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Human Disease Gene Search
BMP4 The human orthologue of this gene is associated
Gene Summary Expression Transcript Levels Other Species Expression JBrowse Gene Official Symbol BMP4 Official Full Name bone morphogenetic protein 4 CGNC ID 49681 also known as BMP-4, bone morphogenetic protein 4, BMP-4, Bone morphogenetic protein 4 precursor gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Molecular Function cytokine activity , growth factor activity Biological Process beak morphogenesis , cartilage development , cell differentiation , cell proliferation , cloacal septation , more... embryonic skeletal system morphogenesis , growth , mesenchymal cell proliferation involved in ureter development , mesenchymal cell proliferation involved in ureteric bud development , ossification , positive regulation of epidermal cell differentiation , regulation of cell fate commitment , ureteric bud morphogenesis Cellular Component extracellular space
Links to other databases
Entry 1 GEISHA Id ChEST895j20 Data Source GEISHA ISH Analysis Forward cDNA Template Probe show GGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGCTCTCCAGAATC
Entry 2 GEISHA Id BMP4.UApcr Data Source GEISHA ISH Analysis Forward cDNA Template Primer TTATAAAAGCTTGCGGCCGCAGAATATATGTTTGGGCTGCGAAGGC Reverse cDNA Template Primer GCTCTAGAAATTAACCCTCACTAAAGGGCGTGGTTGGTGGAGTTGAG cDNA Template Length 860 Complete cDNA Template Probe show AATTTATTTTGGGTTGGGGCCACAATCAGCCGATCCCATTACATGCGTGGATCTCTACGGCCCTTCCGGGAGAAAGGAG
Entry 3 GEISHA Id Bmp4.Kamimura.2004 Data Source Publication Complete cDNA Template Probe show ATGATTCCTGGTAACCGAATGCTGATGGTCATCCTACTATGCCAAGTCCTGCTGGGAGGTACCAACCATGCTAGCCTGA
Citation Kamimura, M, Matsumoto, K, Koshiba-Takeuchi, K, Ogura, T. Vertebrate Crossveinless 2 Is Secreted and Acts as an Extracellular Modulator of the BMP Signalling Cascade. Dev Dyn. 2004 Jul;230(3):434-45. Copyright Wiley-Liss, Inc. 2004 Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_205237).
Entry 4 GEISHA Id Bmp4.Jensen.2005 Data Source Publication Complete cDNA Template Probe show ATGATTCCTGGTAACCGAATGCTGATGGTCATCCTACTATGCCAAGTCCTGCTGGGAGGTACCAACCATGCTAGCCTGA
Citation Jensen A. Potential Roles for BMP and Pax Genes in the Development of Iris Smooth Muscle. Dev Dyn. 2005 Feb;232(2):385-92. Copyright Copyright © 2005 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_205237).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-39 stage 31
stage 36
stage 39
Eye
Entry 5 GEISHA Id Bmp4.Huillard.2004 Data Source Publication Complete cDNA Template Probe show ATGATTCCTGGTAACCGAATGCTGATGGTCATCCTACTATGCCAAGTCCTGCTGGGAGGTACCAACCATGCTAGCCTGA
Citation Huillard E, Marx M. Localized Expression of drm/gremlin in the Central Nervous System of the Chicken Embryo. Dev Dyn. 2004 Mar;229(3):688-94. Copyright Copyright © 2004 Wiley-Liss, Inc. Comments Insufficient information provided to verify exact probe sequence. Sequence provided is entire coding region from Accession # NM_205237.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-30 stage 29
Eye 31-40 stage 36
stage 40
Forebrain Spinal Cord
Entry 6 GEISHA Id Bmp4.Bastida.2004 Data Source Publication Complete cDNA Template Probe show ATGATTCCTGGTAACCGAATGCTGATGGTCATCCTACTATGCCAAGTCCTGCTGGGAGGTACCAACCATGCTAGCCTGA
Citation Bastida MF, Delgado MD, Wang B, Fallon JF, Fernandez-Teran M, Ros MA. Levels of Gli3 repressor correlate with Bmp4 expression and apoptosis during limb development. Dev Dyn. 2004 Sep;231(1):148-60. Erratum in: Dev Dyn. 2005 Aug;233(4):1613. Copyright Wiley-Liss, Inc. 2004 Comments Insufficient information provided to verify exact probe sequence. Sequence provided is entire coding region from Accession # NM_205237.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-23 stage 23
Wing
Entry 7 GEISHA Id BMP4.Chapman.2002 Data Source Publication Complete cDNA Template Probe show ATGATTCCTGGTAACCGAATGCTGATGGTCATCCTACTATGCCAAGTCCTGCTGGGAGGTACCAACCATGCTAGCCTGA
Citation Chapman SC, Schubert FR, Schoenwolf GC, Lumsden A. Analysis of spatial and temporal gene expression patterns in blastula and gastrula stage chick embryos. Dev Biol. 2002 May 1;245(1):187-99. Copyright 2002 Elsevier Science (USA). All rights reserved.
Entry 8 GEISHA Id Bmp4.Chapman.2005 Data Source Publication Complete cDNA Template Probe show ATGATTCCTGGTAACCGAATGCTGATGGTCATCCTACTATGCCAAGTCCTGCTGGGAGGTACCAACCATGCTAGCCTGA
Citation Chapman SC, Cai Q, Bleyl SB, Schoenwolf GC. Restricted expression of Fgf16 within the developing chick inner ear. Dev Dyn. 2006 Aug;235(8):2276-81.
