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Gene Family QuickSearch
Human Disease Gene Search
FGFR1 The human orthologue of this gene is associated
Gene Summary Expression Transcript Levels Other Species Expression JBrowse Gene Official Symbol FGFR1 Official Full Name fibroblast growth factor receptor 1 CGNC ID 49847 also known as fibroblast growth factor receptor 1|FGFR-1|bFGF-R-1|basic fibroblast growth factor receptor 1|cek1 protein|fibroblast growth factor receptor 1-IIIc|tyrosine kinase receptor CEK1, Basic fibroblast growth factor receptor 1 precursor , Tyrosine kinase receptor CEK1 gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Molecular Function ATP binding , fibroblast growth factor-activated receptor activity , fibroblast growth factor binding , more... heparin binding Biological Process epicardial cell to mesenchymal cell transition , limb development , peptidyl-tyrosine phosphorylation , more... positive regulation of cell proliferation , positive regulation of MAP kinase activity , positive regulation of phospholipase C activity , positive regulation of transcription, DNA-templated Cellular Component cytoplasmic membrane-bounded vesicle , cytosol , integral component of membrane , nucleus , plasma membrane
Links to other databases
Entry 1 GEISHA Id FGFR1b.UApcr Data Source GEISHA ISH Analysis Forward cDNA Template Primer TTATAAAAGCTTGCGGCCGCAGAATATGATCCTGAAGCACTCGGGAA Reverse cDNA Template Primer GCTCTAGAAATTAACCCTCACTAAAGGGCTCAGTAGCTTTTGCCAGA cDNA Template Length 147 Forward cDNA Template Probe show NCCCAGGAAAAAANTATAANNTATTATAGCTCTGATGCGGAGGTGCTGACCCTGTATAATGTGACAGAGGCGGAGAGCG
Reverse cDNA Template Probe show ATTTTTANNNGGTGTTGGTTGGGGTCTGGTGACAGTGAGCCACGCAGACTGGTTGGCCTCGCCAATATAATTGGAAACC
Comments FGFR1b is a splice variant of FGFR1. The probe recognizes only the "b" specific region.
Entry 2 GEISHA Id Fgfr1.Lunn.2007 Data Source Publication Complete cDNA Template Probe show CGCCCCATGGAGGGGCGGTTGAGCGCAGTCGCTGAGCAGTAGCCGCAGCAGTGGGATGTTTACCTGGAGGTGCCTCATC
Citation Lunn JS, Fishwick KJ, Halley PA, Storey KG. A spatial and temporal map of FGF/Erk1/2 activity and response repertoires in the early chick embryo.
Dev Biol. 2007 Feb 15;302(2):536-52. Epub 2006 Oct 14. Copyright Copyright © 2006 Elsevier Inc. All rights reserved. Comments Insufficient information in publication to verify exact sequence used to
synthesize probe. Sequence below was obtained from NCBI (acc #NM_205510).
Entry 3 GEISHA Id FGFR4.Ahmed.2006 Data Source Publication Complete cDNA Template Probe show ATGCAGCTGACCAGCAGGCTGCAGGCTGTGTCTGGGGAAGTGATGCCACGTGCTGAGGGCAGTGGGGCTGCAGAGAGCC
Citation Ahmed MU, Cheng L, Dietrich S. Establishment of the epaxial-hypaxial boundary in the avian myotome. Dev Dyn. 2006 Jul;235(7):1884-94. Copyright Copyright © 2006 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI Acc#.XM_003642072.1
Entry 4 GEISHA Id Fgfr1.Shin.2006 Data Source Publication Complete cDNA Template Probe show GGAGGTGCCTCATCCTTTGGGCTGTGCTGGTCACAGCCACGCTGTCTGCTGCCAGACCGGCCCCCACGCTGCCCGACCA
Citation Shin M, Noji S, Neubüser A, Yasugi S.
