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Gene Family QuickSearch
Human Disease Gene Search
COL2A1 The human orthologue of this gene is associated
Gene Summary Expression Transcript Levels Other Species Expression JBrowse Gene Official Symbol COL2A1 Official Full Name collagen type II alpha 1 chain CGNC ID 49161 also known as collagen alpha-1(II) chain|alpha 1 type II procollagen|alpha 1 type IIA collagen|alpha-1 type II collagen|collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital)|procollagen alpha 1(II)|type II collagen gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Molecular Function extracellular matrix structural constituent , identical protein binding , metal ion binding , more... platelet-derived growth factor binding Biological Process cartilage condensation , cartilage development involved in endochondral bone morphogenesis , more... cellular response to BMP stimulus , central nervous system development , chondrocyte differentiation , collagen fibril organization , embryonic skeletal joint morphogenesis , endochondral ossification , heart morphogenesis , inner ear morphogenesis , limb bud formation , negative regulation of extrinsic apoptotic signaling pathway in absence of ligand , notochord development , otic vesicle development , palate development , proteoglycan metabolic process , regulation of gene expression , sensory perception of sound , tissue homeostasis , visual perception Cellular Component basement membrane , collagen type II , cytoplasm , extracellular space
Links to other databases
Entry 1 GEISHA Id COL2A1.UApcr Data Source GEISHA ISH Analysis Forward cDNA Template Primer 5’-TGGATGCCACCCTCAAATCC-3’ Reverse cDNA Template Primer 5’-AATTAACCCTCACTAAAGGTCCACGCCAAACTCCTGATC-3’ cDNA Template Length 676 Complete cDNA Template Probe show TGGATGCCACCCTCAAATCCCTCAACAATCAGATTGAGAGCATCCGCAGCCCCGAGGGCTCCAAGAAGAACCCTGCCAG
Entry 2 GEISHA Id CollagenII.Tylzanowski.2003 Data Source Publication Complete cDNA Template Probe show ACTGCTCGGCCCGACGGACGGTGAGAGGGCCTCCGCCGCCCGCCATGCACGGCCGCCGCCCGCCCCGCTCCGCCGCTCT
Citation Tylzanowski P, De Valck D, Maes V, Peeters J, Luyten FP. Zfhx1a and Zfhx1b mRNAs have non-overlapping expression domains during chick and mouse midgestation limb development. Gene Expr Patterns. 2003 Mar;3(1):39-42. Erratum in: Gene Expr Patterns. 2003 Jun;3(3):383. Copyright Copyright © 2003 Elsevier B.V. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc # NM_204426).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-32 stage 32
stage 32
Leg Mesenchyme
Entry 3 GEISHA Id Col2alpha1.Bendall.2003 Data Source Publication Complete cDNA Template Probe show ACTGCTCGGCCCGACGGACGGTGAGAGGGCCTCCGCCGCCCGCCATGCACGGCCGCCGCCCGCCCCGCTCCGCCGCTCT
Citation Bendall AJ, Hu G, Levi G, Abate-Shen C. Dlx5 regulates chondrocyte differentiation at multiple stages. Int J Dev Biol. 2003 Jun;47(5):335-44. Copyright "Reprinted from Int. J. Dev. Biol., 47, Bendall AJ, Hu G, Levi G, Dlx5 regulates chondrocyte differentiation at multiple stages, 335-44, Copyright (2003), with permission from Copyright © 2003 UBC Press". All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc #NM_204426).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 23
Notochord 25-30 stage 26
Notochord 31-44 stage 32
stage 44
Limb Buds Notochord
Entry 4 GEISHA Id COL2A1.Lizarraga.2002 Data Source Publication Complete cDNA Template Probe show ACTGCTCGGCCCGACGGACGGTGAGAGGGCCTCCGCCGCCCGCCATGCACGGCCGCCGCCCGCCCCGCTCCGCCGCTCT
Citation Lizarraga G, Lichtler A, Upholt WB, Kosher RA. Studies on the role of Cux1 in regulation of the onset of joint formation in the developing limb. Dev Biol. 2002 Mar 1;243(1):44-54. Copyright Copyright © 2002 Elsevier Science (USA). All rights reserved. Comments Insufficient information provided in publication to verify exact sequence to synthesize probe. Sequence below was obtained from NCBI (NM_204426).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-30 stage 25
stage 25
stage 27
stage 29
stage 30
stage 30
Wing Mesenchyme
Entry 5 GEISHA Id Col2.Chimal-Monroy.2003 Data Source Publication Complete cDNA Template Probe show ACTGCTCGGCCCGACGGACGGTGAGAGGGCCTCCGCCGCCCGCCATGCACGGCCGCCGCCCGCCCCGCTCCGCCGCTCT
Citation Chimal-Monroy J, Rodriguez-Leon J, Montero JA, Gañan Y, Macias D, Merino R, Hurle JM. Analysis of the molecular cascade responsible for mesodermal limb chondrogenesis: Sox genes and BMP signaling. Dev Biol. 2003 May 15;257(2):292-301. Copyright Reprinted with permission from Elsevier.
