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Human Disease Gene Search
FGFR2 The human orthologue of this gene is associated
Gene Summary Expression Transcript Levels Other Species Expression JBrowse Gene Official Symbol FGFR2 Official Full Name fibroblast growth factor receptor 2 CGNC ID 49722 also known as BEK, cek3, fibroblast growth factor receptor 2|FGFR-2|chicken tyrosine kinase (cek3)|receptor tyrosine kinase|tyrosine kinase receptor CEK3, Fibroblast growth factor receptor 2 precursor, FGFR-2, Tyrosine kinase receptor CEK3, CEK3, BEK gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Links to other databases
Entry 1 GEISHA Id ChEST827a6 Data Source GEISHA ISH Analysis Forward cDNA Template Probe show GCTGCAGTCCGTGCCGCGGAGCCGCCGCCGCTCGGCGCTTCGCCTCGGCGGAGCCTTCCCGCGGAGCCCTCCGGCTGCA
Entry 2 GEISHA Id FGFR2.UApcr Data Source GEISHA ISH Analysis Forward cDNA Template Primer TTATAAAAGCTTGCGGCCGCAGAATATAGAGCCGCCAACCAAATACC Reverse cDNA Template Primer GCTCTAGAAATTAACCCTCACTAAAGGTCTTTCAGCATCTTCACTGCCAC cDNA Template Length 1057 Complete cDNA Template Probe show AAATGGAGAAAAGGTTACACGCAGTGCCAGCAGCAAACACTGTCAAGTTTCGTTGCCCAGCCATGGGAAACCCAACACC
Entry 3 GEISHA Id FGFR2b.UApcr Data Source GEISHA ISH Analysis Forward cDNA Template Primer TTATAAAAGCTTGCGGCCGCAGAATATGGTTTTAAAGCATTCGGGGA Reverse cDNA Template Primer GCTCTAGAAATTAACCCTCACTAAAGGTTTCAGGAGCTTGTAAACTC cDNA Template Length 150 Forward cDNA Template Probe show GGTTTTAAAGCATTCGGGGATAAATAGTTCCAATGCTGAAGTGCTGACACTGTACAATGTGACAGAGGCGGACGCTGGA
Reverse cDNA Template Probe show CCAGGCTATATTGTCTAGAGCATCCCCTATATAATTGGAGACCTTACAAATATATTCTCCAGCGTCCGCCTCTGTCACA
Comments Probe recognizes the b splice variant of FGFR2
Probe generated by pcr according to Nishita et al, 2011
F1:5'TTATAAAAGCTTGCGGCCGCAGAATATGGTTTTAAAGCATTCGGGGA-3'
B1:5'GCTCTAGAAATTAACCCTCACTAAAGGTTTCAGGAGCTTGTAAACTC-3'
Generates a 150 nt product.
Entry 4 GEISHA Id FGFR2c.UApcr Data Source GEISHA ISH Analysis Forward cDNA Template Primer TTATAAAAGCTTGCGGCCGCAGAATATGGTTTTAAAGGCTGCCGGTG Reverse cDNA Template Primer GCTCTAGAAATTAACCCTCACTAAAGGTTTCAGGAGCTGGCAGAACT cDNA Template Length 144 Forward cDNA Template Probe show GGTTTTAAAGGCTGCCGGTGTTAACACTACGGACAAAGAAATTGAGGTTCTCTATATACGGAATGTAACTTTTGAGGAT
Reverse cDNA Template Probe show AGAAAGGATATCCCAATAGAATTACCCGCCAAGCATGTATACTCCCCAGCATCCTCAAAAGTTACATTCCGTATATAGA
Entry 5 GEISHA Id Fgfr2.Lunn.2007 Data Source Publication Complete cDNA Template Probe show CGCGCGGAACCCTCCGGCTGCAGCCGCTGCCGTTCCCGGTGAGGAGGGATTGCCCTGGCCGAAGGCACTGCGTTCTGTC
Citation Lunn JS, Fishwick KJ, Halley PA, Storey KG. A spatial and temporal map of FGF/Erk1/2 activity and response repertoires in the early chick embryo.
