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Human Disease Gene Search
FRZB The human orthologue of this gene is associated
Gene Summary Expression Transcript Levels Other Species Expression JBrowse Gene Official Symbol FRZB Official Full Name frizzled related protein CGNC ID 1994 also known as Frzb-1, secreted frizzled-related protein 3|frizzled-related protein 1|sFRP-3, Frizzled- related protein 1 (FrzB-1), FRZB, Secreted frizzled-related protein 3 precursor (sFRP-3) gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Molecular Function PDZ domain binding , Wnt-activated receptor activity , Wnt-protein binding Biological Process axonogenesis , brain development , cochlea morphogenesis , epithelium development , gonad development , more... mammary gland involution , negative regulation of canonical Wnt signaling pathway , negative regulation of cartilage development , negative regulation of hepatocyte differentiation , negative regulation of Wnt signaling pathway , vasculature development , Wnt signaling pathway Cellular Component cytoplasm , extracellular space , neuron projection membrane
Links to other databases
Entry 1 GEISHA Id FRZB.UApcr Data Source GEISHA ISH Analysis Forward cDNA Template Primer TTATAAAAGCTTGCGGCCGCAGAATATAGGCACTGGCATTGAACGC Reverse cDNA Template Primer GCTCTAGAAATTAACCCTCACTAAAGGTCCTGACCTTTCCACACCTCAC cDNA Template Length 741 Forward cDNA Template Probe show CAATGCAAACCCATAAAAGCTACCCAGAAGACCTATCTACGCAACAATTACAACTATGTCATTCGAGCAAAAGTGAAGG
Entry 2 GEISHA Id Frzb1.Chapman.2004 Data Source Publication Complete cDNA Template Probe show GGCGCTCGGCCCCTGAGCTCGGGGCCGTCGGCGGCATGTGGCGGGGGCTGCCGGCGCTCGCCCTGGCCGCGCTGCTGCT
Citation Chapman, S, Brown, R, Lees, L, Schoenwolf, G, Lumsden, A. Expression Analysis of Chick Wnt and Frizzled Genes and Selected Inhibitors in Early Chick Patterning. Dev Dyn. 2004 Mar;229(3):668-76. Copyright Wiley-Liss, Inc. 2004 Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # AF218057).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4-5 stage 4
stage 4
stage 4
stage 5
Neural Plate/Tube
Entry 3 GEISHA Id FRZB.Ladher.2000 Data Source Publication Complete cDNA Template Probe show AAGTAAAAGAGATTCTCAAATCTTCCCTGGTGAACATCCCAAAGGACACTGTAAACCTTTACACAAACTCCGGCTGCCT
Citation Ladher RK, Church VL, Allen S, Robson L, Abdelfattah A, Brown NA, Hattersley G, Rosen V, Luyten FP, Dale L, Francis-West PH. Cloning and expression of the Wnt antagonists Sfrp-2 and Frzb during chick development. Dev Biol. 2000 Feb 15;218(2):183-98. Copyright Reprinted with permission from Elsevier.
Copyright © 2000 Elsevier B.V. All rights reserved.
Comments Information provided in publication was used to obtain the sequence below from NCBI (NM_204772).
Entry 4 GEISHA Id FRZB1.Baranski.2000 Data Source Publication Complete cDNA Template Probe show CGCGGCGCTCGGCCCCTGAGCTCGGGGCCGTCGGCGGCATGTGGCGGGGGCTGCCGGCGCTGGCCCTGGCCGCGCTGCT
Citation Baranski M, Berdougo E, Sandler JS, Darnell DK, Burrus LW. The dynamic expression pattern of frzb-1 suggests multiple roles in chick development. Dev Biol. 2000 Jan 1;217(1):25-41. Copyright Copyright © 2000 Academic Press. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204772).
Entry 5 GEISHA Id Frzb.Chapman.2008 Data Source Direct Submission Complete cDNA Template Probe show GGCGCTCGGCCCCTGAGCTCGGGGCCGTCGGCGGCATGTGGCGGGGGCTGCCGGCGCTCGCCCTGGCCGCGCTGCTGCT
Comments Images Provided by Susan Chapman
Entry 6 Entry 7 GEISHA Id FRZB.Allen.2001 Data Source Publication Complete cDNA Template Probe show CGCGGCGCTCGGCCCCTGAGCTCGGGGCCGTCGGCGGCATGTGGCGGGGGCTGCCGGCGCTGGCCCTGGCCGCGCTGCT
Citation Allen SP, Bogardi JP, Barlow AJ, Mir SA, Qayyum SR, Verbeek FJ, Anderson RH, Francis-West PH, Brown NA, Richardson MK (2001). Misexpression of noggin leads to septal defects in the outflow tract of the chick heart. Dev Biol. 2001 Jul 1;235(1):98-109. Copyright Copyright © 2001 Academic Press. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204772).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25 stage 25
Heart Outflow Tract
Entry 8 GEISHA Id FRZB1.Jin.2001 Data Source Publication Complete cDNA Template Probe show CGCGGCGCTCGGCCCCTGAGCTCGGGGCCGTCGGCGGCATGTGGCGGGGGCTGCCGGCGCTGGCCCTGGCCGCGCTGCT
Citation Jin EJ, Erickson CA, Takada S, Burrus LW (2001). Wnt and BMP signaling govern lineage segregation of melanocytes in the avian embryo. Dev Biol. 2001 May 1;233(1):22-37. Copyright Copyright © 2001 Academic Press. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204772).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13 stage 13
stage 13
Neural Crest
Entry 9 GEISHA Id Frzb1.Theodosiou.2003 Data Source Publication Complete cDNA Template Probe show CGCGGCGCTCGGCCCCTGAGCTCGGGGCCGTCGGCGGCATGTGGCGGGGGCTGCCGGCGCTGGCCCTGGCCGCGCTGCT
Citation Theodosiou NA, Tabin CJ. Wnt signaling during development of the gastrointestinal tract. Dev Biol. 2003 Jul 15;259(2):258-71. Copyright Copyright © 2003 Elsevier Science (USA). All rights reserved. Comments Authors indicated probe was made from a ~640 bp fragment. As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_204772).
