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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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PITX1
paired like homeodomain 1

The human orthologue of this gene is associated
with the following human disease:

Clubfoot, congenital

Gene

Official Symbol	PITX1
Official Full Name	paired like homeodomain 1
CGNC ID	4791
also known as	PTX1, pituitary homeobox 1\|cPTX1\|homeobox protein PITX1\|paired-like homeodomain transcription factor 1, Pituitary homeobox 1
gene type	protein-coding

Genomic Map

	Ensembl ID not known
	NCBI
	UCSC

Sequence Information

Genomic
RNA	NM_001167684
Polypeptide	NP_001161156

Gene Expression

In Situ Hybridization

GEISHA

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	5307	ENSG00000069011	MIM:119800	MIM:602149
Mouse	18740	ENSMUSG00000021506	All phenotypic alleles (3):Targeted, knock-out(1) Targeted, other(2)	MGI:107374
Xenopus	493226, 394310			485440
Zebrafish	678598		ZDB-GENE-060421-3623	ZFIN:ZDB-GENE-060421-3623

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Links to other databases

Entrez Gene	374201
Ensembl Gene
KEGG	gga:374201

Entry 1

GEISHA Id	ChEST656i21	Data Source	GEISHA ISH Analysis
Forward cDNA Template Probe	show CACTTTCCTGCCTATGCGGCCGGACTGCCGTGCCTCTCCCCGCGCAGAGCCCGGCGGCTTCCAGGCGCTGCCCAGATCT CTTCCTCCGACACCCTTAAAATAATACTGTTAGTAATAAGTGGATTTGCTTTTGTTTTTTGTTGTGTTTTGTTGTGTTT TTTTTTTTCCCTTAAAGAACAAAAAGGAAAAAAAAAGAGAGAAAAATATATATATATTAAAAAAAAGCTCCTTGTTCCT TTCTGTGTGGAATAAACACCTGCAAACTCCCCCAGGCAGCCCGGCGCCCCCGCCATGGATTCCTTTAAAGGTGGAATGA ATTTGGAGAGACTGCCCGAGAGCTTGAGACCCCAACCCTCCCATGACATGGCTTCCAGCTTCCATTTGCAAAGATCCTC GGAGCCCAGAGACCCGATCGAGAACTCGGCCAGTGAATCCTCCGACACGGAGGTGCCAGAAAAAGAGAGAAGCGGAGAG CAGAAAAACGAGGACGGGGCCGCCGACGACCCGGCGAAGAAGAAGAAGCAACGGAGGCAGCGGACCCACTTCACCAGCC AGCAGCTGCAGGAGCTGGAGGCCACCTTCCAGCGGAACCGCTACCCCGATATGAGCATGCGGGAGGAGATCGCCGTGTG GACGAACCTCACCGAGCCCCGCGTCCGGGTGTGGTTCAAGAACCGCCGAGCCAAGTGGAGAAAGCGGGAGCGGAACCAG CAGATGGACCTGTGCAAGAACCGCTACTTGCCGCAGTTCACCGGGCTGAATGCACCCTACAACGACATGTACGCCGGGT ACCCCTAAAAAAACTGGGCCACCAAGAACCTAAACCCGGGGCCGCTTTCCACAAAAAGCTTAACTTTCTTCAATTCCGT AACCCCCCTTCCCTCGAATTCCATGTTTTCGGCCCCCAAAAGAATCTCCTCAAAAAAAAGCCCTCCGGGAAGGGCCATT TAGCCTTGTGGGGATGGACAAATTCGGGCTCAAAAAATAAAAAAAATAAGAGCTCCTCGTAAACTT

Stage

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Location (click to highlight)

Comments (click to highlight)

4-6

stage 4

stage 5

stage 6

Area Opaca
Lateral Plate Mesoderm

7-12

stage 7

stage 9

stage 10

stage 12

Area Opaca
Endoderm
Extraembryonic
Extraembryonic Blood Vessels
Forebrain
Foregut
Head Process
Headfold
Lateral Plate Mesoderm
Oral Pharynx
Pharynx
Pituitary (Rudiment)
extraembryonic ectoderm
extraembryonic endoderm

