GEISHA - A Chicken Embryo Gene Expression Database
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HAND2
heart and neural crest derivatives expressed 2

Gene
Official SymbolHAND2
Official Full Nameheart and neural crest derivatives expressed 2
CGNC ID49493
also known asdHAND, heart- and neural crest derivatives-expressed protein 2|deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2, Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2, dHAND, Heart- and neural crest derivatives-expressed protein 2
gene typeprotein-coding
Genomic Map
 Ensembl ID not known
NCBI
UCSC
Gallus-Browse
Sequence Information
Genomic
RNANM_204966
PolypeptideNP_990297
Sequence Clusters/ESTsUnigene
Gene Expression
In Situ HybridizationGEISHA
EST ProfileGga.479
Orthology
Entrez GeneEnsembl GeneGenetic PhenotypesMOD
Fruit Fly34379FBgn0032209
Human9464ENSG00000164107MIM:602407
Mouse15111ENSMUSG00000038193All phenotypic alleles (9):Targeted, knock-out(3) Targeted, other(6) MGI:103580
Xenopus100101704, 373641, 373833481425
Zebrafish58150ENSDARG00000008305ZDB-GENE-000511-1ZFIN:ZDB-GENE-000511-1
Gene Ontology
Molecular FunctionDNA binding, protein dimerization activity
Biological Processmulticellular organismal development, regulation of transcription, DNA-templated, more...transcription, DNA-templated
Cellular Componentnucleus
Links to other databases
Entrez Gene395813
Ensembl Gene
KEGGgga:395813

Entry 1

GEISHA IdHAND2.UAlinearData SourceGEISHA ISH Analysis
Forward cDNA Template Probeshow
TCCGGCTGGCTTTCAGCAGCCACCCGGAGATGTCCCCCCCCGACTACAGCATGGCTCTGTCCTACAGCCCCGAGTACGC
CAACGGGGCGCCGGGCATGGACCACTCCCATTACNGGGGGGTGCCGCCCGGGAGCGGCCCGCCCGGGCTCGGGGGGCCC
CGGCCGGTGAAGCGCAGGGGCACGGCNAACCGCAAGGAGCGGCGCAGGACTCAGAGCATCAACAGCGCCTTCGCGGAGC
TGCGCGAGTGCATCCCCAACGTGCCCGCCGACACCAANCTCTCTAANATNAAAACCCTCCGCCTGGCCACCAGCTACAT
CGCCTACCTCATGGACCTGCTGGCCAAGGACGACCAGAACGGGNAGGCGGAGGCTTTCAAGGCAGAGATCAAGAAGACG
GACGTGAAGGAGGAGAAGAGGAAGAAGGAGCTGAACGAAATCTTGAAAAGCACAGTTAGCAGCAGCGATAAGCCTTTAG
TGAGGGTTAATTTTCTAGAGCAA
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
1-3
stage 3
Area Opaca
Early Mesoderm
Extraembryonic Mesoderm
 
4-6
stage 4
stage 6
Extraembryonic Mesoderm
Lateral Plate Mesoderm
 
7-12
stage 8
stage 9
stage 10
stage 10
stage 11
Anterior Intestinal Portal
Anterior/Second Heart Field
Extraembryonic Mesoderm
Heart Tube
Lateral Plate Mesoderm
 
13-18
stage 15
stage 16
Anterior/Second Heart Field
Extraembryonic Mesoderm
Heart
Lateral Plate Mesoderm
Pharyngeal Arches and Clefts
 
19-24
stage 21
stage 24
Allantois
Extraembryonic
Heart
Lateral Plate Mesoderm
Leg Mesenchyme
Limb Buds
Neural Plate/Tube
Pharyngeal Arches and Clefts
Wing Mesenchyme
 
25-26
stage 26
Extraembryonic
Heart
Leg Mesenchyme
Pharyngeal Arches and Clefts
Wing Mesenchyme
 

