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Human Disease Gene Search
SMAD6 Gene Summary Expression Other Species Expression JBrowse Gene Official Symbol SMAD6 Official Full Name SMAD family member 6 CGNC ID 5950 also known as MADH6, mothers against decapentaplegic homolog 6|MAD homolog 6|mothers against DPP homolog 6 gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Molecular Function I-SMAD binding , R-SMAD binding , chromatin binding , co-SMAD binding , metal ion binding , more... sequence-specific DNA binding transcription factor activity , transcription regulatory region DNA binding , transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity , type I activin receptor binding , type I transforming growth factor beta receptor binding , ubiquitin protein ligase binding Biological Process cell-substrate adhesion , immune response , negative regulation of BMP signaling pathway , more... negative regulation of SMAD protein complex assembly , negative regulation of apoptotic process , negative regulation of cell proliferation , negative regulation of pathway-restricted SMAD protein phosphorylation , negative regulation of transforming growth factor beta receptor signaling pathway , response to laminar fluid shear stress , transcription, DNA-templated , transforming growth factor beta receptor signaling pathway , ureteric bud development , zygotic specification of dorsal/ventral axis Cellular Component nucleus , transcription factor complex
Links to other databases
Entry 1 GEISHA Id Smad6.Lincoln.2004 Data Source Publication Complete cDNA Template Probe show CCAGAGTCTCCGCCGCCTCCCTACTCCCGGCTGTCTCCTAACGACGAGCAAAAGCCACTGGATCTCTCGGATTCCACGT
Citation Lincoln J, Alfieri CM, Yutzey KE. Development of heart valve leaflets and supporting apparatus in chicken and mouse embryos. Dev Dyn. 2004 Jun;230(2):239-50. Copyright Wiley-Liss, Inc. 2004
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-30
stage 29
Heart 31-36 stage 36
Heart
Entry 2 GEISHA Id Smad6.Zuzarte.2004 Data Source Publication Complete cDNA Template Probe show GCCACTGGATCTCTCGGATTCCACGTTGTCTTACACTGAAACAGAGGCGACGAACTCACCCAACGTCACGCCCGGGGAG
Citation Zuzarte-Luís V, Montero JA, Rodriguez-León J, Merino R, Rodríguez-Rey JC, Hurlé JM. A new role for BMP5 during limb development acting through the synergic activation of Smad and MAPK pathways. Dev Biol. 2004 Aug 1;272(1):39-52. Copyright Reprinted from Developmental Biology, Volume 272, Issue 1, V Zuzarte-Luıs, J.A. Montero, J Rodriguez-León, R Merino, J.C Rodrıguez-Rey, and J.M Hurlé, A new role for BMP5 during limb development acting through the synergic activation of Smad and MAPK pathways, Pages 39-52, Copyright 2004, with permission from Elsevier.
Copyright © 2004 Elsevier B.V. All rights reserved. Comments Fragments of chicken Smad6 (702 bp) ... ... genes were obtained by RT-PCR. cSmad6, 5′-AGTACAAGCCACTGGATCTGTCCGA-3′(sense) and 5′-CCAGCCCTTGGCGAAGCTGATGC-3′ (antisense)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-30 stage 30
Unlabeled
Entry 3 GEISHA Id SMAD6.Alev.2010 Data Source Publication Complete cDNA Template Probe show CTGAAGGCCCTGTGCGAATGTCAGAGCTTCGGGGCGGCCGACGGCCCCACCGTGTGCTGCAATCCGTACCACTTCAGCC
Citation Alev C, Wu Y, Kasukawa T, Jakt LM, Ueda HR, Sheng G. Transcriptomic landscape of the primitive streak. Development. 2010 Sep 1;137(17):2863-74. Epub 2010 Jul 28. Copyright Published by The Company of Biologists 2010. This material is protected by a copyright retained by the authors. Permission granted by Dr. G Sheng. Comments The probe for SMAD6 was amplified by PCR using the following primers:
Forward Primer: GAAACAGAGGCGACGAACTC
Reverse Primer: GAGCAAGATCTCCAGCCAAC
Base Pair Numbers: 832-1407
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4 stage 4
stage 4
Epiblast
Entry 4 GEISHA Id SMAD6.Xie.2011 Data Source Publication Complete cDNA Template Probe show GCCGCCGGGGACGCCCCCCTCCCCCTTTCTTTTTCCTCCCCCGTTTTATGCCCGGGCGCTGCCCCCCCGCCTCGGCCCC
Citation Xie Z, Chen Y, Li Z, Bai G, Zhu Y, Yan R, Tan F, Chen YG, Guillemot F, Li L, Jing N., Smad6 promotes neuronal differentiation in the intermediate zone of the dorsal neural tube by inhibition of the Wnt/beta-catenin pathway. Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12119-24. Epub 2011 Jul 5. Copyright Copyright ©2012 by the National Academy of Sciences Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_204248.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 24
stage 24
Spinal Cord
Entry 5 GEISHA Id SMAD6.Olivera-Martinez.2014 Data Source Publication Complete cDNA Template Probe show GGCGCTGCGGGCGGCTCCGGGGGCGGCGGCTCCGGGGGCGGAGGCGGCGGACGGGCGATGAGGAGATAGAGGCGCGGAG
Citation Isabel Olivera-Martinez, Nick Schurch, Roman A Li, Junfang Song, Pamela A Halley, Raman M Das, Dave W Burt, Geoffrey J Barton, Kate G Storey. Major transcriptome re-organisation and abrupt changes in signalling, cell cycle and chromatin regulation at neural differentiation in vivo. Development 2014 Aug;141(16):3266-76. Epub 2014 Jul 25. DOI: 10.1242/dev.112623. Copyright Copyright © 2014. Published by The Company of Biologists Ltd. Comments Authors indicated the probe was made from gene construct provided by C. Stern. As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence above was obtained from NCBI (accession number NM_204248.2).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-10 stage 10
Neural Plate/Tube all
Entry 6 GEISHA Id SMAD6.Trevers.2023 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show GGCGCTGCGGGCGGCTCCGGGGGCGGCGGCTCCGGGGGCGGAGGCGGCGGACGGGCGATGAGGAGATAGAGGCGCGGAG
Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204248).
Mouse Frog Fruit Fly Zebra Finch Zebrafish
