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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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GFRA2
GDNF family receptor alpha 2

Gene

Official Symbol	GFRA2
Official Full Name	GDNF family receptor alpha 2
CGNC ID	49594
also known as	NTNRALPHA, GDNF family receptor alpha-2\|GDNF receptor alpha-2\|GDNF receptor beta\|GDNFR-alpha-2\|GDNFR-beta\|GFR-alpha-2\|NRTNR-alpha\|NTNR-alpha\|neurturin receptor alpha, GDNF family receptor alpha-2 precursor , GFR-alpha-2, Neurturin receptor alpha, NTNR-alpha, NRTNR-alpha, GDNFR-beta, GDNF receptor beta
gene type	protein-coding

Genomic Map

	Ensembl
	NCBI
	UCSC

Sequence Information

Genomic
RNA	NM_205101
Polypeptide	NP_990432

Gene Expression

In Situ Hybridization

GEISHA

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	2675			MIM:601956
Mouse	14586	ENSMUSG00000022103	All phenotypic alleles (2):Targeted, knock-out(1) Targeted, other(1)	MGI:1195462
Xenopus	100127717			982253
Zebrafish	564916, 405794	ENSDARG00000044015, ENSDARG00000042723	ZDB-GENE-040630-1, ZDB-GENE-091204-26	ZFIN:ZDB-GENE-040630-1, ZFIN:ZDB-GENE-091204-26

Gene Ontology

Molecular Function	receptor activity
Biological Process
Cellular Component	anchored component of membrane, plasma membrane

Links to other databases

Entrez Gene	395993
Ensembl Gene	ENSGALG00000001795
KEGG	gga:395993

Entry 1

GEISHA Id	GFRA2.Homma.2000	Data Source	Publication
Complete cDNA Template Probe	show CAAGAGGGGCATGAGAAAGGAGATTCAGTGCCTTCAGGTCTACTGGAGTATACACCTCGGGCTGGCCGAAGGAGAAGAG TTTTACGAAGCTTCCCCCTACGAGCCGATCACCTCTCGTCTCTCTGATATATTCAGACTCGCTTCAATTTTCTCAGGAA TGGACCCTGCCACCAATTCCAAAAGCAACCACTGCCTCGACGCGGCCAAAGCGTGCAACCTGAACGACAACTGCAAGCG CCTGCGCTCGGGCTACATCTCCACCTGCAGCAAGGAGATCTCGGCCACCGAGCACTGCAGCAGGAGGAAATGCCACAAA GCCCTGCGCCAGTTCTTCGACAACGTGCCCAGCGAGTACACCTACCGCCTCCTCTTCTGCTCCTGCAAGGACCAGGCGT GCGCCGAGCCGCGGCGGCAAACCATCGTCCCCTTCTGCTCCTACGAGGACAAGGAGAAACCCAACTGCTTGGATCTGCG CAACGTGTGCCGCGCCGACCACCTGTGCCGGTCCCGGCTGGCTGATTTCCACGCCAATTGCCAGGCCTCCTTCCAGTCA CTGACCAGCTGCCCTGGGGACAACTATCAGGCGTGCCTGGGCTCCTACACAGGGCTCATTGGTTTTGATATGACGCCCA ACTACGTGGATGCCAGCACCACCAGCATCACTATCTCGCCCTGGTGCTCCTGCAAAGGCAGCGGCAACTTGGAGGAGGA GTGTGAGAAGTTCCTGCGGGACTTCACTGAGAACCCCTGTCTCCGAAATGCTATCCAAGCCTTCGGCAATG
Citation	Homma S, Oppenheim RW, Yaginuma H, Kimura S. Expression pattern of GDNF, c-ret, and GFRalphas suggests novel roles for GDNF ligands during early organogenesis in the chick embryo. Dev Biol. 2000 Jan 1;217(1):121-37.
Copyright	Reprinted with permission from Elsevier. Copyright © 2000 Elsevier B.V. All rights reserved.
Comments	According to the authors, "The primers were ... 5'-CAAGAGGGGCATGAGAAAG-3' and 5'-CATTGCCGAAGGCTTGGA-3' for GFRa-2. The sequence below was obtained from NCBI (NM_205101) using the primers provided.