Entry 2

GEISHA IddHand.Lopez-Sanchez.2009Data SourcePublication
Complete cDNA Template Probeshow
AGCAGCGGCGATGAGTCTTGTGGGCGGCTTCCCCCACCACCCGGTGGTGCACCATGAGGGTTACCCCCTTCGTCGTCGC
CGCTGTCGTCGCCGCCGCCGTCACCCGCTGCGGCCACGAGGAGAACCCCTACTTCACGGCTGGCTTATCAGCAGCCACC
CGGAGATGTCCCCCCCCGACTACAGCATGGCTCTGTCCTACAGCCCCGAGTACGCCAACGGGGCGCCGGGCATGGACCA
CTCCCATTACGGGGGGGTGCCGCCCGGGAGCGGCCCGCCCGGGCTCGGGGGGCCCCGGCCGGTGAAGCGCAGGGGCACG
GCGAACCGCAAGGAGCGGCGCAGGACTCAGAGCATCAACAGCGCCTTCGCGGAGCTGCGCGAGTGCATCCCCAACGTGC
CCGCCGACACCAAGCTCTCTAAGATCAAAACCCTCCGCCTGGCCACCAGCTACATCGCCTACCTCATGGACCTGCTGCC
CAAGGACGACCAGAACGGGGAGGCGGAGGCTTTCAAGGCAGAGATCAAGAAGACGGACGTGAAGGAGGAGAAGAGGAAG
AAGGAGCTGAACGAAATCTTGAAAAGCACAGTTAGCAGCAGCGATAAGAAAACCAAAGGGCGGACAGGCTGGCCGCAGC
ACGTCTGGGCGCTGGAGCTCAAGCAGTGAGCGCGGCGGG
CitationLopez-Sanchez C, Garcia-Masa N, Gañan CM, Garcia-Martinez V. Movement and commitment of primitive streak precardiac cells during cardiogenesis. Int J Dev Biol. 2009;53(8-10):1445-55.
CopyrightReprinted from Int. J. Dev. Biol. Copyright (2009), with permission from UBC Press. All rights reserved.
CommentsInsufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (NM_204966.1)
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
7-9
stage 8
stage 9
Anterior/Second Heart Field
Lateral Plate Mesoderm
 

Entry 3

GEISHA IdHAND2.Firulli.2005Data SourcePublication
Complete cDNA Template Probeshow
AGCAGCGGCGATGAGTCTTGTGGGCGGCTTCCCCCACCACCCGGTGGTGCACCATGAGGGTTACCCCCTTCGTCGTCGC
CGCTGTCGTCGCCGCCGCCGTCACCCGCTGCGGCCACGAGGAGAACCCCTACTTCACGGCTGGCTTATCAGCAGCCACC
CGGAGATGTCCCCCCCCGACTACAGCATGGCTCTGTCCTACAGCCCCGAGTACGCCAACGGGGCGCCGGGCATGGACCA
CTCCCATTACGGGGGGGTGCCGCCCGGGAGCGGCCCGCCCGGGCTCGGGGGGCCCCGGCCGGTGAAGCGCAGGGGCACG
GCGAACCGCAAGGAGCGGCGCAGGACTCAGAGCATCAACAGCGCCTTCGCGGAGCTGCGCGAGTGCATCCCCAACGTGC
CCGCCGACACCAAGCTCTCTAAGATCAAAACCCTCCGCCTGGCCACCAGCTACATCGCCTACCTCATGGACCTGCTGCC
CAAGGACGACCAGAACGGGGAGGCGGAGGCTTTCAAGGCAGAGATCAAGAAGACGGACGTGAAGGAGGAGAAGAGGAAG
AAGGAGCTGAACGAAATCTTGAAAAGCACAGTTAGCAGCAGCGATAAGAAAACCAAAGGGCGGACAGGCTGGCCGCAGC
ACGTCTGGGCGCTGGAGCTCAAGCAGTGAGCGCGGCGGG
CitationBeth A. Firulli, Dayana Krawchuk, Victoria E. Centonze, David M. Virshup, Simon J. Conway, Peter Cserjesi, Ed Laufer, Anthony B. Firulli. Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities. Nat Genet. 2005 April; 37(4): 373–381.
Copyright© 2012 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
CommentsAs insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_204966.1 ).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
19-24
stage 20
stage 21
stage 24
stage 24
Limb Buds
 
