Geisha

home

contact

A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

Quick Search

Data Class

Enter Text:

Gene Family QuickSearch

	Transcription Factors
	Growth Factors
	Receptors
	MicroRNAs

Human Disease Gene Search

	Downloads
	Protocols
	About GEISHA
	Contact Us

	Transgenic Birds
	Model Organism Databases
	Gene Expression Databases
	Genomic Resources
	Anatomical Atlases
	Chicken Stage Series

HOXB8
homeobox B8

Gene

Official Symbol	HOXB8
Official Full Name	homeobox B8
CGNC ID	49449
also known as	CHOX-2.4, Hoxb-8, OX2.4, homeobox protein Hox-B8\|Homeobox protein Hox-2.4\|homeo box B8, Homeobox protein Hox-B8, Chox-2.4
gene type	protein-coding

Genomic Map

	Ensembl ID not known
	NCBI
	UCSC
	Gallus-Browse

Sequence Information

Genomic
RNA	NM_204911
Polypeptide	NP_990242
Sequence Clusters/ESTs	Unigene

Gene Expression

In Situ Hybridization	GEISHA
EST Profile	Gga.926

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	3218	ENSG00000120068		MIM:142963
Mouse	15416	ENSMUSG00000056648	All phenotypic alleles (10):Targeted, knock-out(3) Targeted, other(7)	MGI:96189
Xenopus	100493882			990960
Zebrafish	30420, 30343	ENSDARG00000054025, ENSDARG00000056027	ZDB-GENE-980526-291, ZDB-GENE-990415-108	ZFIN:ZDB-GENE-980526-291, ZFIN:ZDB-GENE-990415-108

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Links to other databases

Entrez Gene	395737
Ensembl Gene
KEGG	gga:395737

Entry 1

GEISHA Id	HOXB8.UApcr	Data Source	GEISHA ISH Analysis
Forward cDNA Template Primer	CCGACCCAAATCCAGGAGTTCTAC
Reverse cDNA Template Primer	TACCACCCGTGCCTGGATACATGAGGTCTTGTCCGCCTTCTGTGCTTC	cDNA Template Length	571
Forward cDNA Template Probe	show CTTCCAGCATCCGACCCAAATCCAGGAGTTCTACCACGGAGCATCCTCACTCTCCAGCTCCCCTTACCAACAGAATCCC TGCGCCGTGGCGTGCCATGGGGACCCGAGCAACTTCTATGGCTACGACCCTTTGCAAAGGCAGAGCCTCTTCAGCGCCC AGGAGTCGGACTTGGTGCAGTACACGGACTGCAAGCTTGCTGCCAGCGGCCTTGGAGAGGAGGCGGAGAGCTCGGAGCA GAGCCCTTCTCCGACCCAGCTTTTCCCCTGGATGCGACCGCAAGCCGCTGGACGGAGGAGGGGGAGGCAAACCTACAGC CGCTACCAGACGCTGGAACTGGAGAAGGAATTTCTATTTAATCCCTACCTGACCCGCAAACGGAGGATCGAGGTCTCGC ATGCCCTGGGATTGACAGAAAGGCAGGTCAAAATCTGGTTCCAGAACAGGAGGATGAAATGGAAAAAGGAAAACAACAA AGACAAGTTTCCCAGCAGCAAATGCGAGCAGGAAGAACTGGAAAAACAGAAAATGGAAAGAGCCCAGGAGGTGGACGAG GAAGGGGAAGCACAGA

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

4-6

stage 6

Early Mesoderm
Extraembryonic Mesoderm
Primitive Streak

7-12

stage 7

stage 8

stage 9

stage 12

Blood Vessels
Lateral Plate Mesoderm
Neural Plate/Tube
Paraxial Mesoderm
Primitive Streak
Spinal Cord

13-18

stage 13

stage 15

stage 17

Blood Vessels
Extraembryonic
Lateral Plate Mesoderm
Paraxial Mesoderm
Primitive Streak
Spinal Cord
Tail