Dorsal
NOTE: real stain at base of AIP
Ventral

13-18

stage 14

stage 15

stage 16

stage 18

Allantois
Amnion
Endoderm
Extraembryonic
Eye
Foregut
Lateral Plate Mesoderm
Leg Mesenchyme
Midgut
Oral Pharynx
Pharyngeal Arches and Clefts
Pharynx
extraembryonic ectoderm
extraembryonic endoderm

optic cup

stage 25

Allantois
Dermomyotome
Eye
Face Mesenchyme
Gut
Hindgut
Leg
Leg Mesenchyme
Midgut
Oral Pharynx
Pharyngeal Arches and Clefts
Spinal Cord
Spinal Ganglia and Nerves
Wing Mesenchyme

Entry 2

GEISHA Id	Pitx1.Holleville.2007	Data Source	Publication
Complete cDNA Template Probe	show CACTTTCCTGCCTATGCGGCCGGACTGCCGTGCCTCTCCCCGCGCAGAGCCCGGCGGCTTCCAGGCGCTGCCCAGATCT CTTCCTCCGACACCCTTAAAATAATACTGTTAGTAATAAGTGGATTTGCTTTTGTTTTTTGTTGTGTTTTGTTGTGTTT TTTTTTTTTCCCTTAAAGAACAAAAAGGAAAAAAAAAGAGAGAAAAATATATATATATTAAAAAAAAGCTCCTTGTTCC TTTCTGTGTGGAATAAACACCTGCAAACTCCCCCAGGCAGCCCGGCGCCCCCGCCATGGATTCCTTTAAAGGTGGAATG AATTTGGAGAGACTGCCCGAGAGCTTGAGACCCCAACCCTCCCATGACATGGCTTCCAGCTTCCATTTGCAAAGATCCT CGGAGCCCAGAGACCCGATCGAGAACTCGGCCAGTGAATCCTCCGACACGGAGGTGCCAGAAAAAGAGAGAAGCGGAGA GCAGAAAAACGAGGACGGGGCCGCCGACGACCCGGCGAAGAAGAAGAAGCAACGGAGGCAGCGGACCCACTTCACCAGC CAGCAGCTGCAGGAGCTGGAAGCCACTTTCCAGCGGAACCGCTACCCCGATATGAGCATGCGGGAGGAGATCGCCGTGT GGACGAACCTCACCGAGCCCCGCGTCCGGGTGTGGTTCAAGAACCGCCGAGCCAAGTGGAGAAAGCGGGAGCGGAACCA GCAGATGGACCTGTGCAAGAACGGCTACGTGCCGCAGTTCAGCGGGCTGATGCAGCCCTACGACGACATGTACGCCGGG TACCCCTACAACAAATGGGCCACCAAAAGCCTCACCCCGGCGCCGCTCTCCACCAAGAGCTTCACCTTCTTCAACTCCA TGAGCCCCCTCTCCTCGCAGTCCATGTTCTCGGCTCCCAGCAGCATCTCCTCCATGAACATGCCCTCCGGGATGGGCCA CTCGGCCGTGCCGGGCATGGCCAACTCCGGCCTCAACAACATCAACAACATCAGCGGCTCCTCGCTCAACTCGGCCATG TCCTCGCCCGCTTGTCCCTATGGGCCGCCGGGCTCTCCCTACAGCGTGTACCGGGACACTTGTAACTCCAGCCTGGCCA GCCTCAGACTGAAATCAAAGCAGCACTCCAGTTTCGGCTACAGCAGTTTGCAGAGCCCCGGCTCCAGCCTAAACGCCTG TCAGTACAACAGTTGACGGACTTGACACGAACCACCTCCGACGAACACCGCCGACAAAGCAAAAAATACTAAGAAAAAA TAAAAAACAAAGCAGAAACAAAGCGACGTTTAACGGAAATGAATATTTATATATATATGTATGTATGTAGAAACCCGAT GATGTGTAAAAGCAAAACCCGAGCAAGTGAGAGAGGGAAAGAAACAGCACAAAAAGAAAGCAAAAAGGCAAAACAATGA TGATGATAATGATAATAAAACAAAACCCGAAAGCTCTGCGGACTTCGATTGTCTAAAAGATAATAATAATAAACAAAAA CAAATGAATAGAAAAAGAGATCCGACGACACAACCAACAAAGCAGCGCTTTAAAAACAAACCATTTGTAACCATTAAAA AGCAAACCACCAAAAAAAATTAAAAAAAATAAATAAAAATAAAAAACCAAAAAAACGGAAAAGGACCAGAAAACTTTTG CAAGAGACACCGAAATCTGGTACATGGATGAGTTGCAATTTTTCTCTGGATGATGCGGGTTGTATGTGTTTACTTGAAC TTGCACAGGAGGTGGTAAGGCGGCCGCTCCCCGCGGCAGCGCGGCCATTGGGGACGGCCCGGGGGGAGCGCTGGGGGCG GCGGCGGCCGCGGGCGCACGGGGGTGGGGGGTAGGGAGGGGAGGGGGGAAGTTCGGGTGATGTTTACCACTGAGAAACG GAATCACGCTCCAAAAAGGAAAAAAAAAAAAAAAGAAAAAAAGAAGG
Citation	Holleville N, Matéos S, Bontoux M, Bollerot K, Monsoro-Burq AH. Dlx5 drives Runx2 expression and osteogenic differentiation in developing cranial suture mesenchyme. Dev Biol. 2007 Apr 15;304(2):860-74.
Copyright	Reprinted with permission from Elsevier. Copyright © 2007 Elsevier B.V. All rights reserved.
Comments	As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # XM_414626.2).