PMID: 16786592 [PubMed - indexed for MEDLINE] Copyright Copyright © 2006 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205237).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19 stage 19
Ear/Otic Placcode
Entry 9 GEISHA Id Bmp4.Schlueter.2006 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show GCGGCTCGAGTTCGTCTTCAACCTCAGCAGCGTGCCGGACAACGAGGTGATCTCGTCGGCGGAGCTGCGGCTGTACCGG
Comments According to the authors, "a 766 bp partial cDNA clone (ChEST730M5) were identified in the ChickEST Database (Boardman et al., 2002) and obtained from the MRC geneservice." The posted sequence represents the BBSRC read of that est.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-17 stage 13
stage 13
stage 17
stage 17
Proepicardium Sinus Venosus
Entry 10 GEISHA Id BMP4.Kruithof.2006 Data Source Publication Complete cDNA Template Probe show ATGATTCCTGGTAACCGAATGCTGATGGTCATCCTACTATGCCAAGTCCTGCTGGGAGGTACCAACCATGCTAGCCTGA
Citation Kruithof BP, van Wijk B, Somi S, Kruithof-de Julio M, Pérez Pomares JM, Weesie F, Wessels A, Moorman AF, van den Hoff MJ. BMP and FGF regulate the differentiation of multipotential pericardial mesoderm into the myocardial or epicardial lineage. Dev Biol. 2006 Jul 15;295(2):507-22. Epub 2006 Apr 3. Copyright Copyright © 2006 Elsevier B.V. All rights reserved. Comments Authors refer to probe production in another paper which says: "Antisense RNA probes specific for chicken Bmp-4 transcripts were
synthesized with T3 RNA polymerase, using BamHI-linearized p6.1
as a template (nucleotides 1-953)." Thus the first 953 nt are shown as the probe.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-16 stage 16
stage 16
stage 16
Proepicardium
Entry 11 GEISHA Id BMP4.Ohta.2007 Data Source Publication Complete cDNA Template Probe show ATGATTCCTGGTAACCGAATGCTGATGGTCATCCTACTATGCCAAGTCCTGCTGGGAGGTACCAACCATGCTAGCCTGA
Citation Ohta S, Suzuki K, Tachibana K, Tanaka H, Yamada G. Cessation of gastrulation is mediated by suppression of epithelial-mesenchymal transition at the ventral ectodermal ridge. Development. 2007 Dec;134(24):4315-24. Epub 2007 Nov 14. Copyright Published by The Company of Biologists 2007. This material is protected by a copyright retained by the authors. Permission granted by Dr. Yamada. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205237).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-17 stage 17
stage 17
Tail
Entry 12 GEISHA Id Bmp4.Bonafede.2006 Data Source Publication Complete cDNA Template Probe show ATGATTCCTGGTAACCGAATGCTGATGGTCATCCTACTATGCCAAGTCCTGCTGGGAGGTACCAACCATGCTAGCCTGA
Citation Bonafede A, Köhler T, Rodriguez-Niedenführ M, Brand-Saberi B. BMPs restrict the position of premuscle masses in the limb buds by influencing Tcf4 expression. Dev Biol. 2006 Nov 15;299(2):330-44. Epub 2006 Jun 15. Copyright Copyright © 2006 Elsevier B.V. All rights reserved. Comments The following probes were used: Sf/Hgf (Thery et al., 1995), qPax3, MyoD and Myf5, Lbx1, Bmp2 and Bmp4, Tcf4. Probes used in this study were kindly provided by Claudio Stern, Gabrielle Kardon, Christophe Marcelle, Bruce M. Paterson, Susanne Dietrich and Paul Brickell. Thus insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc # NM_205237).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 24
Wing Mesenchyme
Entry 13 GEISHA Id Bmp4.Nissim.2006 Data Source Publication Complete cDNA Template Probe show ATGATTCCTGGTAACCGAATGCTGATGGTCATCCTACTATGCCAAGTCCTGCTGGGAGGTACCAACCATGCTAGCCTGA
Citation Nissim S, Hasso SM, Fallon JF, Tabin CJ. Regulation of Gremlin expression in the posterior limb bud. Dev Biol. 2006 Nov 1;299(1):12-21. Epub 2006 May 26. Copyright Copyright © 2006 Elsevier B.V. All rights reserved. Comments Authors said: DIG-labeled probes were generated for Gremlin (Capdevila et al., 1999), Shh (Riddle et al., 1993), Bmp2 (Francis et al., 1994), Bmp4 (Francis et al., 1994), and Bmp7 (received from L. Niswander). Francis et al said: Antisense RNA probes specific for chicken Bmp-4 transcripts contained the first 953nt. These were taken from Acc# NM_205237.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-22 stage 22
Wing Mesenchyme
Entry 14 GEISHA Id BMP4.Sanchez-Calderon.2007 Data Source Publication Complete cDNA Template Probe show ATGATTCCTGGTAACCGAATGCTGATGGTCATCCTACTATGCCAAGTCCTGCTGGGAGGTACCAACCATGCTAGCCTGA
Citation Sánchez-Calderón H, Francisco-Morcillo J, Martín-Partido G, Hidalgo-Sánchez M (2007). Fgf19 expression patterns in the developing chick inner ear.Gene Expr Patterns. Jan;7(1-2):30-8. Epub 2006 May 19. Copyright Copyright © 2007 Elsevier B.V. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205237).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 20
stage 20
stage 24
stage 24
stage 24
stage 24
stage 24
Ear/Otic Placcode 25-27 stage 27
stage 27
stage 27
stage 27
stage 27
stage 27
Ear/Otic Placcode
Entry 15 GEISHA Id Bmp4.Sanchez-Calderon.2005 Data Source Publication Complete cDNA Template Probe show ATGATTCCTGGTAACCGAATGCTGATGGTCATCCTACTATGCCAAGTCCTGCTGGGAGGTACCAACCATGCTAGCCTGA
Citation Sánchez-Calderón H, Martín-Partido G, Hidalgo-Sánchez M. Pax2 expression patterns in the developing chick inner ear. Gene Expr Patterns. 2005 Aug;5(6):763-73. Copyright Reprinted with permission from Elsevier. Copyright © 2005 Elsevier B.V. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205237).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 20
stage 20
stage 20
stage 20
stage 20
stage 20
stage 24
stage 24
stage 24
stage 24
stage 24
stage 24
stage 24
stage 24
stage 24
Ear/Otic Placcode Unlabeled 25-27 stage 27
stage 27
stage 27
stage 27
stage 27
stage 27
stage 27
stage 27
Ear/Otic Placcode
Entry 16 GEISHA Id BMP4.Shigetani.2000 Data Source Publication Complete cDNA Template Probe show ATGATTCCTGGTAACCGAATGCTGATGGTCATCCTACTATGCCAAGTCCTGCTGGGAGGTACCAACCATGCTAGCCTGA
Citation Shigetani Y, Nobusada Y, Kuratani S. (2000). Ectodermally derived FGF8 defines the maxillomandibular region in the early chick embryo: epithelial-mesenchymal interactions in the specification of the craniofacial ectomesenchyme. Dev Biol. 2000 Dec 1;228(1):73-85. Copyright Reprinted with permission from Elsevier. Copyright © 2000 Academic Press. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205237).
