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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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HEY2
hes related family bHLH transcription factor with YRPW motif 2

Gene

Official Symbol	HEY2
Official Full Name	hes related family bHLH transcription factor with YRPW motif 2
CGNC ID	11008
also known as	hairy/enhancer-of-split related with YRPW motif protein 2\|hairy/enhancer-of-split related with YRPW motif 2, Hairy/enhancer-of-split related with YRPW motif protein 2, Cardiovascular helix-loop-helix factor 1, hCHF1, Hairy and enhancer of split-related protein 2, HESR-2, hHRT2, Hairy-related transcription factor 2
gene type	protein-coding

Genomic Map

	Ensembl ID not known
	NCBI
	Gallus-Browse

Sequence Information

Genomic
RNA	XM_419754
Polypeptide	XP_419754
Sequence Clusters/ESTs	Unigene

Gene Expression

In Situ Hybridization	GEISHA
EST Profile

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly	35764			FBgn0027788
Human	23493	ENSG00000135547		MIM:604674
Mouse	15214	ENSMUSG00000019789	All phenotypic alleles (9):Targeted, knock-out(4) Targeted, other(5)	MGI:1341884
Xenopus	100485328			485922
Zebrafish	58146	ENSDARG00000013441	ZDB-GENE-000526-1	ZFIN:ZDB-GENE-000526-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Links to other databases

Entrez Gene	421718
Ensembl Gene
KEGG	gga:421718

Entry 1

GEISHA Id	HEY2.UApcr	Data Source	GEISHA ISH Analysis
Forward cDNA Template Primer	TGAAGCGACCTTGCGAGGAAAC
Reverse cDNA Template Primer	AATTAACCCTCACTAAAGGTGCCCCACTGCCAGCCTG	cDNA Template Length	959
Forward cDNA Template Probe	show NCCGGGCTNNNNNCCNCGCGGGGGCGGAGAGCTGACCGCCAAGGAGGGGTGATGGCTGTAGCTGCCGCCACCGCAGCAG CAGCTGCGCCTGGGGGGAGCATGGGGAAGGTGCTGGTGAAGGAGAGGGGGAAGCTCTGGGCGGCTGCCGTGGCGGCGGC GGCTGCGGCATGAACTGTGGCCGAGAGGGAGAGGAGAGAGGTAGAGAGTGGGGGGACACAGGGAGCAACGCTGCCCGCT GAGGGGACCCTGAGGGCGGCGTCGGTGTGGGCGAAGGTAGCGGTGAGCAGTGCAGATCCGTGGGGAGGCACTTCTGAGG AGAGTCTGCATGGGGCGGCCTCGGGAGCGTGGAGTCCATTGGGCTGCAGCAGGGCGGCCGGGAGGTGGTGGAAGGCAGC TGCCCAGTGGTGCGGGTGCAGCGGGTGGTGGTGGTGGGCCATGGAGGAGGTCATGGCAGCCGCTTCCCGCTGAGAGGCG CAGGTGCTGAGATGGGACACCAGTCTGACACGCAGCGGGTCAGAGGTGTCGAGGCCTTCCACAGATGTCAGGTACCTCG CAACTTCAGTCAAGCACTCCCGGAAGCCAATGCTCATGAAATCCATGGCCAGTGAGTGAGCGTCAAAATAACCTTTACC TCCGGTCGCTTGAAGCATCTTCAGATGATCCACCGTCATTTGCAGTATTTCCGCTTTTTCTAATTTGGCAGATCCTTGT TTTTCAAAAGCAGTTGGCACCAGCCGCCTCAGCTCAGATAAACTGTTATTTATACGATCCCGGCGCCTTTTCTCTATAA TCCCTCTTCTTTTCTTTCTGGCCATAATCTGAGATGTTGTGGTTGGGGAATTTGGTCGAAGCACAGAGCTATGGCTTTG CCCGCAGTAGTTGTTCTCGCTGCCCACATCGATGGTCTCGTCCATGTCGCTGTCTGAGGTAGTTTCCTCGCAAGGTCCG CTTCAAAA

