Central Nervous System. Dev Dyn. 2004 May;230(1):144-8. Copyright Wiley-Liss, Inc. 2004 Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # XM_419196).
Entry 4 GEISHA Id Snail.Marin.2004 Data Source Publication Complete cDNA Template Probe show GCCACTACACAGCGGAGTGCATGGAGCAGACAATGCGATAGGGACCGATGCGCTCGCAGTGATAGTGTGCGCGTGTGCT
Citation Marin, F, Nieto, MA. Expression of Chicken Slug and Snail in Mesenchymal Components of the Developing Central Nervous System. Dev Dyn. 2004 May;230(1):144-8. Copyright Wiley-Liss, Inc. 2004 Comments sequence info from M Sefton, S Sanchez, and MA Nieto (1998) Conserved and divergent roles for members of the Snail family of transcription factors in the chick and mouse embryo. Development 125: 3111-3121. chick snail nt 258-767
Entry 5 GEISHA Id Slug.Kamimura.2004 Data Source Publication Complete cDNA Template Probe show GCCACTACACAGCGGAGTGCATGGAGCAGACAATGCGATAGGGACCGATGCGCTCGCAGTGATAGTGTGCGCGTGTGCT
Citation Kamimura, M, Matsumoto, K, Koshiba-Takeuchi, K, Ogura, T. Vertebrate Crossveinless 2 Is Secreted and Acts as an Extracellular Modulator of the BMP Signalling Cascade. Dev Dyn. 2004 Jul;230(3):434-45. Copyright Wiley-Liss, Inc. 2004 Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # XM_419196).
Entry 6 GEISHA Id Slug.Schmidt.2007 Data Source Publication Complete cDNA Template Probe show GCCACTACACAGCGGAGTGCATGGAGCAGACAATGCGATAGGGACCGATGCGCTCGCAGTGATAGTGTGCGCGTGTGCT
Citation Schmidt C, McGonnell IM, Allen S, Otto A, Patel K. Wnt6 controls amniote neural crest induction through the non-canonical signaling pathway.Dev Dyn. 2007 Sep;236(9):2502-11. Copyright Copyright © 2007 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (XM_419196).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-12 stage 12
Neural Plate/Tube
Entry 7 GEISHA Id Slug.Ohta.2007 Data Source Publication Complete cDNA Template Probe show GCCACTACACAGCGGAGTGCATGGAGCAGACAATGCGATAGGGACCGATGCGCTCGCAGTGATAGTGTGCGCGTGTGCT
Citation Ohta S, Suzuki K, Tachibana K, Tanaka H, Yamada G. Cessation of gastrulation is mediated by suppression of epithelial-mesenchymal transition at the ventral ectodermal ridge. Development. 2007 Dec;134(24):4315-24. Epub 2007 Nov 14. Copyright Published by The Company of Biologists 2007. This material is protected by a copyright retained by the authors. Permission granted by Dr. Yamada. Comments According to the authors, "Section in situ hybridization was performed by standard procedures using probes of...cSlug (kindly provided by H. Tanaka, Kumamoto University, Kumamoto, Japan). As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence given below was obtained from NCBI (XM_419196).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-17 stage 17
Tail
Entry 8 GEISHA Id Snail2.Graham.2007 Data Source Publication Complete cDNA Template Probe show GCCACTACACAGCGGAGTGCATGGAGCAGACAATGCGATAGGGACCGATGCGCTCGCAGTGATAGTGTGCGCGTGTGCT
Citation Graham A, Blentic A, Duque S, Begbie J.
Delamination of cells from neurogenic placodes does not involve an epithelial-to-mesenchymal transition.