Dev Biol. 2007 Feb 15;302(2):536-52. Epub 2006 Oct 14. Copyright Copyright © 2006 Elsevier Inc. All rights reserved. Comments Insufficient information in publication to verify exact sequence used to
synthesize probe. Sequence below was obtained from NCBI (acc #NM_205319).
Entry 6 GEISHA Id FGFR2.McCabe.2006 Data Source Publication Complete cDNA Template Probe show GTGGCAGTGAAGATGCTGAAAGATGATGCTACGGAAAAGGATCTATCCGACCTGGTGTCAGAGATGGAGATGATGAAGA
Citation McCabe KL, Shiau CE, Bronner-Fraser M.
Identification of candidate secreted factors involved in trigeminal placode induction.
Dev Dyn. 2007 Oct;236(10):2925-35. Copyright Copyright © 2007 Wiley-Liss, Inc. Comments Sequence below was obtained from NCBI (NM_205319) using the primers provided in the publication: fibroblast growth factor receptor-2 (FGFR2) forward primer, 5'-GTGGCAGTGAAGATGCTGAA-3'; and reverse primer, 5'-GGTGCAGTTGGCAGGTTTAT-3'.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-10 stage 8
stage 10
Midbrain Neural Plate/Tube
Entry 7 GEISHA Id Fgfr2.Shin.2006 Data Source Publication Complete cDNA Template Probe show CGCGCGGAACCCTCCGGCTGCAGCCGCTGCCGTTCCCGGTGAGGAGGGATTGCCCTGGCCGAAGGCACTGCGTTCTGTC
Citation Shin M, Noji S, Neubüser A, Yasugi S.
FGF10 is required for cell proliferation and gland formation in the stomach epithelium of the chicken embryo. Dev Biol. 2006 Jun 1;294(1):11-23. Epub 2006 Apr 17. Copyright Reprinted from Developmental Biology, 294, Masahiron Shin, Sumihare Noji, Annette Neubüser, and Sadao Yasugl, 11-23, Copyright 2006, with permission from Elsevier. Copyright © 2005 Elsevier Inc. All rights reserved. Comments According to authors, "Probes were derived from cDNA fragments of... ... cFgfr2, quailFgfr4 (a gift from Dr. C. Marcelle; Marics et al., 2002). As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_205319)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-36 stage 36
Stomach
Entry 8 GEISHA Id Fgfr2.Shin.2005 Data Source Publication Complete cDNA Template Probe show CGCGCGGAACCCTCCGGCTGCAGCCGCTGCCGTTCCCGGTGAGGAGGGATTGCCCTGGCCGAAGGCACTGCGTTCTGTC
Citation Shin M, Watanuki K, Yasugi S (2005).
Expression of Fgf10 and Fgf receptors during development of the embryonic chicken stomach. Gene Expr Patterns. 2005 Apr;5(4):511-6. Copyright Copyright © 2004 Elsevier B.V. All rights reserved. Comments According to authors , "cFgfr2 (a gift from Dr Noji)." As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_205319).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 22
Gut 25-30 stage 27
stage 29
stage 29
stage 30
stage 30
Gizzard Gut 31-39 stage 36
stage 36
stage 39
stage 39
Gizzard Gut all Gizzard Gut
Entry 9 GEISHA Id Fgfr2.Holleville.2007 Data Source Publication Complete cDNA Template Probe show GAAGGCACTGCGTTCTGTCCATGCTCCTGTAGAGGTGCTCAGATGGGATTAAAGTCCACATGGAGATATGGAAATGGAC
Citation Holleville N, Matéos S, Bontoux M, Bollerot K, Monsoro-Burq AH. Dlx5 drives Runx2 expression and osteogenic differentiation in developing cranial suture mesenchyme. Dev Biol. 2007 Apr 15;304(2):860-74. Copyright Reprinted with permission from Elsevier.