Stage

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Location (click to highlight)

Comments (click to highlight)

7-12

stage 9

stage 12

Ear/Otic Placcode
Eye
Head Mesenchyme
Hensen's Node
Hindbrain
Midbrain
Neural Crest
Notochord
Paraxial Mesoderm
Placcode
Rhombomeres
Somites
Surface Ectoderm

Neuroepithelium of Rhombomere 1/2
Rhombomere 1
Rhombomeres 1/2, 3, and 4/5
Trigeminal Placode

13-18

stage 17

stage 18

Cranial Ganglion
Dermomyotome
Ectoderm
Head Mesenchyme
Hindbrain
Lens
Liver
Neural Crest
Pharyngeal Arches and Clefts
Retina
Spinal Cord
Spinal Ganglia and Nerves
Trunk Mesenchyme

Distal Ganglion of the Glossopharyngeal Nerve (IX)
Maxillary Process
Maxillo-Mandibular (mm) Divisions of the Trigeminal Ganglion (V)
Rhombencephalon
Ventral Lip
Vestibuloacoustic Ganglion (VIII)

Entry 2

GEISHA Id	GFRα2.Tatsumi.2007	Data Source	Publication
Complete cDNA Template Probe	show CCTAAACGCACGTGGAGGAACTCGTGGATGTACTAACATGATTTTGGCCAACGCCTTCTGCATCGTCCTCTTTGTAGAT GAGACCCTCCGCTCGCTGGCCGCCCCCCCGTCCCCCCCCGGGCAGGACCTGCAGGGCTGGCGGGTGCCGGTGGACTGCA TACGTGCCAACAAGCTGTGTGCAGCCGAGGGCAGCTGCAGCTCCCGGTACCGCACCCTGCGGCAGTGCCTGGCGGGACG CGACCGCAACACCATGCTGGCCAACAAGGAGTGCCAGGCGGCCCTGGAGGTGCTGCAGGAGAGCCCGCTGTACGACTGC CGTTGCAAGAGGGGCATGAGAAAGGAGATTCAGTGCCTTCAGGTCTACTGGAGTATACACCTCGGGCTGGCCGAAGGAG AAGAGTTTTACGAAGCTTCCCCCTACGAGCCGATCACCTCTCGTCTCTCTGATATATTCAGACTCGCTTCAATTTTCTC AGGAATGGACCCTGCCACCAATTCCAAAAGCAACCACTGCCTCGACGCGGCCAAAGCGTGCAACCTGAACGACAACTGC AAGCGCCTGCGCTCGGGCTACATCTCCACCTGCAGCAAGGAGATCTCGGCCACCGAGCACTGCAGCAGGAGGAAATGCC ACAAAGCCCTGCGCCAGTTCTTCGACAACGTGCCCAGCGAGTACACCTACCGCCTCCTCTTCTGCTCCTGCAAGGACCA GGCGTGCGCCGAGCCGCGGCGGCAAACCATCGTCCCCTTCTGCTCCTACGAGGACAAGGAGAAACCCAACTGCTTGGAT CTGCGCAACGTGTGCCGCGCCGACCACCTGTGCCGGTCCCGGCTGGCTGATTTCCACGCCAATTGCCAGGCCTCCTTCC AGTCACTGACCAGCTGCCCTGGGGACAACTATCAGGCGTGCCTGGGCTCCTACACAGGGCTCATTGGTTTTGATATGAC GCCCAACTACGTGGATGCCAGCACCACCAGCATCACTATCTCGCCCTGGTGCTCCTGCAAAGGCAGCGGCAACTTGGAG GAGGAGTGTGAGAAGTTCCTGCGGGACTTCACTGAGAACCCCTGTCTCCGAAATGCTATCCAAGCCTTCGGCAATGGCA CCGATGTCAACCTCTCCCCCAAGAACCCCTCACCTCCCATCACAATGCTGCCCAAGGTGGAGAAAAGTCCTGCCTTGCC