25-30
stage 27
stage 30
stage 30
Limb Buds
 

Entry 4

GEISHA IdHAND2.Huber.2012Data SourcePublication
Complete cDNA Template Probeshow
AGCAGCGGCGATGAGTCTTGTGGGCGGCTTCCCCCACCACCCGGTGGTGCACCATGAGGGTTACCCCCTTCGTCGTCGC
CGCTGTCGTCGCCGCCGCCGTCACCCGCTGCGGCCACGAGGAGAACCCCTACTTCACGGCTGGCTTATCAGCAGCCACC
CGGAGATGTCCCCCCCCGACTACAGCATGGCTCTGTCCTACAGCCCCGAGTACGCCAACGGGGCGCCGGGCATGGACCA
CTCCCATTACGGGGGGGTGCCGCCCGGGAGCGGCCCGCCCGGGCTCGGGGGGCCCCGGCCGGTGAAGCGCAGGGGCACG
GCGAACCGCAAGGAGCGGCGCAGGACTCAGAGCATCAACAGCGCCTTCGCGGAGCTGCGCGAGTGCATCCCCAACGTGC
CCGCCGACACCAAGCTCTCTAAGATCAAAACCCTCCGCCTGGCCACCAGCTACATCGCCTACCTCATGGACCTGCTGCC
CAAGGACGACCAGAACGGGGAGGCGGAGGCTTTCAAGGCAGAGATCAAGAAGACGGACGTGAAGGAGGAGAAGAGGAAG
AAGGAGCTGAACGAAATCTTGAAAAGCACAGTTAGCAGCAGCGATAAGAAAACCAAAGGGCGGACAGGCTGGCCGCAGC
ACGTCTGGGCGCTGGAGCTCAAGCAGTGAGCGCGGCGGG
CitationHuber L, Ferdin M, Holzmann J, Stubbusch J, Rohrer H. HoxB8 in noradrenergic specification and differentiation of the autonomic nervous system. Dev Biol. 2012 Mar 1;363(1):219-33. Epub 2011 Dec 24.
CopyrightCopyright © 2011 Elsevier Inc. All rights reserved.
CommentsInsufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # NM_204966.1).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
25-30
stage 27
stage 27
Head Mesenchyme
ciliary ganglia
control embryo
31-34
stage 34
stage 34
Cranial Ganglia
control embryo

Entry 5

GEISHA IdDHAND.Howard.2000Data SourcePublication
Complete cDNA Template Probeshow
AGCAGCGGCGATGAGTCTTGTGGGCGGCTTCCCCCACCACCCGGTGGTGCACCATGAGGGTTACCCCCTTCGTCGTCGC
CGCTGTCGTCGCCGCCGCCGTCACCCGCTGCGGCCACGAGGAGAACCCCTACTTCACGGCTGGCTTATCAGCAGCCACC
CGGAGATGTCCCCCCCCGACTACAGCATGGCTCTGTCCTACAGCCCCGAGTACGCCAACGGGGCGCCGGGCATGGACCA
CTCCCATTACGGGGGGGTGCCGCCCGGGAGCGGCCCGCCCGGGCTCGGGGGGCCCCGGCCGGTGAAGCGCAGGGGCACG
GCGAACCGCAAGGAGCGGCGCAGGACTCAGAGCATCAACAGCGCCTTCGCGGAGCTGCGCGAGTGCATCCCCAACGTGC
CCGCCGACACCAAGCTCTCTAAGATCAAAACCCTCCGCCTGGCCACCAGCTACATCGCCTACCTCATGGACCTGCTGCC
CAAGGACGACCAGAACGGGGAGGCGGAGGCTTTCAAGGCAGAGATCAAGAAGACGGACGTGAAGGAGGAGAAGAGGAAG
AAGGAGCTGAACGAAATCTTGAAAAGCACAGTTAGCAGCAGCGATAAGAAAACCAAAGGGCGGACAGGCTGGCCGCAGC
ACGTCTGGGCGCTGGAGCTCAAGCAGTGAGCGCGGCGGG
CitationHoward MJ, Stanke M, Schneider C, Wu X, Rohrer H. The transcription factor dHAND is a downstream effector of BMPs in sympathetic neuron specification. Development. 2000 Sep;127(18):4073-81.
CopyrightCopyright is held by the authors. Published by The Company of Biologists, Ltd.
CommentsAs insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_204966.1
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
19
stage 19
stage 19
Spinal Ganglia and Nerves
 