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

4-6

stage 4

stage 5

Early Mesoderm
Epiblast
Primitive Streak

7-12

stage 8

stage 9

stage 10

stage 11

stage 12

Aorta
Blood Vessels
Dermomyotome
Ectoderm
Endocardium
Extraembryonic Mesoderm
Forebrain
Foregut
Head Mesenchyme
Heart
Heart Tube
Hindbrain
Lateral Plate Mesoderm
Mesencephalon
Midbrain
Neural Crest
Neural Plate/Tube
Paraxial Mesoderm
Pharynx
Primitive Streak
Somites
extraembryonic mesoderm

13-18

stage 14

stage 17

Anterior/Second Heart Field
Heart Tube
Neural Plate/Tube
Paraxial Mesoderm
Somites

19-24

stage 22

stage 23

stage 24

Anterior/Second Heart Field
Outflow Tract
Somites
Spinal Cord
Tail
Ventricles

stage 25

Anterior/Second Heart Field
Somites
Spinal Cord
Ventricles

Entry 2

GEISHA Id	HEY2.Leimeister.2000	Data Source	Publication
Complete cDNA Template Probe	show CATCAGGTGGGAAAGGTTATTTTGACGCTCACTCACTGGCCATGGATTTCATGAGCATTGGCTTCCGGGAGTGCTTGAC TGAAGTTGCGAGGTACCTGACATCTGTGGAAGGCCTCGACACCTCTGACCCGCTGCGTGTCAGACTGGTGTCCCATCTC AGCACCTGCGCCTCTCAGCGGGAAGCGGCTGCCATGACCTCCTCCATGGCCCACCACCACCACCCGCTGCACCCTCACC ACTGGGCAGCCGCCTTCCACCACCTCCCGGCCGCCCTGCTGCAGCCCAATGGACTCCACGCTCCCGAGGCCGCCCCATG CAGACTCTCCTCAGAAGTGCCTCCCCACGGATCTGCACTGCTCACCGCTACCTTCGCCCACACCGACGCCGCCCTCAGG GTCCCCTCAGCGGGCAGCGTTGCTCCCTGTGTCCCCCCACTCTCTACCTCTCTCCTCTCCCTCTCGGCCACAGTTCATG CCGCAGCCGCCGCCGCCACGGCAGCCGCCCAGAGCTTCCCCCTCTCCTTCACCAGCACCTTCCCCATGCTCCCCCCAAG CGCAGCTGCTGCTGCGGTGGCGGCAGCTACAGCCATCACCCCTCCCTTGGCC
Citation	Leimeister C, Dale K, Fischer A, Klamt B, Hrabe de Angelis M, Radtke F, McGrew MJ, Pourquié O, Gessler M. (2000). Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors. Dev Biol. 2000 Nov 1;227(1):91-103.
Copyright	Reprinted with permission from Elsevier. Copyright © 2000 Elsevier B.V. All rights reserved.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (XM_419754).

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

7-12

stage 11

stage 12

Paraxial Mesoderm
Somites

Caudal Presomitic Mesoderm

stage 13

Paraxial Mesoderm
Somites

Caudal Presomitic Mesoderm
Figure 4 compares Hey1 and Hey2 expression patterns in forming somites.

