GEISHA - A Chicken Embryo Gene Expression Database
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_

CTSD
cathepsin D

The human orthologue of this gene is associated
with the following human disease:
Gene
Official SymbolCTSD
Official Full Namecathepsin D
CGNC ID4989
also known ascathepsin D|cathepsin D (lysosomal aspartyl peptidase)|cathepsin D (lysosomal aspartyl protease)|prepro-cathepsin D, prepro-CD, Cathepsin D precursor , Cathepsin D light chain; Cathepsin D heavy chain
gene typeprotein-coding
Genomic Map
 Ensembl
NCBI
UCSC
Gallus-Browse
Sequence Information
Genomic
RNANM_205177
PolypeptideNP_990508
Sequence Clusters/ESTsUnigene
Gene Expression
In Situ HybridizationGEISHA
EST ProfileGga.1094
Orthology
Entrez GeneEnsembl GeneGenetic PhenotypesMOD
Fruit Fly45268FBgn0029093
Human1509ENSG00000117984MIM:610127MIM:116840
Mouse13033ENSMUSG00000007891All phenotypic alleles (3):Targeted, knock-out(2) Targeted, other(1) MGI:88562
Xenopus394561, 4437215906944
Zebrafish65225ENSDARG00000057698ZDB-GENE-010131-8ZFIN:ZDB-GENE-010131-8
Gene Ontology
Molecular Functionaspartic-type endopeptidase activity
Biological Processproteolysis
Cellular Componentextracellular matrix, extracellular space, lysosome
Links to other databases
Entrez Gene396090
Ensembl GeneENSGALG00000006613
KEGGgga:396090

Entry 1

GEISHA IdCTSD.UApcrData SourceGEISHA ISH Analysis
Forward cDNA Template Primer5’-CATCTTGGGCATGGCATTCC-3’
Reverse cDNA Template Primer5’-AATTAACCCTCACTAAAGGGGCGCTTAGACACATTTGGC-3’cDNA Template Length648
Complete cDNA Template Probeshow
CATCTTGGGCATGGCATTCCCAAGAATCTCTGTGGACAAGGTCACACCTTTCTTTGATAATGTCATGCAGCAGAAGCTG
ATTGAGAAAAACATCTTCTCCTTCTACCTGAACAGGGATCCCACAGCTCAGCCAGGCGGTGAGCTGCTGCTTGGGGGGA
CTGACCCCAAATACTACAGTGGTGACTTCAGCTGGGTGAATGTCACACGCAAAGCCTACTGGCAGGTCCACATGGACTC
GGTGGATGTTGCCAATGGGCTGACTCTTTGCAAAGGGGGCTGCGAGGCCATTGTGGACACAGGCACTTCCCTCATCACT
GGCCCCACCAAGGAAGTGAAGGAGCTGCAAACAGCCATTGGTGCAAAACCACTCATCAAAGGCCAGTACGTGATCTCCT
GTGATAAGATCTCGTCTCTGCCTGTTGTCACACTCATGCTAGGTGGGAAGCCCTACCAGCTCACTGGGGAGCAATACGT
CTTCAAGGTTTCTGCACAAGGAGAAACCATCTGCCTGAGTGGGTTTTCTGGCCTGGATGTCCCACCACCTGGAGGCCCA
CTCTGGATCCTGGGAGATGTCTTCATTGGCCCCTACTACACTGTCTTTGACCGTGATAACGACTCTGTTGGTTTCGCCA
AATGTGTCTAAGCGCC
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
1-3
stage 3
Area Opaca
Early Endoderm
Epiblast
Primitive Streak
 
7-12
stage 8
stage 9
stage 11
Anterior Intestinal Portal
Extraembryonic Mesoderm
Head Mesenchyme
Intermediate Mesoderm
Mesoderm
Neural Plate/Tube
Primitive Streak
Somites
Ventricles
extraembryonic ectoderm
extraembryonic endoderm
 
