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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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CXCR4
C-X-C motif chemokine receptor 4

The human orthologue of this gene is associated
with the following human disease:

WHIM syndrome

Gene

Official Symbol	CXCR4
Official Full Name	C-X-C motif chemokine receptor 4
CGNC ID	9386
also known as	C-X-C chemokine receptor type 4\|chemokine (C-X-C motif) receptor 4\|chemokine receptor CXCR4, chemokine (C-X-C motif) receptor 4 , CXCR4
gene type	protein-coding

Genomic Map

	Ensembl
	NCBI
	UCSC
	Gallus-Browse

Sequence Information

Genomic
RNA	NM_204617
Polypeptide	NP_989948
Sequence Clusters/ESTs	Unigene

Gene Expression

In Situ Hybridization	GEISHA
EST Profile	Gga.2305

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	7852	ENSG00000121966	MIM:162643	MIM:162643
Mouse	12767	ENSMUSG00000045382	All phenotypic alleles (8):Targeted, knock-out(5) Targeted, other(3)	MGI:109563
Xenopus	100038176, 100192360, 380373			489916
Zebrafish	100332872, 100332777, 140747, 114447	ENSDARG00000057633, ENSDARG00000041959	ZDB-GENE-020102-1, ZDB-GENE-010614-1	ZFIN:ZDB-GENE-020102-1, ZFIN:ZDB-GENE-010614-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Links to other databases

Entrez Gene	395324
Ensembl Gene	ENSGALG00000012357
KEGG	gga:395324

Entry 1

GEISHA Id	CXCR4.UApcr	Data Source	GEISHA ISH Analysis
Forward cDNA Template Primer	TGCTTGGAGTCATCAGACATCG
Reverse cDNA Template Primer	ATTAACCCTCACTAAAGGACCCACAACAAAAACAACGAGC	cDNA Template Length	728
Forward cDNA Template Probe	show ACATGGTACAGNAGGCAGCTTTAGTTATAAGGTGCCATTTCTACAGCAGAGTTAAGCTATCGTAAACCAAACATCTAGT AAGGCAAAAATATTCAGCCAACATTTAAGAATTTAACAACATTGAAACCATTTACATATAAACAGAAATATTTTCTAAT CTTTTAACAGTCACTTGCTACAATCCAGTGTTTAGTTCACATATCTATACAAACAAACACTCAAGCTTTTGTGAACTAA CCACTTGTCCACAGGACCTGCCTAGACAGTTTATCAATACAAAAGTTTCATATAAATAAGTCAATTAAACTTCACAAAG ACTAAAAGAAGCAATAAAAAATTCCAACTGTAAAATAAATCTGTACAATATGGTCAGTCTTGTTTTTCTGAGATCTTGA GCAACTTTTAAAGTGTCTATTTATGAAGGGATGGCAAGGGAAAGCGTTAGCTGGAATGGAAACTTGAAGACTCTGACTC TGTAGAAACAGAAGAATGTCCCCCACGTTTGCTTTTTGAAAGAATCTTGAGGCTTGATCCTCTGCTAACAGATGTCAAG GCATTTTGTGCTGATGTTTTGAACTTGGCACCCAGGAAGGCGTAAAGAATTGGATTGAGGCAGCAATGGAAGAACGCAA GGGCTTCTGTGATAGAGATCCATTTGTGCACGATTGTGTCCAAGCTGCAGCGATGTCTGATG

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

4-6

stage 4

stage 5

stage 6

Area Opaca
Early Endoderm
Early Mesoderm
Endoderm
Lateral Plate Mesoderm
Notochord

7-12

stage 7

stage 8

stage 9

stage 10

stage 11

stage 12

Anterior Intestinal Portal
Area Opaca
Ectoderm
Endoderm
Extraembryonic
Extraembryonic Mesoderm
Forebrain
Foregut
Heart Tube
Hindbrain
Intermediate Mesoderm
Lateral Plate Mesoderm
Midbrain
Neural Crest
Neural Plate/Tube
Notochord
Paraxial Mesoderm
Pharynx
Somites
Spinal Cord