Entry 17 GEISHA Id BMP4.Sakiyama.2000 Data Source Publication Complete cDNA Template Probe show ATGATTCCTGGTAACCGAATGCTGATGGTCATCCTACTATGCCAAGTCCTGCTGGGAGGTACCAACCATGCTAGCCTGA
Citation Sakiyama J, Yokouchi Y, Kuroiwa A. Coordinated expression of Hoxb genes and signaling molecules during development of the chick respiratory tract. Dev Biol. 2000 Nov 1;227(1):12-27. Copyright Reprinted with permission from Elsevier.
Copyright © 2000 Elsevier B.V. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205237).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 20
stage 24
Lung Trunk Mesenchyme 25-30 stage 27
stage 29
Lung 31-34 stage 34
stage 34
Lung
Entry 18 GEISHA Id BMP4.McPherson.2000 Data Source Publication Complete cDNA Template Probe show ATGATTCCTGGTAACCGAATGCTGATGGTCATCCTACTATGCCAAGTCCTGCTGGGAGGTACCAACCATGCTAGCCTGA
Citation McPherson CE, Varley JE, Maxwell GD. Expression and regulation of type I BMP receptors during early avian sympathetic ganglion development. Dev Biol. 2000 May 1;221(1):220-32. Copyright Reprinted with permission from Elsevier.
Copyright © 2000 Elsevier B.V. All rights reserved.
Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205237). The images are quail.
Entry 19 GEISHA Id Bmp4.Bardot.2004 Data Source Publication Complete cDNA Template Probe show CCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGCTCTCC
Citation Bardot B, Lecoin L, Fliniaux I, Huillard E, Marx M, Viallet JP. Drm/Gremlin, a BMP antagonist, defines the interbud region during feather development. Int J Dev Biol. 2004;48(2-3):149-56. Copyright "Reprinted from Int. J. Dev. Biol., 48, Bardot B, Lecoin L, Fliniaux I, Huillard E, Marx M, Viallet JP, Drm/Gremlin, a BMP antagonist, defines the interbud region during feather development, 149-56, Copyright (2004), with permission from Copyright © 2004 UBC Press". All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc #NM_205237).
Entry 20 GEISHA Id Bmp4.Ashique.2002 Data Source Publication Complete cDNA Template Probe show CCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGCTCTCC
Citation Ashique AM, Fu K, Richman JM. Signalling via type IA and type IB bone morphogenetic protein receptors (BMPR) regulates intramembranous bone formation, chondrogenesis and feather formation in the chicken embryo. Int J Dev Biol. 2002 Mar;46(2):243-53. Copyright "Reprinted from Int. J. Dev. Biol., 46, Ashique AM, Fu K, Richman JM, Signalling via type IA and type IB bone morphogenetic protein receptors (BMPR) regulates intramembranous bone formation, chondrogenesis and feather formation in the chicken embryo, 243-53, Copyright (2002), with permission from Copyright © 2002 UBC Press". All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205237).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-30 stage 29
Face Mesenchyme 31-44 stage 44
Head Mesenchyme
Entry 21 GEISHA Id Bmp4.Christ.2002 Data Source Publication Complete cDNA Template Probe show CCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGCTCTCC
Citation Christ B, Brand-Saberi B. Limb muscle development. Int J Dev Biol. 2002;46(7):905-14. Copyright "Reprinted from Int. J. Dev. Biol., 46, Christ B, Brand-Saberi B, Limb muscle development, 905-14, Copyright (2002), with permission from Copyright © 2002 UBC Press". All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc #NM_205237).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 22
Wing 31-44 stage 44
Wing
Entry 22 GEISHA Id Bmp4.Peters.2002 Data Source Publication Complete cDNA Template Probe show ATGATTCCTGGTAACCGAATGCTGATGGTCATCCTACTATGCCAAGTCCTGCTGGGAGGTACCAACCATGCTAGCCTGA
Citation Peters MA, Cepko CL (2002). The dorsal-ventral axis of the neural retina is divided into multiple domains of restricted gene expression which exhibit features of lineage compartments. Dev Biol. 2002 Nov 1;251(1):59-73. Copyright "Reprinted from Developmental Biology, 251(1), Peters MA, Cepko CL, The dorsal-ventral axis of the neural retina is divided into multiple domains of restricted gene expression which exhibit features of lineage compartments, 59-73, Copyright (2002), with permission from Elsevier". Copyright © ( 2002) Elsevier B.V. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205237).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-18 stage 18
Retina 19-24 stage 22
Retina 31-44 stage 44
stage 44
Retina
Entry 23 GEISHA Id Bmp4.Chapman.2008 Data Source Direct Submission Forward cDNA Template Probe show ATGATTCCTGGTAACCGAATGCTGATGGTCATCCTACTATGCCAAGTCCTGCTGGGAGGTACCAACCATGCTAGCCTGA
Comments Images Provided by Susan Chapman
Entry 24 GEISHA Id Bmp4.Holleville.2007 Data Source Publication Complete cDNA Template Probe show CCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGCTCTCC
Citation Holleville N, Matéos S, Bontoux M, Bollerot K, Monsoro-Burq AH. Dlx5 drives Runx2 expression and osteogenic differentiation in developing cranial suture mesenchyme. Dev Biol. 2007 Apr 15;304(2):860-74. Copyright Reprinted with permission from Elsevier.
