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Human Disease Gene Search
FZD4 The human orthologue of this gene is associated
Gene Summary Expression Transcript Levels Other Species Expression JBrowse Gene Official Symbol FZD4 Official Full Name frizzled class receptor 4 CGNC ID 12957 also known as FZ-4, frizzled-4|cFz-4|frizzled family receptor 4|frizzled homolog 4 gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Molecular Function cytokine binding , G-protein coupled receptor activity , PDZ domain binding , more... protein heterodimerization activity , protein homodimerization activity , ubiquitin protein ligase binding , Wnt-activated receptor activity , Wnt-protein binding Biological Process brain development , canonical Wnt signaling pathway , cerebellum vasculature morphogenesis , more... embryo development , extracellular matrix-cell signaling , locomotion involved in locomotory behavior , negative regulation of cell-substrate adhesion , positive regulation of JUN kinase activity , positive regulation of sequence-specific DNA binding transcription factor activity , positive regulation of transcription, DNA-templated , progesterone secretion , regulation of vascular endothelial growth factor receptor signaling pathway , retinal blood vessel morphogenesis , sensory perception of sound , substrate adhesion-dependent cell spreading , vasculogenesis , Wnt signaling pathway, calcium modulating pathway Cellular Component cell-cell junction , cell projection , cell surface , cytoplasm , integral component of membrane , plasma membrane
Links to other databases
Entry 1 GEISHA Id FZD4.UApcr Data Source GEISHA ISH Analysis Forward cDNA Template Primer GGTGGGCATCACTTCAGGTATG Reverse cDNA Template Primer ATTAACCCTCACTAAAGGAGCACGCACAGTTTCCAGATTC cDNA Template Length 1016 Forward cDNA Template Probe show ACACGTTCCCTATTCTGACATGACCTCGAGCAAGCTTATTTAAAAATGTAAAGTATTGACAGTATCGCAGAATGCTTCA
Comments No specific expression detected at or before stage 6.
Entry 2 GEISHA Id Frizzled4.Chapman.2004 Data Source Publication Complete cDNA Template Probe show TTTGGGTTTGCCTGGCCGGACAGCCTGAACTGCAGCAAATTCCCTCCCCAGAATGATCACAACCACATGTGCATGGAGG
Citation Chapman, S, Brown, R, Lees, L, Schoenwolf, G, Lumsden, A. Expression Analysis of Chick Wnt and Frizzled Genes and Selected Inhibitors in Early Chick Patterning. Dev Dyn. 2004 Mar;229(3):668-76. Copyright Wiley-Liss, Inc. 2004 Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # AB029451).
Entry 3 GEISHA Id Frz-4.Fuhrmann.2003 Data Source Publication Complete cDNA Template Probe show GGAGCGCGGGAGGCAGCGGACGAGCGCCTGGTGTTGACAGCGGGCGCTGCCGACGGGGCTCCCCGACAGCGAGGCGCAG
Citation Fuhrmann S, Stark MR, Heller S. Expression of Frizzled genes in the developing chick eye. Gene Expr Patterns. 2003 Oct;3(5):659-62. Copyright Reprinted from Developmental Biology, Volume 3 Issue 5, Sabine Fuhrmann, Michael R. Stark, and Stefan Heller, Expression of Frizzled genes in the developing chick eye, Pages 659-662, Copyright 2003, with permission from Elsevier.
Copyright © 2003 Elsevier B.V. All rights reserved. Comments Frz-4 is a 474 bp-fragment (position 1065-1538 of accession# AF224316).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-12 stage 10
stage 10
Diencephalon Eye 19-24 stage 23
Retina 25-29 stage 29
Retina
Entry 4 GEISHA Id Fz4.Chapman.2008 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show TTTGGGTTTGCCTGGCCGGACAGCCTGAACTGCAGCAAATTCCCTCCCCAGAATGATCACAACCACATGTGCATGGAGG
Comments Images Provided by Susan Chapman
Entry 5 GEISHA Id Fz4.Theodosiou.2003 Data Source Publication Complete cDNA Template Probe show GGAGCGCGGGAGGCAGCGGACGAGCGCCTGGTGTTGACAGCGGGCGCTGCCGACGGGGCTCCCCGACAGCGAGGCGCAG
Citation Theodosiou NA, Tabin CJ. Wnt signaling during development of the gastrointestinal tract. Dev Biol. 2003 Jul 15;259(2):258-71. Copyright Copyright © 2003 Elsevier Science (USA). All rights reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc# NM_204099).
