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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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BMP10
bone morphogenetic protein 10

Gene

Official Symbol	BMP10
Official Full Name	bone morphogenetic protein 10
CGNC ID	60
also known as	BMP-10, bone morphogenetic protein 10, Bone morphogenetic protein-10, BMP10
gene type	protein-coding

Genomic Map

	Ensembl
	NCBI
	UCSC
	Gallus-Browse

Sequence Information

Genomic
RNA	NM_001278046
Polypeptide	NP_001264975
Sequence Clusters/ESTs	Unigene

Gene Expression

In Situ Hybridization	GEISHA
EST Profile	Gga.9509

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	27302	ENSG00000163217		MIM:608748
Mouse	12154	ENSMUSG00000030046	All phenotypic alleles (6):Targeted, knock-out(1) Targeted, other(5)	MGI:1338820
Xenopus	100487047			478874
Zebrafish	562533	ENSDARG00000061769	ZDB-GENE-060526-211	ZFIN:ZDB-GENE-060526-211

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Links to other databases

Entrez Gene	395177
Ensembl Gene	ENSGALG00000000120
KEGG	gga:395177

Entry 1

GEISHA Id	BMP10.UApcr	Data Source	GEISHA ISH Analysis
Forward cDNA Template Primer	TTATAAAAGCTTGCGGCCGCAGAATATATGGTGGTATCAGAGTGTGGCTG
Reverse cDNA Template Primer	GCTCTAGAAATTAACCCTCACTAAAGGGGTGAGACTGGTTTTAGTTGGTGC	cDNA Template Length	1078
Complete cDNA Template Probe	show TTTTTTAAAACTTGGGCCCCAATTAGGGGTCCAGATGTGCAGATAGAGCAGGGAAGACATGGCACAGGGGGAGTGCACA AGGGGAAGTATTTAATGATTCAGTCTGTAAATTTGTACATTTCGGATTTCCTATTTAATAAGGTATTTAATGAGGCATG TACAGATAATTGTATGTTTCCTGTCACGGGGAATGGGCAAGTCATATGACCGTAGGGAATGTATATTTTTGTTCCATTG CTTGCTTCTTGCTATTCTGTTCAAATTATGTCTGTCTCTCTTCATACCTGAGCATAGAGCACATCACTGGATTGTTTGG GTGGGCTCTTCATGCTAGAAGGAGCACATTCAAATTCACAGGAATAAAGGCATCTTTTTGTGCTTTGTAAATGGTGATT GGCATCTGTAGGGATTTCCAGAGTGACTATAGCTATGGGCAATACGTGCCCAGATTGTTCAGTTGTGTGTAAAATCTTT ATAAAGATCTTTACATACTCAGATATTTTGAAAATTTATCTCTGTAGCTCTTAAATCTCAACAAAAGGTTTAGAATGGT ACCAGTTTACACCAGCTCAGAATCTGGTCCCCCCCAACCAGTCCAGTAAGCTACATGCCATACATCCACGTAACCCAAT TCAGATGGCCGAATAGTATTGCATTTAGTCTGCATAGAAATAGACAGAAAAGGAACCCCCATTGTGCCAGCTAGATAGA GAGGATCTTTCCTTTATGTATGTGCTGAAGTTGTCAATTCATAAAGGTACTGCCCCCCCTTACATGATATATGATGGAG TCACATGCCATGTTTCCGCCACTCTTCTGCAACAAATCGCAGTGATAAGAAGGTGTCGGAGCTGAAAACAATAGACCCG TCACTTTATTTATACTAAGCTGCAAAATTTGTCAGATTCTTGGGAAAGTGTAAGTGACCTGACTCTTTTAGCCTGTACC AGAGCCTACTGTACTGTCCCTGCATCTGTTTTACACTTTTAAGGGAAAGTTATCTCACCTGGAAGTGATAAGGGCCTTT GAAAGAATCCACCCAACACCTTCATGGGATACCTTACTTCCAAACCCGTCCCCCCTTGGGGGGTAATTTAAAAA
Comments	No expression detected from stages 3 to 9.

Stage

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Location (click to highlight)

Comments (click to highlight)

4-6

stage 4

Unlabeled

7-12

stage 7

stage 9

stage 10

Heart Tube
Unlabeled

Stage 9+ to 10-.

