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Human Disease Gene Search
GATA4 The human orthologue of this gene is associated
Gene Summary Expression Transcript Levels Other Species Expression JBrowse Gene Official Symbol GATA4 Official Full Name GATA binding protein 4 CGNC ID 12483 also known as GATA-4, transcription factor GATA-4|GATA-binding factor 4, GATA-binding factor 4, GATA4, Transcription factor GATA-4 gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Molecular Function co-SMAD binding , RNA polymerase II transcription factor binding transcription factor activity , more... sequence-specific DNA binding , sequence-specific DNA binding transcription factor activity , transcription factor binding , transcription regulatory region DNA binding , zinc ion binding Biological Process atrial septum secundum morphogenesis , intestinal epithelial cell differentiation , male gonad development , more... positive regulation of transcription, DNA-templated , response to drug , response to retinoic acid Cellular Component nucleus
Links to other databases
Entry 1 GEISHA Id GATA4.UAlinear Data Source GEISHA ISH Analysis Complete cDNA Template Probe show ATGTACCAGAGCTTAGCCATGGCGGCGAACCCCGGCCCCCCGTCCTACGAAGGGGCAGGTGGCTTCATGCACGGCGCCG
Entry 2 GEISHA Id Gata4.Lincoln.2004 Data Source Publication Complete cDNA Template Probe show ATGTACCAGAGCTTAGCCATGGCGGCGAACCCCGGCCCCCCGTCCTACGAAGGGGCAGGTGGCTTCATGCACGGCGCCG
Citation Lincoln J, Alfieri CM, Yutzey KE. Development of heart valve leaflets and supporting apparatus in chicken and mouse embryos. Dev Dyn. 2004 Jun;230(2):239-50. Copyright Wiley-Liss, Inc. 2004 Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # XM_420041).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-30 stage 29
Heart 31-36 stage 36
Heart
Entry 3 GEISHA Id Gata4.Ghatpande.2006 Data Source Publication Complete cDNA Template Probe show ATGTACCAGAGCTTAGCCATGGCGGCGAACCCCGGCCCCCCGTCCTACGAAGGGGCAGGTGGCTTCATGCACGGCGCCG
Citation Ghatpande S, Brand T, Zile M, Evans T. Bmp2 and Gata4 function additively to rescue heart tube development in the absence of retinoids. Dev Dyn. 2006 Aug;235(8):2030-9. Copyright Copyright © 2006 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (XM_420041).
Entry 4 GEISHA Id Gata4.Shin.2006 Data Source Publication Complete cDNA Template Probe show CACACCGGCCCTTGTTCAAACCTCAGCGGAGGCTGTCGGCTTCCCGTCGCGTCGGCCTCTCTTGTGCCAACTGCCACAC
Citation Shin M, Noji S, Neubüser A, Yasugi S.
FGF10 is required for cell proliferation and gland formation in the stomach epithelium of the chicken embryo. Dev Biol. 2006 Jun 1;294(1):11-23. Epub 2006 Apr 17. Copyright Reprinted from Developmental Biology, 294, Masahiron Shin, Sumihare Noji, Annette Neubüser, and Sadao Yasugl, 11-23, Copyright 2006, with permission from Elsevier. Copyright © 2005 Elsevier Inc. All rights reserved. Comments According to the authors, "Probes were derived from cDNA fragments of ... ... cGata4 (ChEST207P4; Shin et al., 2005).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-38 stage 32
stage 36
stage 37
stage 38
Stomach
Entry 5 GEISHA Id Gata4.Shin.2005 Data Source Publication Complete cDNA Template Probe show ATGTACCAGAGCTTAGCCATGGCGGCGAACCCCGGCCCCCCGTCCTACGAAGGGGCAGGTGGCTTCATGCACGGCGCCG
Citation Shin M, Watanuki K, Yasugi S (2005).
Expression of Fgf10 and Fgf receptors during development of the embryonic chicken stomach. Gene Expr Patterns. 2005 Apr;5(4):511-6. Copyright Copyright © 2004 Elsevier B.V. All rights reserved. Comments According to authors , "cGata4 (a gift from Dr T. Nohno; Ohuchi et al., 1997). As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # XM_420041).
Entry 6 GEISHA Id GATA4.Liberatore.2000 Data Source Publication Complete cDNA Template Probe show ATGTACCAGAGCTTAGCCATGGCGGCGAACCCCGGCCCCCCGTCCTACGAAGGGGCAGGTGGCTTCATGCACGGCGCCG
Citation Liberatore CM, Searcy-Schrick RD, Yutzey KE. Ventricular expression of tbx5 inhibits normal heart chamber development. Dev Biol. 2000 Jul 1;223(1):169-80. Copyright Reprinted with permission from Elsevier.