13-18

stage 13

stage 14

stage 16

Anterior/Second Heart Field
Blood Islands
Blood Vessels
Extraembryonic Blood Vessels
Forebrain
Hindbrain
Intermediate Mesoderm
Lateral Plate Mesoderm
Midbrain
Neural Crest
Neural Plate/Tube
Paraxial Mesoderm
Pharyngeal Arches and Clefts
Spinal Cord

19-24

stage 19

Forebrain
Hindbrain
Midbrain
Spinal Cord
Tail

25-26

stage 26

Forebrain
Hindbrain
Leg Ectoderm
Leg Mesenchyme
Mesonephros
Midbrain
Spinal Cord
Spinal Ganglia and Nerves
Wing Mesenchyme

Entry 2

GEISHA Id	CXCR4.Tonegawa.2003	Data Source	Publication
Complete cDNA Template Probe	show TGCGCTCGTGGCGCTCGGACGGCCCGGACCTACTCGGTGCTCGGAGTATGGACGGCAGCATGGACGGTTTGGATCTGTC CTCTGGCATACTCATTGAATTTGCTGACAATGGCTCGGAGGAGATTGGCTCAGCTGACTATGGAGACTATGGAGAGCCG TGCTTTCAGCATGAAAACGCTGATTTCAACCGGATCTTCTTGCCAACCATCTACTCCATCATCTTCCTAACAGGAATAA TCGGGAATGGATTGGTTATCATTGTTATGGGCTACCAGAAGAAGCAAAGAAGCATGACTGATAAATACAGGCTGCACCT CTCTGTGGCTGACCTCCTCTTTGTCATCACCTTGCCATTCTGGTCTGTGGATGCAGCCATAAGCTGGTACTTCGGAAAT GTCCTGTGTAAGGCAGTTCATGTCATTTACACAGTCAACCTCTATAGCAGTGTCTTGATTTTGGCTTTCATAAGTTTAG ATCGTTACCTGGCAATAGTCCATGCCACCAACAGCCAGCGACCCCGAAAGCTGTTGGCTGAGAAGATTGTGTATGTGGG TGTCTGGCTGCCAGCTGTGCTTCTCACAGTGCCTGATATAATTTTTGCCAGTACGAGTGAAGTAGAAGGACGGTATCTC TGTGATCGCATGTACCCTCATGACAACTGGCTGATTTCTTTCAGATTCCAGCATATCTTGGTAGGACTTGTCTTGCCCG GTCTAATAATCCTGACTTGCTATTGTATTATCATATCTAAGCTGTCACATTCAAAAGGCCACCAGAAGCGCAAAGCCTT GAAGACAACAGTTATCCTCATTCTTACCTTCTTTGCCTGTTGGCTGCCGTATTACATTGGCATCAGCATAGACACGTTC ATCTTGCTTGGAGTCATCAGACATCGCTGCAGCTTGGACACAATCGTGCACAAATGGATCTCTATCACAGAAGCCCTTG CGTTCTTCCATTGCTGCCTCAATCCAATTCTTTACGCCTTCCTGGGTGCCAAGTTCAAAACATCAGCACAAAATGCCTT GACATCTGTTAGCAGAGGATCAAGCCTCAAGATTCTTTCAAAAAGCAAACGTGGGGGACATTCTTCTGTTTCTACAGAG TCAGAGTCTTCAAGTTTCCATTCCAGCTAACGCTTTCCCTTGCCATCCCTTCATAAATAGACACTTTAAAAGTTGCTCA AGATCTCAGAAAAACAAGACTGACCATATTGTACAGATTTATTTTACAGTTGGAATTTTTTATTGCTTCTTTTAGTCTT TGTGAAGTTTAATTGACTTATTTATATGAAACTTTTGTATTGATAAACTGTCTAGGCAGGT
Citation	Tonegawa A, Kasai T, Takahashi Y. Systematic screening for signaling molecules expressed during somitogenesis by the signal sequence trap method. Dev Biol. 2003 Oct 1;262(1):32-50.
Copyright	"Reprinted from DEVELOPMENTAL BIOLOGY, 262, Tonegawa A, Kasai T, Takahashi Y. Systematic screening for signaling molecules expressed during somitogenesis by the signal sequence trap method. 32-50, Copyright (2003), with permission from Elsevier". Copyright © 2003 Elsevier B.V. All rights reserved.
Comments	Accession number was given in the paper.