13-18

stage 14

stage 15

stage 16

Atria
Outflow Tract
Sinus Venosus
Ventricles

19-24

stage 19

stage 21

Anterior/Second Heart Field
Atria
Ventricles

stage 25

Atria
Ventricles

Entry 2

GEISHA Id	BMP10.Kruithof.2006	Data Source	Publication
Complete cDNA Template Probe	show GAAATTGCCAACTTCCATGGACACCCTGGTGAGGAGGCTCTGCTCCAGATGCGTTCTAACATCATTTATGACTCTACTG CTCGAATCCGAAGGAACGCAAAAGGCAACTACTGCAAAAAGACTCCACTCTACATAGATTTCAAGGAGATTGGCTGGGA TTCCTGGATCATCGCTCCAGCAGGATATGAAGCTTATGAGTGCCATGGAGTATGCGCCTACCCCTTAACAGAGCACGTC ACCCCAACAAAACATGCCATTGTCCAGACTTTGGTTCACTTGAAGAATCCCCAGAAAGCCTCCAAGGCCTGCTGCGTGC CCACCAAACTCGATCCTATCTCAATTCTCTACATGGATGCAGGGGTGGTCACCTACAAGTTCAAATATGAAGGCATGGT GGTATCAGAGTGTGGCTGCAGATAGTAGCAGGAAGACATGCACAGGGGAGTGCACAAGGGAAGTATTTAATGATTCAGT CTGTAAATTTGTACATNTCGGATTTCCTATTAATAAGGTTATTTAATGAGGCATGTACAGATAACTGTATGTTTCCTGT CACGGGGAATGGGCAAGTCATATGACCGTAGGGAATGTATA
Citation	Kruithof BP, van Wijk B, Somi S, Kruithof-de Julio M, Pérez Pomares JM, Weesie F, Wessels A, Moorman AF, van den Hoff MJ. BMP and FGF regulate the differentiation of multipotential pericardial mesoderm into the myocardial or epicardial lineage. Dev Biol. 2006 Jul 15;295(2):507-22. Epub 2006 Apr 3.
Copyright	Copyright © 2006 Elsevier B.V. All rights reserved.
Comments	According to the authors: The in situ hybridization procedure and the probes used were recently described (Somi et al., 2004a and Somi et al., 2004b). These sources indicated: Chicken cDNA (604156553F1), which is similar to human and mouse BMP10, was identified in the UMIST Est database (Boardman et al., [2002]) and obtained from the MRC geneservice (Cambridge, UK). This clone is shown as probe.

Stage

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Location (click to highlight)