Copyright © 2007 Elsevier B.V. All rights reserved. Comments According to the authors, the probes were like those from Francis et al., 1994, who said: Antisense RNA probes specific for chicken Bmp-4 (used) nucleotides 1-953 (using Acc# NM_205237.2).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-30 stage 30
stage 30
Face Mesenchyme 31-38 stage 38
stage 38
Face Mesenchyme
Entry 25 GEISHA Id BMP4.Honig.2005 Data Source Publication Complete cDNA Template Probe show CCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGCTCTCC
Citation Honig MG, Camilli SJ, Surineni KM, Knight BK, Hardin HM. The contributions of BMP4, positive guidance cues, and repulsive molecules to cutaneous nerve formation in the chick hindlimb. Dev Biol. 2005 Jun 1;282(1):257-73. Copyright Copyright © 2005 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205237).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 24
Wing Mesenchyme 25-26 stage 26
stage 26
Wing Mesenchyme
Entry 26 GEISHA Id BMP4.Zhang.2001 Data Source Publication Complete cDNA Template Probe show CCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGCTCTCC
Citation Zhang XM, Yang XJ (2001). Temporal and spatial effects of Sonic hedgehog signaling in chick eye morphogenesis. Dev Biol. 2001 May 15;233(2):271-90. Copyright Copyright © 2001 Academic Press. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205237).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-18 stage 14
stage 18
Eye Retina 19-24 stage 22
stage 22
stage 24
stage 24
stage 24
stage 24
Eye Retina
Entry 27 GEISHA Id BMP4.Jin.2001 Data Source Publication Complete cDNA Template Probe show CCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGCTCTCC
Citation Jin EJ, Erickson CA, Takada S, Burrus LW (2001). Wnt and BMP signaling govern lineage segregation of melanocytes in the avian embryo. Dev Biol. 2001 May 1;233(1):22-37. Copyright Copyright © 2001 Academic Press. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205237).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13 stage 13
stage 13
Neural Plate/Tube
Entry 28 GEISHA Id BMP4.Nielsen.2001 Data Source Publication Complete cDNA Template Probe show CCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGCTCTCC
Citation Nielsen C, Murtaugh LC, Chyung JC, Lassar A, Roberts DJ (2001). Gizzard formation and the role of Bapx1. Dev Biol. 2001 Mar 1;231(1):164-74. Copyright Copyright © 2001 Academic Press. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205237).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-30 stage 30
Gizzard Gut
Entry 29 GEISHA Id BMP4.Joubin.1999 Data Source Publication Complete cDNA Template Probe show CCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGCTCTCC
Citation Joubin K, Stern CD. Molecular interactions continuously define the organizer during the cell movements of gastrulation. Cell. 1999 Sep 3;98(5):559-71. Copyright Copyright © 1999 Cell Press. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205237).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4 stage 4
Area Pellucida Epiblast
Entry 30 GEISHA Id BMP4.Streit.1999 Data Source Publication Complete cDNA Template Probe show CCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGCTCTCC
Citation Streit A, Stern CD. Establishment and maintenance of the border of the neural plate in the chick: involvement of FGF and BMP activity. Mech Dev. 1999 Apr;82(1-2):51-66. Copyright Copyright © 1999 Elsevier Science Ireland Ltd. All rights reserved Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205237).
Entry 31 GEISHA Id BMP4.Streit.1998 Data Source Publication Complete cDNA Template Probe show CCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGCTCTCC
Citation Streit A, Lee KJ, Woo I, Roberts C, Jessell TM, Stern CD. Chordin regulates primitive streak development and the stability of induced neural cells, but is not sufficient for neural induction in the chick embryo. Development. 1998 Feb;125(3):507-19. Copyright Printed in Great Britain © The Company of Biologists Limited 1998
DEV4960 Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205237).
Entry 32 GEISHA Id BMP4.McKinnell.2004 Data Source Publication Complete cDNA Template Probe show CCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGCTCTCC
Citation McKinnell IW, Turmaine M, Patel K (2004). Sonic Hedgehog functions by localizing the region of proliferation in early developing feather buds. Dev Biol. 2004 Aug 1;272(1):76-88. Copyright Copyright © 2004 Published by Elsevier Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205237).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-30 stage 30
stage 30
Feathers/Scutae
Entry 33 GEISHA Id BMP4.Nimmagadda.2005 Data Source Publication Complete cDNA Template Probe show CCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGCTCTCC
Citation Nimmagadda S, Geetha Loganathan P, Huang R, Scaal M, Schmidt C, Christ B. (2005) BMP4 and noggin control embryonic blood vessel formation by antagonistic regulation of VEGFR-2 (Quek1) expression. Dev Biol. 2005 Apr 1;280(1):100-10. Copyright Copyright © 2005 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205237).
Entry 34 GEISHA Id BMP4.Holleville.2003 Data Source Publication Complete cDNA Template Probe show CCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGCTCTCC
Citation Holleville N, Quilhac A, Bontoux M, Monsoro-Burq AH. BMP signals regulate Dlx5 during early avian skull development. Dev Biol. 2003 May 1;257(1):177-89. Copyright Copyright © 2003 Elsevier Science (USA) All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205237).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-42 stage 35
stage 42
stage 42
Head Mesenchyme Surface Ectoderm
Entry 35 GEISHA Id BMP4.Basch.2006 Data Source Publication Complete cDNA Template Probe show CCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGCTCTCC
Citation Basch ML, Bronner-Fraser M, García-Castro MI. Specification of the neural crest occurs during gastrulation and requires Pax7. Nature. 2006 May 11;441(7090):218-22. Copyright Copyright © 2006, Nature Publishing Group Comments Insufficient information provided in publication to verify exact sequence to synthesize probe. Sequence below was obtained from NCBI (NM_205237).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4-5 stage 5
stage 5
Early Embryo Neural Plate/Tube
Entry 36 GEISHA Id BMP4.Ezin.2009 Data Source Publication Complete cDNA Template Probe show CCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGCTCTCC
Citation Ezin AM, Fraser SE, Bronner-Fraser M. Fate map and morphogenesis of presumptive neural crest and dorsal neural tube. Dev Biol. 2009 Jun 15;330(2):221-36. Epub 2009 Mar 28. Copyright Copyright © 2009 Published by Elsevier Inc.