Development. 2007 Dec;134(23):4141-5. Epub 2007 Oct 24. Copyright Published by The Company of Biologists 2007 Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (XM_419196).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-17 stage 17
stage 17
stage 17
Hindbrain Neural Plate/Tube
Entry 9 GEISHA Id Slug.Ladher.2000 Data Source Publication Complete cDNA Template Probe show GCCACTACACAGCGGAGTGCATGGAGCAGACAATGCGATAGGGACCGATGCGCTCGCAGTGATAGTGTGCGCGTGTGCT
Citation Ladher RK, Church VL, Allen S, Robson L, Abdelfattah A, Brown NA, Hattersley G, Rosen V, Luyten FP, Dale L, Francis-West PH. Cloning and expression of the Wnt antagonists Sfrp-2 and Frzb during chick development. Dev Biol. 2000 Feb 15;218(2):183-98. Copyright Reprinted with permission from Elsevier.
Copyright © 2000 Elsevier B.V. All rights reserved.
Comments According to the authors, "Slug
(Nieto et al., 1994), ... were used as previously described." As information provided was insufficient to verify exact sequence used to synthesize probe,the sequence below was obtained from NCBI (XM_419196).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-18 stage 13
Neural Crest 25-28 stage 28
Entry 10 GEISHA Id Slug.Martinez-Alvarez.2004 Data Source Publication Complete cDNA Template Probe show GCCACTACACAGCGGAGTGCATGGAGCAGACAATGCGATAGGGACCGATGCGCTCGCAGTGATAGTGTGCGCGTGTGCT
Citation Martínez-Alvarez C, Blanco MJ, Pérez R, Rabadán MA, Aparicio M, Resel E, Martínez T, Nieto MA. (2004) Snail family members and cell survival in physiological and pathological cleft palates. Dev Biol. 2004 Jan 1;265(1):207-18.
Copyright Copyright © 2003 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (XM_419196).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-35 stage 35
Head Mesenchyme
Entry 11 GEISHA Id Slug.Taneyhill.2005 Data Source Publication Complete cDNA Template Probe show GCCACTACACAGCGGAGTGCATGGAGCAGACAATGCGATAGGGACCGATGCGCTCGCAGTGATAGTGTGCGCGTGTGCT
Citation Taneyhill LA, Bronner-Fraser M. Dynamic alterations in gene expression after Wnt-mediated induction of avian neural crest. Mol Biol Cell. 2005 Nov;16(11):5283-93. Epub 2005 Aug 31. Copyright Copyright 2004, MBC Online by The American Society for Cell Biology. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (XM_419196).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-16 stage 16
stage 16
stage 16
Neural Plate/Tube
Entry 12 GEISHA Id Slug.McLarren.2003 Data Source Publication Complete cDNA Template Probe show GCCACTACACAGCGGAGTGCATGGAGCAGACAATGCGATAGGGACCGATGCGCTCGCAGTGATAGTGTGCGCGTGTGCT
Citation McLarren KW, Litsiou A, Streit A. DLX5 positions the neural crest and preplacode region at the border of the neural plate. Dev Biol. 2003 Jul 1;259(1):34-47. Copyright Copyright © 2003 Elsevier Science (USA). All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (XM_419196).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7 stage 7
stage 7
Neural Plate/Tube
Entry 13 GEISHA Id Snail2.Adams.2008 Data Source Publication Complete cDNA Template Probe show GCCACTACACAGCGGAGTGCATGGAGCAGACAATGCGATAGGGACCGATGCGCTCGCAGTGATAGTGTGCGCGTGTGCT
Citation Adams MS, Gammill LS, Bronner-Fraser M. Discovery of transcription factors and other candidate regulators of neural crest development. Dev Dyn. 2008 Apr;237(4):1021-33. Copyright Copyright © 2008 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (XM_419196).