FGF10 is required for cell proliferation and gland formation in the stomach epithelium of the chicken embryo. Dev Biol. 2006 Jun 1;294(1):11-23. Epub 2006 Apr 17. Copyright Reprinted from Developmental Biology, 294, Masahiron Shin, Sumihare Noji, Annette Neubüser, and Sadao Yasugl, 11-23, Copyright 2006, with permission from Elsevier. Copyright © 2005 Elsevier Inc. All rights reserved. Comments Author said: Probes were derived from cDNA fragments of cFgfr1 (a gift from Dr. C. Marcelle; Marics, et al., (2002). They reported: chick FGFR1 IgG 3c isoform, was PCR amplified (the amplified fragment corresponds to amino acids 1 to 373 of the cFGFR1/CEK1 GenBank Accession Number, TVCHFG).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-38 stage 37
stage 38
Stomach
Entry 5 GEISHA Id Fgfr1.Shin.2005 Data Source Publication Complete cDNA Template Probe show CGCCCCATGGAGGGGCGGTTGAGCGCAGTCGCTGAGCAGTAGCCGCAGCAGTGGGATGTTTACCTGGAGGTGCCTCATC
Citation Shin M, Watanuki K, Yasugi S (2005).
Expression of Fgf10 and Fgf receptors during development of the embryonic chicken stomach. Gene Expr Patterns. 2005 Apr;5(4):511-6. Copyright Copyright © 2004 Elsevier B.V. All rights reserved. Comments According to authors , "cFgfr1 was a gift from Dr C. Marcelle; Marics et al., 2002" As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_205510).
Entry 6 GEISHA Id qFgfr4.Shin.2005 Data Source Publication Complete cDNA Template Probe show GCCGCGTCCCACGGGAGGCCCGGAAGATGCTGCCGCTCTGGCTCGTCCTGGCGGGGCTGCTGCTGGCGGTCGGCCCGGC
Citation Shin M, Watanuki K, Yasugi S (2005).
Expression of Fgf10 and Fgf receptors during development of the embryonic chicken stomach. Gene Expr Patterns. 2005 Apr;5(4):511-6. Copyright Copyright © 2004 Elsevier B.V. All rights reserved. Comments According to authors , "cFgfr3 and quail Fgfr4 (a gift from Dr C. Marcelle; Marics et al., 2002)." As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # X76885). Note: a quail probe was used, but we are showing the chick homolog.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 22
Gizzard 25-30 stage 27
stage 29
stage 29
stage 30
stage 30
Gizzard Gut 31-39 stage 36
stage 36
stage 39
stage 39
Gut Unlabeled all
Entry 7 GEISHA Id FgfR1.Holleville.2007 Data Source Publication Complete cDNA Template Probe show TGGGTGGTTCGCCCTACCCCGGCGTGCCCGTGGAGGAGCTCTTCAAGCTGCTGAAGGAAGGCCACAGGATGGACAAGCC
Citation Holleville N, Matéos S, Bontoux M, Bollerot K, Monsoro-Burq AH. Dlx5 drives Runx2 expression and osteogenic differentiation in developing cranial suture mesenchyme. Dev Biol. 2007 Apr 15;304(2):860-74. Copyright Reprinted with permission from Elsevier.
Copyright © 2007 Elsevier B.V. All rights reserved. Comments For the probe, the authors refer to the Wilke et al paper from 1997, which states cRNA for FGFR1 was nucleotides 2124 to 2930. This section was extracted from NCBI Acc# NM_205510.1)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-38 stage 38
stage 38
stage 38
stage 38
Face Mesenchyme
Entry 8 GEISHA Id FGFR1.Yoshioka.2005 Data Source Publication Complete cDNA Template Probe show CGCCCCATGGAGGGGCGGTTGAGCGCAGTCGCTGAGCAGTAGCCGCAGCAGTGGGATGTTTACCTGGAGGTGCCTCATC
Citation Yoshioka H, Ishimaru Y, Sugiyama N, Tsunekawa N, Noce T, Kasahara M, Morohashi K (2005). Mesonephric FGF signaling is associated with the development of sexually indifferent gonadal primordium in chick embryos. Dev Biol. 2005 Apr 1;280(1):150-61. Copyright Copyright © 2005 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205510).