3.7 kb probe
Entry 6 GEISHA Id Fz4.McBride.2003 Data Source Publication Complete cDNA Template Probe show GGAGCGCGGGAGGCAGCGGACGAGCGCCTGGTGTTGACAGCGGGCGCTGCCGACGGGGCTCCCCGACAGCGAGGCGCAG
Citation McBride HJ, Fatke B, Fraser SE. Wnt signaling components in the chicken intestinal tract. Dev Biol. 2003 Apr 1;256(1):18-33. Copyright With permission from Elsevier
Copyright © 2003 Elsevier B.V. All rights reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_204099.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-30 stage 26
Midgut 31-34 stage 34
Midgut
Entry 7 GEISHA Id FZ4.Quinlan.2009 Data Source Publication Complete cDNA Template Probe show TTTGGGTTTGCCTGGCCGGACAGCCTGAACTGCAGCAAATTCCCTCCCCAGAATGATCACAACCACATGTGCATGGAGG
Citation Quinlan R, Graf M, Mason I, Lumsden A, Kiecker C. Complex and dynamic patterns of Wnt pathway gene expression in the developing chick forebrain. Neural Dev. 2009 Sep 4;4:35. Copyright Copyright © 2009 Quinlan et al; licensee BioMed Central Ltd. [This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.] Comments Authors indicated probe is associated with NCBI acc# AB029451.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-18 stage 16
Forebrain 19 stage 19
Forebrain
Entry 8 GEISHA Id FZD4.Trimarchi.2009 Data Source Publication Complete cDNA Template Probe show GGAGCGCGGGAGGCAGCGGACGAGCGCCTGGTGTTGACAGCGGGCGCTGCCGACGGGGCTCCCCGACAGCGAGGCGCAG
Citation Trimarchi JM, Cho SH, Cepko CL. Identification of genes expressed preferentially in the developing peripheral margin of the optic cup. Dev Dyn. 2009 Sep;238(9):2327-9. Copyright Dev. Dyn Copyright © 2009 John Wiley & Sons, Inc. All Rights Reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_204099.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 23
Eye 25-30 stage 29
Eye 31-36 stage 34
stage 36
Eye Retina
Entry 9 GEISHA Id FZD4.Geetha-Loganathan.2009 Data Source Publication Complete cDNA Template Probe show GGAGCGCGGGAGGCAGCGGACGAGCGCCTGGTGTTGACAGCGGGCGCTGCCGACGGGGCTCCCCGACAGCGAGGCGCAG
Citation Geetha-Loganathan, P, Nimmagadda, S, Antoni, L, Fu, K, Whiting, C, Francis-West, P and Richman, J. Expression of WNT signalling pathway genes during chicken craniofacial development. DEVELOPMENTAL DYNAMICS
Volume 238, Issue 5, May 2009, Pages: 11501165. Copyright Dev. Dyn Copyright © 2009 John Wiley & Sons, Inc. All Rights Reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc # NM_204099)
Entry 10 GEISHA Id FZD4.Paxton.2010 Data Source Publication Complete cDNA Template Probe show GGAGCGCGGGAGGCAGCGGACGAGCGCCTGGTGTTGACAGCGGGCGCTGCCGACGGGGCTCCCCGACAGCGAGGCGCAG
Citation Paxton CN, Bleyl SB, Chapman SC, Schoenwolf GC.
Identification of differentially expressed genes in early inner ear development. Gene Expr Patterns. 2010 Jan;10(1):31-43. Epub 2009 Nov 11.
Copyright 2009 Elsevier B.V. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_204099).
Entry 11 GEISHA Id FZD4.Sienknecht.2009 Data Source Publication Complete cDNA Template Probe show ACAGCATGGGATCTAATTCAGATCAGTACATCTGGGTCAAGAGAAACCTGGACTGTGTCCTGAAGTGCGGCTACGACGC
Citation Sienknecht UJ, Fekete DM. Mapping of Wnt, frizzled, and Wnt inhibitor gene expression domains in the avian otic primordium. J Comp Neurol. 2009 Dec 20;517(6):751-64. Copyright Copyright © (2002 Wiley-Liss); This material is used by permission of Wiley-Liss, Inc., a subsidiary of John Wiley & Sons, Inc. Comments Authors gave the NCBI acc# in the paper.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-21 stage 20
stage 21
Ear/Otic Placode
Entry 12 GEISHA Id cFz-4.Stark.2000 Data Source Publication Complete cDNA Template Probe show GGAGCGCGGGAGGCAGCGGACGAGCGCCTGGTGTTGACAGCGGGCGCTGCCGACGGGGCTCCCCGACAGCGAGGCGCAG
Citation Stark MR, Rao MS, Schoenwolf GC, Yang G, Smith D, Mauch TJ. Frizzled-4 expression during chick kidney development. Mech Dev. 2000 Nov;98(1-2):121-5. Copyright Copyright © 2000 Elsevier Science Ireland Ltd. Comments The complete cDNA template sequence was obtained from the information in the publication as described in Stark et al. 2000.
Data from NCBI Unigene EST ProfileGga.1941
Mouse Frog Fruit Fly Zebra Finch Zebrafish
