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Gene Family QuickSearch
Human Disease Gene Search
VSX2 The human orthologue of this gene is associated
Gene Summary Expression Transcript Levels Other Species Expression JBrowse Gene Official Symbol VSX2 Official Full Name visual system homeobox 2 CGNC ID 7768 also known as CHX10, visual system homeobox 2|ceh-10 homeo domain containing homolog|ceh-10 homeodomain containing homolog|homeobox protein Chx10, VSX2, Homeobox protein Chx10, Ceh-10 homeodomain-containing homolog gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Molecular Function sequence-specific DNA binding , sequence-specific DNA binding transcription factor activity Biological Process cell fate commitment , negative regulation of cell proliferation , more... positive regulation of cell proliferation , positive regulation of transcription from RNA polymerase II promoter , response to stimulus , retinal bipolar neuron differentiation , transcription, DNA-templated , visual perception Cellular Component cytoplasm , nucleolus
Links to other databases
Entry 1 GEISHA Id VSX2.UApcr Data Source GEISHA ISH Analysis Forward cDNA Template Primer CGGAAAAAGGGGAGGAAGTG Reverse cDNA Template Primer AATTAACCCTCACTAAAGTAGAAGGGCAATGTCAGCACGG cDNA Template Length 939 Forward cDNA Template Probe show CCGAGCTGTGAATACAGCGGGTTTGGCTGCATGGGTCTGCGTGCACACATGGGGTCAGTGATGACACGTATGTACACAT
Entry 2 GEISHA Id Chx10.Tomonari.2007 Data Source Publication Complete cDNA Template Probe show GCCGCAGCATGACGGGCAAAGCGGGCGCGGCGCTGGCCCCCAGCCTGCCTGGCAAGCCCAAGCCCGACGGCGCGGCCGC
Citation Tomonari S, Takagi A, Noji S, Ohuchi H. Expression pattern of the melanopsin-like (cOpn4m) and VA opsin-like genes in the developing chicken retina and neural tissues. Gene Expr Patterns. 2007 Aug;7(7):746-53. Epub 2007 Jun 13. Copyright "Reprinted from Gene Expression Patterns, Volume number 7, Tomonari S, Takagi A, Noji S, Ohuchi H, Expression pattern of the melanopsin-like (cOpn4m) and VA opsin-like genes in the developing chicken retina and neural tissues.,746-53, Copyright (2007), with permission from Elsevier".
Copyright © (2007) Elsevier B.V. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_204768).
Entry 3 GEISHA Id Chx10.Canto-Soler.2006 Data Source Publication Complete cDNA Template Probe show GCCGCAGCATGACGGGCAAAGCGGGCGCGGCGCTGGCCCCCAGCCTGCCTGGCAAGCCCAAGCCCGACGGCGCGGCCGC
Citation Canto-Soler MV, Adler R. Optic cup and lens development requires Pax6 expression in the early optic vesicle during a narrow time window. Dev Biol. 2006 Jun 1;294(1):119-32. Epub 2006 Mar 27. Copyright Reprinted from Developmental Biology, 294, Issue 1, M. Valeria Canto-Soler and Ruben Adler, Optic cup and lens development requires Pax6 expression in the early optic vesicle during a narrow time window, 119-132, 2006, with permission from Elsevier.
Copyright © 2006 Elsevier B.V. All rights Comments Probes were generated from cDNAs generously provided by the following investigators: Chx10 (Olof Sundin, Johns Hopkins University, Baltimore, MD). As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # AF178671).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-12 stage 11
Retina 13-18 stage 18
Retina
Entry 4 GEISHA Id CHX10.Agarwala.2005 Data Source Publication Complete cDNA Template Probe show GCCGCAGCATGACGGGCAAAGCGGGCGCGGCGCTGGCCCCCAGCCTGCCTGGCAAGCCCAAGCCCGACGGCGCGGCCGC
Citation Agarwala S, Aglyamova GV, Marma AK, Fallon JF, Ragsdale CW. Differential susceptibility of midbrain and spinal cord patterning to floor plate defects in the talpid2 mutant. Dev Biol. 2005 Dec 1;288(1):206-20. Epub 2005 Oct 21. Copyright Copyright © 2005 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204768).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-26 stage 26
Spinal Cord
Entry 5 GEISHA Id CHX10.Plouhinec.2005 Data Source Publication Complete cDNA Template Probe show GCCGCAGCATGACGGGCAAAGCGGGCGCGGCGCTGGCCCCCAGCCTGCCTGGCAAGCCCAAGCCCGACGGCGCGGCCGC
Citation Plouhinec JL, Leconte L, Sauka-Spengler T, Bovolenta P, Mazan S, Saule S (2005). Comparative analysis of gnathostome Otx gene expression patterns in the developing eye: implications for the functional evolution of the multigene family. Dev Biol. 2005 Feb 15;278(2):560-75. Copyright Copyright © 2004 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204768).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-44 stage 37