Entry 9 GEISHA Id Fgfr1.Firnberg.2002 Data Source Publication Complete cDNA Template Probe show CGCCCCATGGAGGGGCGGTTGAGCGCAGTCGCTGAGCAGTAGCCGCAGCAGTGGGATGTTTACCTGGAGGTGCCTCATC
Citation Firnberg N, Neubüser A (2005).FGF signaling regulates expression of Tbx2, Erm, Pea3, and Pax3 in the early nasal region. Dev Biol. 2002 Jul 15;247(2):237-50. Copyright "Reprinted from Developmental Biology, 247(2), Firnberg N, Neubüser A, FGF signaling regulates expression of Tbx2, Erm, Pea3, and Pax3 in the early nasal region, 237-50., Copyright (2002), with permission from Elsevier".
Copyright © (2002) Elsevier B.V. All rights reserved. Comments According to authors, "The plasmids used to prepare the antisense riboprobes employed in this study have
previously been described: (refs)" As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_205510).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-18 stage 18
Forebrain 19-24 stage 24
31-44 stage 44
Forebrain
Entry 10 GEISHA Id FGFR4.Holleville.2003 Data Source Publication Complete cDNA Template Probe show ATGCAGCTGACCAGCAGGCTGCAGGCTGTGTCTGGGGAAGTGATGCCACGTGCTGAGGGCAGTGGGGCTGCAGAGAGCC
Citation Holleville N, Quilhac A, Bontoux M, Monsoro-Burq AH. BMP signals regulate Dlx5 during early avian skull development. Dev Biol. 2003 May 1;257(1):177-89. Copyright Copyright © 2003 Elsevier Science (USA) All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (XM_003642072.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-42 stage 42
stage 42
Head Mesenchyme
Entry 11 GEISHA Id FGFR1.Holleville.2003 Data Source Publication Complete cDNA Template Probe show CGCCCCATGGAGGGGCGGTTGAGCGCAGTCGCTGAGCAGTAGCCGCAGCAGTGGGATGTTTACCTGGAGGTGCCTCATC
Citation Holleville N, Quilhac A, Bontoux M, Monsoro-Burq AH. BMP signals regulate Dlx5 during early avian skull development. Dev Biol. 2003 May 1;257(1):177-89. Copyright Copyright © 2003 Elsevier Science (USA) All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205510).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-42 stage 35
stage 42
stage 42
Head Mesenchyme Surface Ectoderm
Entry 12 GEISHA Id FGFR1.Walshe.2000 Data Source Publication Complete cDNA Template Probe show CGCCCCATGGAGGGGCGGTTGAGCGCAGTCGCTGAGCAGTAGCCGCAGCAGTGGGATGTTTACCTGGAGGTGCCTCATC
Citation Walshe J, Mason I. Expression of FGFR1, FGFR2 and FGFR3 during early neural development in the chick embryo. Mech Dev. 2000 Jan;90(1):103-10. Copyright Copyright © 2000 Elsevier Ireland Ltd. All rights reserved Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc # NM_205510.1)
Entry 13 GEISHA Id FGFR1.Nishita.2011 Data Source Publication Complete cDNA Template Probe show CGCCCCATGGAGGGGCGGTTGAGCGCAGTCGCTGAGCAGTAGCCGCAGCAGTGGGATGTTTACCTGGAGGTGCCTCATC
Citation Nishita J, Ohta S, Bleyl SB, Schoenwolf GC. Detection of isoform-specific fibroblast growth factor receptors by whole-mount in situ hybridization in early chick embryos. Developmental Dynamics 240:1537-1547, 2011.
Copyright Copyright © 2011 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc #: NM_205510 ).
Entry 14 GEISHA Id FGFR1.LeGuen.2009 Data Source Publication Complete cDNA Template Probe show CGCCCCATGGAGGGGCGGTTGAGCGCAGTCGCTGAGCAGTAGCCGCAGCAGTGGGATGTTTACCTGGAGGTGCCTCATC
Citation Le Guen L, Notarnicola C, de Santa Barbara P.