19-24

stage 21

stage 22

stage 23

Lung
Somatic Mesoderm
Spinal Cord
Spinal Ganglia and Nerves
Tail

stage 25

Midgut
Spinal Cord
Spinal Ganglia and Nerves
Tail

Entry 2

GEISHA Id	HOXB8.Sakiyama.2000	Data Source	Publication
Complete cDNA Template Probe	show TCGGCACAAGTTTTCCTCCTCCTCCGTACAAATATTATTATTTAAATTAAGATGAGCTCCTATTTTGTCAACTCACTCT TCTCCAAATACAAAACCGGGGACTCGTTGCGTCCCAATTACTATGACTGCGGGTTCGCTCAGGATCTTGGGGGCAGACC CACGGTGGTGTACGGACCCAGCACGGGGGGCACCTTCCAGCATCCGACCCAAATCCAGGAGTTCTACCACGGAGCATCC TCACTCTCCAGCTCCCCTTACCAACAGAATCCCTGCGCCGTGGCGTGCCATGGGGACCCGAGCAACTTCTATGGCTACG ACCCTTTGCAAAGGCAGAGCCTCTTCAGCGCCCAGGAGTCGGACTTGGTGCAGTACACGGACTGCAAGCTTGCTGCCAG CGGCCTTGGAGAGGAGGCGGAGAGCTCGGAGCAGAGCCCTTCTCCGACCCAGCTTTTCCCCTGGATGCGACCGCAAGCC GCTGGACGGAGGAGGGGGAGGCAAACCTACAGCCGCTACCAGACGCTGGAACTGGAGAAGGAATTTCTATTTAATCCCT ACCTGACCCGCAAACGGAGGATCGAGGTCTCGCATGCCCTGGGATTGACAGAAAGGCAGGTCAAAATCTGGTTCCAGAA CAGGAGGATGAAATGGAAAAAGGAAAACAACAAAGACAAGTTTCCCAGCAGCAAATGCGAGCAGGAAGAACTGGAAAAA CAGAAAATGGAAAGAGCCCAGGAGGTGGACGAGGAAGGGGAAGCACAGAAGGCGGACAAGAAATAAAAAGGAGTTTTGA GGACTGAAAGGAGAGCGCTGCTGGGGTAGAGAGCCCCCCTCCCCCCTTTTTCTTT
Citation	Sakiyama J, Yokouchi Y, Kuroiwa A. Coordinated expression of Hoxb genes and signaling molecules during development of the chick respiratory tract. Dev Biol. 2000 Nov 1;227(1):12-27.
Copyright	Reprinted with permission from Elsevier. Copyright © 2000 Elsevier B.V. All rights reserved.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204911).

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

19-24

stage 24

Lung

25-30

stage 27

stage 29

Lung

31-34

stage 34

Lung

Abdominal Air Sacs (5)
Caudal Thoracic Air Sacs (4)
Cranial Thoracic Air Sacs (3)
Figure 2 compares expression of the Hoxb genes in the developing chick respiratory tract at HH stages 24, 27, 29 and 34.

Entry 3

GEISHA Id	HOXB8.Hughes.2011	Data Source	Publication
Complete cDNA Template Probe	show TCGGCACAAGTTTTCCTCCTCCTCCGTACAAATATTATTATTTAAATTAAGATGAGCTCCTATTTTGTCAACTCACTCT TCTCCAAATACAAAACCGGGGACTCGTTGCGTCCCAATTACTATGACTGCGGGTTCGCTCAGGATCTTGGGGGCAGACC CACGGTGGTGTACGGACCCAGCACGGGGGGCACCTTCCAGCATCCGACCCAAATCCAGGAGTTCTACCACGGAGCATCC TCACTCTCCAGCTCCCCTTACCAACAGAATCCCTGCGCCGTGGCGTGCCATGGGGACCCGAGCAACTTCTATGGCTACG ACCCTTTGCAAAGGCAGAGCCTCTTCAGCGCCCAGGAGTCGGACTTGGTGCAGTACACGGACTGCAAGCTTGCTGCCAG CGGCCTTGGAGAGGAGGCGGAGAGCTCGGAGCAGAGCCCTTCTCCGACCCAGCTTTTCCCCTGGATGCGACCGCAAGCC GCTGGACGGAGGAGGGGGAGGCAAACCTACAGCCGCTACCAGACGCTGGAACTGGAGAAGGAATTTCTATTTAATCCCT ACCTGACCCGCAAACGGAGGATCGAGGTCTCGCATGCCCTGGGATTGACAGAAAGGCAGGTCAAAATCTGGTTCCAGAA CAGGAGGATGAAATGGAAAAAGGAAAACAACAAAGACAAGTTTCCCAGCAGCAAATGCGAGCAGGAAGAACTGGAAAAA CAGAAAATGGAAAGAGCCCAGGAGGTGGACGAGGAAGGGGAAGCACAGAAGGCGGACAAGAAATAAAAAGGAGTTTTGA GGACTGAAAGGAGAGCGCTGCTGGGGTAGAGAGCCCCCCTCCCCCCTTTTTCTTT
Citation	Hughes MW, Wu P, Jiang TX, Lin SJ, Dong CY, Li A, Hsieh FJ, Widelitz RB, Chuong CM. In search of the Golden Fleece: unraveling principles of morphogenesis by studying the integrative biology of skin appendages Integr Biol (Camb). 2011 Apr;3(4):388-407. Epub 2011 Mar 24.
Copyright	© Royal Society of Chemistry 2011
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_204911.1).

