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FZD10 Gene Summary Expression Transcript Levels Other Species Expression JBrowse Gene Official Symbol FZD10 Official Full Name frizzled class receptor 10 CGNC ID 48941 also known as cFz-10, frizzled-10|frizzled 10, seven transmembrane spanning receptor|frizzled family receptor 10|frizzled homolog 10|fz-10|seven transmembrane spanning receptor, Frizzled-10 precursor , Fz-10, cFz-10 gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Molecular Function G-protein coupled receptor activity , PDZ domain binding , Wnt-activated receptor activity , more... Wnt-protein binding Biological Process brain development , canonical Wnt signaling pathway , embryo development , gonad development , more... vasculature development Cellular Component cell projection , cytoplasm , integral component of membrane , plasma membrane
Links to other databases
Entry 1 GEISHA Id Frizzled10.Chapman.2004 Data Source Publication Complete cDNA Template Probe show GGAGCCGTGACCCGCTCTAGGAAGAGGAAAATCCCCGGAGGAGCTCGCTGCACCGAAAGCCGCCCGGGACATGTGCGAG
Citation Chapman, S, Brown, R, Lees, L, Schoenwolf, G, Lumsden, A. Expression Analysis of Chick Wnt and Frizzled Genes and Selected Inhibitors in Early Chick Patterning. Dev Dyn. 2004 Mar;229(3):668-76. Copyright Wiley-Liss, Inc. 2004 Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_204098).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4-5
stage 4
stage 4
stage 5
Primitive Streak
Entry 2 GEISHA Id FZD10.McCabe.2007 Data Source Publication Complete cDNA Template Probe show CCTCAGCGTTTCAAGTACCCTGAGAGGCCCATCATCTTCCTCTCTATGTGCTACTGTGTCTACTCGGTGGGGTACATCA
Citation McCabe KL, Shiau CE, Bronner-Fraser M.
Identification of candidate secreted factors involved in trigeminal placode induction.
Dev Dyn. 2007 Oct;236(10):2925-35. Copyright Copyright © 2007 Wiley-Liss, Inc. Comments Sequence below was obtained from NCBI (NM_204098) using the primers provided in the publication: Frizzeld10 forward primer, 5'-CCTCAGCGTTTCAAGTACCC-3'; and reverse primer, 5'-GGCCACAAAACCAGAAAGAA-3'.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-10 stage 8
stage 10
Neural Plate/Tube
Entry 3 GEISHA Id Fz10.Chesnutt.2004 Data Source Publication Complete cDNA Template Probe show TACCCTGAGAGGCCCATCATCTTCCTCTCTATGTGCTACTGTGTCTACTCGGTGGGGTACATCATCCGCCTCTTTTCGG
Citation Chesnutt C, Burrus LW, Brown AM, Niswander L. Coordinate regulation of neural tube patterning and proliferation by TGFbeta and WNT activity. Dev Biol. 2004 Oct 15;274(2):334-47. Copyright Reprinted from Developmental Biology, Volume 274, Issue 2, Catherine Chesnutt, Laura W. Burrus, Anthony M.C. Brown, and Lee Niswander, Coordinate regulation of neural tube patterning and proliferation by TGFβ and WNT activity, Pages 334-347, Copyright 2004, with permission from Elsevier.
Copyright © 2004 Elsevier B.V. All rights reserved. Comments The following in situ probes were used: ...Fz2, Fz7, Fz10 (Cauthen et al., (2001). They cloned using these primers:
(Upstream) 5′-gtg aat tct ayc cng arm gnc cna t-3′ and (Downstream) 5′-caa cta gtn gcn gcn arr aac ca-3′ (n=a,c,g,t; Y=c/g; and M=a/c).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-18 stage 18
Spinal Cord
Entry 4 GEISHA Id Fz10.Chapman.2008 Data Source Direct Submission Complete cDNA Template Probe show GTGGAAACCCGGCGAGAAGAAAGTTGCCGGGCTCCCCGCAGTAAGTTCGGCGCATCTGTGCGTTGGGGGCACTTCTTCC
Comments Images Provided by Susan Chapman
Entry 5 GEISHA Id FZ10.Quinlan.2009 Data Source Publication Complete cDNA Template Probe show GGAGCCGTGACCCGCTCTAGGAAGAGGAAAATCCCCGGAGGAGCTCGCTGCACCGAAAGCCGCCCGGGACATGTGCGAG
Citation Quinlan R, Graf M, Mason I, Lumsden A, Kiecker C. Complex and dynamic patterns of Wnt pathway gene expression in the developing chick forebrain. Neural Dev. 2009 Sep 4;4:35. Copyright Copyright © 2009 Quinlan et al; licensee BioMed Central Ltd. [This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.] Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (NM_204098.1).
Entry 6 GEISHA Id FZD10.Geetha-Loganathan.2009 Data Source Publication Complete cDNA Template Probe show GGAGCCGTGACCCGCTCTAGGAAGAGGAAAATCCCCGGAGGAGCTCGCTGCACCGAAAGCCGCCCGGGACATGTGCGAG
Citation Geetha-Loganathan, P, Nimmagadda, S, Antoni, L, Fu, K, Whiting, C, Francis-West, P and Richman, J. Expression of WNT signalling pathway genes during chicken craniofacial development. DEVELOPMENTAL DYNAMICS
Volume 238, Issue 5, May 2009, Pages: 11501165. Copyright Dev. Dyn Copyright © 2009 John Wiley & Sons, Inc. All Rights Reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_204098).
Entry 7 GEISHA Id FZD10.Paxton.2010 Data Source Publication Complete cDNA Template Probe show GGAGCCGTGACCCGCTCTAGGAAGAGGAAAATCCCCGGAGGAGCTCGCTGCACCGAAAGCCGCCCGGGACATGTGCGAG
Citation Paxton CN, Bleyl SB, Chapman SC, Schoenwolf GC.
Identification of differentially expressed genes in early inner ear development. Gene Expr Patterns. 2010 Jan;10(1):31-43. Epub 2009 Nov 11.
Copyright 2009 Elsevier B.V. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_204098).
Entry 8 GEISHA Id FZD10.Sienknecht.2009 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show GGAGCCGTGACCCGCTCTAGGAAGAGGAAAATCCCCGGAGGAGCTCGCTGCACCGAAAGCCGCCCGGGACATGTGCGAG
Comments Authors gave the NCBI acc# in the paper
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-23 stage 23
stage 23
Ear/Otic Placode
Entry 9 GEISHA Id FZD10.Alrefaei.2020 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show ATGTGCGAGTGGAAGAGGTGATCGCTCGGATCTGCCCTGATCGCTCCTCGCTTCGAGGGAGGAGGAGGAGCAGGAAGGG
Citation Abdulmajeed Fahad Alrefaei, Andrea E Münsterberg , Grant N Wheeler. FZD10 regulates cell proliferation and mediates Wnt1 induced neurogenesis in the developing spinal cord. PLoS One 2020 Jun 12;15(6):e0219721. DOI: 10.1371/journal.pone.0219721. Copyright Copyright © 2020 Alrefaei et al. Comments The complete cDNA template sequence was obtained from the information provided in the publication as described in Alrefaei et al. 2020.
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Data from NCBI Unigene EST ProfileGga.109
Mouse Frog Fruit Fly Zebra Finch Zebrafish