Stage

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Location (click to highlight)

Comments (click to highlight)

31-38

stage 38

Face Mesenchyme

Entry 3

GEISHA Id	PITX1.Parkinson.2010	Data Source	Publication
Complete cDNA Template Probe	show CACTTTCCTGCCTATGCGGCCGGACTGCCGTGCCTCTCCCCGCGCAGAGCCCGGCGGCTTCCAGGCGCTGCCCAGATCT CTTCCTCCGACACCCTTAAAATAATACTGTTAGTAATAAGTGGATTTGCTTTTGTTTTTTGTTGTGTTTTGTTGTGTTT TTTTTTTTTCCCTTAAAGAACAAAAAGGAAAAAAAAAGAGAGAAAAATATATATATATTAAAAAAAAGCTCCTTGTTCC TTTCTGTGTGGAATAAACACCTGCAAACTCCCCCAGGCAGCCCGGCGCCCCCGCCATGGATTCCTTTAAAGGTGGAATG AATTTGGAGAGACTGCCCGAGAGCTTGAGACCCCAACCCTCCCATGACATGGCTTCCAGCTTCCATTTGCAAAGATCCT CGGAGCCCAGAGACCCGATCGAGAACTCGGCCAGTGAATCCTCCGACACGGAGGTGCCAGAAAAAGAGAGAAGCGGAGA GCAGAAAAACGAGGACGGGGCCGCCGACGACCCGGCGAAGAAGAAGAAGCAACGGAGGCAGCGGACCCACTTCACCAGC CAGCAGCTGCAGGAGCTGGAAGCCACTTTCCAGCGGAACCGCTACCCCGATATGAGCATGCGGGAGGAGATCGCCGTGT GGACGAACCTCACCGAGCCCCGCGTCCGGGTGTGGTTCAAGAACCGCCGAGCCAAGTGGAGAAAGCGGGAGCGGAACCA GCAGATGGACCTGTGCAAGAACGGCTACGTGCCGCAGTTCAGCGGGCTGATGCAGCCCTACGACGACATGTACGCCGGG TACCCCTACAACAAATGGGCCACCAAAAGCCTCACCCCGGCGCCGCTCTCCACCAAGAGCTTCACCTTCTTCAACTCCA TGAGCCCCCTCTCCTCGCAGTCCATGTTCTCGGCTCCCAGCAGCATCTCCTCCATGAACATGCCCTCCGGGATGGGCCA CTCGGCCGTGCCGGGCATGGCCAACTCCGGCCTCAACAACATCAACAACATCAGCGGCTCCTCGCTCAACTCGGCCATG TCCTCGCCCGCTTGTCCCTATGGGCCGCCGGGCTCTCCCTACAGCGTGTACCGGGACACTTGTAACTCCAGCCTGGCCA GCCTCAGACTGAAATCAAAGCAGCACTCCAGTTTCGGCTACAGCAGTTTGCAGAGCCCCGGCTCCAGCCTAAACGCCTG TCAGTACAACAGTTGACGGACTTGACACGAACCACCTCCGACGAACACCGCCGACAAAGC
Citation	Parkinson N, Collins MM, Dufresne L, Ryan AK. Expression patterns of hormones, signaling molecules, and transcription factors during adenohypophysis development in the chick embryo. Dev Dyn. 2010 Apr;239(4):1197-210.
Copyright	Copyright © 2010 Wiley-Liss, Inc.
Comments	As insufficient information is provided in publication to verify the exact sequence used to synthesize the probes, the sequence below was obtained from NCBI (acc# NM_001167684.1)