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13-16

stage 16

Splanchnic Mesoderm

peri-proepicardial mesoderm

Entry 3

GEISHA Id	BMP10.Ishii.2010	Data Source	Publication
Complete cDNA Template Probe	show ATGGATTCCATAGTCCTCCAGCTGTGGGCTGGCCTCTGCCTCTTGGTTCACCTTGCCACTTGCAGTCCCATCCTGAGCT TGGAGCACTCTTCCTTAGAGGAAGGCGAGCCTCTTTTCGATGAATTCCTGTCCGAGCAGGATGGTGTTGATTTCAACAC ATTGCTTCAGAATATGAAGAACGAGTTCCTGAAGACGTTGAACCTCTCCGACATTCCTCTGCACGAGTCGGCCAAAGTG GACCCACCAGAGTACATGTTAGAGCTGTACAACAAGTTTGCCACTGACAGGACATCTATGCCATCTGCAAATATCATTA GGAGCTTCAAAAATGAAGACCTTGCTTCCCACCCTGTTGGCGTCATAGGAGTTCGGAAATACCCCCTTCTGTTCAATGT CTCCATCCCTCATCATGAAGAAATCACCATGGCGGAGCTGAGACTCTACACCTTGGTGGAGAGGGACCAAATGCTTTAT GAAGGGCTCGACCGAAAGGTCACCATTTTTGAAGTGCTGGAAAATGACCATATGGGGGTAGGAGAAGAAAGAAAGATCG TGGCGCTGGCATCCAGACAGATCTATGGCACAAGCAGTGAGTGGGAGAGCTTCGAGGTGACCGAAGCCATCAGGCGTTG GCGAAGGGCAGGGCTGACCACGCACCGGCTGGAGGTTCACATTGAGAGCAGAGAAGGGGAGGAGCAGAATGGAGAGGGG AAACTCGATATCGACATCAACTCTGAGGCTAAGCACGTGCCCCTGTTGATTGTGTTCTCTGATGACCAAAGCAATGATC AGAAAGAGGAGAAGCAAGAGCTGAACGAAATGATAGACCATGAGCAGCTCCTGGACTTGGAGAACCTGGAAGTTGGCAA TTTCCATGGACACCCTGGTGAGGAGGCTCTGCTCCAGATGCGTTCTAACATCATTTATGACTCTACTGCTCGAATCCGA AGGAACGCAAAAGGCAACTACTGCAAAAAGACTCCACTCTACATAGATTTCAAGGAGATTGGCTGGGATTCCTGGATCA TCGCTCCAGCAGGATATGAAGCTTATGAGTGCCATGGAGTATGCGCCTACCCCTTAACAGAGCACGTCACCCCAACAAA ACATGCCATTGTCCAGACTTTGGTTCACTTGAAGAATCCCCAGAAAGCCTCCAAGGCCTGCTGCGTGCCCACCAAACTC GATCCTATCTCAATTCTCTACATGGATGCAGGGGTGGTCACCTACAAGTTCAAATATGAAGGCATGGTGGTATCAGAGT GTGGCTGCAGATAGTAGCAGGGAAGACATGCACAGGGGAGTGCACAAGGGAAGTATTTAATGATTCAGTCTGTAAATTT GTACATTTCGGATTTCCTATTTAATAAGGTTATTTAATGAGGCATGTACAGATAATTGTATGTTTCCTGTCACGGGGAA TGGGCAAGTCATATGACCGTAGGGAATGTATATTTTGTTCCATTGCTTGCTTCTTGCTATTCTGTTCAAATTATGTCTG TCTCTCTTCATACCTGAGCATAGAGCACATCACTGGATTGTTTGGGTGGGCTCTTCATGCTAGAAGGAGCACATTCAAA TTCACAGGAATAAAGGCATCTTTTTGTGCTTTGTAAATGGTGATTGGCATCTGTAGGGATTTCCAGAGTGACTATAGCT ATGGGCAATACGTGCCCAGATTGTTCAGTTGTGTGTAAAATCTTTATAAAGATCTTTACATACTCAGATATTTTGAAAA TTTATCTCTGTAGCTCTTAAATCTCAACAAAAGGTTTAGAATGGTACCAGTTTACACCAGCTCAGAATCTGGTCCCCCC CAACCAGTCCAGTAAGCTACATGCCATACATCCACGTAACCCAATTCAGATGGCCGAATAGTATTGCATTTAGTCTGCA TAGAAATAGACAGAAAAGGAACCCCCATTGTGCCAGCTAGATAGAGAGGATCTTTCCTTTATGTATGTGCTGAAGTTGT CAATTCATAAAGGTACTGCCCCCCCTTACATGATATATGATGGAGTCACATGCCATGTTTCCGCCACTCTTCTGCAACA AATCGCAGTGATAAGAAGGTGTCGGAGCTGAGAAACAATAGACCCGTCACTTTATTTATACTAAGCTGCAAATTTGTCA GATTCTTGGGAAAGTGTAAGTGACACTGACTCTTTTAGCCTGTACCAGAGCCTACTGTACTGTCCCTGCATCTGTTTTA CACTTTTAAGGGAAAGTTATCTTCACTGGAAGTGATAAGGGCCTTTGAAAGAATCACTCTAACACTTCATGGGATTGAA CACTTTATCATGCACCAACTAAAACCAGTCTCACCTATTTTCACACATACTCTTCTGTGCTTCCCATAATTTATTGATC TATTTATTGACTGCCTGCCTCTGTAATATAATGTAGAATACAGAACGTTTTATTTTTGTGCTTGTATGTAACCCCACTT GGATAAAACCTTGTACCGAC
Citation	Ishii Y, Garriock RJ, Navetta AM, Coughlin LE, Mikawa T.. BMP Signals Promote Proepicardial Protrusion Necessary for Recruitment of Coronary Vessel and Epicardial Progenitors to the Heart. Dev Cell. 2010 August 17; 19(2): 307316.
Copyright	Copyright © 2010 Elsevier Inc. All rights reserved.
Comments	As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #XM_417667.1).

