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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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CHRNA1
cholinergic receptor nicotinic alpha 1 subunit

The human orthologue of this gene is associated
with the following human diseases:

Gene

Official Symbol	CHRNA1
Official Full Name	cholinergic receptor nicotinic alpha 1 subunit
CGNC ID	7068
also known as	NACHRA1, acetylcholine receptor subunit alpha\|alpha-1 subunit, nicotinic acetylcholine receptor\|cholinergic receptor, nicotinic, alpha 1 (muscle)\|cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
gene type	protein-coding

Genomic Map

	Ensembl
	NCBI
	UCSC

Sequence Information

Genomic
RNA	NM_204816
Polypeptide	NP_990147

Gene Expression

In Situ Hybridization

GEISHA

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	1134	ENSG00000138435	MIM:253290	MIM:100690
Mouse	11435	ENSMUSG00000027107	All phenotypic alleles (3):Targeted, knock-out(1) Targeted, other(2)	MGI:87885
Xenopus	394991, 444296			5932066
Zebrafish	30725	ENSDARG00000009021	ZDB-GENE-980526-137	ZFIN:ZDB-GENE-980526-137

Gene Ontology

Molecular Function	acetylcholine binding, acetylcholine receptor activity, more...
Biological Process	muscle cell cellular homeostasis, neuromuscular junction development, neuromuscular process, more...
Cellular Component	acetylcholine-gated channel complex, cell junction, cell surface, neuromuscular junction, more...postsynaptic membrane

Links to other databases

Entrez Gene	395608
Ensembl Gene	ENSGALG00000009301
KEGG	gga:395608

Entry 1

GEISHA Id	CHRNA1.UApcr	Data Source	GEISHA ISH Analysis
Forward cDNA Template Primer	5’-AATCCGCATCCCATCAGACG-3’
Reverse cDNA Template Primer	5’-AATTAACCCTCACTAAAGGAAGTTGACAGGCACAGGACC-3’	cDNA Template Length	855
Complete cDNA Template Probe	show AATCCGCATCCCATCAGACGACATCTGGCGCCCAGATCTTGTCCTTTACAACAATGCAGATGGCGATTTTGCCATTGTT AAATACACCAAGGTCCTTCTGGAACACACAGGAAAAATCACCTGGACGCCTCCTGCTATCTTTAAAAGTTACTGTGAAA TTATAGTCACGTACTTCCCATTCGATCAGCAGAACTGTAGCATGAAGCTGGGAACGTGGACGTATGACGGTACAATGGT GGTTATCAACCCGGAGAGCGATCGCCCCGACCTGAGTAACTTCATGGAGAGCGGTGAGTGGGTGATGAAGGACTACCGT GGCTGGAAGCACTGGGTTTACTACGCCTGCTGCCCTGACACCCCCTACCTGGACATCACGTACCACTTCCTCATGCAGC GCCTGCCTCTCTACTTCATCGTCAACGTCATCATCCCCTGCCTGCTCTTCTCCTTTCTGACCGGGTTTGTTTTTTATCT ACCCACAGATTCAGGTGAGAAAATGACCCTCAGCATCTCTGTCTTGCTGTCACTGACTGTGTTCCTGCTGGTCATCGTG GAGCTGATTCCCTCTACCTCCAGCGCAGTGCCTCTGATAGGCAAATACATGTTGTTTACCATGGTGTTTGTCATCGCTT CCATCATCATCACCGTCATCGTCATCAACACCCACCACCGCTCCCCCAGCACTCACACCATGCCACCCTGGGTCAGGAA GATCTTTATTGACACCATCCCAAACATCATGTTTTTCTCTACGATGAAACGACCATCCAGGGATAAACCAGACAAGAAA ATTTTTGCAGAAGATATTGATATCTCTGAAATTTCCGGGAAGCAAGGTCCTGTGCCTGTCAACTT

Stage

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Location (click to highlight)

Comments (click to highlight)

4-6

stage 4

stage 5

Epiblast
Primitive Streak

7-12

stage 8

stage 9

stage 12

Dermomyotome
Extraembryonic Mesoderm
Head Mesenchyme
Intermediate Mesoderm
Lateral Plate Mesoderm
Neural Plate/Tube
Notochord
Sclerotome
extraembryonic mesoderm

