GEISHA - A Chicken Embryo Gene Expression Database
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LRRN1
leucine rich repeat neuronal 1

Gene
Official SymbolLRRN1
Official Full Nameleucine rich repeat neuronal 1
CGNC ID56905
also known asLRCH4, leucine-rich repeat neuronal protein 1|leucine-rich repeats and calponin homology (CH) domain containing 4, Leucine-rich repeat neuronal 1 (Lrrn1), NLRR1
gene typeprotein-coding
Genomic Map
 Ensembl
NCBI
UCSC
Gallus-Browse
Sequence Information
Genomic
RNANM_001097539
PolypeptideNP_001091008
Sequence Clusters/ESTsUnigene
Gene Expression
In Situ HybridizationGEISHA
EST ProfileGga.44964
Orthology
Entrez GeneEnsembl GeneGenetic PhenotypesMOD
Fruit Fly
Human57633ENSG00000175928
Mouse16979ENSMUSG00000034648All phenotypic alleles (1):Targeted, knock-out(1) MGI:106038
Xenopus100127637, 379684, 735038492889
Zebrafish568527ENSDARG00000060115ZDB-GENE-071126-1ZFIN:ZDB-GENE-071126-1
Gene Ontology
Molecular Function
Biological Process
Cellular Component
Links to other databases
Entrez Gene771599
Ensembl GeneENSGALG00000008279
KEGGgga:771599

Entry 1

GEISHA IdLRRN1.Garcia-Calero.2006Data SourcePublication
Complete cDNA Template Probeshow
NGGNATTTGGNGGGGNAAACATTTTNCCCCNGGNAAACCNTTTTNGCCCNTNTTTCCCCCCAAGTTTTTAANTCGCCCC
CNTTAAGGGAAAATTTGGTACCCCNCCCAGGTNCCGGTCCCGAAATTCCCGGGNTGGACCCAGGGGGCCGGGGCCTTTN
TCCTTAANACCAGGGATATTGATTTAANCTGAGTTNTTTTNGCCCTAAANATTCCCTGGACTTTTNCCAAAAAAAGGCC
CCCGGNGGGCCAAGGTTGCCAGCAAANTTCCAGCTTCCAACTTGCAAANCTTCATAAATTTGTTTTGAGAAAGTAATTA
TTGAGCAAGTGTCAAATGTTCANAGCAGGCCTNTTCTTCCCCCACCTTCCTGCAGCACTTGTGCAGNTGTNCCACAAAC
ACTCGGGTAACAACAAGCTTTCACTTGAGCCTCCTGTCCAAAGGGGTCGGCATACGGNAAGGGAAGCAGTGTNTGATGT
GTTCCTTGCCACTGGGGAAATTATGTGCCTGTTCTTCCCTGCAGACCTATTTGGCAGTTTTATGTCATTTGTTATCGTT
ATAGTGCAATGCTGTTAAAGAACAGCAAGAGAAAATGGCCTTATGACAGTCATATACTTCTGGATGTGCTGATCTGTAG
TATTTCAGGGGAGCTGATGTTGCTGGGGCTCTGGCAGANANATGCAGGTTCCCTGACAACAGCTCAACAGCCACAACAC
CCTGTTAGTGCCGCACATTNTGCACATACAGCCACCAGTGACATGTATTTTCAGCCTTGTAATCTATGCCCTTAGAGCT
CTGTACAGTTNTCCTGGAAAGTTAAAATTCTGCTAATAAAAGGAAAAAAAAAAACAACAGTGGGTAAGAGATTAATGAC
ATGTGGCATATAATCTTAGCAAATAACCTTCAGCCTTGTCCTAGCAATTCTGTGCTTGCAGTTTGTTGTAAGCAAAAAT
AAAAATATTCTCTTTGCCTAAAAAAAAAAAAAAAAAAAAAAAAA
CitationGarcía-Calero E, Garda AL, Marín F, Puelles L. Expression of Lrrn1 marks the prospective site of the zona limitans thalami in the early embryonic chicken diencephalon. Gene Expr Patterns. 2006 Oct;6(8):879-85. Epub 2006 Feb 28.
CopyrightReprinted with permission from Elsevier. Copyright © 2006 Elsevier B.V. All rights reserved.
CommentsSequence below was obtained from NCBI using the GenBank Accession No. (BF724065) and primers given in the publication: Lrrn1 forward primer, 5'-TGCTAGGACAAGGCTGAAGG-3'; reverse primer, 5'-CCACAAACACTCGGGTAACA-3'. This sequence is the reverse complement of the 3'end of the gene. The sense strand is shown below.
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
7-12
stage 10
Diencephalon
Midbrain
Rhombomeres
Telencephalon
 