Entry 37 GEISHA Id BMP4.Garcia-Castro.2002 Data Source Publication Complete cDNA Template Probe show CCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGCTCTCC
Citation García-Castro MI, Marcelle C, Bronner-Fraser M. Ectodermal Wnt function as a neural crest inducer. Science. 2002 Aug 2;297(5582):848-51. Copyright Copyright © 2002, The American Association for the Advancement of Science Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_205237.2).
Entry 38 GEISHA Id BMP4.Trimarchi.2009 Data Source Publication Complete cDNA Template Probe show ATGATTCCTGGTAACCGAATGCTGATGGTCATCCTACTATGCCAAGTCCTGCTGGGAGGTACCAACCATGCTAGCCTGA
Citation Trimarchi JM, Cho SH, Cepko CL. Identification of genes expressed preferentially in the developing peripheral margin of the optic cup. Dev Dyn. 2009 Sep;238(9):2327-9. Copyright Dev. Dyn Copyright © 2009 John Wiley & Sons, Inc. All Rights Reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_205237.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 23
stage 23
Retina 25-30 stage 29
Retina 31-34 stage 34
Retina
Entry 39 GEISHA Id BMP4.Selleck.1998 Data Source Publication Complete cDNA Template Probe show CTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGC
Citation Selleck MA, García-Castro MI, Artinger KB, Bronner-Fraser M., Effects of Shh and Noggin on neural crest formation demonstrate that BMP is required in the neural tube but not ectoderm. Development. 1998 Dec;125(24):4919-30. Copyright Published by The Company of Biologists 2007. This material is protected by a copyright retained by the authors. Permission granted by Dr. Bronner Fraser. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_205237).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-10 stage 10
stage 10
Neural Plate/Tube
Entry 40 GEISHA Id BMP4.Sanchez-Calderon.2004 Data Source Publication Complete cDNA Template Probe show CCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGCTCTCC
Citation Sánchez-Calderón H, Martín-Partido G, Hidalgo-Sánchez M. Otx2, Gbx2, and Fgf8 expression patterns in the chick developing inner ear and their possible roles in otic specification and early innervation. Gene Expr Patterns. 2004 Oct;4(6):659-69. Copyright Reprinted with permission from Elsevier. Copyright © 2004 Elsevier B.V. All rights reserved.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 24
stage 24
stage 24
stage 24
stage 24
stage 24
stage 24
stage 24
stage 24
stage 24
stage 24
stage 24
Ear/Otic Placode 25-27 stage 27
stage 27
stage 27
Ear/Otic Placode
Entry 41 GEISHA Id BMP4.Smith.2000 Data Source Publication Complete cDNA Template Probe show CCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGCTCTCC
Citation Smith DM, Grasty RC, Theodosiou NA, Tabin CJ, Nascone-Yoder NM. Evolutionary relationships between the amphibian, avian, and mammalian stomachs. Evol Dev. 2000 Nov-Dec;2(6):348-59. Copyright Copyright © 2000-2011 by John Wiley & Sons, Inc., or related companies. All rights reserved. Comments As insufficient information is provided in publication to verify exact sequence used to suntheisze probe, the sequence below was obtained from NCBI (acc. # NM_205237)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 24
stage 24
Midgut Stomach
Entry 42 GEISHA Id BMP4.Sanchez-Guardado.2011 Data Source Publication Complete cDNA Template Probe show CCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGCTCTCC
Citation Sánchez-Guardado LÓ, Ferran JL, Rodríguez-Gallardo L, Puelles L, Hidalgo-Sánchez M.
Meis gene expression patterns in the developing chicken inner ear. J Comp Neurol. 2011 Jan 1;519(1):125-47.
Copyright © 2010 Wiley-Liss, Inc. Comments The sequence below was obtained from NCBI (acc. #: NM_205237) using the information provided in the publication.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 20
stage 20
stage 20
stage 24
stage 24
stage 24
stage 24
stage 24
stage 24
stage 24
stage 24
stage 24
stage 24
stage 24
stage 24
Ear/Otic Placode Unlabeled 25-27 stage 27
stage 27
stage 27
stage 27
stage 27
stage 27
stage 27
stage 27
stage 27
stage 27
stage 27
Ear/Otic Placode
Entry 43 GEISHA Id BMP4.Fuchs.2010 Data Source Publication Complete cDNA Template Probe show CCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGCTCTCC
Citation Fuchs A, Inthal A, Herrmann D, Cheng S, Nakatomi M, Peters H, Neubüser A. Regulation of Tbx22 during facial and palatal development. Dev Dyn. 2010 Nov;239(11):2860-74.
Copyright © 2010 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_205237).
Entry 44 GEISHA Id BMP4.Parkinson.2010 Data Source Publication Complete cDNA Template Probe show CCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGCTCTCC
Citation Parkinson N, Collins MM, Dufresne L, Ryan AK. Expression patterns of hormones, signaling molecules, and transcription factors during adenohypophysis development in the chick embryo. Dev Dyn. 2010 Apr;239(4):1197-210. Copyright Copyright © 2010 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_205237.2).
Entry 45 GEISHA Id BMP4.Halilagic.2007 Data Source Publication Complete cDNA Template Probe show CCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGCTCTCC
Citation Halilagic A, Ribes V, Ghyselinck NB, Zile MH, Dollé P, Studer M. Retinoids control anterior and dorsal properties in the developing forebrain. Dev Bio 2007 Mar 1;303(1):244-58 Copyright Reprinted with permission from Elsevier.
Copyright © 2007 Elsevier B.V. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_205237.2). Images are quail, but sequence and map shown are chick.
Entry 46 GEISHA Id BMP4.Maier.2010 Data Source Publication Complete cDNA Template Probe show ATGATTCCTGGTAACCGAATGCTGATGGTCATCCTACTATGCCAAGTCCTGCTGGGAGGTACCAACCATGCTAGCCTGA
Citation Maier, E, von Hofsten, J, Nord, H, Fernandes, M, Paek, H, Hebert, JM, Gunhaga, L, Opposing Fgf and Bmp activities regulate the specification of olfactory sensory and respiratory epithelial cell fates. Development. 2010 May 15; 137(10): 16011611. Copyright Copyright © 2010. Held by the authors. Requested Comments Accession number listed has been removed byNCBI. As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_205237.1).
