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EFNA5 Gene Summary Expression Transcript Levels Other Species Expression JBrowse Gene Official Symbol EFNA5 Official Full Name ephrin A5 CGNC ID 49648 also known as RAGS, ephrin-A5|EPH-related receptor tyrosine kinase ligand 7|LERK-7|repulsive axon guidance signal protein, Ephrin-A5 precursor , LERK-7, RAGS protein, EPH-related receptor tyrosine kinase ligand 7 gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Molecular Function chemorepellent activity , ephrin receptor binding Biological Process brain development , ephrin receptor signaling pathway , negative chemotaxis , more... positive regulation of peptidyl-tyrosine phosphorylation , regulation of actin cytoskeleton organization , regulation of cell-cell adhesion , regulation of focal adhesion assembly , regulation of microtubule cytoskeleton organization , regulation of Rac GTPase activity , regulation of Rho GTPase activity , retinal ganglion cell axon guidance Cellular Component anchored component of external side of plasma membrane , plasma membrane
Links to other databases
Entry 1 GEISHA Id EFNA5.UApcr Data Source GEISHA ISH Analysis Forward cDNA Template Primer TTATAAAAGCTTGCGGCCGCAGAATATAACAGCACCAACCCCAGATTC Reverse cDNA Template Primer GCTCTAGAAATTAACCCTCACTAAAGGCAAAAGCATTGCCAGGAGGAAC cDNA Template Length 570 Forward cDNA Template Probe show GACTACCACATCGATGTGTGCATCAACGACTACCTGGATGTATTCTGCCCTCACTATGAAGACTCGGTGCCAGAAGATA
Entry 2 GEISHA Id EphrinA5.Baker.2003 Data Source Publication Complete cDNA Template Probe show ATTTTCCGCATCCGTCTCCCCGCGATGCCGCACGTGGAGATGCTGCTGCTGGCGGTCGCGGCGCTGTGGGTGTGCGTGC
Citation Baker RK, Antin PB. Ephs and ephrins during early stages of chick embryogenesis Dev Dyn. 2003 Sep;228(1):128-42. Copyright 2003 Wiley-Liss, Inc. Comments We are unable to detect ephrinA5 transcription before stage 7. During stages 7-12 (Fig. 1D-F), ephrinA5 expression is prominent in the neural folds, with highest levels present throughout the presumptive brain. Weak ephrinA5 expression is also detected in the head mesenchyme during stages 9-12.
Entry 3 GEISHA Id ephrin-A5.Mühleisen.2006 Data Source Publication Complete cDNA Template Probe show ATTTTCCGCATCCGTCTCCCCGCGATGCCGCACGTGGAGATGCTGCTGCTGGCGGTCGCGGCGCTGTGGGTGTGCGTGC
Citation Mühleisen TW, Agoston Z, Schulte D. Retroviral misexpression of cVax disturbs retinal ganglion cell axon fasciculation and intraretinal pathfinding in vivo and guidance of nasal ganglion cell axons in vivo. Dev Biol. 2006 Sep 1;297(1):59-73. Copyright Reprinted from Developmental Biology, Volume 297, Thomas W. Mühleisen, Zsuzsa Agoston and Dorothea Schulte, Retroviral misexpression of cVax disturbs retinal ganglion cell axon fasciculation and intaretinal pathfinding in vivo and guidance of nasal ganglion cell axons in vitro, Pages 56-73, Copyright 2006, with permission from Elsevier.