13-18

stage 17

Dermomyotome
Foregut
Head Mesenchyme
Leg Mesenchyme
Myotome
Pharyngeal Arches and Clefts
Sinus Venosus
Tail

19-24

stage 19

stage 22

stage 23

Aorta
Atria
Dermatome
Foregut
Head Mesenchyme
Leg Mesenchyme
Lung
Myotome
Neural Plate/Tube
Outflow Tract
Pharyngeal Arches and Clefts
Sclerotome
Sinus Venosus
Ventricles
Widespread Expression
Wing Mesenchyme

stage 25

Dermatome
Foregut
Head Mesenchyme
Leg Mesenchyme
Lung
Mesonephros
Myotome
Pharyngeal Arches and Clefts
Sclerotome
Spinal Cord
Wing Mesenchyme

Entry 2

GEISHA Id	ACHRa.Fontaine.1989	Data Source	Publication
Complete cDNA Template Probe	show CAGGTGATGGAGCTCTGCCGTGTGCTGCTCCTGATCTTCTCCGCAGCCGGGCCGGCCCTGTGCTACGAGCACGAGACGC GCCTGGTCGATGACCTGTTCCGGGAATACAGCAAGGTGGTGCGCCCCGTGGAGAATCACCGCGATGCCGTCGTCGTCAC CGTCGGGCTGCAGCTCATTCAGCTCATCAATGTGGATGAAGTAAATCAGATTGTAACAACCAATGTGCGCCTGAAGCAG CAATGGACAGACATAAACCTGAAGTGGAACCCAGATGACTACGGTGGCGTGAAACAAATCCGCATCCCATCAGACGACA TCTGGCGCCCAGATCTTGTCCTTTACAACAATGCAGATGGCGATTTTGCCATTGTTAAATACACCAAGGTCCTTCTGGA ACACACAGGAAAAATCACCTGGACGCCTCCTGCTATCTTTAAAAGTTACTGTGAAATTATAGTCACGTACTTCCCATTC GATCAGCAGAACTGTAGCATGAAGCTGGGAACGTGGACGTATGACGGTACAATGGTGGTTATCAACCCGGAGAGCGATC GCCCCGACCTGAGTAACTTCATGGAGAGCGGTGAGTGGGTGATGAAGGACTACCGTGGCTGGAAGCACTGGGTTTACTA CGCCTGCTGCCCTGACACCCCCTACCTGGACATCACGTACCACTTCCTCATGCAGCGCCTGCCTCTCTACTTCATCGTC AACGTCATCATCCCCTGCCTGCTCTTCTCCTTTCTGACCGGGTTTGTTTTTTATCTACCCACAGATTCAGGTGAGAAAA TGACCCTCAGCATCTCTGTCTTGCTGTCACTGACTGTGTTCCTGCTGGTCATCGTGGAGCTGATTCCCTCTACCTCCAG CGCAGTGCCTCTGATAGGCAAATACATGTTGTTTACCATGGTGTTTGTCATCGCTTCCATCATCATCACCGTCATCGTC ATCAACACCCACCACCGCTCCCCCAGCACTCACACCATGCCACCCTGGGTCAGGAAGATCTTTATTGACACCATCCCAA ACATCATGTTTTTCTCTACGATGAAACGACCATCCAGGGATAAACCAGACAAGAAAATTTTTGCAGAAGATATTGATAT CTCTGAAATTTCCGGGAAGCAAGGTCCTGTGCCTGTCAACTTCTACTCCCCACTTACCAAAAATCCAGATGTGAAAAAC GCTATAGAGGGAATCAAATACATTGCGGAAACGATGAAGTCAGACCAAGAATCCAGTAATGCGGCTGATGAGTGGAAGT TTGTTGCGATGGTGCTCGATCATCTTCTCCTCGTAATATTTATGCTAGTCTGCATTATTGGAACATTAGCTGTATTTGC CGGTCGCCTTATTGAATTAAATCAGCAAGGATGAACATCAAATGGAAACT
Citation	Fontaine B, Changeux JP. Localization of nicotinic acetylcholine receptor alpha-subunit transcripts during myogenesis and motor endplate development in the chick. J Cell Biol. 1989 Mar;108(3):1025-37.
Copyright	© The Rockefeller University Press
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc # NM_204816.1)