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

13-18

stage 14

Dermomyotome
Neural Plate/Tube
Paraxial Mesoderm

Comparison with other genes

19-20

stage 20

Blood Vessels
Neural Plate/Tube

Comparison with other genes

Entry 3

GEISHA Id	CXCR4.Vasyutina.2005	Data Source	Publication
Complete cDNA Template Probe	show TGCGCTCGTGGCGCTCGGACGGCCCGGACCTACTCGGTGCTCGGAGTATGGACGGCAGCATGGACGGTTTGGATCTGTC CTCTGGCATACTCATTGAATTTGCTGACAATGGCTCGGAGGAGATTGGCTCAGCTGACTATGGAGACTATGGAGAGCCG TGCTTTCAGCATGAAAACGCTGATTTCAACCGGATCTTCTTGCCAACCATCTACTCCATCATCTTCCTAACAGGAATAA TCGGGAATGGATTGGTTATCATTGTTATGGGCTACCAGAAGAAGCAAAGAAGCATGACTGATAAATACAGGCTGCACCT CTCTGTGGCTGACCTCCTCTTTGTCATCACCTTGCCATTCTGGTCTGTGGATGCAGCCATAAGCTGGTACTTCGGAAAT GTCCTGTGTAAGGCAGTTCATGTCATTTACACAGTCAACCTCTATAGCAGTGTCTTGATTTTGGCTTTCATAAGTTTAG ATCGTTACCTGGCAATAGTCCATGCCACCAACAGCCAGCGACCCCGAAAGCTGTTGGCTGAGAAGATTGTGTATGTGGG TGTCTGGCTGCCAGCTGTGCTTCTCACAGTGCCTGATATAATTTTTGCCAGTACGAGTGAAGTAGAAGGACGGTATCTC TGTGATCGCATGTACCCTCATGACAACTGGCTGATTTCTTTCAGATTCCAGCATATCTTGGTAGGACTTGTCTTGCCCG GTCTAATAATCCTGACTTGCTATTGTATTATCATATCTAAGCTGTCACATTCAAAAGGCCACCAGAAGCGCAAAGCCTT GAAGACAACAGTTATCCTCATTCTTACCTTCTTTGCCTGTTGGCTGCCGTATTACATTGGCATCAGCATAGACACGTTC ATCTTGCTTGGAGTCATCAGACATCGCTGCAGCTTGGACACAATCGTGCACAAATGGATCTCTATCACAGAAGCCCTTG CGTTCTTCCATTGCTGCCTCAATCCAATTCTTTACGCCTTCCTGGGTGCCAAGTTCAAAACATCAGCACAAAATGCCTT GACATCTGTTAGCAGAGGATCAAGCCTCAAGATTCTTTCAAAAAGCAAACGTGGGGGACATTCTTCTGTTTCTACAGAG TCAGAGTCTTCAAGTTTCCATTCCAGCTAACGCTTTCCCTTGCCATCCCTTCATAAATAGACACTTTAAAAGTTGCTCA AGATCTCAGAAAAACAAGACTGACCATATTGTACAGATTTATTTTACAGTTGGAATTTTTTATTGCTTCTTTTAGTCTT TGTGAAGTTTAATTGACTTATTTATATGAAACTTTTGTATTGATAAACTGTCTAGGCAGGT
Citation	Vasyutina E, Stebler J, Brand-Saberi B, Schulz S, Raz E, Birchmeier C. CXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells. Genes Dev. 2005 September 15; 19(18): 21872198.
Copyright	Copyright © 2005, Cold Spring Harbor Laboratory Press
Comments	As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #AF294794.1 ).