Entry 3

GEISHA Id	cHAIRY2.Maroto.2005	Data Source	Publication
Complete cDNA Template Probe	show CATCAGGTGGGAAAGGTTATTTTGACGCTCACTCACTGGCCATGGATTTCATGAGCATTGGCTTCCGGGAGTGCTTGAC TGAAGTTGCGAGGTACCTGACATCTGTGGAAGGCCTCGACACCTCTGACCCGCTGCGTGTCAGACTGGTGTCCCATCTC AGCACCTGCGCCTCTCAGCGGGAAGCGGCTGCCATGACCTCCTCCATGGCCCACCACCACCACCCGCTGCACCCTCACC ACTGGGCAGCCGCCTTCCACCACCTCCCGGCCGCCCTGCTGCAGCCCAATGGACTCCACGCTCCCGAGGCCGCCCCATG CAGACTCTCCTCAGAAGTGCCTCCCCACGGATCTGCACTGCTCACCGCTACCTTCGCCCACACCGACGCCGCCCTCAGG GTCCCCTCAGCGGGCAGCGTTGCTCCCTGTGTCCCCCCACTCTCTACCTCTCTCCTCTCCCTCTCGGCCACAGTTCATG CCGCAGCCGCCGCCGCCACGGCAGCCGCCCAGAGCTTCCCCCTCTCCTTCACCAGCACCTTCCCCATGCTCCCCCCAAG CGCAGCTGCTGCTGCGGTGGCGGCAGCTACAGCCATCACCCCTCCCTTGGCC
Citation	Maroto M, Dale JK, Dequéant ML, Petit AC, Pourquié O. Synchronised cycling gene oscillations in presomitic mesoderm cells require cell-cell contact. Int J Dev Biol. 2005;49(2-3):309-15.
Copyright	© UBC Press
Comments	As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI XM_419754.3

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

7-12

stage 12

Paraxial Mesoderm

For the anatomy, I selected "Somite" because it was in the "Presomitic Mesoderm." Should I have picked Paraxial Mesoderm?