Stage

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Location (click to highlight)

Comments (click to highlight)

13-17

stage 17

Heart

Entry 4

GEISHA Id	BMP10.Anderson.2020	Data Source	GEISHA ISH Analysis
Complete cDNA Template Probe	show TCCAAGGCCTGCTGCGTGCCCACCAAACTCGATCCTATCTCAATTCTCTACATGGATGCAGGGGTGGTCACCTACAAGT TCAAATATGAAGGCATGGTGGTATCAGAGTGTGGCTGCAGATAGTAGCAGGGAAGACATGCACAGGGGAGTGCACAAGG GAAGTATTTAATGATTCAGTCTGTAAATTTGTACATTTCGGATTTCCTATTTAATAAGGTTATTTAATGAGGCATGTAC AGATAATTGTATGTTTCCTGTCACGGGGAATGGGCAAGTCATATGACCGTAGGGAATGTATATTTTGTTCCATTGCTTG CTTCTTGCTATTCTGTTCAAATTATGTCTGTCTCTCTTCATACCTGAGCATAGAGCACATCACTGGATTGTTTGGGTGG GCTCTTCATGCTAGAAGGAGCACATTCAAATTCACAGGAATAAAGGCATCTTTTTGTGCTTTGTAAATGGTGATTGGCA TCTGTAGGGATTTCCAGAGTGACTATAGCTATGGGCAATACGTGCCCAGATTGTTCAGTTGTGTGTAAAATCTTTATAA AGATCTTTACATACTCAGATATTTGAAAATTTATCTCTGTAGCTCTTAAATCTCAACAAAAGGGTTAGAATGGTACCAG TTTACACCAGCTCAGAATCTGGTCCCCCCAACAGTCCAGTAAGCTACATGCCATACATCCACGTAACCAATCAGATGGC CGAATAGTATGCATTAGTCT
Comments	Images and probe sequence provided by Claire Anderson; Related article: Anderson C, Hill B, Lu HC, Moverley A, Yang Y, Oliveira NMM, Baldock RA, Stern CD. A 3D molecular atlas of the chick embryonic heart. Dev Biol. 2019 Dec 1;456(1):40-46. doi: 10.1016/j.ydbio.2019.07.003. Epub 2019 Jul 5.

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

7-12

stage 10

stage 12

Atria
Heart Tube
Lateral Plate Mesoderm
Neural Plate/Tube
Notochord
Primitive Streak
Ventricles

section 44; epimyocardium
stage 12+

Entry 5

GEISHA Id	BMP10.Anderson.2019	Data Source	Publication
Complete cDNA Template Probe	show TCCAAGGCCTGCTGCGTGCCCACCAAACTCGATCCTATCTCAATTCTCTACATGGATGCAGGGGTGGTCACCTACAAGT TCAAATATGAAGGCATGGTGGTATCAGAGTGTGGCTGCAGATAGTAGCAGGGAAGACATGCACAGGGGAGTGCACAAGG GAAGTATTTAATGATTCAGTCTGTAAATTTGTACATTTCGGATTTCCTATTTAATAAGGTTATTTAATGAGGCATGTAC AGATAATTGTATGTTTCCTGTCACGGGGAATGGGCAAGTCATATGACCGTAGGGAATGTATATTTTGTTCCATTGCTTG CTTCTTGCTATTCTGTTCAAATTATGTCTGTCTCTCTTCATACCTGAGCATAGAGCACATCACTGGATTGTTTGGGTGG GCTCTTCATGCTAGAAGGAGCACATTCAAATTCACAGGAATAAAGGCATCTTTTTGTGCTTTGTAAATGGTGATTGGCA TCTGTAGGGATTTCCAGAGTGACTATAGCTATGGGCAATACGTGCCCAGATTGTTCAGTTGTGTGTAAAATCTTTATAA AGATCTTTACATACTCAGATATTTGAAAATTTATCTCTGTAGCTCTTAAATCTCAACAAAAGGGTTAGAATGGTACCAG TTTACACCAGCTCAGAATCTGGTCCCCCCAACAGTCCAGTAAGCTACATGCCATACATCCACGTAACCAATCAGATGGC CGAATAGTATGCATTAGTCT
Citation	Anderson C, Hill B, Lu HC, Moverley A, Yang Y, Oliveira NMM, Baldock RA, Stern CD. A 3D molecular atlas of the chick embryonic heart. Dev Biol. 2019 Dec 1;456(1):40-46. doi: 10.1016/j.ydbio.2019.07.003. Epub 2019 Jul 5.
Copyright	Copyright © 2019 Elsevier Inc. All rights reserved.
Comments	The complete cDNA template sequence was obtained from the information from the publication as described in Anderson et al. 2019.