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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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PRRX1
paired related homeobox 1

The human orthologue of this gene is associated
with the following human disease:

Agnathia-otocephaly complex

Gene

Official Symbol	PRRX1
Official Full Name	paired related homeobox 1
CGNC ID	48968
also known as	PMX1, Prx-1, Prx1, gMHox, paired mesoderm homeobox protein 1\|homeobox protein MHOX\|paired-related homeobox protein 1\|paired-related homeotic gene product\|transcription factor Prx1b, Paired mesoderm homeobox protein 1 , Homeobox protein MHOX, GMHOX, Homeobox protein PRX-1, MHOX, PRX-1
gene type	protein-coding

Genomic Map

	Ensembl ID not known
	NCBI
	UCSC
	Gallus-Browse

Sequence Information

Genomic
RNA	NM_001007821
Polypeptide	NP_001007822
Sequence Clusters/ESTs	Unigene

Gene Expression

In Situ Hybridization	GEISHA
EST Profile	Gga.1546

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	5396	ENSG00000116132	MIM:202650	MIM:167420
Mouse	18933	ENSMUSG00000026586	All phenotypic alleles (6):Targeted, knock-out(1) Targeted, other(5)	MGI:97712
Xenopus	100494324			484662
Zebrafish	337089, 406431	ENSDARG00000042027, ENSDARG00000033971	ZDB-GENE-030131-9033, ZDB-GENE-020905-5	ZFIN:ZDB-GENE-030131-9033, ZFIN:ZDB-GENE-020905-5

Gene Ontology

Molecular Function	sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity
Biological Process	multicellular organismal development
Cellular Component	nucleus

Links to other databases

Entrez Gene	373941
Ensembl Gene
KEGG	gga:373941

Entry 1

GEISHA Id	ChEST410i17	Data Source	GEISHA ISH Analysis
Forward cDNA Template Probe	show GCGGCTCGAGGAAGCCAGAGTTCAGGTGTGGTTCCAGAACCGGAGGGCCAAGTTTCGCCGGAATGAGAGGGCCATGCTG GCCAGCAAGAATGCCTCTCTGCTCAAATCCTACTCAGGGGATGTGACCGCCGTGGAGCAGCCCATAGTACCTCGCCCAG CTCCAAGACCCACCGACTATCTCTCCTGGGGTACCGCCTCGCCTTACAGGTTTATTGCTTCTGCTCAATATACTACGAG CTTCTTCAGTTAAGGACAGTCTCACCCTTGTTGTTTTCCATTTTTGTATGGGACTGCAAAAAGAAACCTTCGCTGATCT CAGCCTGCGGCCGCCTCCCACCCAACACCGCGCTGAGGCTCAAAGCTTGCTCCCCCACCCCAGCTCACCCTAGAAGAAG AAATTGTTTGGTCACCGCTTTCCGTTGTATCCACCTGACCTTCCGTCCCCTCCCACGTCCCTTGTGCCACAGAGGCAGT GCCGTTGATGTTGACTGCGAGAAGCCCATTGGGCGCGATGGGCTGGGAAGCATCCCTGCTGGGTCGCCTGGACCACGAC GCAAGGAAGATCTCTGTGGGCTTCGCACACTTTGTCAGCGCCTGGAAAAGCCAGAGAAGAGAGAAAAGCCAATGTGTGT TTGTGAGTGGGGGGGGGGAGGATGGANAA
Comments	No specific expression at stage 5.

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

4-6

stage 4

Primitive Streak

caudal

7-12

stage 7

stage 8

stage 11

stage 12

Anterior Intestinal Portal
Anterior/Second Heart Field
Blood Vessels
Extraembryonic Mesoderm
Head Mesenchyme
Lateral Plate Mesoderm
Neural Plate/Tube
Paraxial Mesoderm
Primitive Streak

13-18

stage 13

stage 15

Extraembryonic
Head Mesenchyme
Lateral Plate Mesoderm
Paraxial Mesoderm

19-23

stage 21

stage 23

Head Mesenchyme
Lateral Plate Mesoderm
Leg Mesenchyme
Paraxial Mesoderm
Pharyngeal Arches and Clefts
Spinal Ganglia and Nerves
Wing Mesenchyme