Entry 14 GEISHA Id Snail2.Coles.2007 Data Source Publication Complete cDNA Template Probe show GCCACTACACAGCGGAGTGCATGGAGCAGACAATGCGATAGGGACCGATGCGCTCGCAGTGATAGTGTGCGCGTGTGCT
Citation Coles EG, Taneyhill LA, Bronner-Fraser M. A critical role for Cadherin6B in regulating avian neural crest emigration. Dev Biol. 2007 Dec 15;312(2):533-44. Epub 2007 Oct 5. Copyright Copyright © 2007 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence to synthesize probe. Sequence below was obtained from NCBI (XM_419196).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-10 stage 10
stage 10
Neural Crest
Entry 15 GEISHA Id Snail2.Taneyhill.2007 Data Source Publication Complete cDNA Template Probe show GCCACTACACAGCGGAGTGCATGGAGCAGACAATGCGATAGGGACCGATGCGCTCGCAGTGATAGTGTGCGCGTGTGCT
Citation Taneyhill LA, Coles EG, Bronner-Fraser M. Snail2 directly represses cadherin6B during epithelial-to-mesenchymal transitions of the neural crest. Development. 2007 Apr;134(8):1481-90. Epub 2007 Mar 7. Copyright Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA. Comments Insufficient information provided in publication to verify exact sequence to synthesize probe. Sequence below was obtained from NCBI (XM_419196).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-14 stage 14
stage 14
Neural Plate/Tube
Entry 16 GEISHA Id SLUG.Selleck.1998 Data Source Publication Complete cDNA Template Probe show CTGCCTTCAAAATGCCACGCTCCTTCCTGGTCAAGAAACATTTCAATTCATCCAAGAAGCCAAACTACAGCGAACTGGA
Citation Selleck MA, García-Castro MI, Artinger KB, Bronner-Fraser M., Effects of Shh and Noggin on neural crest formation demonstrate that BMP is required in the neural tube but not ectoderm. Development. 1998 Dec;125(24):4919-30. Copyright Published by The Company of Biologists 2007. This material is protected by a copyright retained by the authors. Permission granted by Dr. Bronner Fraser. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI ( X77572.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-10 stage 10
stage 10
Neural Plate/Tube
Entry 17 Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-9 stage 9
stage 9
Neural Crest
Entry 18 Entry 19 GEISHA Id SNAIL2.Groysman.2008 Data Source Publication Complete cDNA Template Probe show TGCCACTACACAGCGGAGTGCATGGAGCAGACAATGCGATAGGGACCGATGCGCTCGCAGTGATAGTGTGCGCGTGTGC
Citation Groysman M, Shoval I, Kalcheim C. A negative modulatory role for rho and rho-associated kinase signaling in delamination of neural crest cells. Neural Dev. 2008 Oct 22;3:27. Copyright Copyright © 2008 Groysman et al.; licensee BioMed Central Ltd. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #XM_419196.3).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-12 stage 12
stage 12
Neural Crest Paraxial Mesoderm
Entry 20 GEISHA Id SNAIL2.Acloque.2011 Data Source Publication Complete cDNA Template Probe show TGCCACTACACAGCGGAGTGCATGGAGCAGACAATGCGATAGGGACCGATGCGCTCGCAGTGATAGTGTGCGCGTGTGC
Citation Hervé Acloque, Oscar H. Ocaña, Ander Matheu, Karine Rizzoti, Clare Wise, Robin Lovell-Badge, M. Angela Nieto Reciprocal Repression between Sox3 and Snail Transcription Factors Defines Embryonic Territories at Gastrulation. Dev Cell. 2011 September 13; 21(3): 546558. Copyright Copyright © 2011 Published by Elsevier Inc. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #XM_419196.3).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) X-XIV stage XII
Primitive Streak 1-3 stage 2
stage 3
stage 3
Primitive Streak
Entry 21 GEISHA Id CSNR.Tao.2002 Data Source Publication Complete cDNA Template Probe show CTCTGCAGTGCCACTACACAGCGGAGTGCATGGAGCAGACAATGCGATAGGGACCGATGCGCTCGCAGTGATAGTGTGC
Citation Tao H, Yoshimoto Y, Yoshioka H, Nohno T, Noji S, Ohuchi H. FGF10 is a mesenchymally derived stimulator for epidermal development in the chick embryonic skin. Mech Dev. 2002 Aug;116(1-2):39-49. Copyright Copyright © 2012 Elsevier B.V. All rights reserved. Comments authors identified this as Snail-related, so we selected snai2 sequence. As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # XM_419196.4).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31 stage 31
stage 31
Feathers/Scutae Leg Ectoderm
Entry 22 GEISHA Id SNAIL-2.Dady.2012 Data Source Publication Complete cDNA Template Probe show TGCCACTACACAGCGGAGTGCATGGAGCAGACAATGCGATAGGGACCGATGCGCTCGCAGTGATAGTGTGCGCGTGTGC
Citation Dady A, Blavet C, Duband JL Timing and kinetics of E- to N-cadherin switch during neurulation in the avian embryo DEVELOPMENTAL DYNAMICS. Volume 241, Issue 8, August 2012, Pages: 13331349. Copyright Copyright © 2012 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # XM_419196).
