GEISHA - A Chicken Embryo Gene Expression Database
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ACVR1
activin A receptor type 1

The human orthologue of this gene is associated
with the following human disease:
Gene
Official SymbolACVR1
Official Full Nameactivin A receptor type 1
CGNC ID9529
also known asALK2, ATVR1, activin receptor type-1|activin A receptor, type I|activin receptor type I|serine/threonine-protein kinase receptor|type I TGF B receptor
gene typeprotein-coding
Genomic Map
 Ensembl
NCBI
UCSC
Gallus-Browse
Sequence Information
Genomic
RNANM_204560
PolypeptideNP_989891
Sequence Clusters/ESTsUnigene
Gene Expression
In Situ HybridizationGEISHA
EST ProfileGga.2875
Orthology
Entrez GeneEnsembl GeneGenetic PhenotypesMOD
Fruit Fly35731FBgn0003317
Human90ENSG00000115170MIM:135100MIM:102576
Mouse11477ENSMUSG00000026836All phenotypic alleles (7):Targeted, knock-out(4) Targeted, other(3) MGI:87911
Xenopus550111, 399083, 399103478849
Zebrafish30615ENSDARG00000014986ZDB-GENE-990415-9ZFIN:ZDB-GENE-990415-9
Gene Ontology
Molecular Functionactivin binding, ATP binding, metal ion binding, protein binding, protein homodimerization activity, more...receptor signaling protein activity, receptor signaling protein serine/threonine kinase activity, transforming growth factor beta binding, transforming growth factor beta receptor activity, type I
Biological Processactivin receptor signaling pathway, acute inflammatory response, atrial septum primum morphogenesis, more...BMP signaling pathway, cardiac epithelial to mesenchymal transition, cardiac muscle cell fate commitment, cell migration, embryonic heart tube morphogenesis, endocardial cushion cell fate commitment, endothelial cell activation, G1/S transition of mitotic cell cycle, heart development, intracellular signal transduction, mesenchymal cell differentiation, mitral valve morphogenesis, negative regulation of activin receptor signaling pathway, negative regulation of extrinsic apoptotic signaling pathway, pathway-restricted SMAD protein phosphorylation, peptidyl-threonine phosphorylation, positive regulation of alkaline phosphatase activity, positive regulation of BMP signaling pathway, positive regulation of bone mineralization, positive regulation of determination of dorsal identity, positive regulation of epithelial to mesenchymal transition, positive regulation of osteoblast differentiation, positive regulation of pathway-restricted SMAD protein phosphorylation, positive regulation of transcription, DNA-templated, positive regulation of transcription from RNA polymerase II promoter
Cellular Componentintegral component of plasma membrane
Links to other databases
Entrez Gene395246
Ensembl GeneENSGALG00000012551
KEGGgga:395246

Entry 1

GEISHA IdACVR1.UApcrData SourceGEISHA ISH Analysis
Forward cDNA Template PrimerGCTTGTGG AGTGTGTAGGAAAGGG-
Reverse cDNA Template PrimerGCTCTAGAAATTAACCCTCACTAAAGGGGCTGTTAGTCTTGCTGATGGATTC cDNA Template Length
Forward cDNA Template Probeshow
TCCTGCGAGGGTCTCGAGGATCGATACCAGCATTCTTTCTCAACTTGGCAAGAGATGTTAATGTAGGGTCTGAGAACCA
CCTGTTGGGAATGTTTGGCCTTTGCTGATCTACACAGACCACTTTCCTCATGTCTTCAAAACTGGGATCATTTGGAACC
AGGTCATAAAATGGTGGTTTATAGTCTTCTACAATACCATTGCTAACCATGCGCCTAGCTACCTCCCACAGGACCAGCC
CGAAGGCCCAGATATCGACCCTCTTGTAGGAGTCGAAGCAGTCTGCCTGGATGGTTTCGTCCAAGACCTCCGGAGCCAT
GTAGCGTTTGGTGCCCACTCGGGGGTTGTTCCCCACATCCAACTGGTTCGTGCTTTGGGAGTGCATGACTGCGAGGCCT
AAGTCTGCTATGCAGCACTGTCCATTTTTCTTAACAAGGATATTTTTGCTCTTCAAGTCCCGATGAGAAATGGCAGGCT
TCCCCTGCGTTCCAAATATCTCTATGTGCAAATGTGCAAGGCCGCTGGCTATGGACAGTACTATCCGCAGGCAGCTGAC
AGTGTCCAGGGTGGTGAGCTGCAGATAGTCATACAAAGACCCCATCTCATGGTAGTGAGTAATTAGCCACAGCTGGGTG
CTAGAGTTTCTGGAAGTCATATCGGATGCAATAAAACCTAAAATGTTTTCATGCCGCAGCAACACAGTGTTATACAATT
CAGTTTCCCTGAACCAGGATTTTTCATCCCTAGAAGAGAAGATCTTCACAGCAACATTCTCTCCTTGCCACTGACCCCT
CCAGACTTCTCCATAACGGCCCTTTCCTACACACTCCACAAGCATATTCTGCGGCCGCAGNNTTTTTAAAAAAAA
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
1-3
stage 3
Early Mesoderm
Primitive Streak
 