13-18
stage 14
stage 15
stage 17
stage 18
Diencephalon
Forebrain
Midbrain
Rhombomeres
Telencephalon
Alar Plate
Basal Plate
Chiasmatic Band
Prosencephalic Alar Plate
Zona Limitans
19-24
stage 20
stage 24
Midbrain
Rhombomeres
Telencephalon
Basal Plate,
Chiasmatic Band
Prosencephalic Alar Plate
Retromammillary Area,
Supramammillary Band
25-26
stage 25
stage 26
Midbrain
Telencephalon
Basal Plate
Mammillary body
Retromammillary Area
Supramammillary Band

Entry 2

GEISHA IdNLRR1.Tonegawa.2003Data SourcePublication
Forward cDNA Template Probeshow
GCGGCTCGAGGGGATCGATGTTTGCTGTAATTAGCCTTGCCTCCATTTCTGTTTACATTGCAAAAAGATTTAAGAGAAA
AAACTACCACCATTCACTGAAAAAATATATGCAAAAGACCTCCTCAATCCCCCTGAATGAGCTCTATCCTCCACTTATT
AATCTCTGGGAAGGCGACAGTGATAAGGACAAGGATGGTTCTGCAGAGACCAAGCCAACCCAAGTCGACACATCCAGAA
GCTATTACATGTGGTAACTCAGAGGATATTTTGCTTCTGGTAGTAAGGAGCACAAAGACTTTTTTGCTTTATTCTGCAA
AAATGAGAAGTTGAAGACTTTTGTATTTTTGACTTTGCTAGTTTGTGGCAGAGTGGTGAGGACAGGTGGATATTTCAGA
ATTTTTTAGTATAGCGTATCGCAATTGTTTGACACAAATGGCAGCTTCACCTAGCTTCAAGAGTTCTTTTTTTTTTCCC
CTTTCTCTCTTTTTTTTTTTTTTTTAAGGTTATGGGGCTAAACTTAAGGCGGGCCTAACTACAGGGGCTGAATAAAATT
AAGGAAAGGCGGGGGTTACCCGGGTGATCCAAAAGTAGCAAAACCCCATTCTTCTGAAGCCATCAGTAGAGTCCAGTAT
CTGGCAAAGCTAACATACCAGTTTGGAACCCGGCTTTGAACTAGTTCGGAAGGCGGGCCTGAGGACTCGAGCTGAGAAA
AGGGGGAC
CitationTonegawa A, Kasai T, Takahashi Y. Systematic screening for signaling molecules expressed during somitogenesis by the signal sequence trap method. Dev Biol. 2003 Oct 1;262(1):32-50.
Copyright"Reprinted from DEVELOPMENTAL BIOLOGY, 262, Tonegawa A, Kasai T, Takahashi Y. Systematic screening for signaling molecules expressed during somitogenesis by the signal sequence trap method. 32-50, Copyright (2003), with permission from Elsevier". Copyright © 2003 Elsevier B.V. All rights reserved.
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
13-18
stage 14
stage 14
Neural Plate/Tube
Paraxial Mesoderm
Somites
comparison of several genes
19-20
stage 20
stage 20
stage 20
Dermatome
Dermomyotome
Myotome
Neural Plate/Tube
Somites
Comparison of several genes

Entry 3

GEISHA IdLRRN1.Andreae.2007Data SourcePublication
Complete cDNA Template Probeshow
AAAAACTACCACCATTCACTGAAAAAATATATGCAAAAGACCTCCTCAATCCCCCTGAATGAGCTCTATCCTCCACTTA
TTAATCTCTGGGAAGGCGACAGCGATAAGGACAAGGATGGTTCTGCAGAGACCAAGCCAACCCAAGTTGACACATCCAG
AAGCTATTACATGTGGTAACTCA
CitationAndreae, LC, Peukert, D, Lumsden, A, Gilthorpe, JD, Analysis of Lrrn1 expression and its relationship to neuromeric boundaries during chick neural development. Neural Develop. 2007; 2: 22. Published online 2007 October 31.
CopyrightCopyright © 2007 Andreae et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
CommentsA fragment corresponding to the intracellular domain of the chick Lrrn1, including the translational termination codon, was generated by PCR with primers 5'-ACGGATCCAAAACTACCACCATTCAC-3' and 5'-CGCCTCGAGTTACCACATGTAATAGC-3'
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
1-3
stage 3
Epiblast
 