Entry 23 GEISHA Id SNAIL2.Hu.2012 Data Source Publication Complete cDNA Template Probe show CTCTGCAGTGCCACTACACAGCGGAGTGCATGGAGCAGACAATGCGATAGGGACCGATGCGCTCGCAGTGATAGTGTGC
Citation Hu N, Strobl-Mazzulla P, Sauka-Spengler T, Bronner ME. DNA methyltransferase3A as a molecular switch mediating the neural tube-to-neural crest fate transition. Genes Dev. 2012 November 1; 26(21): 23802385. Copyright Copyright © 2012 by Cold Spring Harbor Laboratory Press Comments
As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI XM_419196.4
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-8 stage 8
stage 8
Neural Crest Neural Plate/Tube
Entry 24 GEISHA Id SNAI2.Ferronha.2013 Data Source Publication Complete cDNA Template Probe show CTCTGCAGTGCCACTACACAGCGGAGTGCATGGAGCAGACAATGCGATAGGGACCGATGCGCTCGCAGTGATAGTGTGC
Citation Ferronha T, Rabadán MA, Gil-Guiñon E, Le Dréau G, de Torres C, Martí E.
LMO4 is an essential cofactor in the Snail2-mediated epithelial-to-mesenchymal transition of neuroblastoma and neural crest cells. J Neurosci. 2013 Feb 13;33(7):2773-83.
Copyright Copyright @ 2013 by the Society of Neuroscience
Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # XM_419196.4).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-10 stage 10
stage 10
Neural Crest
Entry 25 GEISHA Id SLUG.Litsiou.2005 Data Source Publication Complete cDNA Template Probe show CTCTGCAGTGCCACTACACAGCGGAGTGCATGGAGCAGACAATGCGATAGGGACCGATGCGCTCGCAGTGATAGTGTGC
Citation Litsiou A, Hanson S, Streit A. A balance of FGF, BMP and WNT signalling positions the future placode territory in the head. Development. 2005 Sep;132(18):4051-62. Epub 2005 Aug 10 Copyright Authors hold the copyright. Published by the Company of Biologists Ltd. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI XM_419196.4
Entry 26 GEISHA Id Slug.delBarrio.2002 Data Source Publication Complete cDNA Template Probe show GTGCTTGAGAACATCCAGAAGTGATTGGAGGAGCAGAAAACCCTTCCCCCCTGCACCTGACTTGCGGGTATTTACGGCA
Citation Marta G. del Barrio and M. Angela Nieto. Overexpression of Snail family members highlights their ability to promote chick neural crest formation. Development. 2002 Apr;129(7):1583-93. Copyright Copyright © 2002 The Company of Biologists Limited Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence was obtained from NCBI (XM_419196.6). Slug is also known as SNAI2 in NCBI.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-18 stage 13
stage 13
Hindbrain Neural Plate/Tube 31-44 stage 44
stage 44
Mouse Frog Fruit Fly Zebra Finch Zebrafish