Entry 47 GEISHA Id BMP4.Bothe.2011 Data Source Publication Complete cDNA Template Probe show CTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGC
Citation Bothe I, Tenin G, Oseni A, Dietrich S., Dynamic control of head mesoderm patterning., Development. 2011 Jul;138(13):2807-21. Copyright Permission from the authors and the Company of Biologists Ltd. Copyright held by the authors. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_205237 ).
Entry 48 GEISHA Id BMP4.Carré.2011 Data Source Publication Complete cDNA Template Probe show CTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGC
Citation Carré GA, Couty I, Hennequet-Antier C, Govoroun MS. Gene expression profiling reveals new potential players of gonad differentiation in the chicken embryo. PLoS One. 2011;6(9):e23959. Epub 2011 Sep 9. Copyright Creative Commons: http://creativecommons.org/licenses/by/2.5/ Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_205237.3 ).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-36 stage 36
stage 36
stage 36
stage 36
Gonad
Entry 49 GEISHA Id BMP4.Huber.2008 Data Source Publication Complete cDNA Template Probe show CTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGC
Citation Huber K, Franke A, Brühl B, Krispin S, Ernsberger U, Schober A, von Bohlen und Halbach O, Rohrer H, Kalcheim C, Unsicker K. Persistent expression of BMP-4 in embryonic chick adrenal cortical cells and its role in chromaffin cell development. Neural Dev. 2008 Oct 22;3:28. Copyright © 2008 Huber et al; licensee BioMed Central Ltd. (requested from Dr. Unsicker) Comments The probe was amplified by PCR using the following primers:
5'AGGAGCTTCCACCATGAAGA3' and 5'CGGCTAATCCTGACGTGTTT3' and was extracted from NCBI Acc# NM_205237.3.
Entry 50 GEISHA Id BMP4.Grevellec.2011 Data Source Publication Complete cDNA Template Probe show CTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGC
Citation Grevellec A, Graham A, Tucker AS. Shh signalling restricts the expression of Gcm2 and controls the position of the developing parathyroids. Dev Biol. 2011 May 15;353(2):194-205. Epub 2011 Feb 22. Copyright Copyright © 2011 Elsevier Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence was obtained from NCBI (acc # NM_205237.3).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 22
stage 22
stage 24
stage 24
Pharyngeal Arches and Clefts
Entry 51 GEISHA Id BMP4.LeDréau.2012 Data Source Publication Complete cDNA Template Probe show CTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGC
Citation Le Dréau G, Garcia-Campmany L, Rabadán MA, Ferronha T, Tozer S, Briscoe J, Martí E. Canonical BMP7 activity is required for the generation of discrete neuronal populations in the dorsal spinal cord. Development. 2012 Jan;139(2):259-68. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_205237.3).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-18 stage 14
stage 14
stage 18
Neural Plate/Tube 19-24 stage 24
Neural Plate/Tube
Entry 52 GEISHA Id BMP4.Stuhlmiller.2012 Data Source Publication Complete cDNA Template Probe show CTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGC
Citation Stuhlmiller TJ, García-Castro MI. FGF/MAPK signaling is required in the gastrula epiblast for avian neural crest induction. Development. 2012 Jan;139(2):289-300. Copyright © 2012. Published by The Company of Biologists Ltd Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_205237.3).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4-5 stage 5
stage 5
Epiblast Primitive Streak
Entry 53 GEISHA Id BMP4.Battisti.2008 Data Source Publication Complete cDNA Template Probe show CTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGC
Citation Battisti AC, Fekete DM. Slits and Robos in the developing chicken inner ear. Dev Dyn. 2008 Feb;237(2):476-84. Copyright Copyright © 2008 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_205237.3).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 23
stage 23
Ear/Otic Placode 25-27 stage 27
Ear/Otic Placode
Entry 54 GEISHA Id BMP4.Brito.2006 Data Source Publication Complete cDNA Template Probe show CTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGC
Citation José M. Brito, Marie-Aimée Teillet, Nicole M. Le Douarin. An early role for Sonic hedgehog from foregut endoderm in jaw development: Ensuring neural crest cell survival. Proc Natl Acad Sci U S A. 2006 August 1; 103(31): 1160711612. Copyright Copyright © 2006 by The National Academy of Sciences of the USA
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-21 stage 21
stage 21
Ectoderm Oral Pharynx
Entry 55 GEISHA Id BMP4.Gamer.2008 Data Source Publication Complete cDNA Template Probe show CTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGC
Citation Gamer LW, Ho V, Cox K, Rosen V.. Expression and Function of BMP3 During Chick Limb Development. Dev Dyn. 2008 June; 237(6): 16911698. Copyright Copyright © 2008 Wiley-Liss, Inc. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_205237.3).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 24
stage 24
Leg AER
Entry 56 GEISHA Id BMP4.Ishii.2010 Data Source Publication Complete cDNA Template Probe show CTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGC
Citation Ishii Y, Garriock RJ, Navetta AM, Coughlin LE, Mikawa T.. BMP Signals Promote Proepicardial Protrusion Necessary for Recruitment of Coronary Vessel and Epicardial Progenitors to the Heart. Dev Cell. 2010 August 17; 19(2): 307316. Copyright Copyright © 2010 Elsevier Inc. All rights reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_205237.3 ).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-17 stage 17
stage 17
Unlabeled
Entry 57 GEISHA Id BMP4.AhnfeltRonne.2010 Data Source Publication Complete cDNA Template Probe show CTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGC
Citation Jonas Ahnfelt-Rønne, Philippe Ravassard, Corinne Pardanaud-Glavieux, Raphaél Scharfmann, Palle Serup. Mesenchymal Bone Morphogenetic Protein Signaling Is Required for Normal Pancreas Development. Diabetes. 2010 August; 59(8): 19481956. Copyright Copyright © 2010 by the American Diabetes Association. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_205237.3 ).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-18 stage 18
stage 18
stage 18
Pancreas Stomach
Entry 58 GEISHA Id BMP4.Houghton.2005 Data Source Publication Complete cDNA Template Probe show CTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGC
Citation Houghton L, Lindon C, Morgan BA. The ectodysplasin pathway in feather tract development. Development. 2005 Mar;132(5):863-72. Epub 2005 Jan 26. Copyright copyright is held by the authors. Published by the Company of Biologists Ltd. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_205237.3 ).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-34 stage 31
stage 31
stage 34
stage 34
Feathers/Scutae
Entry 59 GEISHA Id BMP4.Chang.2004 Data Source Publication Complete cDNA Template Probe show CTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGC
Citation Chang W, Brigande JV, Fekete DM, Wu DK. The development of semicircular canals in the inner ear: role of FGFs in sensory cristae. Development. 2004 Sep;131(18):4425-34. Epub 2004 Aug 11. Copyright Copyright is held by the authors. Published by the Company of Biologists Ltd. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_205237.3 ).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-21 stage 21
stage 21
Ear/Otic Placode
Entry 60 GEISHA Id BMP4.Wood.2010 Data Source Publication Complete cDNA Template Probe show CTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGC
Citation Wood JL, Hughes AJ, Mercer KJ, Chapman SC. Analysis of chick (Gallus gallus) middle ear columella formation. BMC Dev Biol. 2010; 10: 16. Published online 2010 February 16. Copyright Copyright ©2010 Wood et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_205237.3 ).