4-6
stage 5
Neural Plate/Tube
 
7-12
stage 12
Neural Plate/Tube
double labeled
13-18
stage 13
stage 14
stage 14
stage 15
stage 15
stage 16
stage 16
stage 17
stage 17
stage 17
stage 17
stage 17
stage 17
stage 18
stage 18
stage 18
stage 18
stage 18
stage 18
stage 18
Dermomyotome
Diencephalon
Forebrain
Hindbrain
Midbrain
Neural Plate/Tube
Retina
Rhombomeres
Spinal Cord
Stages 14, 16, and 18
double labeled
19-24
stage 19
stage 19
stage 19
stage 21
stage 22
stage 23
stage 23
stage 23
Diencephalon
Forebrain
Hindbrain
Midbrain
Neural Plate/Tube
Retina
Rhombomeres
double labeled
25
stage 25
stage 25
Hindbrain
 

Entry 4

GEISHA IdLRRN1.Tossell.2011bData SourcePublication
Complete cDNA Template Probeshow
GGCAGGCGGGCGGCAGCGCGGCGCCGCGCTGCGCTCCTCCCTTCTGTCCCTCCGCCTTCTCCCGCCGCGGATGTCGGCG
CCGCCGCTGCGTGGGGGAGAGGAGCGGCTGCGCGGGCAGCGCCCCCCCGGGTGCCGGAACGTCTTCAGGCACGGATTTG
TAGAAGATCCTGGAACACAGAGGAGCAGCTGAGAGCCTTCAGACAATTTATTGTCTTCTCTAACCTTACAGAATCAACT
TTCATCTTCTGGATGTCCAAGCCTTTCACACCAAATTTTAAGCTTTACCTTTCCTGCCTGGCAACAAATTACATTCTCA
GTCTGTTATTTTAAGGGGCTGGGAAGCTGAATTCACTAGCTGACCAGCATGGCTAAGATTAGATTAGTTTTAACTGTTT
GCCAGGTGGTGCTAGAATTGCTAACGAATTCATTAACTGAGTCTTCCGTACAGAGTAATGAATGTCCCCAGCTTTGTGT
ATGCGAAATCAGGCCATGGTTTACACCACAGTCAACATACAGGGAAGCCACAACAGTTGACTGCAATGACCTTCGTTTA
ACAAAAATCCCCAGCAATCTTTCCAGTGACACTCAAGTCCTTCTGTTACAAAGCAACAATATCGCAAAGACCACAGATG
AACTCCAACTGCTATTTAATTTAACAGAGTTAGATTTTTCACAAAATAACTTCACAAGTATCAGAGACGTGGGGCTCTC
AAATCTTACTCAGCTAACTACTTTGCATCTGGAGGAAAATCAGATCATGGAGATGACTGACTACTGCTTGCAAGACCTT
TGCAATCTTCAGGAGTTATATATAAATCATAATCAGATCAGCAGCATTTCTGCAAATGCATTCTCTGGCCTGAAGAATC
TTTTAAGATTACATCTCAACTCCAACAAATTAAAGGTTATTGACAGCCGTTGGTTTGATTCTACTCCTAACTTAGAGAT
TCTTATGATTGGAGAAAATCCAGTGATTGGAATACTAGATATGAACTTCAAACCACTCTCCAATTTAAGGAGTCTTGTT
TTGGCGGGTATGTATCTTACAGACATCCCCGGCAATGCCTTGGTAGGCTTGGACAGTCTTGAAAGTCTTTCCTTCTATG
ACAACAAATTGGTAAAAGTTCCTCAGCTCGCACTTGAGAAAGTTCCAAATCTAAAATTCCTGGATCTCAACAAAAATCC
AATTCATAAAATTCAAGAAGGTGACTTTAGAAACATGCTCAGATTGAAAGAGCTTGGAATCAATAATATGGGAGAGCTT
GTTTCTGTGGATAGGTATGCGCTGGACAACCTGCCTGAACTTACAAAGCTGGAAGCCACCAACAACCCAAAGCTGTCCT
ACATCCATCGTTTGGCATTTCGCAACGTCCCTGCCCTGGAGAGTTTGATGCTGAACAACAACGCCTTGAACGCTGTCTA
CCAAAAAACAGTGGAGTCCCTCCCAAACCTGCGTGAGATTAGCATCCACAGCAACCCCCTCCGGTGCGACTGTGTCATT
CACTGGATCAACTCAAACAAAACCAACATCCGCTTCATGGAACCTCTCTCCATGTTCTGTGCCATGCCTCCAGAGTACA
GAGGACAACAGGTAAAAGAAGTGCTAATACAGGATTCAAACGAGCAATGTCTTCCAATGATCTCTCACGAGACCTTTCC
