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CER1 Gene Summary Expression Other Species Expression JBrowse Gene Official Symbol CER1 Official Full Name cerberus 1, DAN family BMP antagonist CGNC ID 4048 also known as CAR, cerberus|caronte|cerberus 1 homolog, cysteine knot superfamily|cerberus 1, cysteine knot superfamily, homolog, Cerberus precursor gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Molecular Function BMP binding , cytokine activity , morphogen activity , protein homodimerization activity Biological Process anterior/posterior axis specification , bone mineralization , cell migration involved in gastrulation , more... determination of dorsal identity , determination of left/right asymmetry in lateral mesoderm , growth plate cartilage chondrocyte proliferation , heart looping , mesendoderm development , negative regulation of cell proliferation , negative regulation of mesoderm development , negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry , nervous system development , sequestering of BMP in extracellular matrix , signal transduction involved in regulation of gene expression , ureteric bud development Cellular Component extracellular space
Links to other databases
Entry 1 GEISHA Id CER1.UApcr Data Source GEISHA ISH Analysis Forward cDNA Template Primer AGACCACCAAAGTGAACGGCAG Reverse cDNA Template Primer AATTAACCCTCACTAAAGTCAATCAACTCTCGCATCCCC cDNA Template Length 810 Forward cDNA Template Probe show AAAGTAGCTTAGAAAAGTATAAGACGAATCATCTGGACCAGGAAATGAAAGGAACTACACTTGCCAAAACATAGATTGT
Entry 2 GEISHA Id Cerberus.Chapman.2004 Data Source Publication Complete cDNA Template Probe show ATGTCACTGCTCCTCCTTCAGCTGCTAGTGCTCTCGTGTCTTGGAGACACAGAGCCACAGCCAGATTCACAGCAAAGGA
Citation Chapman, S, Brown, R, Lees, L, Schoenwolf, G, Lumsden, A. Expression Analysis of Chick Wnt and Frizzled Genes and Selected Inhibitors in Early Chick Patterning. Dev Dyn. 2004 Mar;229(3):668-76. Copyright Wiley-Liss, Inc. 2004 Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # AF139721).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4-5 stage 4
stage 4
stage 4
stage 5
Endoderm, early
Entry 3 GEISHA Id Cerberus.Chapman.2002 Data Source Publication Complete cDNA Template Probe show ATGTCACTGCTCCTCCTTCAGCTGCTAGTGCTCTCGTGTCTTGGAGACACAGAGCCACAGCCAGATTCACAGCAAAGGA
Citation Chapman SC, Schubert FR, Schoenwolf GC, Lumsden A. Analysis of spatial and temporal gene expression patterns in blastula and gastrula stage chick embryos. Dev Biol. 2002 May 1;245(1):187-99. Copyright 2002 Elsevier Science (USA). All rights reserved.
Entry 4 GEISHA Id Cer.Chapman.2008 Data Source Direct Submission Complete cDNA Template Probe show ATGTCACTGCTCCTCCTTCAGCTGCTAGTGCTCTCGTGTCTTGGAGACACAGAGCCACAGCCAGATTCACAGCAAAGGA
Comments Images Provided by Susan Chapman
Entry 5 GEISHA Id Cer.Zhu.1999 Data Source Publication Complete cDNA Template Probe show ATGTCACTGCTCCTCCTTCAGCTGCTAGTGCTCTCGTGTCTTGGAGACACAGAGCCACAGCCAGATTCACAGCAAAGGA
Citation Zhu L, Marvin MJ, Gardiner A, Lassar AB, Mercola M, Stern CD, Levin M (1999). Curr Biol. 1999 Sep 9;9(17):931-8. Copyright Copyright: © 1999 Zhu, L et al. Comments According to the author, "The sequence
of cCer has been deposited in GenBank and
assigned accession number AF139721." The assigned accession number was looked up in NCBI to obtain exact sequence used to synthesize probe.
Entry 6 GEISHA Id CER.Foley.2000 Data Source Publication Complete cDNA Template Probe show GCAGTGTTCTCTGCAACATTAGCAGATCTACAGCATCAGCAGGACCATGTCACTGCTCCTCCTTCAGCTGCTAGTGCTC
Citation Foley AC, Skromne I, Stern CD. Reconciling different models of forebrain induction and patterning: a dual role for the hypoblast. Development. 2000 Sep;127(17):3839-54.
Copyright Printed in Great Britain © The Company of Biologists Limited 2000 Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204823).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) X-XIV stage XII
Hypoblast 1-3 stage 2
4 stage 4
stage 4
Hypoblast
Entry 7 GEISHA Id cCER.Bento.2011 Data Source Publication Complete cDNA Template Probe show ATGTCACTGCTCCTCCTTCAGCTGCTAGTGCTCTCGTGTCTTGGAGACACAGAGCCACAGCCAGATTCACAGCAAAGGA
Citation Bento M, Correia E, Tavares AT, Becker JD, Belo JA.
Identification of differentially expressed genes in the heart precursor cells of the chick embryo. Gene Expr Patterns. 2011 Oct;11(7):437-47.
Copyright Copyright © 2011 Elsevier B.V. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # AF139721.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4 stage 4
stage 4
Early Endoderm Early Mesoderm
Entry 8 GEISHA Id CER.Tavares.2007 Data Source Publication Complete cDNA Template Probe show ATGTCACTGCTCCTCCTTCAGCTGCTAGTGCTCTCGTGTCTTGGAGACACAGAGCCACAGCCAGATTCACAGCAAAGGA
Citation Tavares AT, Andrade S, Silva AC, Belo JA. Cerberus is a feedback inhibitor of Nodal asymmetric signaling in the chick embryo. Development. 2007 Jun;134(11):2051-60. Copyright copyright 2007 the authors. Published by the Company of Biologists Ltd. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # AF139721.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7 stage 7
stage 7
Lateral Plate Mesoderm
Entry 9 GEISHA Id CAR.WangS.2004 Data Source Publication Complete cDNA Template Probe show GCAGTGTTCTCTGCAACATTAGCAGATCTACAGCATCAGCAGGACCATGTCACTGCTCCTCCTTCAGCTGCTAGTGCTC
Citation Wang S, Yu X, Zhang T, Zhang X, Zhang Z, Chen Y. Chick Pcl2 regulates the left-right asymmetry by repressing Shh expression in Hensen's node. Development. 2004 Sep;131(17):4381-91. Epub 2004 Aug 4. Copyright copyright 2004 to the authors. Published by the Company of Biologists Ltd. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #AF179484.1 ).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-11 stage 11
stage 11
Entry 10 GEISHA Id CARONTE.Katsu.2012 Data Source Publication Complete cDNA Template Probe show GCAGTGTTCTCTGCAACATTAGCAGATCTACAGCATCAGCAGGACCATGTCACTGCTCCTCCTTCAGCTGCTAGTGCTC
Citation Katsu K, Tokumori D, Tatsumi N, Suzuki A, Yokouchi Y. BMP inhibition by DAN in Hensen's node is a critical step for the establishment of left-right asymmetry in the chick embryo. Dev Biol. 2012 Mar 1;363(1):15-26. Copyright Copyright © 2012. Published by Elsevier Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # AF179484.1).
Mouse Frog Fruit Fly Zebra Finch Zebrafish