Entry 61 GEISHA Id BMP4.Daudet.2007 Data Source Publication Complete cDNA Template Probe show CTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGC
Citation Daudet N, Ariza-McNaughton L, Lewis J. Notch signalling is needed to maintain, but not to initiate, the formation of prosensory patches in the chick inner ear. Development. 2007 Jun;134(12):2369-78. Copyright Copyright 2007 the authors. Published by the Company of Biologists Ltd. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_205237.3 ).
Entry 62 GEISHA Id BMP4.Katsu.2012 Data Source Publication Complete cDNA Template Probe show CTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGC
Citation Katsu K, Tokumori D, Tatsumi N, Suzuki A, Yokouchi Y. BMP inhibition by DAN in Hensen's node is a critical step for the establishment of left-right asymmetry in the chick embryo. Dev Biol. 2012 Mar 1;363(1):15-26. Copyright Copyright © 2012. Published by Elsevier Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # NM_205237.3).
Entry 63 GEISHA Id BMP4.Wade.2012 Data Source Publication Complete cDNA Template Probe show CTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGC
Citation Wade C, Brinas I, Welfare M, Wicking C, Farlie PG.
Twist2 contributes to termination of limb bud outgrowth and patterning through direct regulation of Grem1. Dev Biol. 2012 Oct 1;370(1):145-53.
Copyright Copyright © 2012 Elsevier Inc. All rights reserved Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_205237.3).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25 stage 25
stage 25
stage 25
Leg
Entry 64 GEISHA Id BMP4.Mercader.2000 Data Source Publication Complete cDNA Template Probe show CTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGC
Citation Mercader N, Leonardo E, Piedra ME, Martínez-A C, Ros MA, Torres M. Opposing RA and FGF signals control proximodistal vertebrate limb development through regulation of Meis genes. Development. 2000 Sep;127(18):3961-70.
Copyright © The Company of Biologists Limited 2000 Comments According to the authors, "Riboprobes cBmp2, cBmp4 and cBmp7 were kindly provided by C. Tabin and B. Houston." As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence was obtained from NCBI (acc# NM_205237.3).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-22 stage 22
stage 22
Limb Buds
Entry 65 GEISHA Id BMP4.Pernaute.2010 Data Source Publication Complete cDNA Template Probe show CTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGC
Citation Pernaute B, Cañon S, Crespo M, Fernandez-Tresguerres B, Rayon T, Manzanares M. Comparison of extraembryonic expression of Eomes and Cdx2 in pregastrulation chick and mouse embryo unveils regulatory changes along evolution. Dev Dyn. 2010 Feb;239(2):620-9. doi: 10.1002/dvdy.22176.
Copyright Copyright © 2009 Wiley-Liss, Inc. Comments According to the authors, "The probe for chick Bmp4 was a gift from Dr. J.J. Sanz-Ezquerro". As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence was obtained from NCBI (acc# NM_205237.3).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) X-XIV stage XI
Unlabeled 1-3 stage 1
4 stage 4
Epiblast
Entry 66 GEISHA Id BMP4.Sánchez-Guardado.2009 Data Source Publication Complete cDNA Template Probe show CTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGC
Citation Sánchez-Guardado LO, Ferran JL, Mijares J, Puelles L, Rodríguez-Gallardo L, Hidalgo-Sánchez M. Raldh3 gene expression pattern in the developing chicken inner ear. J Comp Neurol. 2009 May 1;514(1):49-65. doi: 10.1002/cne.21984. Copyright Copyright © 19992013 John Wiley & Sons, Inc. All Rights Reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_205237.3
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 21
stage 21
stage 24
stage 24
stage 24
Ear/Otic Placode 25-27 stage 27
stage 27
stage 27
Ear/Otic Placode
Entry 67 GEISHA Id BMP4.BrennerAnantharam.2007 Data Source Publication Complete cDNA Template Probe show CTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGC
Citation Brenner-Anantharam A, Cebrian C, Guillaume R, Hurtado R, Sun TT, Herzlinger D. Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling. Development. 2007 May;134(10):1967-75. Epub 2007 Apr 18. Copyright Copyright held by the authors. Published by the Company of Biologists Ltd. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_205237.3
Entry 68 GEISHA Id BMP4.Tzahor.2003 Data Source Publication Complete cDNA Template Probe show CTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGC
Citation Tzahor E, Kempf H, Mootoosamy RC, Poon AC, Abzhanov A, Tabin CJ, Dietrich S, Lassar AB. Antagonists of Wnt and BMP signaling promote the formation of vertebrate head muscle. Genes Dev. 2003 Dec 15;17(24):3087-99. Comments As insufficient information is provided in publication to verify the exact sequence used to synthesize probe, the sequence was obtained from NCBI (acc #NM_205237.3).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-17 stage 17
stage 17
stage 17
Pharyngeal Arches and Clefts
Entry 69 GEISHA Id BMP4.Zou.1997 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show ATGATTCCTGGTAACCGAATGCTGATGGTCATCCTACTATGCCAAGTCCTGCTGGGAGGTACCAACCATGCTAGCCTGA
Citation Zou H, Wieser R, Massagué J, Niswander L. Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage. Genes Dev 1997 Sep 1;11(17):2191-203. Copyright Copyright © 1997, Cold Spring Harbor Laboratory Press Comments The complete cDNA template sequence was obtained from the information provided in the publication as described in Zou et al. 1997.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-44 stage 31
stage 44
Leg Bones
Entry 70 GEISHA Id Bmp4.Abzhanov.2004 Data Source Publication Complete cDNA Template Probe show CTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGC
Citation Abzhanov A, Tabin CJ. Shh and Fgf8 act synergistically to drive cartilage outgrowth during cranial development. Dev Biol 2004 Sep 1;273(1):134-48. Copyright Copyright © 2004 Elsevier Inc. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence above was obtained from NCBI (acc # NM_205237).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-36 stage 36
stage 36
stage 36
Face Mesenchyme
Entry 71 GEISHA Id BMP4.Zou.1996 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show ATGATTCCTGGTAACCGAATGCTGATGGTCATCCTACTATGCCAAGTCCTGCTGGGAGGTACCAACCATGCTAGCCTGA
Comments The sequence below was obtained from NCBI (Acc # NM_205237.3 ) using the information provided in the publication as described in Zou et al.