Copyright © 2003 Elsevier B.V. All rights reserved.
Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_204426.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31 stage 31
Leg Bones
Entry 6 GEISHA Id ColII.Conen.2009 Data Source Publication Complete cDNA Template Probe show ACTGCTCGGCCCGACGGACGGTGAGAGGGCCTCCGCCGCCCGCCATGCACGGCCGCCGCCCGCCCCGCTCCGCCGCTCT
Citation Conen KL, Nishimori S, Provot S, Kronenberg HM. The transcriptional cofactor Lbh regulates angiogenesis and endochondral bone formation during fetal bone development. Dev Biol. 2009 Sep 15;333(2):348-58. Epub 2009 Jul 14. Copyright Copyright © 2009 Elsevier B.V. All rights reserved.
Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_204426 ).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 1-3 stage 1
stage 1
31-39 stage 33
stage 36
stage 39
Wing Bones
Entry 7 GEISHA Id COL2A1.Roddy.2011 Data Source Publication Complete cDNA Template Probe show GTTTGCAGAGACCATCAACGGCGGTTTCCACTTCAGCTACGGCGATGAGAACCTGTCCCCCAACACCGCCAGCATCCAG
Citation Roddy KA, Prendergast PJ, Murphy P. Mechanical influences on morphogenesis of the knee joint revealed through morphological, molecular and computational analysis of immobilised embryos. PLoS One. 2011 Feb 28;6(2):e17526. Copyright PLoS One is an open access journal. Comments The cDNA template used to generate the probe was obtained from EST - ChEST179L15 as described in the paper.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-27 stage 27
stage 27
stage 27
stage 27
stage 27
Leg
Entry 8 GEISHA Id COLII.Heller.1998 Data Source Publication Complete cDNA Template Probe show ACTGCTCGGCCCGACGGACGGTGAGAGGGCCTCCGCCGCCCGCCATGCACGGCCGCCGCCCGCCCCGCTCCGCCGCTCT
Citation Heller S, Sheane CA, Javed Z, Hudspeth AJ. Molecular markers for cell types of the inner ear and candidate genes for hearing disorders. Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11400-5. Copyright Copyright © 2012 National Academy of Sciences. All rights reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # M74435.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-43 stage 43
stage 43
Ear/Otic Placode
Entry 9 GEISHA Id COL2A1.Ferrari.2006 Data Source Publication Complete cDNA Template Probe show ACTGCTCGGCCCGACGGACGGTGAGAGGGCCTCCGCCGCCCGCCATGCACGGCCGCCGCCCGCCCCGCTCCGCCGCTCT
Citation Ferrari D, Kosher RA. Expression of Dlx5 and Dlx6 during specification of the elbow joint. Int J Dev Biol. 2006;50(8):709-13. Copyright © UBC Press Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_204426.1
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 24
Wing Bones 25-26 stage 25
stage 26
stage 26
Wing Bones
Entry 10 GEISHA Id ColII.Abzhanov.2004 Data Source Publication Complete cDNA Template Probe show ACTGCTCGGCCCGACGGACGGTGAGAGGGCCTCCGCCGCCCGCCATGCACGGCCGCCGCCCGCCCCGCTCCGCCGCTCT
Citation Abzhanov A, Tabin CJ. Shh and Fgf8 act synergistically to drive cartilage outgrowth during cranial development. Dev Biol 2004 Sep 1;273(1):134-48. Copyright Copyright © 2004 Elsevier Inc. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the complete sequence was obtained from NCBI (acc # NM_204426).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-36 stage 36
stage 36
stage 36
Face Mesenchyme
Entry 11 GEISHA Id Col2a.Martinez.2018 Data Source Publication Complete cDNA Template Probe show ACTGCTCGGCCCGACGGACGGTGAGAGGGCCTCCGCCGCCCGCCATGCACGGCCGCCGCCCGCCCCGCTCCGCCGCTCT
Citation Martinez D, Zuhdi N, Reyes M, Ortega B, Giovannone D, Lee VM, de Bellard ME. Screen for Slit/Robo signaling in trunk neural cells reveals new players. Gene Expr Patterns. 2018 Jun;28:22-33. Epub 2018 Feb 7. DIO: 10.1016/j.gep.2018.01.002. Copyright Copyright © 2018 The Authors. Published by Elsevier B.V. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence was obtained from NCBI (NM_204426).
Data from NCBI Unigene EST ProfileGga.2839
Mouse Frog Fruit Fly Zebra Finch Zebrafish