Copyright © 2007 Elsevier B.V. All rights reserved. Comments Authors indicated probes were like those in Wilke et al., 1997 where they indicated FGFR2 probe was nucleotides 601116. These were extracted from NCBI Acc# NM_205319.
no images
Entry 10 GEISHA Id FGFR2.Yoshioka.2005 Data Source Publication Complete cDNA Template Probe show CGCGCGGAACCCTCCGGCTGCAGCCGCTGCCGTTCCCGGTGAGGAGGGATTGCCCTGGCCGAAGGCACTGCGTTCTGTC
Citation Yoshioka H, Ishimaru Y, Sugiyama N, Tsunekawa N, Noce T, Kasahara M, Morohashi K (2005). Mesonephric FGF signaling is associated with the development of sexually indifferent gonadal primordium in chick embryos. Dev Biol. 2005 Apr 1;280(1):150-61. Copyright Copyright © 2005 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205319).
Entry 11 GEISHA Id Fgfr2.Firnberg.2002 Data Source Publication Complete cDNA Template Probe show CGCGCGGAACCCTCCGGCTGCAGCCGCTGCCGTTCCCGGTGAGGAGGGATTGCCCTGGCCGAAGGCACTGCGTTCTGTC
Citation Firnberg N, Neubüser A (2005).FGF signaling regulates expression of Tbx2, Erm, Pea3, and Pax3 in the early nasal region. Dev Biol. 2002 Jul 15;247(2):237-50. Copyright "Reprinted from Developmental Biology, 247(2), Firnberg N, Neubüser A, FGF signaling regulates expression of Tbx2, Erm, Pea3, and Pax3 in the early nasal region, 237-50., Copyright (2002), with permission from Elsevier".
Copyright © (2002) Elsevier B.V. All rights reserved. Comments According to authors, "The plasmids used to prepare the antisense riboprobes employed in this study have
previously been described: refs" As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_205319).
Entry 12 GEISHA Id FGFR2.Holleville.2003 Data Source Publication Complete cDNA Template Probe show CGCGCGGAACCCTCCGGCTGCAGCCGCTGCCGTTCCCGGTGAGGAGGGATTGCCCTGGCCGAAGGCACTGCGTTCTGTC
Citation Holleville N, Quilhac A, Bontoux M, Monsoro-Burq AH. BMP signals regulate Dlx5 during early avian skull development. Dev Biol. 2003 May 1;257(1):177-89. Copyright Copyright © 2003 Elsevier Science (USA) All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205319).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-38 stage 35
stage 35
stage 38
stage 38
Head Mesenchyme
Entry 13 GEISHA Id FGFR2.Nishita.2011 Data Source Publication Complete cDNA Template Probe show CGCGCGGAACCCTCCGGCTGCAGCCGCTGCCGTTCCCGGTGAGGAGGGATTGCCCTGGCCGAAGGCACTGCGTTCTGTC
Citation Nishita J, Ohta S, Bleyl SB, Schoenwolf GC. Detection of isoform-specific fibroblast growth factor receptors by whole-mount in situ hybridization in early chick embryos. Developmental Dynamics 240:1537-1547, 2011.
Copyright Copyright © 2011 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI acc#: NM_205319.1.
Entry 14 GEISHA Id FGFR2.LeGuen.2009 Data Source Publication Complete cDNA Template Probe show CGCGCGGAACCCTCCGGCTGCAGCCGCTGCCGTTCCCGGTGAGGAGGGATTGCCCTGGCCGAAGGCACTGCGTTCTGTC
Citation Le Guen L, Notarnicola C, de Santa Barbara P.
Intermuscular tendons are essential for the development of vertebrate stomach.
