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Human Disease Gene Search
HES5 Gene Summary Expression Transcript Levels Other Species Expression JBrowse Gene Official Symbol HES5 Official Full Name hes family bHLH transcription factor 5 CGNC ID 773 also known as transcription factor HES-5|hairy and enhancer of split 5 gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Molecular Function Biological Process Cellular Component
Links to other databases
Entry 1 GEISHA Id HES5.Hayes.2007 Data Source Publication Complete cDNA Template Probe show GGCTCGAGCCAGCTTCGTGCTGACAGCAGCTCTCGGATAATGGCACCCAGCGCTCTCTCCCTGGAAATCCTGACACCCA
Citation Hayes S, Nelson BR, Buckingham B, Reh TA.
Notch signaling regulates regeneration in the avian retina (2007). Dev Biol. 2007 Dec 1;312(1):300-11. Epub 2007 Sep 29. Copyright Copyright © 2007 Elsevier Inc. All rights reserved. Comments According to authors , "Hes5 plasmid was described in (Ref)." As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_001012695)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-44
stage 44
stage 44
Retina
Entry 2 GEISHA Id HES5-1.Fior.2005 Data Source Publication Complete cDNA Template Probe show GGCTCGAGCCAGCTTCGTGCTGACAGCAGCTCTCGGATAATGGCACCCAGCGCTCTCTCCCTGGAAATCCTGACACCCA
Citation Fior R, Henrique D (2005). A novel hes5/hes6 circuitry of negative regulation controls Notch activity during neurogenesis. Dev Biol. 2005 May 15;281(2):318-33. Copyright Copyright © 2005 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_001012695).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4-6 stage 5
Neural Plate/Tube 7-8 stage 7
stage 8
stage 8
Neural Plate/Tube
Entry 3 GEISHA Id HES5-2.Fior.2005 Data Source Publication Complete cDNA Template Probe show GGCTCGAGCCAGCTTCGTGCTGACAGCAGCTCTCGGATAATGGCACCCAGCGCTCTCTCCCTGGAAATCCTGACACCCA
Citation Fior R, Henrique D (2005). A novel hes5/hes6 circuitry of negative regulation controls Notch activity during neurogenesis. Dev Biol. 2005 May 15;281(2):318-33. Copyright Copyright © 2005 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_001012695).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4-6 stage 5
Neural Plate/Tube 7-8 stage 7
stage 8
stage 8
Neural Plate/Tube
Entry 4 GEISHA Id HES5-3.Fior.2005 Data Source Publication Complete cDNA Template Probe show GGCTCGAGCCAGCTTCGTGCTGACAGCAGCTCTCGGATAATGGCACCCAGCGCTCTCTCCCTGGAAATCCTGACACCCA
Citation Fior R, Henrique D (2005). A novel hes5/hes6 circuitry of negative regulation controls Notch activity during neurogenesis. Dev Biol. 2005 May 15;281(2):318-33. Copyright Copyright © 2005 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_001012695).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4-6 stage 5
Neural Plate/Tube 7-8 stage 7
stage 8
stage 8
Neural Plate/Tube
Entry 5 GEISHA Id HES5.Maier.2009 Data Source Publication Complete cDNA Template Probe show GGCTCGAGCCAGCTTCGTGCTGACAGCAGCTCTCGGATAATGGCACCCAGCGCTCTCTCCCTGGAAATCCTGACACCCA
Citation Maier E, Gunhaga L. Dynamic expression of neurogenic markers in the developing chick olfactory epithelium. Dev Dyn. 2009 Jun;238(6):1617-25. Copyright Dev. Dyn Copyright © 2009 John Wiley & Sons, Inc. All Rights Reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_001012695.1).
Entry 6 GEISHA Id HES5.Paxton.2010 Data Source Publication Complete cDNA Template Probe show CCAGAGACACCAACCCAACTCCAAGCTGGAGAAAGCCGACATCCTGGAGATGACTGTCAGCTACCTGAAATACAGCCGA
Citation Paxton CN, Bleyl SB, Chapman SC, Schoenwolf GC.
Identification of differentially expressed genes in early inner ear development. Gene Expr Patterns. 2010 Jan;10(1):31-43. Epub 2009 Nov 11.