AAATCACTTAAACTTGGACATTGGCATGACAGTATTTTTAGACTGCAGGGCCATGGCAGAACCCGAGCCAGAAATTTAC
TGGGTCACTCCCCTCGGAAATAAAGTAACTGTTGAAAGCCTCTCTGACAAATACAAGCTAAGCAGCGAAGGCACCTTGG
AAATCTCCAATATTCAGATTGAAGACTCTGGGAGGTACACCTGTGTTGCTCAGAACATAGAAGGAGCTGACACGAGGGT
CGCCACAATCCGGGTGAACGGAACACTTCTGGATGGCACCCAGGTTCTGAAAATCTTTGTGAAGCAAGCTGAATCGCAT
TCCATTTTAGTTTCTTGGAAAGTTAACTCCAATGTCATGACTTCCAATTTAAAGTGGTCATCAGCTACTATGAAGATTG
ACAACCCTCACATTACATACACCGCTCGGGTCCCAGTTGATGTACATGAATATAACCTCACGCATTTACAACCTTCTAC
AGATTATGAAGTGTGTCTCACTGTGTCCAACATCCACCAACAAACACAAAAGTCCTGTGTTAATGTTACAACAAAAAAT
GCAGCTTTTGCGCTGGATATTTCAGACCAAGAAACCAGCACTGCTCTGGCAGCGGTAATGGGATCGATGTTTGCTGTAA
TTAGCCTTGCCTCCATTTCTGTTTACATTGCAAAAAGATTTAAGAGAAAAAACTACCACCATTCACTGAAAAAATATAT
GCAAAAGACCTCCTCAATCCCCCTGAATGAGCTCTATCCTCCACTTATTAATCTCTGGGAAGGCGACAGCGATAAGGAC
AAGGATGGTTCTGCAGAGACCAAGCCAACCCAAGTTGACACATCCAGAAGCTATTACATGTGGTAACTCAGAGGATATT
TTGCTTCTGGTAGTAAGGAGCACAAAGACTTTTTTGCTTTATTCTGCAAAAATGAGAAGTTGAAGACCTTTGTATTTTT
GACTTTGCTAGTTTGTGGCAGAGTGGTGAGGACAGGTGGATATTTCAGAATTTTTTAGTATAGCGTATCGCAATTGTTT
GACACAAATGGCAGCTTCACCTAGCTTCCAGAGTTCTTTTTTTTTTCCCTTTCTCTCTCTCTTTTTTTTTTTTTTAGTT
ATTGTGCTAAACTTAATGCTGTTACTAACCACAGTGCTGAATAAAATTAATGAGAGGCTGGGGTTACCCTGTGATTCAA
AAGTAGCACAACCCCATTCTTCTGAAGCCATCAGTAGAGTACAGTATCTGCCAAGCTAGCATACAGTTTTGA
CitationTossell K, Andreae LC, Cudmore C, Lang E, Muthukrishnan U, Lumsden A, Gilthorpe JD, Irving C. Lrrn1 is required for formation of the midbrain-hindbrain boundary and organiser through regulation of affinity differences between midbrain and hindbrain cells in chick. Dev Biol. 2011 Apr 15;352(2):341-52.
CopyrightCopyright © 2011 Elsevier Inc.
CommentsInsufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_001097539.1).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
7-12
stage 9
stage 9
stage 9
stage 11
stage 11
stage 11
Eye
Forebrain
Head Mesenchyme
Hindbrain
Midbrain
Neural Plate/Tube
Rhombomeres
Double labeled, FGF8 red, Lrrn1 blue.
13-18
stage 15
stage 15
stage 15
Eye
Hindbrain
Midbrain
Rhombomeres
Double labeled, :LFNG red, Lrrn1 blue
Double labeled, LFNG red, Lrrn1 blue
19-20
stage 20
stage 20
Eye
Midbrain
Neural Plate/Tube
 
 Data from NCBI Unigene EST Profile
Unigene ID: Gga.44964

Mouse

EmageMGI:106038
EurexpressMGI:106038
MGI GXDMGI:106038

Frog

Xenbase492889

Fruit Fly

BDGP

Zebra Finch

ZEBrA

Zebrafish

ZFINZDB-GENE-071126-1
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