Intermuscular tendons are essential for the development of vertebrate stomach.
Development. 2009 Mar;136(5):791-801. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_205510).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-30 stage 29
stage 29
Gizzard Stomach 31-35 stage 35
Stomach
Entry 15 GEISHA Id FGFR1.Hardy.2011 Data Source Publication Complete cDNA Template Probe show CGCCCCATGGAGGGGCGGTTGAGCGCAGTCGCTGAGCAGTAGCCGCAGCAGTGGGATGTTTACCTGGAGGTGCCTCATC
Citation Hardy KM, Yatskievych TA, Konieczka J, Bobbs AS, Antin PB. FGF signalling through RAS/MAPK and PI3K pathways regulates cell movement and gene expression in the chicken primitive streak without affecting E-cadherin expression. BMC Dev Biol. 2011 Mar 21;11:20.
Copyright © 2011 Hardy et al; licensee BioMed Central Ltd. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc #NM_205510).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4 stage 4
stage 4
stage 4
Epiblast Primitive Streak
Entry 16 GEISHA Id FGFR1.Moura.2011 Data Source Publication Complete cDNA Template Probe show CGCCCCATGGAGGGGCGGTTGAGCGCAGTCGCTGAGCAGTAGCCGCAGCAGTGGGATGTTTACCTGGAGGTGCCTCATC
Citation Moura RS, Coutinho-Borges JP, Pacheco AP, Damota PO, Correia-Pinto J. FGF signaling pathway in the developing chick lung: expression and inhibition studies. PLoS One. 2011 Mar 11;6(3):e17660. Copyright PLoS One is an open access journal Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_205510).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 24
stage 24
Lung 25-29 stage 27
stage 29
Lung
Entry 17 GEISHA Id FGFR4.Moura.2011 Data Source Publication Complete cDNA Template Probe show ATGCAGCTGACCAGCAGGCTGCAGGCTGTGTCTGGGGAAGTGATGCCACGTGCTGAGGGCAGTGGGGCTGCAGAGAGCC
Citation Moura RS, Coutinho-Borges JP, Pacheco AP, Damota PO, Correia-Pinto J. FGF signaling pathway in the developing chick lung: expression and inhibition studies. PLoS One. 2011 Mar 11;6(3):e17660. Copyright PLoS One is an open access journal Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc # XM_003642072.1)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 24
stage 24
Unlabeled 25-29 stage 27
stage 29
Lung Unlabeled
Entry 18 GEISHA Id FGFR1.Sheeba.2010 Data Source Publication Complete cDNA Template Probe show CGCCCCATGGAGGGGCGGTTGAGCGCAGTCGCTGAGCAGTAGCCGCAGCAGTGGGATGTTTACCTGGAGGTGCCTCATC
Citation Sheeba CJ, Andrade RP, Duprez D, Palmeirim I.
Comprehensive analysis of fibroblast growth factor receptor expression patterns during chick forelimb development. Int J Dev Biol. 2010;54(10):1517-26.
Copyright © UBC Press Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_205510).
Entry 19 GEISHA Id FGFR4.Sheeba.2010 Data Source Publication Complete cDNA Template Probe show ATGCAGCTGACCAGCAGGCTGCAGGCTGTGTCTGGGGAAGTGATGCCACGTGCTGAGGGCAGTGGGGCTGCAGAGAGCC
Citation Sheeba CJ, Andrade RP, Duprez D, Palmeirim I.
Comprehensive analysis of fibroblast growth factor receptor expression patterns during chick forelimb development. Int J Dev Biol. 2010;54(10):1517-26.
Copyright © UBC Press Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI Acc#XM_003642072.1).