13-18
stage 17
Widespread Expression
 
19-24
stage 19
Widespread Expression
 
25-26
stage 26
stage 26
stage 26
stage 26
stage 26
Widespread Expression
 

Entry 2

GEISHA IdCathepsinD.Zuzarte-Luis.2007bData SourcePublication
Complete cDNA Template Probeshow
TTCTGCGCTTCTGCTTTAGGGGGTGTAGTGCGTTGTAAGCGTTCCGCCGCTATGGCGCCCCGCGGCCTTCTCGTCCTGC
TGCTCCTCGCCCTGGTGGGGCCCTGCGCGGCACTCATCAGGATCCCCCTCACCAAATTCACCTCCACGCGCCGCATGCT
GACCGAGGTGGGCAGCGAGATCCCTGACATGAACGCCATCACCCAGTTCCTCAAGTTCAAGCTGGGTTTTGCTGACCTG
GCTGAGCCCACCCCGGAAATCCTCAAGAATTACATGGATGCCCAGTATTATGGTGAGATTGGCATTGGGACCCCCCCAC
AGAAGTTCACTGTGGTCTTTGACACGGGCTCCTCCAACCTCTGGGTGCCGTCAGTGCACTGTCACCTGCTAGACATCGC
CTGTTTGCTACACCACAAGTATGATGCATCCAAATCTAGCACCTATGTGGAGAATGGCACTGAGTTTGCCATCCACTAT
GGGACTGGGAGCCTCTCTGGATTCCTGAGCCAGGACACAGTCACACTTGGTAACTTGAAAATCAAGAACCAGATCTTCG
GGGAGGCTGTGAAGCAGCCAGGCATCACCTTTATTGCTGCCAAGTTCGATGGCATCTTGGGCATGGCATTCCCAAGAAT
CTCTGTGGACAAGGTCACACCTTTCTTTGATAATGTCATGCAGCAGAAGCTGATTGAGAAAAACATCTTCTCCTTCTAC
CTGAACAGGGATCCCACAGCTCAGCCAGGCGGTGAGCTGCTGCTTGGGGGGACTGACCCCAAATACTACAGTGGTGACT
TCAGCTGGGTGAATGTCACACGCAAAGCCTACTGGCAGGTCCACATGGACTCGGTGGATGTTGCCAATGGGCTGACTCT
TTGCAAAGGGGGCTGCGAGGCCATTGTGGACACAGGCACTTCCCTCATCACTGGCCCCACCAAGGAAGTGAAGGAGCTG
CAAACAGCCATTGGTGCAAAACCACTCATCAAAGGCCAGTACGTGATCTCCTGTGATAAGATCTCGTCTCTGCCTGTTG
TCACACTCATGCTAGGTGGGAAGCCCTACCAGCTCACTGGGGAGCAATACGTCTTCAAGGTTTCTGCACAAGGAGAAAC
CATCTGCCTGAGTGGGTTTTCTGGCCTGGATGTCCCACCACCTGGAGGCCCACTCTGGATCCTGGGAGATGTCTTCATT
GGCCCCTACTACACTGTCTTTGACCGTGATAACGACTCTGTTGGTTTCGCCAAATGTGTCTAAGCGCCTGACCCCCCCC
TCCCTCCTCACTGTCTCTGCTACACACAAACACTTGCATACACACACAGGAGCTGTAGAGAAGTTGTAGAGAAAGATTA
TCAGGATTAGAAACCCACTCA
CitationZuzarte-Luis V, Montero JA, Torre-Perez N, Garcia-Porrero JA, Hurle JM. Cathepsin D gene expression outlines the areas of physiological cell death during embryonic development. Dev Dyn. 2007 Mar;236(3):880-5.
CopyrightCopyright © 2007 Wiley-Liss, Inc.
CommentsAuthors said: For in situ hybridization, antisense probes for cathepsin D, B, and L (Zuzarte-Luis et al.,[2007]), where they said:cCatD—fwd: 5′-TTC TGC GCT TCT GCT TTA GGG-3′ and rev: 5′-TGA GTG GGT TTC TAA TCC TGA-3. The sequences presented was excerpted from the full length using these sequences.
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
13-18
stage 17
Lens
Unsure of stage, as it's not given in the paper.
19-24
stage 20
stage 21
Somatopleure
Somites
"interappendicular mesodermal tissue."
25-30
stage 30
Limb Buds
Unsure of embryo stage. Not clear in paper.
31
stage 31
stage 31
stage 31
Leg
Leg Ectoderm
Leg Mesenchyme
Outflow Tract
 

