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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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ANXA2
annexin A2

Gene

Official Symbol	ANXA2
Official Full Name	annexin A2
CGNC ID	49740
also known as	ANXA2P2, annexin A2\|PAP-IV\|annexin A2 pseudogene 2\|annexin II\|annexin-2\|calpactin I heavy chain\|calpactin-1 heavy chain\|chromobindin-8\|lipocortin II\|p36\|placental anticoagulant protein IV\|protein I
gene type	protein-coding

Genomic Map

	Ensembl
	NCBI
	UCSC

Sequence Information

Genomic
RNA	NM_205351
Polypeptide	NP_990682

Gene Expression

In Situ Hybridization

GEISHA

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	302	ENSG00000182718		MIM:151740
Mouse	12306	ENSMUSG00000032231	All phenotypic alleles (3):Targeted, knock-out(1) Targeted, other(2)	MGI:88246
Xenopus	394517, 397735, 397754			945314
Zebrafish	325557, 799806	ENSDARG00000003216, ENSDARG00000053625	ZDB-GENE-030131-4282, ZDB-GENE-030131-1089	ZFIN:ZDB-GENE-030131-4282, ZFIN:ZDB-GENE-030131-1089

Gene Ontology

Molecular Function	calcium ion binding, calcium-dependent phospholipid binding, cytoskeletal protein binding, more...phospholipase inhibitor activity
Biological Process	positive regulation of vesicle fusion
Cellular Component	Schmidt-Lanterman incisure, basement membrane, extracellular vesicular exosome, lipid particle, midbody, more...myelin sheath adaxonal region

Links to other databases

Entrez Gene	396297
Ensembl Gene	ENSGALG00000003770
KEGG	gga:396297

Entry 1

GEISHA Id	ANXA2.UApcr	Data Source	GEISHA ISH Analysis
Forward cDNA Template Primer	CAAGGGCAAAAGGTGTGAAGATAC
Reverse cDNA Template Primer	ATTAACCCTCACTAAAGGTGGGGAATGTTAGTTTCTCTGGC	cDNA Template Length	724
Forward cDNA Template Probe	show GCTGGTTAGGAAGTTTGGCAGAACCAAGCAGAGCGCTGCTGCTGAAGAAGTGCAGGCAGCACCAGAAGCACACGGCGTC GGTGGTGTGGCAGGTATTGGGGCAGGGAAGGGTTTGCATGGCGGCTCGATTTTGTCGGGGGTTGCAGTAAAACGAAGAG CAGAATAGGCATGTCTCTGCGTTTCCATTTCCCACATCACAGCTTTCAGTCCTCTCCACCACACAGGTTCAGCAGCGCC CTCTGGTAATCACCTTTTGTGTCTTGCTGGATGAAATAATAGAGGGATTTTCCGTATTTCCTCTTGAATTCACTCTTAA TTTTCAGCATGTCAACCTCACAGCGGGAGACCATAATCCTAATCAGGACCTTGTCACGGGTTCCCTTGCCCTTCATGGA ATCATAGAGTCTGTCTGCAAAGTATAGCTGCTTGTTCTGAATGCACTGAACAAGATTAAGGAAGGCATTCTCCAGATCT CCCTTAACTTCCTTCTTGATGCTCTCCAACATATCATATGGGCTGTAGCTCTTGTACCTTTCAAACACTTTCTGCAGAT GTGGAACACTTCTTTCAGTCATAATGTTGATCCACTTGGGAACATCTGTTCCCTTTCTCTTGACACCAGCATCATAGAG CTCCCTAGCGTCTTGGTCAATCAGTTCATAGTCAATCACAGAAGTATCTTCACACCTTTNGGCCCTTG

Stage

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Location (click to highlight)

Comments (click to highlight)

4-6

stage 4

stage 6

Area Opaca

7-12

stage 9

stage 10

Amnion
Ectoderm
Notochord
extraembryonic ectoderm

19-24

stage 19

stage 21

Allantois
Amnion
Aorta
Ectoderm
Endoderm
Eye
Foregut
Head Mesenchyme
Hindgut
Liver
Notochord
Pharyngeal Arches and Clefts
Yolk Sack or Stalk

dorsal mesentery, ventral body wall

25-27

stage 27

Allantois
Aorta
Atria
Ectoderm
Extraembryonic
Foregut
Head Mesenchyme
Heart
Hindbrain
Hindgut
Leg Ectoderm
Liver
Lung
Midbrain
Nasal Placode/Nerve
Notochord
Oral Pharynx
Outflow Tract
Pharyngeal Arches and Clefts
Sclerotome
Somatic Mesoderm
Spinal Cord
Spinal Ganglia and Nerves
Ventricles
Wing Ectoderm
Wing Mesenchyme
Yolk Sack or Stalk

