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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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GDF5
growth differentiation factor 5

The human orthologue of this gene is associated
with the following human diseases:

Gene

Official Symbol	GDF5
Official Full Name	growth differentiation factor 5
CGNC ID	1254
also known as	growth/differentiation factor 5\|GDF-5 protein\|growth differentiation factor 5 (cartilage-derived morphogenetic protein-1)
gene type	protein-coding

Genomic Map

	Ensembl ID not known
	NCBI
	UCSC

Sequence Information

Genomic
RNA	NM_204338
Polypeptide	NP_989669

Gene Expression

In Situ Hybridization

GEISHA

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	8200	ENSG00000125965	MIM:201250	MIM:601146
Mouse	14563	ENSMUSG00000038259	All phenotypic alleles (7):Spontaneous(5) Chemically induced(2)	MGI:95688
Xenopus	100189547, 446295			481783
Zebrafish	30195, 100334210	ENSDARG00000002760	ZDB-GENE-990415-39, ZDB-GENE-990415-39	ZFIN:ZDB-GENE-990415-39, ZFIN:ZDB-GENE-990415-39

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Links to other databases

Entrez Gene	374249
Ensembl Gene
KEGG	gga:374249

Entry 1

GEISHA Id	GDF5.UApcr	Data Source	GEISHA ISH Analysis
Forward cDNA Template Primer	TTATAAAAGCTTGCGGCCGCAGAATATAGCAGTCACAGAGGCAAAGGTAGG
Reverse cDNA Template Primer	GCTCTAGAAATTAACCCTCACTAAAGGGTTGATTCGGGGTCCATTGAG	cDNA Template Length	1083
Complete cDNA Template Probe	show AGCAGTCACAGAGGCAAAGGTAGGACATCTCCCGAGCAGACCTTCTGCAGTAAGGACGGTGACTCCAAAGGTCCCAAAT CTTGGCAGCAAGGCGGCTCTGAAGAAAACTGGCACGGGCGGCACTGATGCCAGCTCCTTCAAAACGAAGAAGACTAAAG AGCCTGTGACCCAAAGGGAAGCTAAGGAAACCTTCAGCAGGCCCCCTATAACGCCACATGAATACATGCTCTCTTTGTA CAGGACTCTCTCAGATGCAGAAAGAAAAGGTGTTAATGGAAGTGTAAAACTGGAGGCTGGACTCGCCAATACAATAACC AGCTTTATAGACAAGGGACAAGATGAGCGAGCGCCAACCATAAGAAAACAAAAATATATTTTTGACATCAGTGCATTAG AAAAAGATGGCCTGCTGGTAGCAGAGCTTCGAATACTGAGGAAAAATCCTTCTGATACGTGGAAGTCTCATTCTTCTGG AAAAACTTCCCAGGTGAAATTATTTAGTTGCTCTACCAACAGACAAGCAGCAACACTGCTGGACTCTCGTACCGTCAGT ATCACGGACACACCAAAATGGGAAGTGTTTGACATCTGGAAGCTTTTTAGGAACTTTAAAAACTTGGTTAACTTGTGTT TCGAACTGGAAACTTTTGACAGGGGGAGAGCGGTTGATCTCAGGACTGTGGGATTTAACAGAACGGGAAGACAGGTCAA CGAAAAGGCTCTCTTCTTGGTATTTGGGAGGACAAAGAAAAGGGACTTATTTTTCAATGAAATCAAAGCTAGATCCGGC CAGGACGACAAAACCGTGTATGAGTACTTATTCAATCAGAGGCGGAAGAGAAGAGCTCCTCTGGCAACACGCCAAGGGA AGAGGCCCAGTAAGAACCTGAAGCCAAGGTGTAGCAGAAAAGCCCTCCATGTGAATTTTAAGGACATGGGCTGGGATGA CTGGATAATAGCACCCCTGGAATACGAAGCGTATCACTGCGAAGGTCTGTGTGAGTTCCCCCTCCGATCCCACCTGGAG CCCACCAATCACGCCGTTATCCAAACTTTAATGAACTCAATGGACCCCGAATCAAC
Comments	No specific expression detected at or below stage 18.