Entry 3

GEISHA IdCTSD.Gammill.2002Data SourcePublication
Complete cDNA Template Probeshow
GGGGCCCCGTCAGCTGACGCTCCGTGCCGGGCCTGAGGCCGCCGCTACAAAAGCGGGGTGGCAGGCGAGGCGGGTTCTG
CGCTTCTGCTTTAGGGGGTGTAGTGCGTTGTAAGCGTTCCGCCGCTATGGCGCCCCGCGGCCTTCTCGTCCTGCTGCTC
CTCGCCCTGGTGGGGCCCTGCGCGGCACTCATCAGGATCCCCCTCACCAAATTCACCTCCACGCGCCGCATGCTGACCG
AGGTGGGCAGCGAGATCCCTGACATGAACGCCATCACCCAGTTCCTCAAGTTCAAGCTGGGTTTTGCTGACCTGGCTGA
GCCCACCCCGGAAATCCTCAAGAATTACATGGATGCCCAGTATTATGGTGAGATTGGCATTGGGACCCCCCCACAGAAG
TTCACTGTGGTCTTTGACACGGGCTCCTCCAACCTCTGGGTGCCGTCAGTGCACTGTCACCTGCTAGACATCGCCTGTT
TGCTACACCACAAGTATGATGCATCCAAATCTAGCACCTATGTGGAGAATGGCACTGAGTTTGCCATCCACTATGGGAC
TGGGAGCCTCTCTGGATTCCTGAGCCAGGACACAGTCACACTTGGTAACTTGAAAATCAAGAACCAGATCTTCGGGGAG
GCTGTGAAGCAGCCAGGCATCACCTTTATTGCTGCCAAGTTCGATGGCATCTTGGGCATGGCATTCCCAAGAATCTCTG
TGGACAAGGTCACACCTTTCTTTGATAATGTCATGCAGCAGAAGCTGATTGAGAAAAACATCTTCTCCTTCTACCTGAA
CAGGGATCCCACAGCTCAGCCAGGCGGTGAGCTGCTGCTTGGGGGGACTGACCCCAAATACTACAGTGGTGACTTCAGC
TGGGTGAATGTCACACGCAAAGCCTACTGGCAGGTCCACATGGACTCGGTGGATGTTGCCAATGGGCTGACTCTTTGCA
AAGGGGGCTGCGAGGCCATTGTGGACACAGGCACTTCCCTCATCACTGGCCCCACCAAGGAAGTGAAGGAGCTGCAAAC
AGCCATTGGTGCAAAACCACTCATCAAAGGCCAGTACGTGATCTCCTGTGATAAGATCTCGTCTCTGCCTGTTGTCACA
CTCATGCTAGGTGGGAAGCCCTACCAGCTCACTGGGGAGCAATACGTCTTCAAGGTTTCTGCACAAGGAGAAACCATCT
GCCTGAGTGGGTTTTCTGGCCTGGATGTCCCACCACCTGGAGGCCCACTCTGGATCCTGGGAGATGTCTTCATTGGCCC
CTACTACACTGTCTTTGACCGTGATAACGACTCTGTTGGTTTCGCCAAATGTGTCTAAGCGCCTGACCCCCCCCTCCCT
CCTCACTGTCTCTGCTACACACAAACACTTGCATACACACACAGGAGCTGTAGAGAAGTTGTAGAGAAAGATTATCAGG
ATTAGAAACCCACTCAGTGGGGAAGA
CitationGammill LS, Bronner-Fraser M. Genomic analysis of neural crest induction. Development. 2002 Dec;129(24):5731-41.
CopyrightPublished by The Company of Biologists 2002. This material is protected by a copyright retained by the authors. Permission granted by Dr. Bronner-Fraser.
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
7-10
stage 10
Neural Crest
 