Entry 72 GEISHA Id BMP4.Li.2004 Data Source Publication Complete cDNA Template Probe show CTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGC
Citation Li H, Liu H, Sage C, Huang M, Chen ZY, Heller S. Islet-1 expression in the developing chicken inner ear. J Comp Neurol. 2004 Sep 6;477(1):1-10 Copyright Copyright © 1999 - 2018 John Wiley & Sons, Inc. All Rights Reserved Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # NM_205237.3).
Entry 73 GEISHA Id BMP‐4.Belecky-Adams.2001 Data Source Publication Complete cDNA Template Probe show CTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGC
Citation Belecky-Adams T, Adler R. Developmental expression patterns of bone morphogenetic proteins, receptors, and binding proteins in the chick retina. J Comp Neurol. 2001 Feb 19;430(4):562-72. Copyright Copyright © 2001 Wiley‐Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205237.3).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-18 stage 18
stage 18
Retina 31-44 stage 44
Entry 74 GEISHA Id Bmp‐4.Barlow.1999 Data Source Publication Complete cDNA Template Probe show CTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGC
Citation Barlow AJ, Bogardi JP, Ladher R, Francis-West PH. Expression of chick Barx-1 and its differential regulation by FGF-8 and BMP signaling in the maxillary primordia. Dev Dyn. 1999 Apr;214(4):291-302. Copyright Copyright © 1999 Wiley‐Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205237).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 23
Ectoderm 31-44 stage 44
Entry 75 GEISHA Id BMP4.Kiernan.1997 Data Source Publication Complete cDNA Template Probe show CTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGC
Citation Kiernan AE, Nunes F, Wu DK, Fekete DM. The expression domain of two related homeobox genes defines a compartment in the chicken inner ear that may be involved in semicircular canal formation. Dev Biol. 1997 Nov 15;191(2):215-29. Copyright Copyright q 1997 by Academic Press. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205237).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 19
stage 19
stage 23
stage 23
stage 24
Ear/Otic Placode 25-30 stage 30
Ear/Otic Placode 31-44 stage 44
stage 44
stage 44
Entry 76 GEISHA Id BMP4.Sela-Donenfeld.2002 Data Source Publication Complete cDNA Template Probe show CTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGC
Citation Sela-Donenfeld D, Kalcheim C. Localized BMP4-noggin interactions generate the dynamic patterning of noggin expression in somites. Dev Biol. 2002 Jun 15;246(2):311-28. Copyright Copyright © 2002 Elsevier Science (USA). Comments The complete cDNA template sequence was obtained from the information in the publication as described in Sela-Donenfeld et al. 2002.
Entry 77 GEISHA Id BMP4.Anderson.2020 Data Source Direct Submission Complete cDNA Template Probe show CTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGC
Comments Images provided by Claire Anderson. As insufficient information was provided to verify exact sequence used to synthesize probe, the sequence above was obtained from NCBI (accession number NM_205237.3).
Entry 78 GEISHA Id BMP4.Liem.1995 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show CTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCTGGC
Citation Liem Jr., K.F, Tremml G, Roelink H, Jessell T.M. Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm. Cell. 1995; 82: 969-979. Comments As insufficient information was provided to verify exact sequence used to synthesize probe, the sequence above was obtained from NCBI (accession number NM_205237.3).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-10 stage 10
stage 10
stage 10
stage 10
Ectoderm Neural Plate/Tube all
Entry 79 GEISHA Id BMP4.Brown.2005 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show GCACTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCT
Citation Stephen T Brown 1, Juemei Wang, Andrew K Groves. Dlx gene expression during chick inner ear development. J Comp Neurol. 2005 Feb 28;483(1):48-65.0 Copyright © 2005 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence was obtained from NCBI accession number: NM_205237.4.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-30 stage 30
stage 30
stage 30
Ear/Otic Placode all
Entry 80 GEISHA Id BMP4.Anderson.2019 Data Source Publication Complete cDNA Template Probe show GCACTGCGCCCGGGCGGCGATCGCGGGAGGCGCTCGGCAGCCGCTGCCCCGGAGGCTTTCGGCGCGCTGGGTCCGCGCT
Citation Anderson C, Hill B, Lu HC, Moverley A, Yang Y, Oliveira NMM, Baldock RA, Stern CD. A 3D molecular atlas of the chick embryonic heart. Dev Biol. 2019 Dec 1;456(1):40-46. doi: 10.1016/j.ydbio.2019.07.003. Epub 2019 Jul 5. Copyright Copyright © 2019 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205237).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-12 stage 12
stage 12
Heart
Data from NCBI Unigene EST ProfileGga.686
Mouse Frog Fruit Fly Zebra Finch Zebrafish