Entry 20 Entry 21 Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 24
stage 24
Wing Mesenchyme 31 stage 31
Wing Bones
Entry 22 GEISHA Id FGFR4.Dude.2009 Data Source Publication Complete cDNA Template Probe show ATGCAGCTGACCAGCAGGCTGCAGGCTGTGTCTGGGGAAGTGATGCCACGTGCTGAGGGCAGTGGGGCTGCAGAGAGCC
Citation Dude CM, Kuan CY, Bradshaw JR, Greene ND, Relaix F, Stark MR, Baker CV. Activation of Pax3 target genes is necessary but not sufficient for neurogenesis in the ophthalmic trigeminal placode. Dev Biol. 2009 Feb 15;326(2):314-26. Epub 2008 Dec 7. Copyright Copyright © 2009 Published by Elsevier Inc. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # XM_003642072.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-14 stage 14
stage 14
stage 14
stage 14
stage 14
stage 14
stage 14
stage 14
stage 14
Placode
Entry 23 GEISHA Id FGFR1.Stuhlmiller.2012 Data Source Publication Complete cDNA Template Probe show AACAGTGAAATTCAAGTGCCCCTCAGGTGGGACGCCCAACCCCACGCTGCGCTGGCTGAAGAACGGCAAGGAGTTCAAG
Citation Stuhlmiller TJ, García-Castro MI. FGF/MAPK signaling is required in the gastrula epiblast for avian neural crest induction. Development. 2012 Jan;139(2):289-300. Copyright © 2012. Published by The Company of Biologists Ltd Comments The sequence below was obtained from NCBI (acc # NM_205510.1 - Showing 409 bp region from base 565 to 973) using the information provided in the publication.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 1-3 stage 3
stage 3
stage 3
Epiblast 4 stage 4
stage 4
Epiblast Neural Plate/Tube
Entry 24 GEISHA Id FGFR4.Stuhlmiller.2012 Data Source Publication Complete cDNA Template Probe show ATGCAGCTGACCAGCAGGCTGCAGGCTGTGTCTGGGGAAGTGATGCCACGTGCTGAGGGCAGTGGGGCTGCAGAGAGCC
Citation Stuhlmiller TJ, García-Castro MI. FGF/MAPK signaling is required in the gastrula epiblast for avian neural crest induction. Development. 2012 Jan;139(2):289-300. Copyright © 2012. Published by The Company of Biologists Ltd Comments FGFR4 in situs were done with a quail FREK Probe. Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (XM_003642072.1) and is the chicken FGFR4/FREK.
Entry 25 Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-42 stage 37
stage 37
stage 42
Ovary
Entry 26 GEISHA Id FGFR4.Havis.2012 Data Source Publication Complete cDNA Template Probe show ATGCAGCTGACCAGCAGGCTGCAGGCTGTGTCTGGGGAAGTGATGCCACGTGCTGAGGGCAGTGGGGCTGCAGAGAGCC
Citation Havis E, Coumailleau P, Bonnet A, Bismuth K, Bonnin MA, Johnson R, Fan CM, Relaix F, Shi DL, Duprez D. Sim2 prevents entry into the myogenic program by repressing MyoD transcription during limb embryonic myogenesis. Development. 2012 Jun;139(11):1910-20. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # XM_003642072.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 22
stage 22
stage 22
Wing 25-26 stage 26
stage 26
Wing
Entry 27 GEISHA Id FgfR1.Abzhanov.2007 Data Source Publication Complete cDNA Template Probe show CGCCCCATGGAGGGGCGGTTGAGCGCAGTCGCTGAGCAGTAGCCGCAGCAGTGGGATGTTTACCTGGAGGTGCCTCATC
Citation Abzhanov, A., Cordero, D. R., Sen, J., Tabin, C. J. and Helms, J. A. Cross–regulatory interactions between Fgf8 and Shh in the avian frontonasal prominence. Congenit Anom (Kyoto). 2007 Dec;47(4):136-48. Copyright Copyright © 2007 The Authors, Journal compilation © 2007 Japanese Teratology Society Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence above was obtained from NCBI (acc # NM_205510.1).
Data from NCBI Unigene EST ProfileGga.870
Mouse Frog Fruit Fly Zebra Finch Zebrafish