dorsal mesentery

Entry 2

GEISHA Id	ANXA2.Krishnan.2004	Data Source	Publication
Complete cDNA Template Probe	show CCCGCCGCCAGAGCAGCCTTGCCCGCCCCGGCCAGCATTCTGCCAACATGTCTACTGTCCATGAAATTTTAAGCAAGCT CAGTCTGGAAGGAGATCATTCTCTCCCTCCAAGTGCATATGCCACAGTTAAGGCTTACTCAAACTTTGATGCTGACCGG GATGCTGCAGCCCTGGAAGCAGCCATCAAGACCAAAGGTGTGGATGAAGTTACCATCATCAACATCCTGACAAACCGCA GCAATGAACAGAGGCAGGATATTGCCTTTGCCTATCAGAGGAGAACCAAAAAGGAACTTTCTGCAGCACTTAAGTCTGC TCTGTCAGGTCATTTAGAGGCAGTGATCTTGGGCTTGCTGAAGACACCATCACAGTATGATGCGTCTGAACTGAAAGCT GCCATGAAGGGCCTGGGAACTGATGAAGACACACTTATCGAAATCATTTGCTCACGGACAAATCAGGAGCTTAATGAAA TTAATAGAGTCTATAGGGAAATGTACAAAACAGAACTGGAAAAGGACATTATATCAGACACATCTGGTGACTTCCGCAA GCTAATGGTTGCCCTGGCCAAGGGCAAAAGGTGTGAAGATACTTCTGTGATTGACTATGAACTGATTGACCAAGACGCT AGGGAGCTCTATGATGCTGGTGTCAAGAGAAAGGGAACAGATGTTCCCAAGTGGATCAACATTATGACTGAAAGAAGTG TTCCACATCTGCAGAAAGTGTTTGAAAGGTACAAGAGCTACAGCCCATATGATATGTTGGAGAGCATCAAGAAGGAAGT TAAGGGAGATCTGGAGAATGCCTTCCTTAATCTTGTTCAGTGCATTCAGAACAAGCAGCTATACTTTGCAGACAGACTC TATGATTCCATGAAGGGCAAGGGAACCCGTGACAAGGTCCTGATTAGGATTATGGTCTCCCGCTGTGAGGTTGACATGC TGAAAATTAAGAGTGAATTCAAGAGGAAATACGGAAAATCCCTCTATTATTTCATCCAGCAAGACACAAAAGGTGATTA CCAGAGGGCGCTGCTGAACCTGTGTGGTGGAGAGGACTGAAAGCTGTGATGTGGGAAATGGAAACGCAGAGACATGCCT ATCTGCTCTTCGTTTTACTCCAACCCCCGACAAAATCGAGCCGCCATGCAAACCCTTCCCTGCCCCAATACCTGCCACA CCACCGACGCCGTGTGCTTCTGGTGCTGCCTGCACTTCTCAGCAGCAGCGCTCTGCTTGGTTCTGCCAAACTTCCTAAC AGCGTAAAGCCAGAGAAACTAACATTCCCCAGAGATAAAGGTTAAACGTGCTTGTTGAGGATGCCTCCTTGTGTAATGT TTCTAATAAAACATAAATAAAACA
Citation	Krishnan S, Deora AB, Annes JP, Osoria J, Rifkin DB, Hajjar KA. (2004) Annexin II-mediated plasmin generation activates TGF-beta3 during epithelial-mesenchymal transformation in the developing avian heart. Dev Biol. 2004 Jan 1;265(1):140-54.
Copyright	Copyright © 2003 Elsevier Inc. All rights reserved.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205351).

Stage

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Location (click to highlight)

Comments (click to highlight)

