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Gene Family QuickSearch
Human Disease Gene Search
MSX2 The human orthologue of this gene is associated
Gene Summary Expression Transcript Levels Other Species Expression JBrowse Gene Official Symbol MSX2 Official Full Name msh homeobox 2 CGNC ID 2130 also known as HOX-8, Msx-2, homeobox protein MSX-2|CHOX-8|GHox-8|homeobox protein Hox-8|homeobox-containing Hox-8|msh homeo box homolog 2|msh homeobox homolog 2, Homeobox protein MSX-2 , GHox-8, CHOX-8 gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Molecular Function sequence-specific DNA binding , sequence-specific DNA binding transcription factor activity , more... transcription cofactor activity , transcription factor binding , transcription regulatory region DNA binding Biological Process activation of meiosis , anagen , anterior/posterior pattern specification , more... BMP signaling pathway involved in heart development , bone trabecula formation , branching involved in mammary gland duct morphogenesis , cellular response to estradiol stimulus , cellular response to growth factor stimulus , chondrocyte development , embryonic forelimb morphogenesis , embryonic hindlimb morphogenesis , embryonic nail plate morphogenesis , enamel mineralization , endochondral bone growth , epithelial to mesenchymal transition involved in endocardial cushion formation , frontal suture morphogenesis , negative regulation of apoptotic process , negative regulation of cell proliferation , negative regulation of CREB transcription factor activity , negative regulation of fat cell differentiation , negative regulation of keratinocyte differentiation , negative regulation of transcription from RNA polymerase II promoter , negative regulation of transcription regulatory region DNA binding , osteoblast development , outflow tract septum morphogenesis , positive regulation of BMP signaling pathway , positive regulation of catagen , positive regulation of mesenchymal cell apoptotic process , positive regulation of osteoblast differentiation , signal transduction involved in regulation of gene expression , transcription, DNA-templated , wound healing, spreading of epidermal cells Cellular Component cytoplasm , nucleus , transcription factor complex
Links to other databases
Entry 1 GEISHA Id MSX2.UApcr Data Source GEISHA ISH Analysis Forward cDNA Template Primer CGAGGAGCACCACAAAGTCAAG Reverse cDNA Template Primer AATTAACCCTCACTAAAGGACAGGAGTAGCATAGAGTCCAACG cDNA Template Length 688 Forward cDNA Template Probe show TCCNGGGAAAATCACGGGCGGGAAGGAAGCACAGGTCTGTGNAAAGGGTAGGATGTTCCGTACAGTGAGGCGGCCTGGA
Entry 2 GEISHA Id MSX2.Fernández-Terán.2006 Data Source Publication Complete cDNA Template Probe show CGGCTCCGCAGCGCCTCACTCGCGCAGTCCCCGCGCAGGGCCGGGCAGAGGCGCACGCAGCTCCCCGGGCGGCCCCGCT
Citation Fernández-Terán MA, Hinchliffe JR, Ros MA. Birth and death of cells in limb development: a mapping study. Dev Dyn. 2006 Sep;235(9):2521-37. Copyright Copyright © 2006 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204559).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 20
stage 20
stage 21
stage 21
stage 22
stage 22
stage 23
stage 23
stage 24
stage 24
Leg Limb Buds Wing 25-30 stage 25
stage 25
stage 26
stage 26
stage 27
stage 27
stage 28
stage 28
stage 29
stage 29
stage 30
stage 30
Leg Limb Buds Wing 31-32 stage 31
stage 31
stage 32
stage 32
Leg Limb Buds Wing
Entry 3 GEISHA Id Msx2.Holleville.2007 Data Source Publication Complete cDNA Template Probe show CGGCTCCGCAGCGCCTCACTCGCGCAGTCCCCGCGCAGGGCCGGGCAGAGGCGCACGCAGCTCCCCGGGCGGCCCCGCT
Citation Holleville N, Matéos S, Bontoux M, Bollerot K, Monsoro-Burq AH. Dlx5 drives Runx2 expression and osteogenic differentiation in developing cranial suture mesenchyme. Dev Biol. 2007 Apr 15;304(2):860-74. Copyright Reprinted with permission from Elsevier.
Copyright © 2007 Elsevier B.V. All rights reserved. Comments Authors indicated the probe was described in Monsoro-Burq et al, 1995, who said: Msx2 specific fragment was
taken 3 to the homeobox as described in Takahashi et al.
(1990). As information provided is insufficient to verify exact sequence used to synthesize the probe, the sequence below was obtained from NCBI (Acc# NM_205488.1)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-38 stage 38
Face Mesenchyme
Entry 4 GEISHA Id MSX2.Gamer.2001 Data Source Publication Complete cDNA Template Probe show CGGCTCCGCAGCGCCTCACTCGCGCAGTCCCCGCGCAGGGCCGGGCAGAGGCGCACGCAGCTCCCCGGGCGGCCCCGCT
Citation Gamer LW, Cox KA, Small C, Rosen V (2001). Gdf11 is a negative regulator of chondrogenesis and myogenesis in the developing chick limb. Dev Biol. 2001 Jan 15;229(2):407-20. Copyright Copyright © 2000 Academic Press. All rights reserved.
Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204559).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 24
Wing
Entry 5 GEISHA Id MSX2.Basch.2006 Data Source Publication Complete cDNA Template Probe show CGGCTCCGCAGCGCCTCACTCGCGCAGTCCCCGCGCAGGGCCGGGCAGAGGCGCACGCAGCTCCCCGGGCGGCCCCGCT
Citation Basch ML, Bronner-Fraser M, García-Castro MI. Specification of the neural crest occurs during gastrulation and requires Pax7. Nature. 2006 May 11;441(7090):218-22. Copyright Copyright © 2006, Nature Publishing Group Comments Insufficient information provided in publication to verify exact sequence to synthesize probe. Sequence below was obtained from NCBI (NM_204559).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4-6 stage 6
stage 6
Neural Crest
Entry 6 Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 1-3 stage 1
31-35 stage 35
stage 35
stage 35
stage 35
Intermediate Mesoderm Unlabeled
Entry 7 GEISHA Id MSX2.Houweling.2002 Data Source Publication Complete cDNA Template Probe show CGGCTCCGCAGCGCCTCACTCGCGCAGTCCCCGCGCAGGGCCGGGCAGAGGCGCACGCAGCTCCCCGGGCGGCCCCGCT
Citation Houweling AC, Somi S, Van Den Hoff MJ, Moorman AF, Christoffels VM. Developmental pattern of ANF gene expression reveals a strict localization of cardiac chamber formation in chicken. Anat Rec. 2002 Feb 1;266(2):93-102. Copyright Copyright © 19992012 John Wiley & Sons, Inc. All Rights Reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_204559.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-30 stage 28
stage 28
stage 30
stage 30
Heart
Entry 8 GEISHA Id MSX2.Wade.2012 Data Source Publication Complete cDNA Template Probe show CGGCTCCGCAGCGCCTCACTCGCGCAGTCCCCGCGCAGGGCCGGGCAGAGGCGCACGCAGCTCCCCGGGCGGCCCCGCT
Citation Wade C, Brinas I, Welfare M, Wicking C, Farlie PG.
Twist2 contributes to termination of limb bud outgrowth and patterning through direct regulation of Grem1. Dev Biol. 2012 Oct 1;370(1):145-53.
Copyright Copyright © 2012 Elsevier Inc. All rights reserved Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_204559.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25 stage 25
stage 25
stage 25
Leg
Entry 9 GEISHA Id MSX2.Anderson.2022 Data Source Publication Complete cDNA Template Probe show GGGACGCGCACAGCCCCCCCGGGGCTCTTACAAAAACCTTCGACACCGCTTCGGTCAAATCGGAGAACTCGGAGGACGG
Citation Anderson C, Hill B, Lu HC, Moverley A, Yang Y, Oliveira NMM, Baldock RA, Stern CD. A 3D molecular atlas of the chick embryonic heart. Dev Biol. 2019 Dec 1;456(1):40-46. doi: 10.1016/j.ydbio.2019.07.003. Epub 2019 Jul 5. Copyright Copyright © 2019 Elsevier Inc. All rights reserved. Comments Images and probe sequence provided by Claire Anderson. The probe was synthesized from cDNA clone ChEST860d14. Related paper: Anderson C, Hill B, Lu HC, Moverley A, Yang Y, Oliveira NMM, Baldock RA, Stern CD. A 3D molecular atlas of the chick embryonic heart. Dev Biol. 2019 Dec 1;456(1):40-46. doi: 10.1016/j.ydbio.2019.07.003. Epub 2019 Jul 5.
Entry 10 GEISHA Id MSX2.Anderson.2019 Data Source Publication Complete cDNA Template Probe show GGGACGCGCACAGCCCCCCCGGGGCTCTTACAAAAACCTTCGACACCGCTTCGGTCAAATCGGAGAACTCGGAGGACGG
Citation Anderson C, Hill B, Lu HC, Moverley A, Yang Y, Oliveira NMM, Baldock RA, Stern CD. A 3D molecular atlas of the chick embryonic heart. Dev Biol. 2019 Dec 1;456(1):40-46. doi: 10.1016/j.ydbio.2019.07.003. Epub 2019 Jul 5. Copyright Copyright © 2019 Elsevier Inc. All rights reserved. Comments The complete cDNA template sequence was obtained from the information from the publication as described in Anderson et al. 2019.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-12 stage 12
stage 12
Outflow Tract
Data from NCBI Unigene EST ProfileGga.4977
Mouse Frog Fruit Fly Zebra Finch Zebrafish