Development. 2009 Mar;136(5):791-801. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_205319.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-29 stage 29
stage 29
Gizzard Stomach
Entry 15 GEISHA Id FGFR2.Hardy.2011 Data Source Publication Complete cDNA Template Probe show CGCGCGGAACCCTCCGGCTGCAGCCGCTGCCGTTCCCGGTGAGGAGGGATTGCCCTGGCCGAAGGCACTGCGTTCTGTC
Citation Hardy KM, Yatskievych TA, Konieczka J, Bobbs AS, Antin PB. FGF signalling through RAS/MAPK and PI3K pathways regulates cell movement and gene expression in the chicken primitive streak without affecting E-cadherin expression. BMC Dev Biol. 2011 Mar 21;11:20.
Copyright © 2011 Hardy et al; licensee BioMed Central Ltd. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_205319).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4 stage 4
stage 4
stage 4
Epiblast
Entry 16 GEISHA Id FGFR2.Moura.2011 Data Source Publication Complete cDNA Template Probe show CGCGCGGAACCCTCCGGCTGCAGCCGCTGCCGTTCCCGGTGAGGAGGGATTGCCCTGGCCGAAGGCACTGCGTTCTGTC
Citation Moura RS, Coutinho-Borges JP, Pacheco AP, Damota PO, Correia-Pinto J. FGF signaling pathway in the developing chick lung: expression and inhibition studies. PLoS One. 2011 Mar 11;6(3):e17660. Copyright PLoS One is an open access journal Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_205319).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 24
stage 24
Lung 25-29 stage 27
stage 29
Lung
Entry 17 GEISHA Id FGFR2.Sheeba.2010 Data Source Publication Complete cDNA Template Probe show CGCGCGGAACCCTCCGGCTGCAGCCGCTGCCGTTCCCGGTGAGGAGGGATTGCCCTGGCCGAAGGCACTGCGTTCTGTC
Citation Sheeba CJ, Andrade RP, Duprez D, Palmeirim I.
Comprehensive analysis of fibroblast growth factor receptor expression patterns during chick forelimb development. Int J Dev Biol. 2010;54(10):1517-26.
Copyright © UBC Press Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_205319).
Entry 18 GEISHA Id FGFR2.Chambers.2006 Data Source Publication Complete cDNA Template Probe show CGCGCGGAACCCTCCGGCTGCAGCCGCTGCCGTTCCCGGTGAGGAGGGATTGCCCTGGCCGAAGGCACTGCGTTCTGTC
Citation Chambers, D, Mason, I, A high throughput messenger RNA differential display screen identifies discrete domains of gene expression and novel patterning processes along the developing neural tube. BMC Dev Biol. 2006; 6: 9. Published online 2006 February 24. Copyright Copyright © 2006 Chambers and Mason; licensee BioMed Central Ltd.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_205319 ).
Entry 19 GEISHA Id FGFR2.Chang.2004 Data Source Publication Complete cDNA Template Probe show CGCGCGGAACCCTCCGGCTGCAGCCGCTGCCGTTCCCGGTGAGGAGGGATTGCCCTGGCCGAAGGCACTGCGTTCTGTC
Citation Chang W, Brigande JV, Fekete DM, Wu DK. The development of semicircular canals in the inner ear: role of FGFs in sensory cristae. Development. 2004 Sep;131(18):4425-34. Epub 2004 Aug 11. Copyright Copyright is held by the authors. Published by the Company of Biologists Ltd. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_205319.1 ).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-26 stage 26
stage 26
Ear/Otic Placode
Entry 20 Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) X-XIV stage X
stage X
Unlabeled 4 stage 4
Neural Plate/Tube
Entry 21 GEISHA Id FGFR2.Havens.2006 Data Source Publication Complete cDNA Template Probe show AAGGCACTGCGTTCTGTCCATGCTCCTGTAGAGGTGCTCAGATGGGATTAAAGTCCACATGGAGATATGGAAATGGACC
Citation Havens BA, Rodgers B, Mina M. Tissue-specific expression of Fgfr2b and Fgfr2c isoforms, Fgf10 and Fgf9 in the developing chick mandible. Arch Oral Biol. 2006 Feb;51(2):134-45. Epub 2005 Aug 18. Copyright Copyright © 2005 Elsevier Ltd. All rights reserved. Comments The complete cDNA template sequence was obtained from the information provided in the publication as described in Havens. et al. 2006.