Entry 2

GEISHA Id	ChEST410i17.redo	Data Source	GEISHA ISH Analysis
Forward cDNA Template Probe	show GCGGCTCGAGGAAGCCAGAGTTCAGGTGTGGTTCCAGAACCGGAGGGCCAAGTTTCGCCGGAATGAGAGGGCCATGCTG GCCAGCAAGAATGCCTCTCTGCTCAAATCCTACTCAGGGGATGTGACCGCCGTGGAGCAGCCCATAGTACCTCGCCCAG CTCCAAGACCCACCGACTATCTCTCCTGGGGTACCGCCTCGCCTTACAGGTTTATTGCTTCTGCTCAATATACTACGAG CTTCTTCAGTTAAGGACAGTCTCACCCTTGTTGTTTTCCATTTTTGTATGGGACTGCAAAAAGAAACCTTCGCTGATCT CAGCCTGCGGCCGCCTCCCACCCAACACCGCGCTGAGGCTCAAAGCTTGCTCCCCCACCCCAGCTCACCCTAGAAGAAG AAATTGTTTGGTCACCGCTTTCCGTTGTATCCACCTGACCTTCCGTCCCCTCCCACGTCCCTTGTGCCACAGAGGCAGT GCCGTTGATGTTGACTGCGAGAAGCCCATTGGGCGCGATGGGCTGGGAAGCATCCCTGCTGGGTCGCCTGGACCACGAC GCAAGGAAGATCTCTGTGGGCTTCGCACACTTTGTCAGCGCCTGGAAAAGCCAGAGAAGAGAGAAAAGCCAATGTGTGT TTGTGAGTGGGGGGGGGGAGGATGGANAA

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

13-18

stage 17

stage 18

Extraembryonic
Head Mesenchyme
Limb Buds
Paraxial Mesoderm
Pharyngeal Arches and Clefts
Somatic Mesoderm

19-24

stage 22

stage 23

Ear/Otic Placode
Leg Mesenchyme
Pharyngeal Arches and Clefts
Somatic Mesoderm
Somites
Wing Mesenchyme

stage 25

Ear/Otic Placode
Eye
Face Mesenchyme
Leg Mesenchyme
Paraxial Mesoderm
Pharyngeal Arches and Clefts
Somatic Mesoderm
Somites
Wing Mesenchyme

Entry 3

GEISHA Id	Prx1.Holleville.2007	Data Source	Publication
Reverse cDNA Template Probe	show CGGCACGAGGAAAAGCCCCCGCTCGGCACCATGGCGTCCAGCTATGCCCACGCCATGGAGAGGCAGGCCCTGCTGCCAG CCCGCCTCGACGGCCCCGCCGGCCTGGACAATTTACAAGCCAAGAAGAACTTTTCCGTGAGTCACCTGCTGGACCTGGA GGAGGCGGGCGACATGGTGGCCGCGCAGGGGGACGAGGGCGGCGGCGAGCCCGGCCGGAGCTTGTTGGAGTCCCCCGGG CTGACCAGCGGCAGCGACACCCCGCAGCAGGACAATGATCAGCTGAATTCAGAAGAGAAGAAGAAAAGGAAGCAGAGAA GGAACAGGACTACCTTCAACAGCAGCCAGCTCCAGGCACTAGAGAGGGTCTTTGAGAGGACACACTACCCCGATGCCTT TGTACGGGAAGACCTTGCACGCAGAGTCAACCTCACTGAAGCCAGAGTTCAGGTGTGGTTCCAGAACCGGAGGGCCAAG TTTCGCCGGAATGAGAGGGCCATGCTGGCCAGCAAGAACGCCTCTCTGCTCAAATCCTACTCAGGGGATGTGACCGCCG TGGAGCAGCCCATAGTACCTCGCCCAGCTCCAAGACCCACCGACTATCTCTCCTGGGGTACCGCCTCGCCTTACAGTGC CATGGCCACCTACTCCACCACGTGTACCAACGCCAGCCCGGCGCAGGGCATGAATATGGCCAACAGTATTGCCAACCTG AGACTGAAGGCAAAAGAATATAGTTTACAGAGGAATCAAGTGCCCACAGTCAATTAATGACTGGGGGCAGCTGCTTCGC AGAAGGAGAAAATACGACAGCACCCGTCTGCTTCGCAACTTCTGTGCTGAAATTTTAAAAAAATATATTAAAAATATTA AAAAAAAGAAAAAAAAAAAAAAAAAA
Citation	Holleville N, Matéos S, Bontoux M, Bollerot K, Monsoro-Burq AH. Dlx5 drives Runx2 expression and osteogenic differentiation in developing cranial suture mesenchyme. Dev Biol. 2007 Apr 15;304(2):860-74.
Copyright	Reprinted with permission from Elsevier. Copyright © 2007 Elsevier B.V. All rights reserved.
Comments	As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_001007821.1).