Stage

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Location (click to highlight)

Comments (click to highlight)

19-24

stage 22

stage 23

Eye

stage 25

Eye
Leg Mesenchyme
Pharyngeal Arches and Clefts
Wing Mesenchyme

Entry 2

GEISHA Id	GDF5.Lizarraga.2002	Data Source	Publication
Complete cDNA Template Probe	show ATGAAAATCCTGCATTTTCTCACTTTACTGCTTTGGCATTTGACTTGGCTGTCTCTGGATCGTGTTCCTGGAGCACTGA GTAACTCCGAAGCAGGCCAGAGTAATCCAGGGTCTAAAACAGATCTGTTAAAAGCAGAAGGAAAAGAGAGGACTGCCTC AGCACGGTCGGGCGCGCCGCGGGCTGCGAACCATGGATTTAGCACCGGGACCTCGAAGGCGAGGGCTAAAAGCAACGCT GCTCAGGCTGGAGCTCTGCTGGCCAAGAACGATGAATCACAGAGGGTTCTTTCAAGAACAGCAGTCACAGAGGCAAAGG TAGGACATCTCCCGAGCAGACCTTCTGCAGTAAGGACGGTGACTCCAAAGGTCCCAAATCTTGGCAGCAAGGCGGCTCT GAAGAAAACTGGCACGGGCGGCACTGATGCCAGCTCCTTCAAAACGAAGAAGACTAAAGAGCCTGTGACCCAAAGGGAA GCTAAGGAAACCTTCAGCAGGCCCCCTATAACGCCACATGAATACATGCTCTCTTTGTACAGGACTCTCTCAGATGCAG AAAGAAAAGGTGTTAATGGAAGTGTAAAACTGGAGGCTGGACTCGCCAATACAATAACCAGCTTTATAGACAAGGGACA AGATGAGCGAGCGCCAACCATAAGAAAACAAAAATATATTTTTGACATCAGTGCATTAGAAAAAGATGGCCTGCTGGTA GCAGAGCTTCGAATACTGAGGAAAAATCCTTCTGATACGTGGAAGTCTCATTCTTCTGGAAAAACTTCCCAGGTGAAAT TATTTAGTTGCTCTACCAACAGACAAGCAGCAACACTGCTGGACTCTCGTACCGTCAGTATCACGGACACACCAAAATG GGAAGTGTTTGACATCTGGAAGCTTTTTAGGAACTTTAAAAACTTGGTTAACTTGTGTTTCGAACTGGAAACTTTTGAC AGGGGGAGAGCGGTTGATCTCAGGACTGTGGGATTTAACAGAACGGGAAGACAGGTCAACGAAAAGGCTCTCTTCTTGG TATTTGGGAGGACAAAGAAAAGGGACTTATTTTTCAATGAAATCAAAGCTAGATCCGGCCAGGACGACAAAACCGTGTA TGAGTACTTATTCAATCAGAGGCGGAAGAGAAGAGCTCCTCTGGCAACACGCCAAGGGAAGAGGCCCAGTAAGAACCTG AAGCCAAGGTGTAGCAGAAAAGCCCTCCATGTGAATTTTAAGGACATGGGCTGGGATGACTGGATAATAGCACCCCTGG AATACGAAGCGTATCACTGCGAAGGTCTGTGTGAGTTCCCCCTCCGATCCCACCTGGAGCCCACCAATCACGCCGTTAT CCAAACTTTAATGAACTCAATGGACCCCGAATCAACGCCTCCAACTTGCTGTGTCCCAACCAGGCTGAGTCCTATCAGC ATTCTCTTCATTGACTCTGCAAACAATGTGGTCTACAAGCAGTACGAGGACATGGTGGTGGAGTCGTGTGGCTGCAGGT AGCAGAACAGTTGCTCATGTGAATGGTGTT
Citation	Lizarraga G, Lichtler A, Upholt WB, Kosher RA. Studies on the role of Cux1 in regulation of the onset of joint formation in the developing limb. Dev Biol. 2002 Mar 1;243(1):44-54.
Copyright	Copyright © 2002 Elsevier Science (USA). All rights reserved.
Comments	Insufficient information provided in publication to verify exact sequence to synthesize probe. Sequence below was obtained from NCBI (NM_204338).

