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Human Disease Gene Search
HES4 Gene Summary Expression Other Species Expression JBrowse Gene Official Symbol HES4 Official Full Name hes family bHLH transcription factor 4 CGNC ID 49182 also known as HAIRY1, HES1, c-hairy1A, transcription factor HES-4|C-HAIRY1|c-hairy1B|hairy and enhancer of split 4|transcription factor HES-1, HES-1, C-HAIRY1 gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Links to other databases
Entry 1 GEISHA Id L11 Data Source GEISHA ISH Analysis Forward cDNA Template Probe show TTTCAGACAGCACACAACTTCCTTTACTTTGCTTTGCTTGAACAGAGATAGATCAGCATGTTCAAGTGCGTTGGGTTGA
Reverse cDNA Template Probe show GAAGCTCTCTCCCCTAAAGTCTATGGGGGTTTCCAGCTCGTCCCGGCCACTGATGGTCAATTCGCCTTCCTCATCCCCA
Entry 2 GEISHA Id pgp1n.pk008.b9 Data Source GEISHA ISH Analysis Forward cDNA Template Probe show CAAAACCCTTCCGAGGAAGCTTCTTGAGACCTCCCTGCCATGAATTTGCTCTTCCTTTTTTCTTCCTGCAGCCGCTCTC
Entry 3 GEISHA Id pgr1n.pk001.b14 Data Source GEISHA ISH Analysis Forward cDNA Template Probe show GCGCCGCCTCCCGCCCGCCGCCCGCACGGGGCTCCGCGCCCGCCCCCGTGGGGCCGCCCTCCCGCTGCCGTGCCGCGTT
Entry 4 GEISHA Id HES1.UApcr Data Source GEISHA ISH Analysis Forward cDNA Template Primer TTATAAAAGCTTGCGGCCGCAGAATATAGCGTGCTGGGCAAATACC Reverse cDNA Template Primer GCTCTAGAAATTAACCCTCACTAAAGGAACCACAACGGGGCTCCATAC cDNA Template Length 685 Complete cDNA Template Probe show TTTTATAAAAAGCTTGCGGCCGCAGAATATAGCGTGCTGGGCAAATACCGGGCTGGTTTCAATGAGTGCATGAACGAGG
Entry 5 GEISHA Id Hairy1.Rodrigues.2006 Data Source Publication Complete cDNA Template Probe show ATGCCCGCCGACACGGGCATGGAAAAACCCACCGCTTCCCCCATCGCGGGGGCACCGGCCAGCGCCAGCCACACGCCGG
Citation Rodrigues S, Santos J, Palmeirim I.
Molecular characterization of the rostral-most somites in early somitic stages of the chick embryo.
Gene Expr Patterns. 2006 Oct;6(7):673-7. Epub 2006 Feb 20. Copyright Reprinted with permission from Elsevier. Copyright © 2006 Elsevier B.V. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_001005848).
Entry 6 GEISHA Id Hairy1.Vasiliauskas.2003 Data Source Publication Complete cDNA Template Probe show ATGCCCGCCGACACGGGCATGGAAAAACCCACCGCTTCCCCCATCGCGGGGGCACCGGCCAGCGCCAGCCACACGCCGG
Citation Vasiliauskas D, Laufer E, Stern CD. A role for hairy1 in regulating chick limb bud growth. Dev Biol. 2003 Oct 1;262(1):94-106.
Copyright Copyright © 2003 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_001005848)
Entry 7 GEISHA Id HAIRY1.Sheeba.2007 Data Source Publication Complete cDNA Template Probe show ATGCCCGCCGACACGGGCATGGAAAAACCCACCGCTTCCCCCATCGCGGGGGCACCGGCCAGCGCCAGCCACACGCCGG
Citation Sheeba, CJ, Palmeirim, I, Andrade, RP, Chick Hairy1 protein interacts with Sap18, a component of the Sin3/HDAC transcriptional repressor complex. BMC Dev Biol. 2007; 7: 83. Published online 2007 July 10. Copyright
Copyright © 2007 Sheeba et al; licensee BioMed Central Ltd.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments The probe was amplified by PCR using the following primers:
5'ATGCCCGCCGACACGGGCATG3' and 5'CTACCACGGCCGCCAGACG3' and was extracted from NCBI Acc#NM_001005848.1.
Entry 8 GEISHA Id HAIRY1.Tossell.2011 Data Source Publication Complete cDNA Template Probe show GGGCCCGCCGCCAGCCAATGGGAGGGAGCGCCGCCGTTCGCCCGTCGCCTATTGGCTCCGAGGTCGGGAGAAGGGAGGG
Citation Tossell K, Kiecker C, Wizenmann A, Lang E, Irving C.
Notch signalling stabilises boundary formation at the midbrain-hindbrain organiser. Development. 2011 Sep;138(17):3745-57. Epub 2011 Jul 27.
Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # AB045236.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-10 stage 10
stage 10
Isthmus/MHB Rhombomeres
Entry 9 GEISHA Id Hairy1.Bell.2004 Data Source Publication Complete cDNA Template Probe show CCATGCCCGCCGACACGGGCATGGAAAAACCCACCGCTTCCCCCATCGCGGGGGCACCGGCCAGCGCCAGTCACACGCC
Citation Bell GW, Yatskievych TA, Antin PB. GEISHA, a whole-mount in situ hybridization gene expression screen in chicken embryos. Dev Dyn. 2004 Mar;229(3):677-87. Copyright Copyright © 2004 Wiley-Liss, Inc. Comments The probe sequence below was obtained from the GEISHA database using information provided in the publication, Geisha L11.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4-6 stage 4
stage 4
Hensen's Node 7-12 stage 12
stage 12
Somites
Entry 10 GEISHA Id HES1.Moran.2012 Data Source Publication Complete cDNA Template Probe show CGGAAGGTAAATGGCAGCGGATGGCGGCGAGCCCGCGGCCGGGCCGAGTCCTCCAAACCCATCATGGAGAAGCGACGGC
Citation Moran CM, Myers CT, Lewis CM, Krieg PA. Hedgehog regulates angiogenesis of intersegmental vessels through the VEGF signaling pathway. Dev Dyn. 2012 Jun;241(6):1034-42. Comments The cDNA template for the probe was obtained from BBSRC - HES1 (ChEST900h16 5) as described in the publication Moran et al., 2012.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-10 stage 10
stage 10
Primitive Streak Somites
Entry 11 GEISHA Id c-hairy1.Aulehla.1999 Data Source Publication Complete cDNA Template Probe show CCATGCCCGCCGACACGGGCATGGAAAAACCCACCGCTTCCCCCATCGCGGGGGCACCGGCCAGCGCCAGCCACACGCC
Citation Aulehla A, Johnson RL. Dynamic expression of lunatic fringe suggests a link between notch signaling and an autonomous cellular oscillator driving somite segmentation. Dev Biol. 1999 Mar 1;207(1):49-61. Copyright Copyright © 1999 Academic Press. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_001005848.2). c-hairy1 is also known as HES4 in NCBI.
Mouse Frog Fruit Fly Zebra Finch Zebrafish