stage 40
stage 44
stage 44
Retina
Entry 6 GEISHA Id CHX10.Hyre.2003 Data Source Publication Complete cDNA Template Probe show GCCGCAGCATGACGGGCAAAGCGGGCGCGGCGCTGGCCCCCAGCCTGCCTGGCAAGCCCAAGCCCGACGGCGCGGCCGC
Citation Hyer J, Kuhlman J, Afif E, Mikawa T. Optic cup morphogenesis requires pre-lens ectoderm but not lens differentiation. Dev Biol. 2003 Jul 15;259(2):351-63. Copyright Copyright © 2003 Elsevier Science (USA) All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204768).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13 stage 13
Eye Retina
Entry 7 GEISHA Id CHX10.Ma.2008 Data Source Publication Complete cDNA Template Probe show GCCGCAGCATGACGGGCAAAGCGGGCGCGGCGCTGGCCCCCAGCCTGCCTGGCAAGCCCAAGCCCGACGGCGCGGCCGC
Citation Ma W, Yan RT, Mao W, Wang SZ. Neurogenin3 promotes early retinal neurogenesis. Mol Cell Neurosci. 2009 Feb;40(2):187-98. Epub 2008 Nov 6. Copyright Copyright © 2008 Elsevier Inc. All rights reserved. Comments As insufficient information is provided in the publication to verify the exact sequence used to synthesize the probe, the sequence below was obtained from NCBI (acc #NM_204768).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-32 stage 32
stage 32
stage 32
Retina
Entry 8 GEISHA Id CHX10.Li.2008 Data Source Publication Complete cDNA Template Probe show GGCCCTGGTTTCTTCACGTGGGGCTACCCCAAGGGTACCCCAGGCTACCCCAGCCTGCTCCCCTGAAGCGCAGCCTGTA
Citation Li X, Glubrecht DD, Mita R, Godbout R. Expression of AP-2delta in the developing chick retina. Dev Dyn. 2008 Nov;237(11):3210-21. Copyright Copyright © 2008 Wiley-Liss, Inc. Comments The probe was amplified by PCR using the following primers:
5' -GGCCCTGGTTTCTTCACGTG-3' and 5' -TACAGCTCCATATCTCAAACAC-
3' and was extracted from NCBI Acc#AF178671.1
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-30 stage 26
Retina 31-41 stage 31
stage 37
stage 41
stage 41
Retina
Entry 9 GEISHA Id CHX10.BeleckyAdams.1997 Data Source Publication Complete cDNA Template Probe show GCCGCAGCATGACGGGCAAAGCGGGCGCGGCGCTGGCCCCCAGCCTGCCTGGCAAGCCCAAGCCCGACGGCGCGGCCGC
Citation Belecky-Adams T, Tomarev S, Li HS, Ploder L, McInnes RR, Sundin O, Adler R. Pax-6, Prox 1, and Chx10 homeobox gene expression correlates with phenotypic fate of retinal precursor cells. Invest Ophthalmol Vis Sci. 1997 Jun;38(7):1293-303. Copyright Copyright Association for Research in Vision and Ophthalmology Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #AF178671.1 ).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 23
Retina 25-30 stage 26
Retina 31-44 stage 34
stage 41
stage 41
stage 44
stage 44
Retina
Entry 10 GEISHA Id CHX10.Tsukiji.2009 Data Source Publication Complete cDNA Template Probe show GAGAAGTCCAGTGCATCACAGAAAGAGGAGAAGCTGATCTAGGGGGACAGAGGCTGCGGAAGCCAGCCCTGACAGATAC
Citation Tsukiji N, Nishihara D, Yajima I, Takeda K, Shibahara S, Yamamoto H. Mitf functions as an in ovo regulator for cell differentiation and proliferation during development of the chick RPE. Dev Biol. 2009 Feb 15;326(2):335-46. doi: 10.1016/j.ydbio.2008.11.029. Epub 2008 Dec 7. Copyright Copyright © 2013 Elsevier B.V. All rights reserved. Comments The probe was amplified by PCR using the following primers:
5'- GAGAAGTCCAGTGCATCACAGAAAG -3' and 5'-TACACAGCGTGGGCTATAATCTAAC -3' and was extracted from NCBI Acc# NM_204768.1.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-22 stage 22
stage 22
stage 22
Retina
Entry 11 GEISHA Id CHX10.Hirashima.2008 Data Source Publication Complete cDNA Template Probe show GCCGCAGCATGACGGGCAAAGCGGGCGCGGCGCTGGCCCCCAGCCTGCCTGGCAAGCCCAAGCCCGACGGCGCGGCCGC
Citation Hirashima M, Kobayashi T, Uchikawa M, Kondoh H, Araki M. Anteroventrally localized activity in the optic vesicle plays a crucial role in the optic development. Dev Biol. 2008 May 15;317(2):620-31. doi: 10.1016/j.ydbio.2008.03.010. Epub 2008 Mar 20. Copyright Copyright © 2008 Elsevier Inc. All rights reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_204768.1
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-11 stage 11
stage 11
Eye
Data from NCBI Unigene EST ProfileGga.289
Mouse Frog Fruit Fly Zebra Finch Zebrafish