Entry 4

GEISHA IdCathepsinD.Zuzarte-Luis.2007aData SourceGEISHA ISH Analysis
Complete cDNA Template Probeshow
TTCTGCGCTTCTGCTTTAGGGGGTGTAGTGCGTTGTAAGCGTTCCGCCGCTATGGCGCCCCGCGGCCTTCTCGTCCTGC
TGCTCCTCGCCCTGGTGGGGCCCTGCGCGGCACTCATCAGGATCCCCCTCACCAAATTCACCTCCACGCGCCGCATGCT
GACCGAGGTGGGCAGCGAGATCCCTGACATGAACGCCATCACCCAGTTCCTCAAGTTCAAGCTGGGTTTTGCTGACCTG
GCTGAGCCCACCCCGGAAATCCTCAAGAATTACATGGATGCCCAGTATTATGGTGAGATTGGCATTGGGACCCCCCCAC
AGAAGTTCACTGTGGTCTTTGACACGGGCTCCTCCAACCTCTGGGTGCCGTCAGTGCACTGTCACCTGCTAGACATCGC
CTGTTTGCTACACCACAAGTATGATGCATCCAAATCTAGCACCTATGTGGAGAATGGCACTGAGTTTGCCATCCACTAT
GGGACTGGGAGCCTCTCTGGATTCCTGAGCCAGGACACAGTCACACTTGGTAACTTGAAAATCAAGAACCAGATCTTCG
GGGAGGCTGTGAAGCAGCCAGGCATCACCTTTATTGCTGCCAAGTTCGATGGCATCTTGGGCATGGCATTCCCAAGAAT
CTCTGTGGACAAGGTCACACCTTTCTTTGATAATGTCATGCAGCAGAAGCTGATTGAGAAAAACATCTTCTCCTTCTAC
CTGAACAGGGATCCCACAGCTCAGCCAGGCGGTGAGCTGCTGCTTGGGGGGACTGACCCCAAATACTACAGTGGTGACT
TCAGCTGGGTGAATGTCACACGCAAAGCCTACTGGCAGGTCCACATGGACTCGGTGGATGTTGCCAATGGGCTGACTCT
TTGCAAAGGGGGCTGCGAGGCCATTGTGGACACAGGCACTTCCCTCATCACTGGCCCCACCAAGGAAGTGAAGGAGCTG
CAAACAGCCATTGGTGCAAAACCACTCATCAAAGGCCAGTACGTGATCTCCTGTGATAAGATCTCGTCTCTGCCTGTTG
TCACACTCATGCTAGGTGGGAAGCCCTACCAGCTCACTGGGGAGCAATACGTCTTCAAGGTTTCTGCACAAGGAGAAAC
CATCTGCCTGAGTGGGTTTTCTGGCCTGGATGTCCCACCACCTGGAGGCCCACTCTGGATCCTGGGAGATGTCTTCATT
GGCCCCTACTACACTGTCTTTGACCGTGATAACGACTCTGTTGGTTTCGCCAAATGTGTCTAAGCGCCTGACCCCCCCC
TCCCTCCTCACTGTCTCTGCTACACACAAACACTTGCATACACACACAGGAGCTGTAGAGAAGTTGTAGAGAAAGATTA
TCAGGATTAGAAACCCACTCA
CommentsAuthors indicated probes were derived using these primers:for cCatD—fwd: 5′-TTC TGC GCT TCT GCT TTA GGG-3′ and rev: 5′-TGA GTG GGT TTC TAA TCC TGA-3′ probe was extracted from NCBI acc# NM_205177.1
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
19-24
stage 21
Leg
 
31-33
stage 31
stage 32
stage 32
stage 33
stage 33
Leg
 
 Data from NCBI Unigene EST Profile
Unigene ID: Gga.1094

Mouse

EmageMGI:88562
EurexpressMGI:88562
MGI GXDMGI:88562

Frog

Xenbase5906944

Fruit Fly

BDGPFBgn0029093

Zebra Finch

ZEBrA

Zebrafish

ZFINZDB-GENE-010131-8
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