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

25-29

stage 26

stage 29

Dermis

epithelium

Entry 4

GEISHA Id	HOXB8.Huber.2012	Data Source	Publication
Complete cDNA Template Probe	show TCGGCACAAGTTTTCCTCCTCCTCCGTACAAATATTATTATTTAAATTAAGATGAGCTCCTATTTTGTCAACTCACTCT TCTCCAAATACAAAACCGGGGACTCGTTGCGTCCCAATTACTATGACTGCGGGTTCGCTCAGGATCTTGGGGGCAGACC CACGGTGGTGTACGGACCCAGCACGGGGGGCACCTTCCAGCATCCGACCCAAATCCAGGAGTTCTACCACGGAGCATCC TCACTCTCCAGCTCCCCTTACCAACAGAATCCCTGCGCCGTGGCGTGCCATGGGGACCCGAGCAACTTCTATGGCTACG ACCCTTTGCAAAGGCAGAGCCTCTTCAGCGCCCAGGAGTCGGACTTGGTGCAGTACACGGACTGCAAGCTTGCTGCCAG CGGCCTTGGAGAGGAGGCGGAGAGCTCGGAGCAGAGCCCTTCTCCGACCCAGCTTTTCCCCTGGATGCGACCGCAAGCC GCTGGACGGAGGAGGGGGAGGCAAACCTACAGCCGCTACCAGACGCTGGAACTGGAGAAGGAATTTCTATTTAATCCCT ACCTGACCCGCAAACGGAGGATCGAGGTCTCGCATGCCCTGGGATTGACAGAAAGGCAGGTCAAAATCTGGTTCCAGAA CAGGAGGATGAAATGGAAAAAGGAAAACAACAAAGACAAGTTTCCCAGCAGCAAATGCGAGCAGGAAGAACTGGAAAAA CAGAAAATGGAAAGAGCCCAGGAGGTGGACGAGGAAGGGGAAGCACAGAAGGCGGACAAGAAATAAAAAGGAGTTTTGA GGACTGAAAGGAGAGCGCTGCTGGGGTAGAGAGCCCCCCTCCCCCCTTTTTCTTT
Citation	Huber L, Ferdin M, Holzmann J, Stubbusch J, Rohrer H. HoxB8 in noradrenergic specification and differentiation of the autonomic nervous system. Dev Biol. 2012 Mar 1;363(1):219-33. Epub 2011 Dec 24.
Copyright	Copyright © 2011 Elsevier Inc. All rights reserved.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # NM_204911.1).