TGATGACATCAACGACAGCAACACCATGTACGACACGAGCATCATCACCACCTGCACCTCCATCCAGGAGCACGGACAG AAGCTAAACAAGTCCAAAGAGCAGAGCCTGTGCTACTCAGAGACCCAGCTCACCACGGACACGATGCCAGACCAGAAGA CCTTTGTGGATCAGAAGGCAGCCGGCAGCCGGCACCGGGCAGCCCGGATCCTTCCAGCTGTGCCCATTGTGCTGCTGAA GCTGCTGCTATAGGGGACAATTGCCGCATCTCAGCTCCGGAGTGCTGGGCTCATCTCGGGCTCCAGACTGCAAGCGGAA CACCAGCGATGCCCAAGGCCAGAAGGACCCTCACAGTGATGGGAAACTTCAGTGGTTTTCTTTTTTTTTTTTTCCTTTT CCTTCTTTTTTTTTGGCCTTTTTGTTCGTTTGATGGTGCGTTGGGTTTCTACTGCTGGAGCACGAGCCCGGCACAACCC ACCCAGGCAACCACAAAGGGGAACCAATGCAATCAACGGCACCGGGGAGGGGAGAAAGGCAGCGAGCAGAGCTGTGGGA TGAGGGCTGTCTGCAGGGCTACCAACCCAGCGTGCTGAGGGACCCGTTGGGGACGTGGGACGTTTGCGCATCGCCGCGG CACAGCGGTGCCATTGGGGCTCCTTTGGGCACAGACTCTCCGCTGCCCCACGTCGTCCCCGGGACTGTTTTCTTTTCCT TTCCCGTGGTTGGTGAGAGTTTTCAAATCAGAAAAGAAACCAATATTCAAACGGTGTGAGGCTGTCCTGATGTTTTCTA TCTGTCACTCGGAGGGGGAGGTTTTCCTTTTTATTATTTACCCTTTCTTTTTCATTATGCCTTTCTTTCCCATCTTCAT TCCATCGGATTTGGGTTGGGATGGGATCCGACCCCAGCGGCGGTTGGAGTCCTCTGTATGTTACTCAGTTTTCTTTTAT ATATACATATATAGTGTATGTATATAGCGCTCACCTATACCTACAGCTATGTATGTATAGACGTAACCATAGAGATCTA CCGGCGTGGCTCTCTAAGGTTTCCTTTCAAAAAAGGAGGGCTGCAAAATGTATGATTGTAAAGTTTATTTTTTTTAAAC GATGTCTATAATGGAAATAATAATAATAATTAATAATAATAATAATAATAAAAGGAGAAGAAAGAACCAAGAGGAGAAC AAAGCACCACCTGAGGGGAGGAAGGGGGGGGTCCGACGTCCCATAGAGCATCCCAAGCCCTGGCTGCATGCTGGGGGAT GCTCAGCTATAGAGAGGCACAGATTTGGGTCAACCCCACACGTCTTGCAGTGCTGCAGGACGCCTCGCCTGGCTGTTTG GCTCTGGGAGACGTGCAAACAAGCAAACATTTCAAAGGAGCTGACAGGTTGCTCGCGTGGCAGAGCTCTTTTTTCTTTA AAGCACCTCATCCTCCGTGCTGCTTCTTTTTCCCCACCCCCCAGTGCTTAAAACCCAAACGAAGGTTGAAATTTGGGTC ACGCAAAACCTCGTGTTCCTCCTCCTCCCCCCTTCCCCAGTCAGAAGTCCTTTTCCCACCTTCTGCTCGCACCGTGCAG CAGCAGCAGCACCGACCCGCAGGCAGCTCTGCGCAGTGGGGCTCCAAGGCTGCCGAGACCCCATTGCAAAAGGAGGGGC AAATCTTCCCCTTTGCAAAGCAGGGAGCGAAAACACGTTTGATGTGCAAGTTGGCACGGGGAAAATAAACATGTCACGT CTCTCGCCGG
Citation	Tatsumi N, Miki R, Katsu K, Yokouchi Y. Neurturin-GFRalpha2 signaling controls liver bud migration along the ductus venosus in the chick embryo. Dev Biol. 2007 Jul 1;307(1):14-28. Epub 2007 Apr 3.
Copyright	Reprinted with permission from Elsevier. Copyright © 2007 Elsevier B.V. All rights reserved.
Comments	Authors said probe from GFRα2 (Genbank accession no. U90542).