Entry 10 GEISHA Id Frzb1.McBride.2003 Data Source Publication Complete cDNA Template Probe show CGCGGCGCTCGGCCCCTGAGCTCGGGGCCGTCGGCGGCATGTGGCGGGGGCTGCCGGCGCTGGCCCTGGCCGCGCTGCT
Citation McBride HJ, Fatke B, Fraser SE. Wnt signaling components in the chicken intestinal tract. Dev Biol. 2003 Apr 1;256(1):18-33. Copyright With permission from Elsevier
Copyright © 2003 Elsevier B.V. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc # NM_204772)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-30 stage 26
stage 26
stage 29
stage 30
Hindgut
Entry 11 GEISHA Id SFRP3.Quinlan.2009 Data Source Publication Complete cDNA Template Probe show CGCGGCGCTCGGCCCCTGAGCTCGGGGCCGTCGGCGGCATGTGGCGGGGGCTGCCGGCGCTGGCCCTGGCGCGCTGCTG
Citation Quinlan R, Graf M, Mason I, Lumsden A, Kiecker C. Complex and dynamic patterns of Wnt pathway gene expression in the developing chick forebrain. Neural Dev. 2009 Sep 4;4:35. Copyright Copyright © 2009 Quinlan et al; licensee BioMed Central Ltd. [This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.] Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc # NM_204772)
Entry 12 GEISHA Id FRZB1.Geetha-Loganathan.2009 Data Source Publication Complete cDNA Template Probe show CGCGGCGCTCGGCCCCTGAGCTCGGGGCCGTCGGCGGCATGTGGCGGGGGCTGCCGGCGCTGGCCCTGGCCGCGCTGCT
Citation Geetha-Loganathan, P, Nimmagadda, S, Antoni, L, Fu, K, Whiting, C, Francis-West, P and Richman, J. Expression of WNT signalling pathway genes during chicken craniofacial development. DEVELOPMENTAL DYNAMICS
Volume 238, Issue 5, May 2009, Pages: 11501165. Copyright Dev. Dyn Copyright © 2009 John Wiley & Sons, Inc. All Rights Reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_204772 ).
Entry 13 GEISHA Id FRZB.Sienknecht.2009 Data Source Publication Complete cDNA Template Probe show CTGCAGTAGTGGAAGTAAAAGAGATTCTCAAATCTTCCCTGGTGAACATCCCAAAGGACACTGTAAACCTTTACACAAA
Citation Sienknecht UJ, Fekete DM. Mapping of Wnt, frizzled, and Wnt inhibitor gene expression domains in the avian otic primordium. J Comp Neurol. 2009 Dec 20;517(6):751-64. Copyright Copyright © (2002 Wiley-Liss); This material is used by permission of Wiley-Liss, Inc., a subsidiary of John Wiley & Sons, Inc. Comments NCBI Acc.# provided in paper.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 1-3 stage 1
stage 1
stage 1
13-18 stage 16
stage 16
stage 17
stage 18
Ear/Otic Placode Rhombomeres 19-24 stage 20
stage 22
stage 24
Ear/Otic Placode
Entry 14 GEISHA Id FRZB.Tzahor.2003 Data Source Publication Complete cDNA Template Probe show CGCGGCGCTCGGCCCCTGAGCTCGGGGCCGTCGGCGGCATGTGGCGGGGGCTGCCGGCGCTGGCCCTGGCCGCGCTGCT
Citation Tzahor E, Kempf H, Mootoosamy RC, Poon AC, Abzhanov A, Tabin CJ, Dietrich S, Lassar AB. Antagonists of Wnt and BMP signaling promote the formation of vertebrate head muscle. Genes Dev. 2003 Dec 15;17(24):3087-99. Comments As insufficient information is provided in publication to verify the exact sequence used to synthesize probe, the sequence was obtained from NCBI (acc #NM_204772.2).
Data from NCBI Unigene EST ProfileGga.4955
Mouse Frog Fruit Fly Zebra Finch Zebrafish