Copyright 2009 Elsevier B.V. All rights reserved. Comments The cDNA template used to generate the probe was obtained by PCR as described 5-ccagagacaccaacccaact-3; 5-agatgtacccgtgcaacctc-3
Entry 7 GEISHA Id HES5.Maier.2010 Data Source Publication Complete cDNA Template Probe show GGCTCGAGCCAGCTTCGTGCTGACAGCAGCTCTCGGATAATGGCACCCAGCGCTCTCTCCCTGGAAATCCTGACACCCA
Citation Maier, E, von Hofsten, J, Nord, H, Fernandes, M, Paek, H, Hebert, JM, Gunhaga, L, Opposing Fgf and Bmp activities regulate the specification of olfactory sensory and respiratory epithelial cell fates. Development. 2010 May 15; 137(10): 16011611. Copyright Copyright © 2010. Held by the authors. Requested Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_001012695.1)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-18 stage 14
stage 14
19-24 stage 22
stage 22
stage 22
stage 22
Forebrain Nasal Placode/Nerve 25-27 stage 25
stage 25
stage 25
stage 25
stage 27
stage 27
stage 27
stage 27
stage 27
Nasal Placode/Nerve
Entry 8 GEISHA Id HES5.1.Akai.2005 Data Source Publication Complete cDNA Template Probe show GGCTCGAGCCAGCTTCGTGCTGACAGCAGCTCTCGGATAATGGCACCCAGCGCTCTCTCCCTGGAAATCCTGACACCCA
Citation Jun Akai, Pam A. Halley, Kate G. Storey. FGF-dependent Notch signaling maintains the spinal cord stem zone. Genes Dev. 2005 December 1; 19(23): 28772887. Copyright Copyright © 2005, Cold Spring Harbor Laboratory Press
Entry 9 GEISHA Id HES5.1.Daudet.2007 Data Source Publication Complete cDNA Template Probe show GGCTCGAGCCAGCTTCGTGCTGACAGCAGCTCTCGGATAATGGCACCCAGCGCTCTCTCCCTGGAAATCCTGACACCCA
Citation Daudet N, Ariza-McNaughton L, Lewis J. Notch signalling is needed to maintain, but not to initiate, the formation of prosensory patches in the chick inner ear. Development. 2007 Jun;134(12):2369-78. Copyright Copyright 2007 the authors. Published by the Company of Biologists Ltd. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_001012695.1 ).
Entry 10 GEISHA Id HES5.3.Daudet.2007 Data Source Publication Complete cDNA Template Probe show GGCTCGAGCCAGCTTCGTGCTGACAGCAGCTCTCGGATAATGGCACCCAGCGCTCTCTCCCTGGAAATCCTGACACCCA
Citation Daudet N, Ariza-McNaughton L, Lewis J. Notch signalling is needed to maintain, but not to initiate, the formation of prosensory patches in the chick inner ear. Development. 2007 Jun;134(12):2369-78. Copyright Copyright 2007 the authors. Published by the Company of Biologists Ltd. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_001012695.1 ).
Entry 11 GEISHA Id HES5.Ratie.2013 Data Source Publication Complete cDNA Template Probe show GGCTCGAGCCAGCTTCGTGCTGACAGCAGCTCTCGGATAATGGCACCCAGCGCTCTCTCCCTGGAAATCCTGACACCCA
Citation Leslie Ratié, Michelle Ware, Frédérique Barloy-Hubler, Hélène Romé, Isabelle Gicquel, Christèle Dubourg, Véronique David and Valérie Dupé. Novel genes upregulated when NOTCH signalling is disrupted during hypothalamic development. Neural Dev. 2013 Dec 23;8:25. doi: 10.1186/1749-8104-8-25. Copyright © 2013 Ratié et al.; licensee BioMed Central Ltd. Comments The sequence below was obtained from NCBI (acc # NM_001012695.1) using the information provided in the publication as described in Ratie et al.
Entry 12 GEISHA Id HES5.Ware.2014 Data Source Publication Complete cDNA Template Probe show GGCTCGAGCCAGCTTCGTGCTGACAGCAGCTCTCGGATAATGGCACCCAGCGCTCTCTCCCTGGAAATCCTGACACCCA
Citation Ware M, Hamdi-Rozé H and Dupé V (2014) Notch signaling and proneural genes work together to control the neural building blocks for the initial scaffold in the hypothalamus. Front Neuroanat. 2014 Dec 2;8:140. doi: 10.3389/fnana.2014.00140. Copyright Copyright © 2014 Ware, Hamdi-Rozé and Dupé Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (Acc. # NM_001012695.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-10 stage 10
stage 10
Hypothalamus
Data from NCBI Unigene EST ProfileGga.11242
Mouse Frog Fruit Fly Zebra Finch Zebrafish