Stage

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Location (click to highlight)

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25-30

stage 30

Wing Mesenchyme

Carpometacarpal Joints
Presumptive Elbow Joint
Wrist Joint

31-35

stage 35

Wing Mesenchyme

Interphalangeal Joints

Entry 3

GEISHA Id	GDF-5.Pacifici.2005	Data Source	Publication
Complete cDNA Template Probe	show ATGAAAATCCTGCATTTTCTCACTTTACTGCTTTGGCATTTGACTTGGCTGTCTCTGGATCGTGTTCCTGGAGCACTGA GTAACTCCGAAGCAGGCCAGAGTAATCCAGGGTCTAAAACAGATCTGTTAAAAGCAGAAGGAAAAGAGAGGACTGCCTC AGCACGGTCGGGCGCGCCGCGGGCTGCGAACCATGGATTTAGCACCGGGACCTCGAAGGCGAGGGCTAAAAGCAACGCT GCTCAGGCTGGAGCTCTGCTGGCCAAGAACGATGAATCACAGAGGGTTCTTTCAAGAACAGCAGTCACAGAGGCAAAGG TAGGACATCTCCCGAGCAGACCTTCTGCAGTAAGGACGGTGACTCCAAAGGTCCCAAATCTTGGCAGCAAGGCGGCTCT GAAGAAAACTGGCACGGGCGGCACTGATGCCAGCTCCTTCAAAACGAAGAAGACTAAAGAGCCTGTGACCCAAAGGGAA GCTAAGGAAACCTTCAGCAGGCCCCCTATAACGCCACATGAATACATGCTCTCTTTGTACAGGACTCTCTCAGATGCAG AAAGAAAAGGTGTTAATGGAAGTGTAAAACTGGAGGCTGGACTCGCCAATACAATAACCAGCTTTATAGACAAGGGACA AGATGAGCGAGCGCCAACCATAAGAAAACAAAAATATATTTTTGACATCAGTGCATTAGAAAAAGATGGCCTGCTGGTA GCAGAGCTTCGAATACTGAGGAAAAATCCTTCTGATACGTGGAAGTCTCATTCTTCTGGAAAAACTTCCCAGGTGAAAT TATTTAGTTGCTCTACCAACAGACAAGCAGCAACACTGCTGGACTCTCGTACCGTCAGTATCACGGACACACCAAAATG GGAAGTGTTTGACATCTGGAAGCTTTTTAGGAACTTTAAAAACTTGGTTAACTTGTGTTTCGAACTGGAAACTTTTGAC AGGGGGAGAGCGGTTGATCTCAGGACTGTGGGATTTAACAGAACGGGAAGACAGGTCAACGAAAAGGCTCTCTTCTTGG TATTTGGGAGGACAAAGAAAAGGGACTTATTTTTCAATGAAATCAAAGCTAGATCCGGCCAGGACGACAAAACCGTGTA TGAGTACTTATTCAATCAGAGGCGGAAGAGAAGAGCTCCTCTGGCAACACGCCAAGGGAAGAGGCCCAGTAAGAACCTG AAGCCAAGGTGTAGCAGAAAAGCCCTCCATGTGAATTTTAAGGACATGGGCTGGGATGACTGGATAATAGCACCCCTGG AATACGAAGCGTATCACTGCGAAGGTCTGTGTGAGTTCCCCCTCCGATCCCACCTGGAGCCCACCAATCACGCCGTTAT CCAAACTTTAATGAACTCAATGGACCCCGAATCAACGCCTCCAACTTGCTGTGTCCCAACCAGGCTGAGTCCTATCAGC ATTCTCTTCATTGACTCTGCAAACAATGTGGTCTACAAGCAGTACGAGGACATGGTGGTGGAGTCGTGTGGCTGCAGGT AGCAGAACAGTTGCTCATGTGAATGGTGTT
Citation	Pacifici M, Koyama E, Iwamoto M. Mechanisms of synovial joint and articular cartilage formation: recent advances, but many lingering mysteries. Birth Defects Res C Embryo Today. 2005 Sep;75(3):237-48.
Copyright	Copyright © 2005 Wiley-Liss, Inc.
Comments	As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_204338.1).