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

19-24

stage 21

Pituitary (Rudiment)

25-30

stage 27

Pituitary (Rudiment)

31-36

stage 32

stage 36

Pituitary (Rudiment)

Entry 4

GEISHA Id	PITX1.Brito.2006	Data Source	Publication
Complete cDNA Template Probe	show CACTTTCCTGCCTATGCGGCCGGACTGCCGTGCCTCTCCCCGCGCAGAGCCCGGCGGCTTCCAGGCGCTGCCCAGATCT CTTCCTCCGACACCCTTAAAATAATACTGTTAGTAATAAGTGGATTTGCTTTTGTTTTTTGTTGTGTTTTGTTGTGTTT TTTTTTTTTCCCTTAAAGAACAAAAAGGAAAAAAAAAGAGAGAAAAATATATATATATTAAAAAAAAGCTCCTTGTTCC TTTCTGTGTGGAATAAACACCTGCAAACTCCCCCAGGCAGCCCGGCGCCCCCGCCATGGATTCCTTTAAAGGTGGAATG AATTTGGAGAGACTGCCCGAGAGCTTGAGACCCCAACCCTCCCATGACATGGCTTCCAGCTTCCATTTGCAAAGATCCT CGGAGCCCAGAGACCCGATCGAGAACTCGGCCAGTGAATCCTCCGACACGGAGGTGCCAGAAAAAGAGAGAAGCGGAGA GCAGAAAAACGAGGACGGGGCCGCCGACGACCCGGCGAAGAAGAAGAAGCAACGGAGGCAGCGGACCCACTTCACCAGC CAGCAGCTGCAGGAGCTGGAAGCCACTTTCCAGCGGAACCGCTACCCCGATATGAGCATGCGGGAGGAGATCGCCGTGT GGACGAACCTCACCGAGCCCCGCGTCCGGGTGTGGTTCAAGAACCGCCGAGCCAAGTGGAGAAAGCGGGAGCGGAACCA GCAGATGGACCTGTGCAAGAACGGCTACGTGCCGCAGTTCAGCGGGCTGATGCAGCCCTACGACGACATGTACGCCGGG TACCCCTACAACAAATGGGCCACCAAAAGCCTCACCCCGGCGCCGCTCTCCACCAAGAGCTTCACCTTCTTCAACTCCA TGAGCCCCCTCTCCTCGCAGTCCATGTTCTCGGCTCCCAGCAGCATCTCCTCCATGAACATGCCCTCCGGGATGGGCCA CTCGGCCGTGCCGGGCATGGCCAACTCCGGCCTCAACAACATCAACAACATCAGCGGCTCCTCGCTCAACTCGGCCATG TCCTCGCCCGCTTGTCCCTATGGGCCGCCGGGCTCTCCCTACAGCGTGTACCGGGACACTTGTAACTCCAGCCTGGCCA GCCTCAGACTGAAATCAAAGCAGCACTCCAGTTTCGGCTACAGCAGTTTGCAGAGCCCCGGCTCCAGCCTAAACGCCTG TCAGTACAACAGTTGACGGACTTGACACGAACCACCTCCGACGAACACCGCCGACAAAGC
Citation	José M. Brito, Marie-Aimée Teillet, Nicole M. Le Douarin. An early role for Sonic hedgehog from foregut endoderm in jaw development: Ensuring neural crest cell survival. Proc Natl Acad Sci U S A. 2006 August 1; 103(31): 1160711612.
Copyright	Copyright © 2006 by The National Academy of Sciences of the USA

