GEISHA - A Chicken Embryo Gene Expression Database
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MSTN
myostatin

The human orthologue of this gene is associated
with the following human disease:
Gene
Official SymbolMSTN
Official Full Namemyostatin
CGNC ID16892
also known asGDF-8, GDF8, growth/differentiation factor 8, MSTN, Myostatin
gene typeprotein-coding
Genomic Map
 Ensembl ID not known
NCBI
UCSC
Gallus-Browse
Sequence Information
Genomic
RNANM_001001461
PolypeptideNP_001001461
Sequence Clusters/ESTsUnigene
Gene Expression
In Situ HybridizationGEISHA
EST ProfileGga.560
Orthology
Entrez GeneEnsembl GeneGenetic PhenotypesMOD
Fruit Fly43811FBgn0026199
Human2660ENSG00000138379MIM:601788MIM:601788
Mouse17700ENSMUSG00000026100All phenotypic alleles (7):Spontaneous(1) Chemically induced(1) Targeted, knock-out(2) Targeted, other(3) MGI:95691
Xenopus100491923855712
Zebrafish798441, 445816ENSDARG00000069133, ENSDARG00000042947ZDB-GENE-990415-165, ZDB-GENE-050208-735ZFIN:ZDB-GENE-990415-165, ZFIN:ZDB-GENE-050208-735
Gene Ontology
Molecular Functioncytokine activity, growth factor activity, identical protein binding
Biological Processembryo development ending in birth or egg hatching, growth, more...positive regulation of transcription, DNA-templated, regulation of cell differentiation, regulation of growth, skeletal muscle tissue development, transforming growth factor beta receptor signaling pathway
Cellular Componentextracellular space
Links to other databases
Entrez Gene373964
Ensembl Gene
KEGGgga:373964

Entry 1

GEISHA IdMSTN.UApcrData SourceGEISHA ISH Analysis
Forward cDNA Template PrimerTTATAAAAGCTTGCGGCCGCAGAATATTGCCACAACCGAGACGATTATC
Reverse cDNA Template PrimerGCTCTAGAAATTAACCCTCACTAAAGGAGCCTCTGGGATTTGCTTGGcDNA Template Length668
Forward cDNA Template Probeshow
AAACAATCCTACGGAGTCTGATTTTCTTGTACAATGGAGGGAAAACCAAAATGTTCGCTTCTTTAAGTTTAGCTCTAAA
ATACAATATAACAAAGTAGTAAAGGCACAATTATGGATATACTTGAGGCAAGTCCAAAAACCTACAACGGTGTTTGTGC
AGATCCTGAGACTCATTAAGCCCATGAAAGACGGTACAAGATATACTGGAATTCGATCTTTGAAACTTGACATGAACCC
AGGCACTGGTATCTGGCAGAGTATTGATGTGAAGACAGTGCTGCAAAATTGGCTCAAACAGCCAGAATCCAATTTAGGC
ATCGAAATAAAAGCTTTTGATGAGACTGGACGAGATCTTGCTGTCACATTCCCAGGACCGGGTGAAGATGGATTGAACC
CATTTTTAGAGGTCAGAGTTACAGACACACCGAAACGGTCCCGCAGAGATTTTGGCCTTGACTGTGATGAGCACTCAAC
GGAATCCCGATGTTGTCGCTACCCGCTGACAGTGGATTTCGAAGCTTTTGGATGGGACTGGATTATAGCACCTAAAAGA
TACAAAGCCAATTACTGCTCCGGAGAATGCGAATTTGTGTTTCTACAGAAATACCCGCACACTCACCTGGTACACCAAG
CAAATCCCAGAGGCTCCTTTAGTGAGGGTTAATATCTAGAGCAAAA
Reverse cDNA Template Probeshow
TTGTACCAGGGTGAGTGTGCGGGTATTTCTGTAGAAACACAAATTCGCATTCTCCGGAGCAGTAATTGGCTTTGTATCT
TTTAGGTGCTATAATCCAGTCCCATCCAAAAGCTTCGAAATCCACTGTCAGCGGGTAGCGACAACATCGGGATTCCGTT
GAGTGCTCATCACAGTCAAGGCCAAAATCTCTGCGGGACCGTTTCGGTGTGTCTGTAACTCTGACCTCTAAAAATGGGT
TCAATCCATCTTCACCCGGTCCTGGGAATGTGACAGCAAGATCTCGTCCAGTCTCATCAAAAGCTTTTATTTCGATGCC
TAAATTGGATTCAGGCTGTTTGAGCCAATTTTGCAGCACTGTCTTCACATCAATACTCTGCCAGATACCAGTGCCTGGG
TTCATGTCAAGTTTCAAAGATCGAATTCCAGTATATCTTGTACCGTCTTTCATGGGCTTAATGAGTCTCAGGATCTGCA
CAAACACCGTTGTAGGTTTTTGGACTTGCCTCAAGTATATCCATAATTGTGCCTTTACTACTTTGTTATATTGTATTTT
AGAGCTAAACTTAAAGAAGCAACATTTTGGTTTTCCCTCCATTTGTACAAGAAAATCAGACTCCGTAGGCATTGTGATA
ATCGTCTCGGTTGTGGCAATATTCTGCGGCCGCAAGCTTTTATAAAAA
CommentsNo specific expression detected at or below stage 13.
no images