Copyright © 2006 Elsevier B.V. All rights reserved. Comments According to the authors, "The cDNA clones used to generate in situ probes for EphA3, EphA4, ephrin-A5, ephrin-A2, EphB2, EphB3, ephrin-B1, ephrin-B2 or RCS, which recognizes a viral core protein, were described elsewhere (Schulte et al., 1999) or were gifts from J. Flanagan, C. Cepko (Harvard Medical School, Boston), or E. Pasquale (The Burnham Institute, La Jolla, California; Holash and Pasquale, 1995 and Cheng et al., 1995). As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_205184)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-22 stage 22
Eye Retina
Entry 4 GEISHA Id Ephrin-A5.Marin.2001 Data Source Publication Complete cDNA Template Probe show ATTTTCCGCATCCGTCTCCCCGCGATGCCGCACGTGGAGATGCTGCTGCTGGCGGTCGCGGCGCTGTGGGTGTGCGTGC
Citation Marín O, Blanco MJ, Nieto MA (2001). Differential expression of Eph receptors and ephrins correlates with the formation of topographic projections in primary and secondary visual circuits of the embryonic chick forebrain. Dev Biol. 2001 Jun 15;234(2):289-303. Copyright Copyright © 2001 Academic Press. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205184).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-38 stage 35
stage 35
stage 35
stage 35
stage 38
stage 38
stage 38
stage 38
stage 38
Diencephalon Midbrain
Entry 5 GEISHA Id EPHRINA5.Takahashi.2003 Data Source Publication Complete cDNA Template Probe show ATGCCGCACGTGGAGATGCTGCTGCTGGCGGTCGCGGCGCTGTGGGTGTGCGTGCGCGGGCAGGAGCCCGGCCGCAAGG
Citation Takahashi H, Shintani T, Sakuta H, Noda M. CBF1 controls the retinotectal topographical map along the anteroposterior axis through multiple mechanisms. Development. 2003 Nov;130(21):5203-15. Epub 2003 Sep 3. Copyright Published by The Company of Biologists 2007. This material is protected by a copyright retained by the authors. Comments The authors indicated the probe was the 681 bp fragment of chick ephrin A5 (25-705; X90377)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-12 stage 12
Retina 13-18 stage 18
stage 18
stage 18
stage 18
Retina 31-34 stage 34
stage 34
stage 34
stage 34
stage 34
Retina
Entry 6 GEISHA Id EPHA5.Jayasena.2005 Data Source Publication Complete cDNA Template Probe show GGTGGCCGACCGCTACGCCGTCTACTGGAACAGCACCAACCCCAGATTCCAGCAGGGAGACTACCACATCGATGTGTGC
Citation Jayasena CS, Flood WD, Koblar SA. High EphA3 expressing ophthalmic trigeminal sensory axons are sensitive to ephrin-A5-Fc: implications for lobe specific axon guidance. Neuroscience. 2005;135(1):97-109. Copyright Copyright © 2005 IBRO. Published by Elsevier Ltd. All rights reserved. Comments The complete cDNA template sequence was obtained from the information provided in the publication as described in Jayasena et al., 2005.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13 stage 13
stage 13
stage 13
Eye Head Mesenchyme Midbrain all
Entry 7 GEISHA Id ephrin‐A5.Iwamasa.1999 Data Source Publication Complete cDNA Template Probe show TTTTCCGCATCCGTCTCCCCGCGATGCCGCACGTGGAGATGCTGCTGCTGGCGGTCGCGGCGCTGTGGGTGTGCGTGCG
Citation Iwamasa H, Ohta K, Yamada T, Ushijima K, Terasaki H, Tanaka H. Expression of Eph receptor tyrosine kinases and their ligands in chick embryonic motor neurons and hindlimb muscles. Dev Growth Differ. 1999 Dec;41(6):685-98. Copyright Copyright © 1999 John Wiley & Sons, Inc. Comments The complete cDNA template sequence was obtained from the information from the publication as described in Iwamasa et al.1999.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 23
stage 23
stage 23
stage 23
Spinal Cord 25-30 stage 27
stage 27
stage 27
stage 27
stage 29
stage 29
stage 29
stage 29
Spinal Cord 31-44 stage 32
stage 32
stage 32
stage 32
stage 44
Spinal Cord
Entry 8 GEISHA Id ephrin-A5.Araujo.1998 Data Source Publication Complete cDNA Template Probe show TTTTCCGCATCCGTCTCCCCGCGATGCCGCACGTGGAGATGCTGCTGCTGGCGGTCGCGGCGCTGTGGGTGTGCGTGCG
Citation Araujo M, Piedra ME, Herrera MT, Ros MA, Nieto MA. The expression and regulation of chick EphA7 suggests roles in limb patterning and innervation. Development. 1998 Nov;125(21):4195-204. Copyright © The Company of Biologists Limited 1998 Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205184.2).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-26 stage 26
stage 26
stage 26
stage 26
Spinal Cord Unlabeled
Entry 9 GEISHA Id EFNA5.Anderson.2020 Data Source Direct Submission Complete cDNA Template Probe show GTAAAACTTAAAGCTATGTTCTTTAAATTCTGTATTATTAGCAACCTCTGTTGTATATAGTGTTTGATAATAAAGTATT
Comments Images and probe sequence provided by Claire Anderson. The probe was synthesized from cDNA clone ChEST290o16 (GenBank: CR406662.1).
Data from NCBI Unigene EST ProfileGga.651
Mouse Frog Fruit Fly Zebra Finch Zebrafish