4-6
stage 4
stage 5
stage 6
stage 6
stage 6
Area Pellucida
Early Mesoderm
Intermediate Mesoderm
Lateral Plate Mesoderm
Paraxial Mesoderm
Primitive Streak
 
7-12
stage 7
stage 7
stage 8
stage 9
stage 11
Anterior Intestinal Portal
Area Opaca
Blood Islands
Endocardium
Head Mesenchyme
Heart Tube
Intermediate Mesoderm
Lateral Plate Mesoderm
Mesoderm
Myocardium
Neural Plate/Tube
Paraxial Mesoderm
Primitive Streak
Somites
 
13-18
stage 13
stage 14
stage 16
stage 16
stage 17
Blood Islands
Endocardium
Head Mesenchyme
Heart
Intermediate Mesoderm
Lateral Plate Mesoderm
Myocardium
Neural Plate/Tube
Somites
Widespread Expression
 
19-24
stage 20
stage 22
Endocardium
Heart
Outflow Tract
Widespread Expression
 
25
stage 25
stage 25
Endocardium
Heart
Outflow Tract
Widespread Expression
 

Entry 2

GEISHA IdALK2.Desgrosellier.2005Data SourcePublication
Complete cDNA Template Probeshow
TCGCCTCCCTGAGCATTAACGATGGTGCTAAGGTTTACCAGAAAGGCTGCTTCCAAGTCTATGAACAAGGGAAAATGAC
GTGCAAAACTCCGCCATCTCCTGACCAAGCTGTGGAGTGCTGCCAAGGATACCTTTGCAACATGAATATCACTGCGAAG
TTGCCCTCTTCTAAAGGGCAAACCCTGCAAGGGGAAGCTGCAGGTTACAGCATGGAAACACTAATC
CitationDesgrosellier JS, Mundell NA, McDonnell MA, Moses HL, Barnett JV. (2005) Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation. Dev Biol. 2005 Apr 1;280(1):201-10.
CopyrightCopyright © 2005 Elsevier Inc. All rights reserved.
CommentsAccording to the authors, "Probes were as follows: chicken ALK2 (GenBank Accession # U38622; nt 245–468)..." The sequence below was obtained from NCBI using the information provided.
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
13-18
stage 14
stage 15
stage 18
Atria
Endocardium
Outflow Tract
Ventricles
Atrioventricular Cushion
19
stage 19
  

Entry 3

GEISHA IdALK2.Zhang.2003Data SourcePublication
Complete cDNA Template Probeshow
GATCAGCAAAGGCCAAACATTCCCAACAGGTGGTTCTCAGACCCTACATTAACATCTCTTGCCAAGTTGATGAAAGAAT
GCTGGTATCAGAATCCATCAGCAAGACTAACAGCCCTGCGAATCAAAAAGACTTTGACCAAAATTGATAATTCCTTAGA
TAAACTGAAGGCTGACTGTTGACCTTCTTCTTGTGGTGCTTTCCTGACGGGAAGGCACCTGTCTGGCTCAGAGGCAGCC
CGGCCAGGCAGTTCATGTCATCGGTCCCCATGTGGCTTCTTACAGAGGCAGC
CitationZhang D, Schwarz EM, Rosier RN, Zuscik MJ, Puzas JE, O'Keefe RJ.ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development. J Bone Miner Res. 2003 Sep; 18(9):1593-604
CopyrightCopyright © 1999 - 2018 John Wiley & Sons, Inc.
CommentsThe sequence below was obtained from NCBI (acc # NM_204560.1) using the information provided in the publication as described in Zhang et al. 2003.
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
7-12
stage 11
Wing
 
25-30
stage 26
Wing
 
31-35
stage 31
stage 35
Wing
 
 Data from NCBI Unigene EST Profile
Unigene ID: Gga.2875

Mouse

EmageMGI:87911
EurexpressMGI:87911
MGI GXDMGI:87911

Frog

Xenbase478849

Fruit Fly

BDGPFBgn0003317

Zebra Finch

ZEBrA

Zebrafish

ZFINZDB-GENE-990415-9
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