Entry 2

GEISHA IdMyostatin.Amthor.2002Data SourcePublication
Complete cDNA Template Probeshow
ATGCAAAAGCTAGCAGTCTATGTTTATATTTACCTGTTCATGCAGATCGCGGTTGATCCAGTGGCTCTGGATGGCAGTA
GTCAGCCCACAGAGAACGCTGAAAAAGACGGACTGTGCAATGCTTGTACGTGGAGACAGAATACAAAATCCTCCAGAAT
AGAAGCCATAAAAATTCAAATCCTCAGCAAACTGCGCCTGGAACAAGCACCTAACATTAGCAGGGACGTTATTAAGCAG
CTTTTACCCAAAGCTCCTCCACTGCAGGAACTGATTGATCAGTATGATGTCCAGAGGGACGACAGTAGCGATGGCTCTT
TGGAAGACGATGACTATCATGCCACAACCGAGACGATTATCACAATGCCTACGGAGTCTGATTTTCTTGTACAAATGGA
GGGAAAACCAAAATGTTGCTTCTTTAAGTTTAGCTCTAAAATACAATATAACAAAGTAGTAAAGGCACAATTATGGATA
TACTTGAGGCAAGTCCAAAAACCTACAACGGTGTTTGTGCAGATCCTGAGACTCATTAAGCCCATGAAAGACGGTACAA
GATATACTGGAATTCGATCTTTGAAACTTGACATGAACCCAGGCACTGGTATCTGGCAGAGTATTGATGTGAAGACAGT
GCTGCAAAATTGGCTCAAACAGCCTGAATCCAATTTAGGCATCGAAATAAAAGCTTTTGATGAGACTGGACGAGATCTT
GCTGTCACATTCCCAGGACCGGGTGAAGATGGATTGAACCCATTTTTAGAGGTCAGAGTTACAGACACACCGAAACGGT
CCCGCAGAGATTTTGGCCTTGACTGTGATGAGCACTCAACGGAATCCCGATGTTGTCGCTACCCGCTGACAGTGGATTT
CGAAGCTTTTGGATGGGACTGGATTATAGCACCTAAAAGATACAAAGCCAATTACTGCTCCGGAGAATGTGAATTTGTG
TTTCTACAGAAATACCCGCACACTCACCTGGTACACCAAGCAAATCCCAGAGGCTCAGCAGGCCCTTGCTGCACACCCA
CCAAGATGTCCCCTATAAACATGCTGTATTTCAATGGAAAAGAACAAATAATATATGGAAAGATACCAGCCATGGTTGT
AGATCGTTGCGGGTGCTCATGA
CitationAmthor H, Huang R, McKinnell I, Christ B, Kambadur R, Sharma M, Patel K. The regulation and action of myostatin as a negative regulator of muscle development during avian embryogenesis. Dev Biol. 2002 Nov 15;251(2):241-57.
Copyright"Reprinted from Dev Biol., 251(2), Amthor H, Huang R, McKinnell I, Christ B, Kambadur R, Sharma M, Patel K, The regulation and action of myostatin as a negative regulator of muscle development during avian embryogenesis, 241-57, Copyright (2002), with permission from Elsevier". Copyright © 2007 Elsevier B.V. All rights reserved.
CommentsAccording to the authors,"chick myostatin, 1-kb fragment was a kind gift from Professor Se Jin Lee;" As information provided wa insufficient to verify exact sequence used to synthesize probe, the sequence below was obtained form NCB1 (acc # NM_001001461).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
13-18
stage 15
stage 17
Pharyngeal Arches and Clefts
Somites
Tail
Tongue
19-24
stage 19
stage 20
stage 20
stage 20
stage 21
stage 21
stage 22
stage 22
stage 22
stage 22
stage 22
stage 22
stage 23
stage 23
Dermomyotome
Limb Buds
Myotome
Pharyngeal Arches and Clefts
Somites
Wing Muscles
Hypoglossal cord
Tongue
Tongue/Hypoglossal cord
hypoglossal cord
25-30
stage 25
stage 25
stage 25
stage 27
stage 28
stage 29
stage 30
Dermomyotome
Leg
Myotome
Somites
Wing
Wing Muscles
 
31-44
stage 31
stage 32
stage 32
stage 44
Wing
Wing Muscles
 
 Data from NCBI Unigene EST Profile
Unigene ID: Gga.560

Mouse

EmageMGI:95691
EurexpressMGI:95691
MGI GXDMGI:95691

Frog

Xenbase855712

Fruit Fly

BDGPFBgn0026199

Zebra Finch

ZEBrA

Zebrafish

ZFINZDB-GENE-990415-165, ZDB-GENE-050208-735
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