Entry 22 Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 20
stage 20
stage 22
stage 22
Leg Mesenchyme Unlabeled 25-30 stage 27
stage 30
Limb Buds Unlabeled
Entry 23 GEISHA Id FgfR2.Abzhanov.2007 Data Source Publication Complete cDNA Template Probe show CGCGGAACCCTCCGGCTGCAGCCGCTGCCGTTCCCGGTGAGGAGGGATTGCCCTGGCCGAAGGCACTGCGTTCTGTCCA
Citation Abzhanov, A., Cordero, D. R., Sen, J., Tabin, C. J. and Helms, J. A. Cross–regulatory interactions between Fgf8 and Shh in the avian frontonasal prominence. Congenit Anom (Kyoto). 2007 Dec;47(4):136-48. Copyright Copyright © 2007 The Authors, Journal compilation © 2007 Japanese Teratology Society Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence above was obtained from NCBI (acc # NM_205319.2 ).
Entry 24 GEISHA Id FGFR2.Anderson.2020 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show CGCGGAACCCTCCGGCTGCAGCCGCTGCCGTTCCCGGTGAGGAGGGATTGCCCTGGCCGAAGGCACTGCGTTCTGTCCA
Comments Images provided by Claire Anderson. Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence was obtained from NCBI (NM_205319.2).
Related article: Anderson C, Hill B, Lu HC, Moverley A, Yang Y, Oliveira NMM, Baldock RA, Stern CD. A 3D molecular atlas of the chick embryonic heart. Dev Biol. 2019 Dec 1;456(1):40-46. doi: 10.1016/j. yd bio. 2019.07.003. Epub 2019 Jul 5. (PMID: 31283921)
Entry 25 GEISHA Id FGFR2.Olivera-Martinez.2014 Data Source Publication Complete cDNA Template Probe show CGCGGAACCCTCCGGCTGCAGCCGCTGCCGTTCCCGGTGAGGAGGGATTGCCCTGGCCGAAGGCACTGCGTTCTGTCCA
Citation Isabel Olivera-Martinez, Nick Schurch, Roman A Li, Junfang Song, Pamela A Halley, Raman M Das, Dave W Burt, Geoffrey J Barton, Kate G Storey. Major transcriptome re-organisation and abrupt changes in signalling, cell cycle and chromatin regulation at neural differentiation in vivo. Development 2014 Aug;141(16):3266-76. Epub 2014 Jul 25. DOI: 10.1242/dev.112623. Copyright Copyright © 2014. Published by The Company of Biologists Ltd. Comments Authors indicated the probe was made from gene construct provided by E. Pasquale. As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence above was obtained from NCBI (accession number NM_205319.2).
Entry 26 GEISHA Id FGFR2.Anderson.2019 Data Source Publication Complete cDNA Template Probe show GGCTTGACAAAGCTGCGGCGGCACGGGGAGGGCGGCTGGATGGAGCGGAGCAGGACCCGCAGCGATGCCCGCGCGGGGG
Citation Anderson C, Hill B, Lu HC, Moverley A, Yang Y, Oliveira NMM, Baldock RA, Stern CD. A 3D molecular atlas of the chick embryonic heart. Dev Biol. 2019 Dec 1;456(1):40-46. doi: 10.1016/j.ydbio.2019.07.003. Epub 2019 Jul 5. Copyright Copyright © 2019 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205319 ).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-12 stage 12
Proepicardium all
Data from NCBI Unigene EST ProfileGga.1680
Mouse Frog Fruit Fly Zebra Finch Zebrafish
