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Human Disease Gene Search
CDH2 Gene Summary Expression Transcript Levels Other Species Expression JBrowse Gene Official Symbol CDH2 Official Full Name cadherin 2 CGNC ID 11259 also known as cadherin-2, cadherin-2|N-cadherin|cadherin 2, type 1, N-cadherin (neuronal)|neural cadherin|neural calcium-dependent cell adhesion molecule, Neural-cadherin precursor, N-cadherin, Cadherin-2 gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Molecular Function alpha-catenin binding , calcium ion binding , extracellular matrix binding , gamma-catenin binding , more... protein binding , protein phosphatase binding Biological Process blood vessel morphogenesis , calcium-dependent cell-cell adhesion , cartilage condensation , cell adhesion , more... cell migration , heterophilic cell-cell adhesion , homophilic cell adhesion , limb development , negative regulation of canonical Wnt signaling pathway , positive regulation of MAPK cascade , striated muscle cell differentiation Cellular Component adherens junction , apical plasma membrane , catenin complex , fascia adherens , integral component of membrane , more... lamellipodium , synapse
Links to other databases
Entry 1 GEISHA Id I17 Data Source GEISHA ISH Analysis Forward cDNA Template Probe show GACTTACTGTAGCTGCAGAAAATCAAGTGCCTTTGGCTAAGGGGATTCAGCATCCTCCTCAGTCAACAGCAACCGTGTC
Entry 2 GEISHA Id CDH2.UApcr Data Source GEISHA ISH Analysis Forward cDNA Template Primer TTATAAAAGCTTGCGGCCGCAGAATATTGACAACTTTCACTGCT Reverse cDNA Template Primer GCTCTAGAAATTAACCCTCACTAAAGGTAAGAGGGAATCGTAT cDNA Template Length 1068 Complete cDNA Template Probe show TTTTTTAAAAAATTTGGCCACCATTGATTTCATGCAGGGACCCAAACTACTCAGAAGTTTTTAGCTAAAATTTCGGACC
Entry 3 GEISHA Id N-Cad.Jiankai.2007 Data Source Publication Complete cDNA Template Probe show GGGGGCCGCCCCGCCGCCGCCCCTCCTCGCCTCCATGTGCCGGATAGCGGGAACGCCGCCGCGGATCCTGCCGCCGCTG
Citation Luo J, Wang H, Lin J, Redies C. Cadherin expression in the developing chicken cochlea. Dev Dyn. 2007 Aug;236(8):2331-7. Copyright Copyright © 2007 Wiley-Liss, Inc. Comments Authors indicate: ""For in situ hybridization, purified plasmids containing the full-length sequences encoding chicken Cad6B, Cad7, N-Cad, and R-Cad (kind gifts of Dr. S. Nakagawa and Dr. M. Takeichi), ... were used as templates for the in vitro synthesis of cRNA probes." Sequence below was obtained from NCBI (NM_001001615).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-44 stage 37
stage 40
stage 44
Ear/Otic Placcode
Entry 4 GEISHA Id N-Cadherin.Matsumata.2005 Data Source Publication Complete cDNA Template Probe show GGGGGCCGCCCCGCCGCCGCCCCTCCTCGCCTCCATGTGCCGGATAGCGGGAACGCCGCCGCGGATCCTGCCGCCGCTG
Citation Matsumata M, Uchikawa M, Kamachi Y, Kondoh H. Multiple N-cadherin enhancers identified by systematic functional screening indicate its Group B1 SOX-dependent regulation in neural and placodal development. Dev Biol. 2005 Oct 15;286(2):601-17. Epub 2005 Sep 16. Copyright Copyright © 2005 Elsevier Inc. All rights reserved. Comments According to the authors, "The N-cadherin probe was a 5′ fragment of the cDNA (positions 1845; DDBJ database accession number X07277)."
Entry 5 GEISHA Id Ncadherin.Garcia-Castro.2000 Data Source Publication Complete cDNA Template Probe show GGGGGCCGCCCCGCCGCCGCCCCTCCTCGCCTCCATGTGCCGGATAGCGGGAACGCCGCCGCGGATCCTGCCGCCGCTG
Citation García-Castro MI, Vielmetter E, Bronner-Fraser M. N-Cadherin, a cell adhesion molecule involved in establishment of embryonic left-right asymmetry. Science. 2000 May 12;288(5468):1047-51. Copyright Copyright © 2000, The American Association for the Advancement of Science Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_001001615).