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

19-24

stage 24

Spinal Cord
Spinal Ganglia and Nerves

25-30

stage 27

stage 29

Spinal Cord
Spinal Ganglia and Nerves
Unlabeled

stage 31

Spinal Cord
Spinal Ganglia and Nerves
Unlabeled

Entry 5

GEISHA Id	HOXB8.Barak.2012	Data Source	Publication
Complete cDNA Template Probe	show TCGGCACAAGTTTTCCTCCTCCTCCGTACAAATATTATTATTTAAATTAAGATGAGCTCCTATTTTGTCAACTCACTCT TCTCCAAATACAAAACCGGGGACTCGTTGCGTCCCAATTACTATGACTGCGGGTTCGCTCAGGATCTTGGGGGCAGACC CACGGTGGTGTACGGACCCAGCACGGGGGGCACCTTCCAGCATCCGACCCAAATCCAGGAGTTCTACCACGGAGCATCC TCACTCTCCAGCTCCCCTTACCAACAGAATCCCTGCGCCGTGGCGTGCCATGGGGACCCGAGCAACTTCTATGGCTACG ACCCTTTGCAAAGGCAGAGCCTCTTCAGCGCCCAGGAGTCGGACTTGGTGCAGTACACGGACTGCAAGCTTGCTGCCAG CGGCCTTGGAGAGGAGGCGGAGAGCTCGGAGCAGAGCCCTTCTCCGACCCAGCTTTTCCCCTGGATGCGACCGCAAGCC GCTGGACGGAGGAGGGGGAGGCAAACCTACAGCCGCTACCAGACGCTGGAACTGGAGAAGGAATTTCTATTTAATCCCT ACCTGACCCGCAAACGGAGGATCGAGGTCTCGCATGCCCTGGGATTGACAGAAAGGCAGGTCAAAATCTGGTTCCAGAA CAGGAGGATGAAATGGAAAAAGGAAAACAACAAAGACAAGTTTCCCAGCAGCAAATGCGAGCAGGAAGAACTGGAAAAA CAGAAAATGGAAAGAGCCCAGGAGGTGGACGAGGAAGGGGAAGCACAGAAGGCGGACAAGAAATAAAAAGGAGTTTTGA GGACTGAAAGGAGAGCGCTGCTGGGGTAGAGAGCCCCCCTCCCCCCTTTTTCTTT
Citation	Barak H, Preger-Ben Noon E, Reshef R. Comparative spatiotemporal analysis of Hox gene expression in early stages of intermediate mesoderm formation. Dev Dyn. 2012 Oct;241(10):1637-49.
Copyright	Copyright © 2012 Wiley Periodicals, Inc.
Comments	As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_204911.1).

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

4-6

stage 4

stage 6

Hensen's Node
Lateral Plate Mesoderm
Neural Plate/Tube
Primitive Streak

7-11

stage 7

stage 8

stage 9

stage 10

stage 11

Central Nervous System
Lateral Plate Mesoderm
Neural Plate/Tube
Paraxial Mesoderm
Primitive Streak

Entry 6

GEISHA Id	Hoxb8.Bel-Vialar.2002	Data Source	GEISHA ISH Analysis
Complete cDNA Template Probe	show TTTTCCTCCTCCTCCGTACAAATATTATTATTTAAATTAAGATGAGCTCCTATTTTGTCAACTCACTCTTCTCCAAATA CAAAACCGGGGACTCGTTGCGTCCCAATTACTATGACTGCGGGTTCGCTCAGGATCTTGGGGGCAGACCCACGGTGGTG TACGGACCCAGCACGGGGGGCACCTTCCAGCATCCGACCCAAATCCAGGAGTTCTACCACGGAGCATCCTCACTCTCCA GCTCCCCTTACCAACAGAATCCCTGCGCCGTGGCGTGCCATGGGGACCCGAGCAACTTCTATGGCTACGACCCTTTGCA AAGGCAGAGCCTCTTCAGCGCCCAGGAGTCGGACTTGGTGCAGTACACGGACTGCAAGCTTGCTGCCAGCGGCCTTGGA GAGGAGGCGGAGAGCTCGGAGCAGAGCCCTTCTCCGACCCAGCTTTTCCCCTGGATGCGACCGCAAGCCGCTGGACGGA GGAGGGGGAGGCAAACCTACAGCCGCTACCAGACGCTGGAACTGGAGAAGGAATTTCTATTTAATCCCTACCTGACCCG CAAACGGAGGATCGAGGTCTCGCATGCCCTGGGATTGACAGAAAGGCAGGTCAAAATCTGGTTCCAGAACAGGAGGATG AAATGGAAAAAGGAAAACAACAAAGACAAGTTTCCCAGCAGCAAATGCGAGCAGGAAGAACTGGAAAAACAGAAAATGG AAAGAGCCCAGGAGGTGGACGAGGAAGGGGAAGCACAGAAGGCGGACAAGAAATAAAAAGGAGTTTTGAGGACTGAAAG GAGAGCGCTGCTGGGGTAGAGAGCCCCC
Citation	Sophie Bel-Vialar, Nobue Itasaki, Robb Krumlauf. Initiating Hox gene expression: in the early chick neural tube differential sensitivity to FGF and RA signaling subdivides the HoxB genes in two distinct groups. Development 2002 Nov;129(22):5103-15.
Copyright	Copyright © The Company of Biologists Limited 2002.
Comments	Authors indicated the probe was a gift from K. Olberg. As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence above was obtained from NCBI (accession number NM_204911.2).