Stage

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Location (click to highlight)

Comments (click to highlight)

31-35

stage 35

Leg Bones

Entry 4

GEISHA Id	GDF5.Ferrari.2006	Data Source	Publication
Complete cDNA Template Probe	show ATGAAAATCCTGCATTTTCTCACTTTACTGCTTTGGCATTTGACTTGGCTGTCTCTGGATCGTGTTCCTGGAGCACTGA GTAACTCCGAAGCAGGCCAGAGTAATCCAGGGTCTAAAACAGATCTGTTAAAAGCAGAAGGAAAAGAGAGGACTGCCTC AGCACGGTCGGGCGCGCCGCGGGCTGCGAACCATGGATTTAGCACCGGGACCTCGAAGGCGAGGGCTAAAAGCAACGCT GCTCAGGCTGGAGCTCTGCTGGCCAAGAACGATGAATCACAGAGGGTTCTTTCAAGAACAGCAGTCACAGAGGCAAAGG TAGGACATCTCCCGAGCAGACCTTCTGCAGTAAGGACGGTGACTCCAAAGGTCCCAAATCTTGGCAGCAAGGCGGCTCT GAAGAAAACTGGCACGGGCGGCACTGATGCCAGCTCCTTCAAAACGAAGAAGACTAAAGAGCCTGTGACCCAAAGGGAA GCTAAGGAAACCTTCAGCAGGCCCCCTATAACGCCACATGAATACATGCTCTCTTTGTACAGGACTCTCTCAGATGCAG AAAGAAAAGGTGTTAATGGAAGTGTAAAACTGGAGGCTGGACTCGCCAATACAATAACCAGCTTTATAGACAAGGGACA AGATGAGCGAGCGCCAACCATAAGAAAACAAAAATATATTTTTGACATCAGTGCATTAGAAAAAGATGGCCTGCTGGTA GCAGAGCTTCGAATACTGAGGAAAAATCCTTCTGATACGTGGAAGTCTCATTCTTCTGGAAAAACTTCCCAGGTGAAAT TATTTAGTTGCTCTACCAACAGACAAGCAGCAACACTGCTGGACTCTCGTACCGTCAGTATCACGGACACACCAAAATG GGAAGTGTTTGACATCTGGAAGCTTTTTAGGAACTTTAAAAACTTGGTTAACTTGTGTTTCGAACTGGAAACTTTTGAC AGGGGGAGAGCGGTTGATCTCAGGACTGTGGGATTTAACAGAACGGGAAGACAGGTCAACGAAAAGGCTCTCTTCTTGG TATTTGGGAGGACAAAGAAAAGGGACTTATTTTTCAATGAAATCAAAGCTAGATCCGGCCAGGACGACAAAACCGTGTA TGAGTACTTATTCAATCAGAGGCGGAAGAGAAGAGCTCCTCTGGCAACACGCCAAGGGAAGAGGCCCAGTAAGAACCTG AAGCCAAGGTGTAGCAGAAAAGCCCTCCATGTGAATTTTAAGGACATGGGCTGGGATGACTGGATAATAGCACCCCTGG AATACGAAGCGTATCACTGCGAAGGTCTGTGTGAGTTCCCCCTCCGATCCCACCTGGAGCCCACCAATCACGCCGTTAT CCAAACTTTAATGAACTCAATGGACCCCGAATCAACGCCTCCAACTTGCTGTGTCCCAACCAGGCTGAGTCCTATCAGC ATTCTCTTCATTGACTCTGCAAACAATGTGGTCTACAAGCAGTACGAGGACATGGTGGTGGAGTCGTGTGGCTGCAGGT AGCAGAACAGTTGCTCATGTGAATGGTGTT
Citation	Ferrari D, Kosher RA. Expression of Dlx5 and Dlx6 during specification of the elbow joint. Int J Dev Biol. 2006;50(8):709-13.
Copyright	© UBC Press
Comments	As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_204338.1