Copyright © date Elsevier B.V. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (XM_420041).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-11 stage 11
Atria Sinus Venosus
Entry 7 GEISHA Id Gata4.Lopez-Sanchez.2009 Data Source Publication Complete cDNA Template Probe show ATGTACCAGAGCTTAGCCATGGCGGCGAACCCCGGCCCCCCGTCCTACGAAGGGGCAGGTGGCTTCATGCACGGCGCCG
Citation Lopez-Sanchez C, Garcia-Masa N, Gañan CM, Garcia-Martinez V. Movement and commitment of primitive streak precardiac cells during cardiogenesis. Int J Dev Biol. 2009;53(8-10):1445-55. Copyright Reprinted from Int. J. Dev. Biol. Copyright (2009), with permission from UBC Press. All rights reserved. Comments As insufficient information is provided in publication to verify exact
sequence used to synthesize probe, the sequence below was obtained
from NCBI (acc #XM_420041).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4-6 stage 4
stage 4
Splanchnic Mesoderm 7-9 stage 8
stage 8
stage 9
stage 9
Splanchnic Mesoderm
Entry 8 GEISHA Id GATA4.Chapman.2007 Data Source Publication Complete cDNA Template Probe show ATGTACCAGAGCTTAGCCATGGCGGCGAACCCCGGCCCCCCGTCCTACGAAGGGGCAGGTGGCTTCATGCACGGCGCCG
Citation Chapman SC, Matsumoto K, Cai Q, Schoenwolf GC.
Specification of germ layer identity in the chick gastrula. BMC Dev Biol. 2007 Jul 30;7:91.
Copyright © 2007 Chapman et al; licensee BioMed Central Ltd. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # XM_420041.1).
Entry 9 GEISHA Id GATA4.Nathan.2008 Data Source Publication Complete cDNA Template Probe show GGGTGGTGGGGAGGGGGGGTGAAGGACAAAATCCCATCGCTGGCCACAGTTCGGTCAGGGCCGCGAGGTTGGACCCACG
Citation Nathan E, Monovich A, Tirosh-Finkel L, Harrelson Z, Rousso T, Rinon A, Harel I, Evans SM, Tzahor E. The contribution of Islet1-expressing splanchnic mesoderm cells to distinct branchiomeric muscles reveals significant heterogeneity in head muscle development. Development. 2008 Feb;135(4):647-57. doi: 10.1242/dev.007989. Epub 2008 Jan 9. Copyright Copyright held by the authors. Published by the Company of Biologists Ltd. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI XM_420041.2
Entry 10 GEISHA Id GATA4.Acloque.2008 Data Source Publication Complete cDNA Template Probe show TGGGTGGTGGGGAGGGGGGGTGAAGGACAAAATCCCATCGCTGGCCACAGTTCGGTCAGGGCCGCGAGGTTGGACCCAC
Citation Acloque H, Wilkinson DG, Nieto MA. In situ hybridization analysis of chick embryos in whole-mount and tissue sections. Methods Cell Biol. 2008;87:169-85. doi: 10.1016/S0091-679X(08)00209-4. Copyright Copyright © 2013 Elsevier B.V. All rights reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI XM_004935896.1
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-10 stage 10
stage 10
Heart Tube Sinus Venosus
Entry 11 GEISHA Id GATA-4.Wittler.2008 Data Source Publication Complete cDNA Template Probe show ATGTACCAGAGCTTAGCCATGGCGGCGAACCCCGGCCCCCCGTCCTACGAAGGGGCAGGTGGCTTCATGCACGGCGCCG
Citation Wittler L, Saborowski M, Kessel M. Expression of the chick Sizzled gene in progenitors of the cardiac outflow tract. Gene Expr Patterns. 2008 Jul;8(6):471-6. Epub 2008 Feb 29. Copyright Copyright © 2008 Elsevier B.V. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_001293106).
Entry 12 GEISHA Id GATA4.Anderson.2021 Data Source Direct Submission Complete cDNA Template Probe show CCACCAGGGTCCCCTCCATGCTCCCCAGCCTGCCCTACCTGCCCAGCAGCGGCTCTTCCCAGCAAGCCAGCCCCGTCTC
Comments Images and probe sequence provided by Claire Anderson. The probe was kindly supplied by Bertrand Pain.
Entry 13 GEISHA Id GATA4.Trevers.2023 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show GGGGGGGGGGAGCCGATGGATGGAGCCCGGTGGTAGAAGCTAAGGCCAAGCAGGAGCTAAAGGGACCGGGACTGCTGGC
Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_001293106).
Data from NCBI Unigene EST ProfileGga.795
Mouse Frog Fruit Fly Zebra Finch Zebrafish