Entry 4

GEISHA Id	HEY2.Anderson.2020	Data Source	GEISHA ISH Analysis
Complete cDNA Template Probe	show CCCTGCCGCCCTGCCTCCCTCCCTCCCGTCCTCCCGACGGGGCGGGCCTGGCCGGGGGCGGGCCGGCGCGCTTGAGGCT GTGCCGCGGCGTGGGAAAGCGCCTCAGAGAGGGTTCGCTCTGCTGGCTGTGCCGTGCGGTGCCGTGCCGGAGCCGCCGT CCGGATTTATTTCTCTTTGCCCCACGCCGGCTGCGGGTTGAGCCGCGATGAAGCGACCTTGCGAGGAAACTACCTCAGA CAGCGACATGGACGAGACCATCGATGTGGGCAGCGAGAACAACTACTGCGGGCAAAGCCATAGCTCTGTGCTTCGACCA AATTCCCCAACCACAACATCTCAGATTATGGCCAGAAAGAAAAGAAGAGGGATTATAGAGAAAAGGCGCCGGGATCGTA TAAATAACAGTTTATCTGAGCTGAGGCGGCTGGTGCCAACTGCTTTTGAAAAACAAGGATCTGCCAAATTAGAAAAAGC GGAAATACTGCAAATGACGGTGGATCATCTGAAGATGCTTCAAGCGACCGGAGGTAAAGGTTATTTTGACGCTCACTCA CTGGCCATGGATTTCATGAGCATTGGCTTCCGGGAGTGCTTGACTGAAGTTGCGAGGTACCTGACATCTGTGGAAGGCC TCGACACCTCTGACCCGCTGCGTGTCAGACTGGTGTCCCATCTCAGCACCTGCGCCTCTCAGCGGGAAGCGGCTGCCAT GACCTCCTCCATGGCCCACCACCACCACCCGCTGCACCCGCACCACTGGGCAGCCGCCTTCCACCACCTCCCGGCCGCC CTGCTGCAGCCCAATGGACTCCACGCTCCCGAGGCCGCCCCATGCAGACTCTCCTCAGAAGTGCCTCCCCACGGATCTG CACTGCTCACCGCTACCTTCGCCCACACCGACGCCGCCCTCAGGGTCCCCTCAGCGGGCAGCGTTGCTCCCTGTGTCCC CCCACTCTCTACCTCTCTCCTCTCCCTCTCGGCCACAGTTCATGCCGCAGCCGCCGCCGCCACGGCAGCCGCCCAGAGC TTCCCCCTCTCCTTCACCAGCACCTTCCCCATGCTCCCCCCAAGCGCAGCTGCTGCTGCGGTGGCGGCAGCTACAGCCA TCACCCCTCCCTTGGCCGTGTCAGCCTCATCCAGCCCCCAGCAGGCTGGCAGTGGGGCAAGTGGCAAGCCCTACCGGCC TTGGGGGACGGAGGTCGGAGCCTTCTAAGTGCCCCCTCTTCTTCCCTACCCAGCTCCCTCTTCTCCCTCCACGCACACA CACACACACACACGCGCACACACACACACACACACAGACACACACACGGCTCCTGTGACCTCGCTGAGGGCCAAGGGCC GCTGTCACCCGGGGTCTGGCAGCCAGCCCAGGCACTGCCCTTGCTGCAGGCACTGGAGGGGACACGGGCAGCCTGCTCC TCTTGGCAGGTGTGCTGAGGGCACCTTGAGGCAGTGGCTTTCAGAAGCGTCACCACTGCATTGGCATGTGGATGTTCCC CAGGAGATAAATAGGCACTAGGGCTAACAGTTCTCTGGCTGCACATTCACACTTGGCGGAGAGGCGAGGGATCATCCCC ATCAGGTCTCCTGGGGCTCAAAAAAGAATTTGACTTTCCTAAGTGCCTGACATTTAAACGATAATAATAATAATAAAAA AAAGAAATAAAACTTATATATACGTGTGTTCTGCTAAAACCAATAACATTGCACAGGTATGGGAGTGATCTGGGAGAGA GAGGCAGTCCTGCGTGCAGCTTCAGGACAGCGATATTCTTCCAGAAAAGAGTGTGCTCTTTAAGCAGACAGGTTCATTT ATCCAAAAGGCTGCTGAGAAACAACATCCATTTGACAGGCCTGGAACTCGCTTACTTAGTCTCCTTCCTTTGTACAGGC TTGCCAAATTGTGACATCTAGCACAGCCCTGGTAAAAGCGATTATCTTATCAGTGCTTAGATTAATGAACGTTTCAGCA GTGCCTGTGAGCCTTGAGGCACCCTTTTTTATGGCTTAACTATGGTGCTAGCTTGTATCTGCACAAACAGTAGGTTGTC ATGCACCCAGAAGTAACCACCTGCTGACAGTATGCACGCTTCCATGGGGTTGGCTCATGCCAATACAAGAGACCTGGTG TTGTGAGAGTTCCATTTAACTTATTTAGCTGCGTTCAGACGTTTACTTCTAGCCAACTCTGTGCAAAATCCCTCTTCTT TTCGCTATCAACTTCTGGGATAACAGTCGCTCTGGGTATGAATGAAGTGATGGTAGGGACAATTTTAAATTGGCTGTTA GCATGCCAACATTGTAATGTGGGTTTGATTCCAAACCAAAATGAATGTATTAAAGGGGATGGCAGTAAGTTATTTTGTC AATACCCAGACAACTAGTGCTGCATAAGATGTTTTGCTTTCATTTTTTATTACGGTGACTTAAAATAACCTAAGTATTT TAATACGTCAAGTCAAAAACTAGAGATTTTATGTTAAAAAAAAAGAAGTAAAAATAAAACACAGCATGTATTATTATGC ACTTGATTTCTCTGCTGTGTGGAGAAAGCAGTAAGCATTGAGAATGTTAAACATTACGCAAAATATACTTTAAAATATT TGTTTTAAAAATACTGTACCTAGTTGGTCTTTTATGCATTACTTTGTTAACCTTTTTCTATGCAAAAGTCTTTACATAT CACTAATTAAACGAAGTCCTTTTTGACTGCG
Comments	Images provided by Claire Anderson; Sequence was obtained from NCBI accession number (XM_015284442.2).