Entry 6

GEISHA IdHAND2.Wu.2002Data SourcePublication
Complete cDNA Template Probeshow
GCAGCGGCGATGAGTCTGGTGGGCGGCTTCCCCCACCACCCGGTGGTGCACCATGAGGGTTACCCCTTCGCCGCCGCCG
CTGCCGCCGCCGCCGCCGCCACCCGCTGCGGCCACGAGGAGAACCCCTACTTCCACGGCTGGCTTATCAGCAGCCACCC
GGAGATGTCCCCCCCCGACTACAGCATGGCTCTGTCCTACAGCCCCGAGTACGCCAACGGGGCGCCGGGCATGGACCAC
TCCCATTACGGGGGGGTGCCGCCCGGGAGCGGCCCGCCCGGGCTCGGGGGGCCCCGGCCGGTGAAGCGCAGGGGCACGG
CGAACCGCAAGGAGCGGCGCAGGACTCAGAGCATCAACAGCGCTTTCGCTGAGCTGCGCGAGTGCATCCCCAACGTGCC
CGCCGACACCAAGCTCTCTAAGATCAAAACCCTCCGCCTGGCCACCAGCTACATCGCCTACCTCATGGACCTGCTGGCC
AAGGACGACCAGAACGGGGAGGCGGAGGCTTTCAAGGCAGAGATCAAGAAGACGGACGTGAAGGAGGAGAAGAGGAAGA
AGGAGCTGAACGAAATCTTGAAAAGCACAGTTAGCAGCAGCGATAAGAAAACCAAAGGGCGGACAGGCTGGCCGCAGCA
CGTCTGGGCGCTGGAGCTCAAGCAGTGAGCGCGGCGGG
CitationWu X, Howard MJ. Transcripts encoding HAND genes are differentially expressed and regulated by BMP4 and GDNF in developing avian gut. Gene Expr. 2002;10(5-6):279-93.
Copyrightcopyright @ 2002 Cognizant Comm. Corp.
CommentsInsufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence was obtained from NCBI (NM_204966.2).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
25-30
stage 25
stage 25
stage 25
stage 25
stage 25
stage 25
stage 25
stage 25
stage 25
stage 25
stage 25
stage 25
Esophagus
Gizzard
Hindgut
Midgut
 
31-44
stage 34
stage 34
stage 34
stage 34
stage 34
stage 34
stage 34
stage 34
stage 34
stage 34
stage 34
stage 34
stage 44
stage 44
Esophagus
Gizzard
Hindgut
Midgut
 

Entry 7

GEISHA IdHAND2.Anderson.2021Data SourceDirect Submission
Complete cDNA Template Probeshow
CAGCGGCGATGAGTCTGGTGGGCGGCTTCCCCCACCACCCGGTGGTGCACCATGAGGGTTACCCNTTCGCCGCCGCCGC
TGCCGCCGCCGCCGCCGCCACCCGCTGCGGCCACGAGGAGAACCCCTACTTCCACGGCTGGCTTATCAGCAGCCACCCG
GAGATGTCCCCCCCCGACTACAGCATGGCTCTGTCCTACAGCCCCGAGTACGCCAACGGGGCGCCGGGCATGGACCACT
CCCATTACGGGGGGGTGCCGCCCGGGAGCGGCCCGCCCGGGCTCGGGGGGCCCCGGCCGGTGAAGCGCAGGGGCACGGC
GAACCGCAAGGAGCGGCGCAGGACTCAGAGCATCAACAGCGCCTTCGCGGAGCTGCGCGAGTGCATCCCCAACGTGCCC
GCCGACACCAAGCTCTCTAAGATCAAAACCCTCCGCCTGGCCACCAGCTACATCGCCTACCTCATGGACCTGCTGGCCA
AGGACGACCAGAACGGGGAGGCGGAGGCTTTCAAGGCAGAGATCAAGAAGACGGACGTGAAGGAGGAGAAGAGGAAGAA
GGAGCTGAACGAAATCTTGAAAAGCACAGTTAGCAGCAGCGATAAGAAAACCAAAGGGCGGACAGGCTGGCCGCAGCAC
GTCTGGGCGCTGGAGCTCAAGCAGTGAGCGCGGCGGG
CommentsImages and probe sequence information provided by Claire Anderson.
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
4-6
stage 6
Lateral Plate Mesoderm
extraembryonic mesoderm
 
7-12
stage 7
stage 8
stage 8
stage 9
stage 10
stage 12
stage 12
stage 12
Amnion
Anterior Intestinal Portal
Atria
Endocardium
Endoderm
Extraembryonic Blood Vessels
Lateral Plate Mesoderm
Myocardium
Sinus Venosus
Splanchnic Mesoderm
Ventricles
extraembryonic endoderm
extraembryonic mesoderm
HH8+, Ventral view
HH8-, Ventral view
Ventral view
section 40
section 52
 Data from NCBI Unigene EST Profile
Unigene ID: Gga.479

Mouse

EmageMGI:103580
EurexpressMGI:103580
MGI GXDMGI:103580

Frog

Xenbase481425

Fruit Fly

BDGPFBgn0032209

Zebra Finch

ZEBrA

Zebrafish

ZFINZDB-GENE-000511-1
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