Entry 6 GEISHA Id CDH2.Hardy.2011 Data Source Publication Complete cDNA Template Probe show TTTTTTAAAAAATTTGGCCACCATTGATTTCATGCAGGGACCCAAACTACTCAGAAGTTTTTAGCTAAAATTTCGGACC
Citation Hardy KM, Yatskievych TA, Konieczka J, Bobbs AS, Antin PB. FGF signalling through RAS/MAPK and PI3K pathways regulates cell movement and gene expression in the chicken primitive streak without affecting E-cadherin expression. BMC Dev Biol. 2011 Mar 21;11:20.
Copyright © 2011 Hardy et al; licensee BioMed Central Ltd.
Entry 7 GEISHA Id CDH2.Yan.2011 Data Source Publication Complete cDNA Template Probe show GGGGGCCGCCCCGCCGCCGCCCCTCCTCGCCTCCATGTGCCGGATAGCGGGAACGCCGCCGCGGATCCTGCCGCCGCTG
Citation Yan X, Lin J, Rolfs A, Luo J. Differential expression of the ADAMs in developing chicken retina. Dev Growth Differ. 2011 Jun;53(5):726-39. Copyright copyright 2011 The Authors Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_001001615).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-35 stage 35
stage 35
Retina
Entry 8 GEISHA Id NCDH.Lin.2010 Data Source Publication Complete cDNA Template Probe show GGGGGCCGCCCCGCCGCCGCCCCTCCTCGCCTCCATGTGCCGGATAGCGGGAACGCCGCCGCGGATCCTGCCGCCGCTG
Citation Lin J, Luo J, Redies C. Molecular characterization and expression analysis of ADAM12 during chicken embryonic development. Dev Growth Differ. 2010 Dec;52(9):757-69. Copyright © 2010 The Authors. Journal compilation © 2010 Japanese Society of Developmental Biologists. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_001001615).
Entry 9 GEISHA Id CDH2.Bell.2004 Data Source Publication Complete cDNA Template Probe show GGGGGCCGCCCCGCCGCCGCCCCTCCTCGCCTCCATGTGCCGGATAGCGGGAACGCCGCCGCGGATCCTGCCGCCGCTG
Citation Bell GW, Yatskievych TA, Antin PB. GEISHA, a whole-mount in situ hybridization gene expression screen in chicken embryos. Dev Dyn. 2004 Mar;229(3):677-87. Copyright Copyright © 2004 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe from Geisha I17. Sequence below was obtained from NCBI (Acc. # NM_001001615).
Entry 10 GEISHA Id N-CADHERIN.Dady.2012 Data Source Publication Complete cDNA Template Probe show GGGGGCCGCCCCGCCGCCGCCCCTCCTCGCCTCCATGTGCCGGATAGCGGGAACGCCGCCGCGGATCCTGCCGCCGCTG
Citation Dady A, Blavet C, Duband JL Timing and kinetics of E- to N-cadherin switch during neurulation in the avian embryo DEVELOPMENTAL DYNAMICS. Volume 241, Issue 8, August 2012, Pages: 13331349. Copyright Copyright © 2012 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_001001615.1).
Entry 11 GEISHA Id NCADHERIN.Blackmore.2006 Data Source Publication Complete cDNA Template Probe show GGGGGCCGCCCCGCCGCCGCCCCTCCTCGCCTCCATGTGCCGGATAGCGGGAACGCCGCCGCGGATCCTGCCGCCGCTG
Citation Blackmore M, Letourneau PC. L1, beta1 integrin, and cadherins mediate axonal regeneration in the embryonic spinal cord. J Neurobiol. 2006 Dec;66(14):1564-83. Copyright copyright 2006 Wiley Periodicals, Inc. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_001001615.1
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-42 stage 35
stage 42
stage 42
Spinal Cord
Entry 12 GEISHA Id NCDH.Lin.2012B Data Source Publication Complete cDNA Template Probe show TTTTTTAAAAAATTTGGCCACCATTGATTTCATGCAGGGACCCAAACTACTCAGAAGTTTTTAGCTAAAATTTCGGACC
Citation Lin J, Redies C. Histological evidence: housekeeping genes beta-actin and GAPDH are of limited value for normalization of gene expression. Dev Genes Evol. 2012 Copyright © Springer-Verlag Berlin Heidelberg 2012 Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # NM_001001615).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-36 stage 36
stage 36
Heart
Data from NCBI Unigene EST ProfileGga.1917
Mouse Frog Fruit Fly Zebra Finch Zebrafish