13-15

stage 15

Endocardium
Heart
Notochord

Entry 3

GEISHA Id	ANXA2.Anderson.2020	Data Source	GEISHA ISH Analysis
Complete cDNA Template Probe	show ACCCGTATACATCACTATAGGGCATCGTTTACACCGCGGGGCGGCGCGGTGCATTCACAAAACAGAACTGGAAAAGGAC ATTATATCAGACACATCTGGTGACTTCCGCAAGCTAATGGTTGCCCTGGCCAAGGGCAAAAGGTGTGAAGATACTTCTG TGATTGACTATGAACTGATTGACCAAGACGCTAGGGAGCTCTATGATGCTGGTGTCAAGAGAAAGGGAACAGATGTTCC CAAGTGGATCAACATTATGACTGAAAGAAGTGTTCCACATCTGCAGAAAGTGTTTGAAAGGTACAAGAGCTACAGCCCA TATGATATGTTGGAGAGCATCAAGAAGGAAGTTAAGGGAGATCTGGAGAATGCCTTCCTTAATCTTGTTCAGTGCATTC AGAACAAGCAGCTATACTTTGCAGACAGACTCTATGATTCCATGAAGGGCAAGGGAACCCGTGACAAGGTCCTGATTAG GATTATGGTCTCCCGCTGTGAGGTTGACATGCTGAAAATTAAGAGTGAATTCAAGAGGAAATACGGAAAATCCCTCTAT TATTTCATCCAGCAAGACACAAAAGGTGATTACCAGAGGGCGCTGCTGAACCTGTGTGGTGGAGAGGACTGAAAGCTGT GATGTGGGAAATGGAAACGCAGAGACATGCCTATTCTGCTCTTCGTTTTACTGCAACCCCCGACAAAATCGAGCCGCCA TGCAAAACCCTTCCCTGCCCCAATACCTGCCACACCACCGACGCCGTGTGCTTCTGGTGCTGCCTGCACTTCTCAGCAG CAGCGCTCTGCTTGGTTCTGCCAAACTTCCTAACAGGCGTAAAGCCAGAGAAACTAACATTCCCCAGAGATTAACGGTT AAACGTGCTTTGTTGAGGAATGCCTCCCTTGGTGTAATGTTTCTAATAAAACATTAATAAACCGATGTATCTCTCTCAA AAA
Comments	Images Provided by Claire Anderson; Anderson C, Hill B, Lu HC, Moverley A, Yang Y, Oliveira NMM, Baldock RA, Stern CD. A 3D molecular atlas of the chick embryonic heart. Dev Biol. 2019 Dec 1;456(1):40-46. doi: 10.1016/j.ydbio.2019.07.003. Epub 2019 Jul 5.

Stage

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Location (click to highlight)

Comments (click to highlight)

7-12

stage 12

Area Opaca
Ectoderm
Lateral Plate Mesoderm
Notochord
Primitive Streak
Proepicardium
Somites
Splanchnic Mesoderm
extraembryonic endoderm
extraembryonic mesoderm

Entry 4

GEISHA Id	ANXA2.Anderson.2019	Data Source	Publication
Complete cDNA Template Probe	show ACCCGTATACATCACTATAGGGCATCGTTTACACCGCGGGGCGGCGCGGTGCATTCACAAAACAGAACTGGAAAAGGAC ATTATATCAGACACATCTGGTGACTTCCGCAAGCTAATGGTTGCCCTGGCCAAGGGCAAAAGGTGTGAAGATACTTCTG TGATTGACTATGAACTGATTGACCAAGACGCTAGGGAGCTCTATGATGCTGGTGTCAAGAGAAAGGGAACAGATGTTCC CAAGTGGATCAACATTATGACTGAAAGAAGTGTTCCACATCTGCAGAAAGTGTTTGAAAGGTACAAGAGCTACAGCCCA TATGATATGTTGGAGAGCATCAAGAAGGAAGTTAAGGGAGATCTGGAGAATGCCTTCCTTAATCTTGTTCAGTGCATTC AGAACAAGCAGCTATACTTTGCAGACAGACTCTATGATTCCATGAAGGGCAAGGGAACCCGTGACAAGGTCCTGATTAG GATTATGGTCTCCCGCTGTGAGGTTGACATGCTGAAAATTAAGAGTGAATTCAAGAGGAAATACGGAAAATCCCTCTAT TATTTCATCCAGCAAGACACAAAAGGTGATTACCAGAGGGCGCTGCTGAACCTGTGTGGTGGAGAGGACTGAAAGCTGT GATGTGGGAAATGGAAACGCAGAGACATGCCTATTCTGCTCTTCGTTTTACTGCAACCCCCGACAAAATCGAGCCGCCA TGCAAAACCCTTCCCTGCCCCAATACCTGCCACACCACCGACGCCGTGTGCTTCTGGTGCTGCCTGCACTTCTCAGCAG CAGCGCTCTGCTTGGTTCTGCCAAACTTCCTAACAGGCGTAAAGCCAGAGAAACTAACATTCCCCAGAGATTAACGGTT AAACGTGCTTTGTTGAGGAATGCCTCCCTTGGTGTAATGTTTCTAATAAAACATTAATAAACCGATGTATCTCTCTCAA AAA
Citation	Anderson C, Hill B, Lu HC, Moverley A, Yang Y, Oliveira NMM, Baldock RA, Stern CD. A 3D molecular atlas of the chick embryonic heart. Dev Biol. 2019 Dec 1;456(1):40-46. doi: 10.1016/j.ydbio.2019.07.003. Epub 2019 Jul 5.
Copyright	Copyright © 2019 Elsevier Inc. All rights reserved.
Comments	The complete cDNA template sequence was obtained from the information from the publication as described in Anderson et al. 2019.