Stage

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Location (click to highlight)

Comments (click to highlight)

19-21

stage 21

Pharyngeal Arches and Clefts

Entry 5

GEISHA Id	PITX1.Szeto.1999	Data Source	Publication
Complete cDNA Template Probe	show CACTTTCCTGCCTATGCGGCCGGACTGCCGTGCCTCTCCCCGCGCAGAGCCCGGCGGCTTCCAGGCGCTGCCCAGATCT CTTCCTCCGACACCCTTAAAATAATACTGTTAGTAATAAGTGGATTTGCTTTTGTTTTTTGTTGTGTTTTGTTGTGTTT TTTTTTTTTCCCTTAAAGAACAAAAAGGAAAAAAAAAGAGAGAAAAATATATATATATTAAAAAAAAGCTCCTTGTTCC TTTCTGTGTGGAATAAACACCTGCAAACTCCCCCAGGCAGCCCGGCGCCCCCGCCATGGATTCCTTTAAAGGTGGAATG AATTTGGAGAGACTGCCCGAGAGCTTGAGACCCCAACCCTCCCATGACATGGCTTCCAGCTTCCATTTGCAAAGATCCT CGGAGCCCAGAGACCCGATCGAGAACTCGGCCAGTGAATCCTCCGACACGGAGGTGCCAGAAAAAGAGAGAAGCGGAGA GCAGAAAAACGAGGACGGGGCCGCCGACGACCCGGCGAAGAAGAAGAAGCAACGGAGGCAGCGGACCCACTTCACCAGC CAGCAGCTGCAGGAGCTGGAAGCCACTTTCCAGCGGAACCGCTACCCCGATATGAGCATGCGGGAGGAGATCGCCGTGT GGACGAACCTCACCGAGCCCCGCGTCCGGGTGTGGTTCAAGAACCGCCGAGCCAAGTGGAGAAAGCGGGAGCGGAACCA GCAGATGGACCTGTGCAAGAACGGCTACGTGCCGCAGTTCAGCGGGCTGATGCAGCCCTACGACGACATGTACGCCGGG TACCCCTACAACAAATGGGCCACCAAAAGCCTCACCCCGGCGCCGCTCTCCACCAAGAGCTTCACCTTCTTCAACTCCA TGAGCCCCCTCTCCTCGCAGTCCATGTTCTCGGCTCCCAGCAGCATCTCCTCCATGAACATGCCCTCCGGGATGGGCCA CTCGGCCGTGCCGGGCATGGCCAACTCCGGCCTCAACAACATCAACAACATCAGCGGCTCCTCGCTCAACTCGGCCATG TCCTCGCCCGCTTGTCCCTATGGGCCGCCGGGCTCTCCCTACAGCGTGTACCGGGACACTTGTAACTCCAGCCTGGCCA GCCTCAGACTGAAATCAAAGCAGCACTCCAGTTTCGGCTACAGCAGTTTGCAGAGCCCCGGCTCCAGCCTAAACGCCTG TCAGTACAACAGTTGACGGACTTGACACGAACCACCTCCGACGAACACCGCCGACAAAGC
Citation	Szeto DP, Rodriguez-Esteban C, Ryan AK, O'Connell SM, Liu F, Kioussi C, Gleiberman AS, Izpisúa-Belmonte JC, Rosenfeld. Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development. Genes Dev. 1999 February 15; 13(4): 484494.
Copyright	Copyright © 1999, Cold Spring Harbor Laboratory Press
Comments	As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_001167684.1).